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1.147 Quantitative analysis of the finger-tapping test in Parkinson's disease by accelerometer
Poster Presentations: Parkinsonism Conclusion: The results of this investigation demonstrate that changes in sexual functions are common and can be most relevant for quality of life of patients with Parkinson’s disease.
1.145 Testosteron levels, fatigue and apathy in Parkinson’s disease G. Kenangil1° , E. Ur, D. Necioglu, M. Celik, ¸ H. Forta Turkey
S45
contractures. Thirty patients subjectively had weakness of grip. In only a quarter of patients their impaired hand function was only attributable to their symptoms of PD such as tremor, incoordination, proprioceptive abnormalities, rigidity or dyskinesia. Conclusion: Three-quarters of the sample had significantly impaired hand function which was caused by musculoskeletal problems combined with PD. Further investigation is required to identify whether treatment of these musculoskeletal problems will lead to improved hand function.
1 Istanbul,
Objective: Fatigue and apathy are frequent non-motor symtoms in patients with Parkinson’s disease (PD). Testosteron deficiency in male patients may cause similar symptomatology. We aimed to investigate the correlation of testesteron levels with fatigue and apathy in male patients with PD. Method: Total and free testosteron levels were obtained from 34 PD patients and 20 age and sex-matched healthy control subjects between 08 am and 10 am. Patients with a history of drug or alcohol abuse, any kind of malignancy, psychosis, dementia, thyroid hormon dysfunction and depression were excluded. A total of 29 patients were evaluated. Nine item Fatigue Severity Scale (FSS) and Apathy Evaluation Scale (AES-C, 18 items) were used for evaluation of fatigue and apathy. SPSS 11 statistical package was used for the statistical analysis. Results: The frequences of apathy and fatigue were 65% and 44% in PD patients, respectively. The mean scores of FSS, and AES-C were significantly higher in PD patients than the control group (p = 0.005 and 0.004 respectively). Mean total and free testesterone levels were lower in PD group although no significant difference could be detected between them (p = 0.6 and p = 0.07 respectively). The UPDRS scores were significantly correlated with FSS and AES-C scores (p = 0.004, r = 0.52 and p = 0.006, r = 0.50 respectively). When AES-C and FSS scores were evaluated in all of 49 cases, significant inverse correlations were detected between ftestestoron levels and AES-C and FSS scores (p = 0.04; r = −0.29; p = 0.05, r = −0.28). Conclusion: Apathy and fatigue are frequent in PD patients and their scores showed significant correlation with the severity of the disease. Not only PD itself but also free testosterone levels might operate in the occurrence and severity of apathy and fatigue in PD patients.
1.146 Observational study of musculoskeletal problems affecting hand function in Parkinson’s disease. S. Green1° , P. Maddison, J. Hindle United Kingdom
1 Llandudno,
Objective: Parkinson’s disease (PD) can cause hand deformities such as swan-necking or ulnar deviation of fingers. Hand function in PD can also be influenced by independent musculoskeletal problems such as Osteoarthritis (OA), Carpal Tunnel Syndrome or Dupytren’s contracture. Over 40 years have elapsed since the last observational study in this area, and since then there have been significant advances in the treatment of PD. We present a detailed observational study of the musculoskeletal problems found in the hands of PD patients. Method: Consecutive patients with Idiopathic PD attending the Movement Disorders clinics in North West Wales were approached. Those consenting to take part had both a Modified Hoehn and Yahr Staging (H&Y) and Unified PD Rating Scale motor section (UPDRS III) performed. They completed 2 questionnaires on their hand functioning prior to review by a rheumatologist. Assessment of the musculoskeletal system was made by history, examination and further investigations where clinically indicated. Results: Forty-six patients were reviewed, 37 males and 9 females. Their mean age was 73 years old (range 46−88 years). The mean H&Y was 2.1 and mean UPDRS III was 16.9. Four patients had swan-necking of their fingers and 2 patients had ulnar deviation. Thirty-two patients had OA of the fingers, 23 patients had OA at the base of the thumb, 3 patients had symptoms of carpal tunnel syndrome, and 5 patients had Dupytren’s
1.147 Quantitative analysis of the finger-tapping test in Parkinson’s disease by accelerometer M. Yokoe1° , R. Okuno, K. Abe, K. Akazawa, S. Sakoda Japan
1 Suita,
Objective: In order to assess finger dynamics in the finger-tapping test, we developed a new system consisting of two 3-axis accelerometers and a pair of touch sensors. Method: We recruited 16 patients with Parkinson’s disease (PD) and 30 age-matched volunteers. Unified Parkinson’s disease Rating Scale (UPDRS) motor scores were collected for each patient. Each participant was asked to execute the finger-tapping movements as quickly and widely as possible for 60 seconds. Using our new system, we analyzed several parameters; velocity, distance and rhythm of repetitive index-to-thumb oppositions. Results: The quantitative dates showed that the average of maximum single finger-tapping distances and velocities decreased and the standard deviation of single finger-tapping intervals increased in accordance with deterioration of rating score of ‘finger taps’ in UPDRS. The radar chart for velocity, distance and rhythm revealed the difference between PD patients and age-matched volunteers. Conclusion: We conclude that this new system is a useful tool for quantitative assessment of the finger-tapping test in PD.
