- Email: [email protected]
110 TISSUE SAMPLING IS NOT ADEQUATE IN THE DETECTION OF PROSTATE CANCER IN TRANSITION ZONE
JHQHUDWHDQRPRJUDPWKDWSUHGLFWVWKHSUREDELOLW\RI(&(DWUDGLFDOSURVWDWHFWRP\ 5HFHLYHURSHUDWLQJFKDUDFWHULVWLF 52& DQDO\VHVZHUHDOVRSHUIRUPHGWRDVVHVV WKH SUHGLFWLYH YDOXH RI HDFK YDULDEOH DORQH DQG LQ FRPELQDWLRQ $GGLWLRQDOO\ WKH LQWHUQDOYDOLGDWLRQZDVFDOFXODWHGIURPERRWVWUDSUHVDPSOHಬVWRUHGXFHRYHUᚏW ELDV Results: 2YHUDOO SDWLHQWV KDG (&( $JH 36$ ELRSV\ *OHDVRQ VFRUH SRVLWLYH FRUH UDWLR DQG PD[LPXP RI ELRSV\ WXPRXU ZHUH REVHUYHG WR EH LQGHSHQGHQW SUHGLFWRUV RI WKH SUHVHQFH RI (&( DOO S YDOXHV 7KH QRPRJUDP SUHGLFWHG (&( ZLWK JRRG GLVFULPLQDWLRQ DQ DUHD XQGHU WKH UHFHLYHU RSHUDWLQJFKDUDFWHULVWLFFXUYHRI 7KHUHVXOWLQJQRPRJUDPVZHUHLQWHUQDOO\ YDOLGDWHGDQGFDOLEUDWLRQVKRZHGH[FHOOHQWSUHGLFWHGSUREDELOLW\ Conclusions: 2XUQRPRJUDPDOORZVIRUWKHSUHRSHUDWLYHLGHQWLᚏFDWLRQRISDWLHQWV ZLWKDQ(&(LQSURVWDWHFDQFHUDQGLWPD\DOVRSURYHXVHIXOLQVHOHFWLQJSDWLHQWVWR UHFHLYHQHUYHVSDULQJUDGLFDOSURVWDWHFWRP\
108
TEMPLATE TRANSPERINEAL PROSTATE MAPPING BIOPSIES FOR PROSTATE CANCER RISK STRATIFICATION AND CANCER LOCALIZATION
6LQJK3%$KPHG+86WHYHQV'*XUXQJ3)UHHPDQ$(PEHUWRQ0 1 University College London, Dept. of Surgery and Interventional Sciences, London, United Kingdom, 2University College London Hospitals Nhs Trust, Dept. of Histopathology, London, United Kingdom Introduction & Objectives: 0HQZLWKDSURVWDWHFDQFHUGLDJQRVLVZKRDUHVXLWDEOH IRU DFWLYH VXUYHLOODQFH UHTXLUH DFFXUDWH ULVN VWUDWLᚏFDWLRQ 7HPSODWH WUDQVSHULQHDO SURVWDWHPDSSLQJ 730 ELRSVLHVPD\VHUYHWKLVSXUSRVH Material & Methods: PHQXQGHUZHQWWHPSODWHELRSVLHVEHWZHHQDQG RIWKHVHPHQKDG730DVDFRQVHTXHQFHRIUHFODVVLᚏFDWLRQUHTXLUHPHQW LQ WKH FRQWH[W RI D SULRU QHJDWLYH 7586 ELRSV\ Q RU ORZLQWHUPHGLDWH ULVN SURVWDWH FDQFHU Q 730 ZHUH FRQGXFWHG WR D PP VDPSOLQJ IUDPH UHIHUHQFHG WR D JULG ZLWK DSLFDO DQG EDVDO QHHGOH GHSOR\PHQWV WR VDPSOH WKH = D[LV 7KH SURFHGXUH ZDV SHUIRUPHG LQ DQ DPEXODWRU\ FDUH VHWWLQJ XVLQJ HLWKHU UHJLRQDORUJHQHUDODQDHVWKHVLD Results: 0HDQDJHZDV\HDUV UDQJH \ DQGPHDQ36$QJPO UDQJH 1XPEHURIELRSV\FRUHVWDNHQDW7586DQGSURVWDWHPDSSLQJZDVPHDQ UDQJH DQG UDQJH UHVSHFWLYHO\6LGHHᚎHFWVDWWULEXWHGWR730 LQFOXGHG PLOGHFFK\PRVHVLQDOOSDWLHQWVXULQDU\UHWHQWLRQKDHPDWXULD UHTXLULQJDGPLVVLRQ1RHSLVRGHVRIVHSVLVZHUHUHFRUGHG*OHDVRQXSJUDGLQJRQ SURVWDWHPDSSLQJRFFXUUHGLQ RIWKRVHZLWK*OHDVRQVFRUHFDQFHURQWKH RULJLQDO7586ELRSVLHV7ZRWKLUGVRIWKRVHZLWKXQLODWHUDOFDQFHURQ7586KDG ELODWHUDOGLVHDVHRQWHPSODWHPDSSLQJ Conclusions: 3URVWDWHPDSSLQJJLYHVSUHFLVHULVNVWUDWLᚏFDWLRQZLWKORZPRUELGLW\ 7KHVHRXWFRPHVKDYHLPSOLFDWLRQVIRUXVLQJGLDJQRVWLF7586ELRSV\WRGHFLGHRQ DFWLYH VXUYHLOODQFH RYHU DFWLYH WKHUDS\ $OWKRXJK WKH XSIURQW KHDOWKFDUH EXUGHQ DQGFRVWLVVLJQLᚏFDQWWKHJUHDWHUSUHFLVLRQPRUHDFFXUDWHULVNVWUDWLᚏFDWLRQDQG ZLWKWLPHPRUHDSSURSULDWHWUHDWPHQWDOORFDWLRQPD\LQGLFDWHWKDWWKHRYHUDOOFRVWV RILOOQHVVDUHUHGXFHG
109
VALUE OF REAL-TIME ELASTOGRAPHY TARGETED AND SYSTEMATIC TRANSRECTAL ULTRASOUND-GUIDED BIOPSY FOR PROSTATE CANCER DETECTION
9RLJW6*ULPP02:LUWK03 Technical University of Dresden, Dept. of Urology, Dresden, Germany Introduction & Objectives: :HSHUIRUPHGWKLVSURVSHFWLYHVWXG\WRVHHZKHWKHU FRPELQLQJUHDOWLPHHODVWRJUDSK\WDUJHWHGDQGV\VWHPDWLFWUDQVUHFWDOXOWUDVRXQG JXLGHG 7586 ELRSV\FDQLPSURYHSURVWDWHFDQFHUGHWHFWLRQDQGWRDVVHVVWKH YDOXHRIHODVWRJUDSK\WDUJHWHGELRSV\DORQH Material & Methods: %HWZHHQ-XQHDQG0D\ SDWLHQWVXQGHUZHQW 7586ELRSV\DQGHODVWRJUDSK\$OOH[DPLQDWLRQDQGELRSVLHVZHUHFDUULHGRXWZLWK WKH (%8+9 +LWDFKL PHGLFDO 7KH PHGLDQ QXPEHU RI V\VWHPDWLF ELRSVLHV ZDV 7KHPHGLDQQXPEHURIDGGLWLRQDOHODVWRJUDSK\WDUJHWHGELRSVLHV WDNHQIURPVXVSLFLRXVDUHDVZDV
