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135: NT-proBNP, but not BNP, is increased in patients with severe obesity
Multiple Risk Factors in Cardiovascular Disease—Abstracts
134 OXIDATIVE STRESS IN PATIENTS SUBJECTED TO CABG SURGERY AS ASSESSED BY A GLOBAL INDEX (OXY-SCORE) F. Veglia1, I. Squellerio1, E. Sisillo1, A. Parolari1, F. Minardi1, E. Tremoli1,2, V. Cavalca3. 1Centro Cardiologico Monzino, IRCCS, Milan, Italy, 2 Dept. of Pharmac. Sciences, University of Milan, Milan, Italy, 3Inst. of Cardiology, University of Milan, Milan, Italy Objective: Coronary artery bypass graft (CABG) surgery, especially with concomitant cardiopulmonary bypass (CPB) is associated with an increased oxidative stress, potentially harmful for patients.We evaluated the time-course of oxidative stress, using as biochemical markers either the OXY-SCORE, a recently proposed global index of oxidative status, or its individual components, in two clinical circumstances characterized by different production of oxidative stressors, i.e. CABG with CPB or without (OPCAB). Methods: Patients undergoing CABG were randomly assigned to CPB (n=25) or OPCAB (n=22). Plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, alphaand gamma-tocopherol and urinary isoprostanes were measured before, during, and after surgery. The global index was computed as the average of standardized measures. The performances of the individual biomarkers and of OXY-SCORE in discriminating the two classes of patients and in assessing major and minor variations in the oxidative balance were then compared. Results: The ability of OXY-SCORE to correctly classify the patients was very good, with an area under the ROC curve of 0.90 and 0.78 during and after surgery respectively. Free MDA performed slightly better in this task, but, in contrast with OXY-SCORE, it was insensitive to the minor variations of the oxidative balance in the OPCAB group. The performance of all the other individual biomarkers was definitely worse. Conclusion: OXY-SCORE is a single number global index with high sensitivity and high discriminant power.
R. Marius, M. Popescu, A. Toadere. University, Oradea, Romania Left ventricular enlargement and eccentric hypertrophy are the most common cardiac morphological abnormalities in obese individuals. This cardiac remodelling depends on severity and duration of obesity. To investigate the cardiac involvement in patients with severe obesity using NT-proBNP and BNP, correlating their levels with body mass index (BMI), duration of obesity (DO) and waist circumference (WC). Thirty-three patients with obesity (20 females, mean age 41 years) and normal systolic ventricular function were compared to 30 healthy thin individuals (IMC<25 kg/m2, 7 females, mean age 45 years). The T test was used to assess the difference between groups, and Spearman correlation was used to analyze the relation between duration of obesity, BMI and WC.All patients had level III obesity (mean BMI of 46.39 kg/m2), long-term obesity (mean of 15.64 years) and abnormal WC (mean 131.37cm). There was a significant increase in LogNT-proBNP (p=0.003) in patients with obesity (mean 1.67, CI 95%: 1.50-1.83 log pg/mL)when compared to control group (mean 1.32, CI 95%: 1.17-1.47 log pg/mL). The log NT-proBNP correlated with duration of obesity in these patients (r=0.339, p < 0.004). However, when the BNP was analyzed, there were no differences in the Log-BNP (p=0.63) in patients with obesity (mean 0.73, CI 95%: 0.46-1.00 log pg/ mL)when compared to control group (mean 0.66, CI 95%:0.51-0.81 log pg/ml). Conclusion: NTproBNP, but not BNP, is increased in patients with severe obesity and is correlated with duration of obesity. NT-proBNP may be helpful as an early diagnostic tool for detection of cardiac burden due to obesity. Funding: none
Funding: none
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135
B-TYPE NATRIURETIC PEPTIDE CONCENTRATIONS IN ONE ELITE POTHOLER DURING AN IMMERSION IN A SIPHON PLACED ON THE BOTTOM OF A CAVE OF 350 M DEPTH
