1159. Gene Transfer and Its Biodistribution of Adenoviral Vector after Ocular Local Delivery in New Zealand Rabbits

1159. Gene Transfer and Its Biodistribution of Adenoviral Vector after Ocular Local Delivery in New Zealand Rabbits

""            85           ' 7 D"89            ...

135KB Sizes 0 Downloads 13 Views

""            85       

   ' 7 D"89 

     

          3  89 

    

            0     

 



      ' 7 D"89  

   *    ' 7DN  

       

     -   =/   &9H            ' 7 D"89  

    

 

      -  9 8/89

           D"89                  ?(%A              

    D"89 3                      (               

    0 >*>     

1159. Gene T ransfer and Its Biodistribution of Transfer ector after Ocular Local Delivery in New Vector Adenoviral V Zealand Rabbits Shu Fen Wen,1 Zoe Chen,2 Jonathan Nery,1 Beth Hutchins,1 Dan Maneval,2 Barbara Faha.2 1 Process Sciences, Canji, San Diego, CA, United States; 2 Pharmacology, Canji, San Diego, CA, United States. 0                                         ,80'?8%"8    - ' ",8/            

  

         -  /   "         

E E   ' ",8    (3 *  N    

    E 

     899   ' ",8 -5&3 8989     /    E   '     

  8   6

      )   

        

          @*' $*'  3 

  3  899       8D   

      S  ' " ,8 $*'   @*'     

   1  !@   @ "!@  ( 1   $    ;;99  G               !@    1

      

         

 ' ",8    

  

  '      

    8   6          3       2       

         E     &′ =9′ ,    8    E  - M =%  /        -E 

  /       ' ",8 $*'-8B389;±,5389B   1 ->/%    8 :6389B±;5389B>%   6/ @*'-8:389; ±88389; %   8 88389B±=&389& %        6/      B%B   D      ' ",8 $*'    

   8%B    "          ' ",8           -883 89& >%D     =9′/   

 -B6 3 898 >%        / )  

   

       ' ",8 @*' -8= 3 89, >%    /          

     E  ' ",8 $*'                   ;& 3 89: >%  &′  89 3 89B >%  ,6  ' 8         

              

      ' ",8 @*'   $*' '        3 "E 

              E E           3            3         E E              

            

1160. Extracellular Superoxide Dismutase Gene Transfer to Lung Attenuates Bleomycin-Derived Apoptosis Mikko O. Laukkanen, Minna K. Karkkainen, Jonne Naarala, VeliMatti Kosma, Arja Halinen, Pia Leppanen, Stefan L. Marklund, Seppo P. A. Yla-Herttuala. '         

  

                           

                             '                         3               >"()$   

 3     

      

      

  3 "



   

Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy

        >"()$        

  -99& 4  &9  95H  /          

>"()$ -M,;/   DN     -M,;/ 



        -9& 3 89: / #     

 85                   G

                     3       

     

                                    C                     

         



             

           "=          

            

   -O99,=/        >"()$  

DN          

           >"()$   DN" 

             E     

       C         

  

                   " 

    

                       " 

         



         3  

          



  >"()$                         >"()$            

   

1161. Development of a Small Animal Model for Extracorporeal Circulatory Support during Endothelial Permeabilization for Systemic Gene Therapy Leonard T. Su,1 James A. Lesniewski,1 James M. Burkman,1 Zhonglin Wang,1 Xiang G. Zheng,1 Charles R. Bridges,1 Hansell H. Stedman.1 1 Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA, United States. !        

                              G       

                1           

       G      C                                  

  

                                   0     

                   G                          

            G      

  "E                       

'                   

  ""                              

                           3        

                

          "             1        3              

                               

   C8 C, '             '         

  

    

          

  

                   8&U           

                         

            G

   

            

            '   

                

         ′  

     "  

          

                          0          

                                                                                         !                     '              

    4   !     '     4





S377