Results: 0HDQ DJH ZDV \HDUV 0HDQ 36$ ZDV QJPO ,Q FDVHV ZH KDG VXVSLFLRXV ᚏQGLQJV LQ WKH GLJLWDO UHFWDO H[DPLQDWLRQ ,QFDVHVWKHUHZDVDWOHDVWRQH PHDQ SULRUELRSV\RIWKHSURVWDWH ,Q FDVHV SURVWDWH FDQFHU ZDV KLVWRORJLFDOO\ FRQᚏUPHG 7KHUHE\ FDQFHU ZDV IRXQGLQ RIWKHV\VWHPDWLFFRUHVDQGLQ RIWKH HODVWRJUDSK\ WDUJHWHG FRUHV &DQFHU ZDV GLDJQRVHG LQ FDVHV E\V\VWHPDWLFELRSV\ RQO\DQGLQ FDVHVE\HODVWRJUDSK\ WDUJHWHG ELRSV\RQO\,Q FDVHVFDQFHUZDVIRXQGSDUDOOHOLQELRSVLHVRIERWK PHWKRGV ᚏJXUH Conclusions: &RPSDULQJ ERWK PHWKRGV WKHUH LV QR VWDWLVWLFDO GLᚎHUHQFH IRU SURVWDWHFDQFHUGHWHFWLRQ+RZHYHUPRVWRIWKHFDVHVZLWKSURVWDWHFDQFHUZHUH GHWHFWHGE\V\VWHPDWLFELRSV\$OWKRXJKZHGLDJQRVHGDGGLWLRQDOFDUFLQRPDVLW LVQRW\HWSRVVLEOHWRVWDWLVWLFDOO\GHPRQVWUDWHWKDWFRPELQLQJV\VWHPDWLF7586DQG HODVWRJUDSK\WDUJHWHGELRSV\FDQLPSURYHFDQFHUGHWHFWLRQ
110
TISSUE SAMPLING IS NOT ADEQUATE IN THE DETECTION OF PROSTATE CANCER IN TRANSITION ZONE
'RJDQ%6HUHIRJOX(&$WPDFD$)&DQGD$($NEXOXW=%DOED\0' Ankara Atatürk Training and Research Hospital, Dept. of 1st Urology, Ankara, Turkey Introduction & Objectives: 7RDVVHVVLIWUDQVLWLRQDO]RQHVDPSOLQJRIWKHSURVWDWH LVQHFHVVDU\GXULQJUHSHDWSURVWDWHELRSV\ 3%[ SURFHGXUHV Material & Methods: %HWZHHQ $SULO -XO\ SDWLHQWV ZKR XQGHUZHQW WUDQVXUHWKUDO UHVHFWLRQ RIWKHSURVWDWH 7853 DQG ZKR KDG SULRU QHJDWLYH 3%[ UHVXOWVZHUHUHWURVSHFWLYHO\HYDOXDWHG5HVXOWVRIKLVWRSDWKRORJLFDOHYDOXDWLRQVRI VXUJLFDOVSHFLPHQVDQGFDQFHUGHWHFWLRQUDWHVZHUHDVVHVVHG Results: $WRWDORISDWLHQWVXQGHUZHQW7853DQGKDGDWOHDVWQHJDWLYH3%[ 2YHUDOO ELRSV\ SURFHGXUHV ZHUH SHUIRUPHG KDG RQO\ RQH KDG WZR KDG WKUHH DQG KDG IRXU 3%[ 7UDQVLWLRQDO ]RQH VDPSOLQJ ZDV SHUIRUPHG LQ 3%[ SHUIRUPHG RQ SDWLHQWV DQG SURVWDWH FDQFHU 3&D ZDV GHWHFWHG LQ WKH VXUJLFDO VSHFLPHQ RI RQH SDWLHQW 7UDQVLWLRQDO ]RQH VDPSOLQJ ZDV QRW LQFOXGHGLQSURVWDWHELRSVLHV SHUIRUPHGRQSDWLHQWV DQG3&DZDVGHWHFWHG LQWKHVXUJLFDOVSHFLPHQRISDWLHQWV 0HDQSDWLHQWDJHZDV\HDUV PHDQ VHUXP SURVWDWH VSHFLᚏF DQWLJHQ 36$ ZDV QJP/ PHDQ SURVWDWH YROXPHZDVFF3DWKRORJ\UHVXOWVRIWKH3%[ZHUHDVIROORZV EHQLJQ LQᚐDPPDWLRQ KLJKJUDGH SURVWDWLF LQWUDHSLWKHOLDO QHRSODVLD +*3,1 3&D 3DWKRORJ\UHVXOWVRIWKH7853SURFHGXUHVZHUHDVIROORZV EHQLJQ LQᚐDPPDWLRQ +*3,1 3&D Conclusions: 6LQFH WKHUH ZDV QR VLJQLᚏFDQW GLᚎHUHQFH EHWZHHQ SDWLHQW JURXSV ZLWK RU ZLWKRXW WUDQVLWLRQDO ]RQH ELRSVLHV LQ GHWHFWLRQ RI 3&D LQ WUDQVLWLRQ ]RQH VWUDWHJLHVLQFOXGLQJLQFUHDVLQJQXPEHURIFDVHVWREHWDNHQIURPWUDQVLWLRQ]RQHRI WKHSURVWDWHVKRXOGEHFRQVLGHUHG
