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109 WITHDRAWN:Â Elevated Nitric Oxide Drives Diastolic Dysfuction; Regulation by Caveolae Proteins
S85
Abstracts
criteria and LVH on TTE (p-value 0.018). The sensitivity of ECG for detecting LVH was 47.1% and the specificity was 93.3%.
https://doi.org/10.1016/j.hlc.2020.09.114 108
21 Patients commenced to low dose (24/26mg BD). Of these, 4 patients tolerated only the low dose, 7 titrated to 49/51mg BD (mean time to dose- 78 days). 10 patients titrated 97/ 103mg BD (mean time to dose 82 days). 34 Patients commenced on medium dose (49/51mg BD) with 3 remaining on this dose. 31 patients titrated to maximum dose 97/103mg BD (mean time of 67days). 1 Patient was converted to maximum dose at initiation of conversion. The mean ejection fraction was 27% (n=60, range 10-35%) At 3 months mean EF was 36% (n=39, range 13-60%). Conclusion: Conversion to ENTRESTO was straight forward with high rates, however extended titration resulted from constraints in CNS time and clinical response. Improved awareness across the healthcare network about ENTRESTO should allow primary care to safely undertake initiation and titration with support from the Heart Function team
This abstract has been withdrawn
https://doi.org/10.1016/j.hlc.2020.09.117
https://doi.org/10.1016/j.hlc.2020.09.115
111
109
Epicardial Echocardiography in a Novel Ovine Model of Cardiopulmonary Failure
WITHDRAWN: Elevated Nitric Oxide Drives Diastolic Dysfuction; Regulation by Caveolae Proteins
K. Sato 1,2,*, S. Heinsar 1, S. Rozencwajg 5, S. Colombo 1,6, K. Wildi 1, J. Jung 1,7, C. Ainola 1, X. Wang 1, G. Abbate 1, N. Sato 1, J. Reid 1, M. Bouquet 1, V. Lo Cocco 8, E. Wood 1, J. Suen 1, A. Combes 5, R. Lorusso 8, A. Pesenti 6, G. Li Bassi 1,2, J. Chan 3,4, J. Fraser 1,2
This abstract has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/ article-withdrawal. https://doi.org/10.1016/j.hlc.2020.09.116
110 ENTRESTO (Salcubitril/Valsartan) Conversion Outcomes at NMDHB P. Peacock *, T. Pegg Nelson Marlborough Health, Nelson, New Zealand Background: ENTRESTO became available for Heart Failure reduced Ejection Fraction management in New Zealand from 1/10/2018. The identification, conversion and titration of ENTRESTO was led by CNS Heart Function within NMDHB. Method: A retrospective evaluation of ENTRESTO titration timelines with analysis of Ejection Fraction outcomes from 1/10/2018 to 30/9/2019. Results: 60 patients identified as suitable for ENTRESTO. There were 56 tolerated conversions with 4 withdrawals (1 death, 1 deterioration Renal function, 1 intolerance, 1 selfwithdrawal of all medications). There was only 1 significant adverse event relating to co prescription of ACE inhibitor after a discharge from hospital.
1 Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia 2 School of Medicine, University of Queensland, Brisbane, Australia 3 Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia 4 School of Medicine, Griffith University, Gold Coast, Australia 5 Institute of Cardiometabolism and Nutrition, Sorbonne Université, UPMC Univ Paris 06, Paris, France 6 Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy 7 Department of Thoracic & Cardiovascular Surgery, Korea University, Seoul, Republic of Korea 8 Cardio-Thoracic Surgery Department, Maastricht University Medical Centre, Maastricht, Netherlands
We aimed to evaluate cardiac function by trans-epicardial echocardiography in a pioneering ovine model of severe cardiopulmonary failure (CPF). Six healthy female sheep (weight 6166.5 kg) were anesthetized, tracheally intubated and mechanically ventilated. An arterial catheter was placed for blood sampling and pressure monitoring. Left femoral artery and right jugular vein were cannulated and veno-arterial extracorporeal membrane oxygenation support commenced at a rate of 1.5760.60 L/min. A left mini-thoracotomy was performed to access the pericardial sac. Heart failure was developed through intra-myocardial ethanol injections in the left
Abstracts
criteria and LVH on TTE (p-value 0.018). The sensitivity of ECG for detecting LVH was 47.1% and the specificity was 93.3%.