1.148 Electroencephalographic criteria of epileptic syndrome in patients with parkinsonism T. Elistratova1° , P. Sidorov, A. Soloviev Russia
1 Arkhangelsk,
Objective: In spite of pathogenetic similarity of Parkinson’s disease (PD) and idiopathic epilepsy, they are usually considered as antagonistic diseases. It is known that in PD patients, epilepsy occurs three times less often than in the rest of the population, and PD addition in patients with epilepsy results in less frequent occurrence and disappearance of epileptic attacks. However, one should distinguish between epileptic syndrome (ES) in chronic alcoholic intoxication (CAI) not requiring special treatment with antiepileptic preparations owing to development of toxic and metabolic encephalopathy and not occurring repeatedly after stopping of alcohol abuse and idiopathic epilepsy. At the same time, there is no clear data about a correlation between CAI and PD [or Parkinson’s syndromes (PS)], and ES of alcoholic genesis (ESAG) occurs also among patients suffering from CAI and PD (PS). Implementation of a comparative analysis of electroencephalograms (EEG) of patients with ESAG, patients with ESAG and PD (PS) can be used as an additional criterion of differentiated diagnosis. Method: With the goal of studying EEG-peculiarities of patients with PD and PS with ESAG, we have analyzed EEG of 154 patients at the age older than 45 yrs; 33 of them had ESAG without PD (PS), 7 – ESAG in combination with PD (PS), 15 – PD, 25 – PS of vascular or toxic genesis, 17 – idiopathic epilepsy, 19 – symptomatic epilepsy, 38 patients did not have ES and PD (PS), but they suffered from discircular encephalopathy (DE) I−II stages (practically, patients with brain age changes). Results: The EEG of all the patients with ESAG irrespective of PD (PS) occurrence, as well as the overwhelming majority of the EEG (92.5%) of the patients with PD (PS) not suffering from ES, in addition to a change of amplitude-frequency indices in the direction of slowing down,
1.145 Testosteron levels, fatigue and apathy in Parkinson’s disease G. Kenangil1° , E. Ur, D. Necioglu, M. Celik, ¸ H. Forta Turkey
S45
contractures. Thirty patients subjectively had weakness of grip. In only a quarter of patients their impaired hand function was only attributable to their symptoms of PD such as tremor, incoordination, proprioceptive abnormalities, rigidity or dyskinesia. Conclusion: Three-quarters of the sample had significantly impaired hand function which was caused by musculoskeletal problems combined with PD. Further investigation is required to identify whether treatment of these musculoskeletal problems will lead to improved hand function.
1 Istanbul,
Objective: Fatigue and apathy are frequent non-motor symtoms in patients with Parkinson’s disease (PD). Testosteron deficiency in male patients may cause similar symptomatology. We aimed to investigate the correlation of testesteron levels with fatigue and apathy in male patients with PD. Method: Total and free testosteron levels were obtained from 34 PD patients and 20 age and sex-matched healthy control subjects between 08 am and 10 am. Patients with a history of drug or alcohol abuse, any kind of malignancy, psychosis, dementia, thyroid hormon dysfunction and depression were excluded. A total of 29 patients were evaluated. Nine item Fatigue Severity Scale (FSS) and Apathy Evaluation Scale (AES-C, 18 items) were used for evaluation of fatigue and apathy. SPSS 11 statistical package was used for the statistical analysis. Results: The frequences of apathy and fatigue were 65% and 44% in PD patients, respectively. The mean scores of FSS, and AES-C were significantly higher in PD patients than the control group (p = 0.005 and 0.004 respectively). Mean total and free testesterone levels were lower in PD group although no significant difference could be detected between them (p = 0.6 and p = 0.07 respectively). The UPDRS scores were significantly correlated with FSS and AES-C scores (p = 0.004, r = 0.52 and p = 0.006, r = 0.50 respectively). When AES-C and FSS scores were evaluated in all of 49 cases, significant inverse correlations were detected between ftestestoron levels and AES-C and FSS scores (p = 0.04; r = −0.29; p = 0.05, r = −0.28). Conclusion: Apathy and fatigue are frequent in PD patients and their scores showed significant correlation with the severity of the disease. Not only PD itself but also free testosterone levels might operate in the occurrence and severity of apathy and fatigue in PD patients.