111
FRACTAL DIMENSION AS A NOVEL MEASURE OF PROSTATE CANCER GRADING
:DOLV]HZVNL3$EX(LG5.ULEXV66FKDIKDXVHU:6WHQ]O$ 1 St. Elisabeth Klinikum, Dept. of Urology, Straubing, Germany, 2University of Aberdeen, School of Dentistry, Aberdeen, United Kingdom, 3Pathology Office, Dept. of Pathology, Hof, Germany, 4Prostate Cancer Center, Dept. of Urology, Marktredwitz, Germany, 5Eberhard-Karls University of Tübingen, Dept. of Urology, Tübingen, Germany Introduction & Objectives: %RWKGLᚎHUHQWLDWLRQRISURVWDWHFDQFHUFHOOVDQGWKHLU RUJDQL]DWLRQ LQWR WLVVXH VWUXFWXUHV RI WKH KLJKHU RUGHU VXFK DV JODQGV LV VFRUHG DFFRUGLQJ WR WKH VXEMHFWLYH *OHDVRQ V\VWHP 7KHUH LV D QHHG IRU DQ REMHFWLYH PHDVXUHRIWXPRXUJUDGLQJ Material & Methods: 7RUHDFKWKDWJRDODVSDWLDOGLVWULEXWLRQRIDVHWRIQRUPDORU FDQFHUFHOOQXFOHLDVZHOODVVRPHJHRPHWULFDOIHDWXUHVRIVLQJOHFHOOVVXFKDVWKH DUHDSHULPHWHU GLPHQVLRQ WKHLU VSDWLDO IUDFWDO GLPHQVLRQ FHOO DUHD )HUHW DQJOH FHOO EUHDGWK FRQYH[LW\ DQG VSKHULFLW\ ZHUH LQYHVWLJDWHG LQ WKH WZR GLPHQVLRQDO WLVVXHVOLGHVVWDLQHGZLWKKDHPDWR[\OLQHRVLQDIWHUDSSO\LQJDFRORXUGHFRQYROXWLRQ DOJRULWKP'HᚏQLHQV7LVVXH0DSZDVXVHGIRUWKHDXWRPDWLFLGHQWLᚏFDWLRQRI FHOOQXFOHL)UDFWDODQDO\VLVZDVGRQHZLWK%HQRLWDQG,PDJH-T Results: $ JHRPHWULFDO REMHFW SRVVHVVHV IUDFWDO VWUXFWXUH LI WKHUH LV D OLQHDU UHODWLRQVKLS EHWZHHQ WKH ORJDULWKP RI D ER[ VL]H DQG WKH ORJDULWKP RI D QXPEHU RI WKH ER[HV FRYHULQJ WKDW REMHFW 6XFK WKH OLQHDU UHODWLRQVKLS ZDV IRXQG LQ DOO FDVHVDQDO\]HG7KHVSDWLDOIUDFWDOGLPHQVLRQIRUWKHQRUPDODSSHDULQJSURVWDWH WLVVXHLV Q IRUWKH*OHDVRQSDWWHUQ Q IRUWKH *OHDVRQSDWWHUQ Q DQGIRUWKH*OHDVRQSDWWHUQ Q ,QDGGLWLRQGLᚎHUHQWDUHDVRIWKHVDPHWXPRXUSRVVHVVHGDVLPLODUYDOXH RIWKHVSDWLDOIUDFWDOGLPHQVLRQ7KHUHLVQRVWDWLVWLFDOO\VLJQLᚏFDQWGLᚎHUHQFHLQWKH DUHDSHULPHWHU GLPHQVLRQ EHWZHHQ WKH QRUPDO FHOO QXFOHL DQG FDQFHU FHOO QXFOHL RI DOO *OHDVRQ SDWWHUQV VWXGLHG :LWK UHJDUGV WR WKH PRUSKRPHWULF FHOO DQDO\VLV WKH PLQLPDO FHOO UDGLXV DVSHFW UDWLR FHOO URXQGQHVV DQG FRPSDFWQHVV ZHUH DOO VWDWLVWLFDOO\GLᚎHUHQWDFURVVDOO*OHDVRQVFRUHFDVHV $129$S 6SKHULFLW\ VROLGLW\ VKDSH DQG FLUFXODULW\ ZHUH VWDWLVWLFDOO\ GLᚎHUHQW EHWZHHQ FDVHV ZLWK *OHDVRQVFRUHDQGWKRVHZLWKDVFRUHRIDQG $129$S +RZHYHU WKHVHSDUDPHWHUVZHUHQRWGLᚎHUHQWEHWZHHQFDVHVZLWKD*OHDVRQVFRUHRIDQG
Eur Urol Suppl 2010;9(2):67
108
TEMPLATE TRANSPERINEAL PROSTATE MAPPING BIOPSIES FOR PROSTATE CANCER RISK STRATIFICATION AND CANCER LOCALIZATION
6LQJK3%$KPHG+86WHYHQV'*XUXQJ3)UHHPDQ$(PEHUWRQ0 1 University College London, Dept. of Surgery and Interventional Sciences, London, United Kingdom, 2University College London Hospitals Nhs Trust, Dept. of Histopathology, London, United Kingdom Introduction & Objectives: 0HQZLWKDSURVWDWHFDQFHUGLDJQRVLVZKRDUHVXLWDEOH IRU DFWLYH VXUYHLOODQFH UHTXLUH DFFXUDWH ULVN VWUDWLᚏFDWLRQ 7HPSODWH WUDQVSHULQHDO SURVWDWHPDSSLQJ 730 ELRSVLHVPD\VHUYHWKLVSXUSRVH Material & Methods: PHQXQGHUZHQWWHPSODWHELRSVLHVEHWZHHQDQG RIWKHVHPHQKDG730DVDFRQVHTXHQFHRIUHFODVVLᚏFDWLRQUHTXLUHPHQW LQ WKH FRQWH[W RI D SULRU QHJDWLYH 7586 ELRSV\ Q RU ORZLQWHUPHGLDWH ULVN SURVWDWH FDQFHU Q 730 ZHUH FRQGXFWHG WR D PP VDPSOLQJ IUDPH UHIHUHQFHG WR D JULG ZLWK DSLFDO DQG EDVDO QHHGOH GHSOR\PHQWV WR VDPSOH WKH = D[LV 7KH SURFHGXUH ZDV SHUIRUPHG LQ DQ DPEXODWRU\ FDUH VHWWLQJ XVLQJ HLWKHU UHJLRQDORUJHQHUDODQDHVWKHVLD Results: 0HDQDJHZDV\HDUV UDQJH \ DQGPHDQ36$QJPO UDQJH 1XPEHURIELRSV\FRUHVWDNHQDW7586DQGSURVWDWHPDSSLQJZDVPHDQ UDQJH DQG UDQJH UHVSHFWLYHO\6LGHHᚎHFWVDWWULEXWHGWR730 LQFOXGHG PLOGHFFK\PRVHVLQDOOSDWLHQWVXULQDU\UHWHQWLRQKDHPDWXULD UHTXLULQJDGPLVVLRQ1RHSLVRGHVRIVHSVLVZHUHUHFRUGHG*OHDVRQXSJUDGLQJRQ SURVWDWHPDSSLQJRFFXUUHGLQ RIWKRVHZLWK*OHDVRQVFRUHFDQFHURQWKH RULJLQDO7586ELRSVLHV7ZRWKLUGVRIWKRVHZLWKXQLODWHUDOFDQFHURQ7586KDG