NT-PROBNP, BUT NOT BNP, IS INCREASED IN PATIENTS WITH SEVERE OBESITY
S62
134 OXIDATIVE STRESS IN PATIENTS SUBJECTED TO CABG SURGERY AS ASSESSED BY A GLOBAL INDEX (OXY-SCORE) F. Veglia1, I. Squellerio1, E. Sisillo1, A. Parolari1, F. Minardi1, E. Tremoli1,2, V. Cavalca3. 1Centro Cardiologico Monzino, IRCCS, Milan, Italy, 2 Dept. of Pharmac. Sciences, University of Milan, Milan, Italy, 3Inst. of Cardiology, University of Milan, Milan, Italy Objective: Coronary artery bypass graft (CABG) surgery, especially with concomitant cardiopulmonary bypass (CPB) is associated with an increased oxidative stress, potentially harmful for patients.We evaluated the time-course of oxidative stress, using as biochemical markers either the OXY-SCORE, a recently proposed global index of oxidative status, or its individual components, in two clinical circumstances characterized by different production of oxidative stressors, i.e. CABG with CPB or without (OPCAB). Methods: Patients undergoing CABG were randomly assigned to CPB (n=25) or OPCAB (n=22). Plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, alphaand gamma-tocopherol and urinary isoprostanes were measured before, during, and after surgery. The global index was computed as the average of standardized measures. The performances of the individual biomarkers and of OXY-SCORE in discriminating the two classes of patients and in assessing major and minor variations in the oxidative balance were then compared. Results: The ability of OXY-SCORE to correctly classify the patients was very good, with an area under the ROC curve of 0.90 and 0.78 during and after surgery respectively. Free MDA performed slightly better in this task, but, in contrast with OXY-SCORE, it was insensitive to the minor variations of the oxidative balance in the OPCAB group. The performance of all the other individual biomarkers was definitely worse. Conclusion: OXY-SCORE is a single number global index with high sensitivity and high discriminant power.
R. Marius, M. Popescu, A. Toadere. University, Oradea, Romania Left ventricular enlargement and eccentric hypertrophy are the most common cardiac morphological abnormalities in obese individuals. This cardiac remodelling depends on severity and duration of obesity. To investigate the cardiac involvement in patients with severe obesity using NT-proBNP and BNP, correlating their levels with body mass index (BMI), duration of obesity (DO) and waist circumference (WC). Thirty-three patients with obesity (20 females, mean age 41 years) and normal systolic ventricular function were compared to 30 healthy thin individuals (IMC<25 kg/m2, 7 females, mean age 45 years). The T test was used to assess the difference between groups, and Spearman correlation was used to analyze the relation between duration of obesity, BMI and WC.All patients had level III obesity (mean BMI of 46.39 kg/m2), long-term obesity (mean of 15.64 years) and abnormal WC (mean 131.37cm). There was a significant increase in LogNT-proBNP (p=0.003) in patients with obesity (mean 1.67, CI 95%: 1.50-1.83 log pg/mL)when compared to control group (mean 1.32, CI 95%: 1.17-1.47 log pg/mL). The log NT-proBNP correlated with duration of obesity in these patients (r=0.339, p < 0.004). However, when the BNP was analyzed, there were no differences in the Log-BNP (p=0.63) in patients with obesity (mean 0.73, CI 95%: 0.46-1.00 log pg/ mL)when compared to control group (mean 0.66, CI 95%:0.51-0.81 log pg/ml). Conclusion: NTproBNP, but not BNP, is increased in patients with severe obesity and is correlated with duration of obesity. NT-proBNP may be helpful as an early diagnostic tool for detection of cardiac burden due to obesity. Funding: none
Funding: none
136
135
B-TYPE NATRIURETIC PEPTIDE CONCENTRATIONS IN ONE ELITE POTHOLER DURING AN IMMERSION IN A SIPHON PLACED ON THE BOTTOM OF A CAVE OF 350 M DEPTH
NT-PROBNP, BUT NOT BNP, IS INCREASED IN PATIENTS WITH SEVERE OBESITY
S62