1.146 Observational study of musculoskeletal problems affecting hand function in Parkinson’s disease. S. Green1° , P. Maddison, J. Hindle United Kingdom
1 Llandudno,
Objective: Parkinson’s disease (PD) can cause hand deformities such as swan-necking or ulnar deviation of fingers. Hand function in PD can also be influenced by independent musculoskeletal problems such as Osteoarthritis (OA), Carpal Tunnel Syndrome or Dupytren’s contracture. Over 40 years have elapsed since the last observational study in this area, and since then there have been significant advances in the treatment of PD. We present a detailed observational study of the musculoskeletal problems found in the hands of PD patients. Method: Consecutive patients with Idiopathic PD attending the Movement Disorders clinics in North West Wales were approached. Those consenting to take part had both a Modified Hoehn and Yahr Staging (H&Y) and Unified PD Rating Scale motor section (UPDRS III) performed. They completed 2 questionnaires on their hand functioning prior to review by a rheumatologist. Assessment of the musculoskeletal system was made by history, examination and further investigations where clinically indicated. Results: Forty-six patients were reviewed, 37 males and 9 females. Their mean age was 73 years old (range 46−88 years). The mean H&Y was 2.1 and mean UPDRS III was 16.9. Four patients had swan-necking of their fingers and 2 patients had ulnar deviation. Thirty-two patients had OA of the fingers, 23 patients had OA at the base of the thumb, 3 patients had symptoms of carpal tunnel syndrome, and 5 patients had Dupytren’s
1.147 Quantitative analysis of the finger-tapping test in Parkinson’s disease by accelerometer M. Yokoe1° , R. Okuno, K. Abe, K. Akazawa, S. Sakoda Japan
1 Suita,
Objective: In order to assess finger dynamics in the finger-tapping test, we developed a new system consisting of two 3-axis accelerometers and a pair of touch sensors. Method: We recruited 16 patients with Parkinson’s disease (PD) and 30 age-matched volunteers. Unified Parkinson’s disease Rating Scale (UPDRS) motor scores were collected for each patient. Each participant was asked to execute the finger-tapping movements as quickly and widely as possible for 60 seconds. Using our new system, we analyzed several parameters; velocity, distance and rhythm of repetitive index-to-thumb oppositions. Results: The quantitative dates showed that the average of maximum single finger-tapping distances and velocities decreased and the standard deviation of single finger-tapping intervals increased in accordance with deterioration of rating score of ‘finger taps’ in UPDRS. The radar chart for velocity, distance and rhythm revealed the difference between PD patients and age-matched volunteers. Conclusion: We conclude that this new system is a useful tool for quantitative assessment of the finger-tapping test in PD.
1.148 Electroencephalographic criteria of epileptic syndrome in patients with parkinsonism T. Elistratova1° , P. Sidorov, A. Soloviev Russia
1 Arkhangelsk,
Objective: In spite of pathogenetic similarity of Parkinson’s disease (PD) and idiopathic epilepsy, they are usually considered as antagonistic diseases. It is known that in PD patients, epilepsy occurs three times less often than in the rest of the population, and PD addition in patients with epilepsy results in less frequent occurrence and disappearance of epileptic attacks. However, one should distinguish between epileptic syndrome (ES) in chronic alcoholic intoxication (CAI) not requiring special treatment with antiepileptic preparations owing to development of toxic and metabolic encephalopathy and not occurring repeatedly after stopping of alcohol abuse and idiopathic epilepsy. At the same time, there is no clear data about a correlation between CAI and PD [or Parkinson’s syndromes (PS)], and ES of alcoholic genesis (ESAG) occurs also among patients suffering from CAI and PD (PS). Implementation of a comparative analysis of electroencephalograms (EEG) of patients with ESAG, patients with ESAG and PD (PS) can be used as an additional criterion of differentiated diagnosis. Method: With the goal of studying EEG-peculiarities of patients with PD and PS with ESAG, we have analyzed EEG of 154 patients at the age older than 45 yrs; 33 of them had ESAG without PD (PS), 7 – ESAG in combination with PD (PS), 15 – PD, 25 – PS of vascular or toxic genesis, 17 – idiopathic epilepsy, 19 – symptomatic epilepsy, 38 patients did not have ES and PD (PS), but they suffered from discircular encephalopathy (DE) I−II stages (practically, patients with brain age changes). Results: The EEG of all the patients with ESAG irrespective of PD (PS) occurrence, as well as the overwhelming majority of the EEG (92.5%) of the patients with PD (PS) not suffering from ES, in addition to a change of amplitude-frequency indices in the direction of slowing down,