ELODWHUDOGLVHDVHRQWHPSODWHPDSSLQJ Conclusions: 3URVWDWHPDSSLQJJLYHVSUHFLVHULVNVWUDWLᚏFDWLRQZLWKORZPRUELGLW\ 7KHVHRXWFRPHVKDYHLPSOLFDWLRQVIRUXVLQJGLDJQRVWLF7586ELRSV\WRGHFLGHRQ DFWLYH VXUYHLOODQFH RYHU DFWLYH WKHUDS\ $OWKRXJK WKH XSIURQW KHDOWKFDUH EXUGHQ DQGFRVWLVVLJQLᚏFDQWWKHJUHDWHUSUHFLVLRQPRUHDFFXUDWHULVNVWUDWLᚏFDWLRQDQG ZLWKWLPHPRUHDSSURSULDWHWUHDWPHQWDOORFDWLRQPD\LQGLFDWHWKDWWKHRYHUDOOFRVWV RILOOQHVVDUHUHGXFHG
109
VALUE OF REAL-TIME ELASTOGRAPHY TARGETED AND SYSTEMATIC TRANSRECTAL ULTRASOUND-GUIDED BIOPSY FOR PROSTATE CANCER DETECTION
9RLJW6*ULPP02:LUWK03 Technical University of Dresden, Dept. of Urology, Dresden, Germany Introduction & Objectives: :HSHUIRUPHGWKLVSURVSHFWLYHVWXG\WRVHHZKHWKHU FRPELQLQJUHDOWLPHHODVWRJUDSK\WDUJHWHGDQGV\VWHPDWLFWUDQVUHFWDOXOWUDVRXQG JXLGHG 7586 ELRSV\FDQLPSURYHSURVWDWHFDQFHUGHWHFWLRQDQGWRDVVHVVWKH YDOXHRIHODVWRJUDSK\WDUJHWHGELRSV\DORQH Material & Methods: %HWZHHQ-XQHDQG0D\ SDWLHQWVXQGHUZHQW 7586ELRSV\DQGHODVWRJUDSK\$OOH[DPLQDWLRQDQGELRSVLHVZHUHFDUULHGRXWZLWK WKH (%8+9 +LWDFKL PHGLFDO 7KH PHGLDQ QXPEHU RI V\VWHPDWLF ELRSVLHV ZDV 7KHPHGLDQQXPEHURIDGGLWLRQDOHODVWRJUDSK\WDUJHWHGELRSVLHV WDNHQIURPVXVSLFLRXVDUHDVZDV
Results: 0HDQ DJH ZDV \HDUV 0HDQ 36$ ZDV QJPO ,Q FDVHV ZH KDG VXVSLFLRXV ᚏQGLQJV LQ WKH GLJLWDO UHFWDO H[DPLQDWLRQ ,QFDVHVWKHUHZDVDWOHDVWRQH PHDQ SULRUELRSV\RIWKHSURVWDWH ,Q FDVHV SURVWDWH FDQFHU ZDV KLVWRORJLFDOO\ FRQᚏUPHG 7KHUHE\ FDQFHU ZDV IRXQGLQ RIWKHV\VWHPDWLFFRUHVDQGLQ RIWKH HODVWRJUDSK\ WDUJHWHG FRUHV &DQFHU ZDV GLDJQRVHG LQ FDVHV E\V\VWHPDWLFELRSV\ RQO\DQGLQ FDVHVE\HODVWRJUDSK\ WDUJHWHG ELRSV\RQO\,Q FDVHVFDQFHUZDVIRXQGSDUDOOHOLQELRSVLHVRIERWK PHWKRGV ᚏJXUH Conclusions: &RPSDULQJ ERWK PHWKRGV WKHUH LV QR VWDWLVWLFDO GLᚎHUHQFH IRU SURVWDWHFDQFHUGHWHFWLRQ+RZHYHUPRVWRIWKHFDVHVZLWKSURVWDWHFDQFHUZHUH GHWHFWHGE\V\VWHPDWLFELRSV\$OWKRXJKZHGLDJQRVHGDGGLWLRQDOFDUFLQRPDVLW LVQRW\HWSRVVLEOHWRVWDWLVWLFDOO\GHPRQVWUDWHWKDWFRPELQLQJV\VWHPDWLF7586DQG HODVWRJUDSK\WDUJHWHGELRSV\FDQLPSURYHFDQFHUGHWHFWLRQ