https://doi.org/10.1016/j.hlc.2020.09.114 108
21 Patients commenced to low dose (24/26mg BD). Of these, 4 patients tolerated only the low dose, 7 titrated to 49/51mg BD (mean time to dose- 78 days). 10 patients titrated 97/ 103mg BD (mean time to dose 82 days). 34 Patients commenced on medium dose (49/51mg BD) with 3 remaining on this dose. 31 patients titrated to maximum dose 97/103mg BD (mean time of 67days). 1 Patient was converted to maximum dose at initiation of conversion. The mean ejection fraction was 27% (n=60, range 10-35%) At 3 months mean EF was 36% (n=39, range 13-60%). Conclusion: Conversion to ENTRESTO was straight forward with high rates, however extended titration resulted from constraints in CNS time and clinical response. Improved awareness across the healthcare network about ENTRESTO should allow primary care to safely undertake initiation and titration with support from the Heart Function team
This abstract has been withdrawn
https://doi.org/10.1016/j.hlc.2020.09.117
https://doi.org/10.1016/j.hlc.2020.09.115
111
109
Epicardial Echocardiography in a Novel Ovine Model of Cardiopulmonary Failure
WITHDRAWN: Elevated Nitric Oxide Drives Diastolic Dysfuction; Regulation by Caveolae Proteins
K. Sato 1,2,*, S. Heinsar 1, S. Rozencwajg 5, S. Colombo 1,6, K. Wildi 1, J. Jung 1,7, C. Ainola 1, X. Wang 1, G. Abbate 1, N. Sato 1, J. Reid 1, M. Bouquet 1, V. Lo Cocco 8, E. Wood 1, J. Suen 1, A. Combes 5, R. Lorusso 8, A. Pesenti 6, G. Li Bassi 1,2, J. Chan 3,4, J. Fraser 1,2
This abstract has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/ article-withdrawal. https://doi.org/10.1016/j.hlc.2020.09.116
110 ENTRESTO (Salcubitril/Valsartan) Conversion Outcomes at NMDHB P. Peacock *, T. Pegg Nelson Marlborough Health, Nelson, New Zealand Background: ENTRESTO became available for Heart Failure reduced Ejection Fraction management in New Zealand from 1/10/2018. The identification, conversion and titration of ENTRESTO was led by CNS Heart Function within NMDHB. Method: A retrospective evaluation of ENTRESTO titration timelines with analysis of Ejection Fraction outcomes from 1/10/2018 to 30/9/2019. Results: 60 patients identified as suitable for ENTRESTO. There were 56 tolerated conversions with 4 withdrawals (1 death, 1 deterioration Renal function, 1 intolerance, 1 selfwithdrawal of all medications). There was only 1 significant adverse event relating to co prescription of ACE inhibitor after a discharge from hospital.
1 Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia 2 School of Medicine, University of Queensland, Brisbane, Australia 3 Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia 4 School of Medicine, Griffith University, Gold Coast, Australia 5 Institute of Cardiometabolism and Nutrition, Sorbonne Université, UPMC Univ Paris 06, Paris, France 6 Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy 7 Department of Thoracic & Cardiovascular Surgery, Korea University, Seoul, Republic of Korea 8 Cardio-Thoracic Surgery Department, Maastricht University Medical Centre, Maastricht, Netherlands
We aimed to evaluate cardiac function by trans-epicardial echocardiography in a pioneering ovine model of severe cardiopulmonary failure (CPF). Six healthy female sheep (weight 6166.5 kg) were anesthetized, tracheally intubated and mechanically ventilated. An arterial catheter was placed for blood sampling and pressure monitoring. Left femoral artery and right jugular vein were cannulated and veno-arterial extracorporeal membrane oxygenation support commenced at a rate of 1.5760.60 L/min. A left mini-thoracotomy was performed to access the pericardial sac. Heart failure was developed through intra-myocardial ethanol injections in the left