110
TISSUE SAMPLING IS NOT ADEQUATE IN THE DETECTION OF PROSTATE CANCER IN TRANSITION ZONE
'RJDQ%6HUHIRJOX(&$WPDFD$)&DQGD$($NEXOXW=%DOED\0' Ankara Atatürk Training and Research Hospital, Dept. of 1st Urology, Ankara, Turkey Introduction & Objectives: 7RDVVHVVLIWUDQVLWLRQDO]RQHVDPSOLQJRIWKHSURVWDWH LVQHFHVVDU\GXULQJUHSHDWSURVWDWHELRSV\ 3%[ SURFHGXUHV Material & Methods: %HWZHHQ $SULO -XO\ SDWLHQWV ZKR XQGHUZHQW WUDQVXUHWKUDO UHVHFWLRQ RIWKHSURVWDWH 7853 DQG ZKR KDG SULRU QHJDWLYH 3%[ UHVXOWVZHUHUHWURVSHFWLYHO\HYDOXDWHG5HVXOWVRIKLVWRSDWKRORJLFDOHYDOXDWLRQVRI VXUJLFDOVSHFLPHQVDQGFDQFHUGHWHFWLRQUDWHVZHUHDVVHVVHG Results: $WRWDORISDWLHQWVXQGHUZHQW7853DQGKDGDWOHDVWQHJDWLYH3%[ 2YHUDOO ELRSV\ SURFHGXUHV ZHUH SHUIRUPHG KDG RQO\ RQH KDG WZR KDG WKUHH DQG KDG IRXU 3%[ 7UDQVLWLRQDO ]RQH VDPSOLQJ ZDV SHUIRUPHG LQ 3%[ SHUIRUPHG RQ SDWLHQWV DQG SURVWDWH FDQFHU 3&D ZDV GHWHFWHG LQ WKH VXUJLFDO VSHFLPHQ RI RQH SDWLHQW 7UDQVLWLRQDO ]RQH VDPSOLQJ ZDV QRW LQFOXGHGLQSURVWDWHELRSVLHV SHUIRUPHGRQSDWLHQWV DQG3&DZDVGHWHFWHG LQWKHVXUJLFDOVSHFLPHQRISDWLHQWV 0HDQSDWLHQWDJHZDV\HDUV PHDQ VHUXP SURVWDWH VSHFLᚏF DQWLJHQ 36$ ZDV QJP/ PHDQ SURVWDWH YROXPHZDVFF3DWKRORJ\UHVXOWVRIWKH3%[ZHUHDVIROORZV EHQLJQ LQᚐDPPDWLRQ KLJKJUDGH SURVWDWLF LQWUDHSLWKHOLDO QHRSODVLD +*3,1 3&D 3DWKRORJ\UHVXOWVRIWKH7853SURFHGXUHVZHUHDVIROORZV EHQLJQ LQᚐDPPDWLRQ +*3,1 3&D Conclusions: 6LQFH WKHUH ZDV QR VLJQLᚏFDQW GLᚎHUHQFH EHWZHHQ SDWLHQW JURXSV ZLWK RU ZLWKRXW WUDQVLWLRQDO ]RQH ELRSVLHV LQ GHWHFWLRQ RI 3&D LQ WUDQVLWLRQ ]RQH VWUDWHJLHVLQFOXGLQJLQFUHDVLQJQXPEHURIFDVHVWREHWDNHQIURPWUDQVLWLRQ]RQHRI WKHSURVWDWHVKRXOGEHFRQVLGHUHG
111
FRACTAL DIMENSION AS A NOVEL MEASURE OF PROSTATE CANCER GRADING
:DOLV]HZVNL3$EX(LG5.ULEXV66FKDIKDXVHU:6WHQ]O$ 1 St. Elisabeth Klinikum, Dept. of Urology, Straubing, Germany, 2University of Aberdeen, School of Dentistry, Aberdeen, United Kingdom, 3Pathology Office, Dept. of Pathology, Hof, Germany, 4Prostate Cancer Center, Dept. of Urology, Marktredwitz, Germany, 5Eberhard-Karls University of Tübingen, Dept. of Urology, Tübingen, Germany Introduction & Objectives: %RWKGLᚎHUHQWLDWLRQRISURVWDWHFDQFHUFHOOVDQGWKHLU RUJDQL]DWLRQ LQWR WLVVXH VWUXFWXUHV RI WKH KLJKHU RUGHU VXFK DV JODQGV LV VFRUHG DFFRUGLQJ WR WKH VXEMHFWLYH *OHDVRQ V\VWHP 7KHUH LV D QHHG IRU DQ REMHFWLYH PHDVXUHRIWXPRXUJUDGLQJ Material & Methods: 7RUHDFKWKDWJRDODVSDWLDOGLVWULEXWLRQRIDVHWRIQRUPDORU FDQFHUFHOOQXFOHLDVZHOODVVRPHJHRPHWULFDOIHDWXUHVRIVLQJOHFHOOVVXFKDVWKH DUHDSHULPHWHU GLPHQVLRQ WKHLU VSDWLDO IUDFWDO GLPHQVLRQ FHOO DUHD )HUHW DQJOH FHOO EUHDGWK FRQYH[LW\ DQG VSKHULFLW\ ZHUH LQYHVWLJDWHG LQ WKH WZR GLPHQVLRQDO WLVVXHVOLGHVVWDLQHGZLWKKDHPDWR[\OLQHRVLQDIWHUDSSO\LQJDFRORXUGHFRQYROXWLRQ DOJRULWKP'HᚏQLHQV7LVVXH0DSZDVXVHGIRUWKHDXWRPDWLFLGHQWLᚏFDWLRQRI FHOOQXFOHL)UDFWDODQDO\VLVZDVGRQHZLWK%HQRLWDQG,PDJH-T Results: $ JHRPHWULFDO REMHFW SRVVHVVHV IUDFWDO VWUXFWXUH LI WKHUH LV D OLQHDU UHODWLRQVKLS EHWZHHQ WKH ORJDULWKP RI D ER[ VL]H DQG WKH ORJDULWKP RI D QXPEHU RI WKH ER[HV FRYHULQJ WKDW REMHFW 6XFK WKH OLQHDU UHODWLRQVKLS ZDV IRXQG LQ DOO FDVHVDQDO\]HG7KHVSDWLDOIUDFWDOGLPHQVLRQIRUWKHQRUPDODSSHDULQJSURVWDWH WLVVXHLV Q IRUWKH*OHDVRQSDWWHUQ Q IRUWKH *OHDVRQSDWWHUQ Q DQGIRUWKH*OHDVRQSDWWHUQ Q ,QDGGLWLRQGLᚎHUHQWDUHDVRIWKHVDPHWXPRXUSRVVHVVHGDVLPLODUYDOXH RIWKHVSDWLDOIUDFWDOGLPHQVLRQ7KHUHLVQRVWDWLVWLFDOO\VLJQLᚏFDQWGLᚎHUHQFHLQWKH DUHDSHULPHWHU GLPHQVLRQ EHWZHHQ WKH QRUPDO FHOO QXFOHL DQG FDQFHU FHOO QXFOHL RI DOO *OHDVRQ SDWWHUQV VWXGLHG :LWK UHJDUGV WR WKH PRUSKRPHWULF FHOO DQDO\VLV WKH PLQLPDO FHOO UDGLXV DVSHFW UDWLR FHOO URXQGQHVV DQG FRPSDFWQHVV ZHUH DOO VWDWLVWLFDOO\GLᚎHUHQWDFURVVDOO*OHDVRQVFRUHFDVHV $129$S 6SKHULFLW\ VROLGLW\ VKDSH DQG FLUFXODULW\ ZHUH VWDWLVWLFDOO\ GLᚎHUHQW EHWZHHQ FDVHV ZLWK *OHDVRQVFRUHDQGWKRVHZLWKDVFRUHRIDQG $129$S +RZHYHU WKHVHSDUDPHWHUVZHUHQRWGLᚎHUHQWEHWZHHQFDVHVZLWKD*OHDVRQVFRUHRIDQG
Eur Urol Suppl 2010;9(2):67