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1405 The effect of response type on the Intracerebral Distribution of the slow cortical potentials in contingent negative variation paradigm
Poster Abstracts in effort of understanding complex comorbidity of those patients. Regarding already existing knowledge of extremely central monoamine release in early postischaemia, the aim of the study was to detemfine somato-visceral repercussions among those patients. Patients: The study included 110 out of 330 patients who were treated on the intensive care uuit and with CT-verified acute ishenffc lesion. Condition for including the group was without history o f somatic diseases. Beside neurological examination, ECG, the biochemical status analyses, the physical examination, necessary additional diagnostic exams and internal exanffnation were practiced on reception. Vital parameters were obtained in three hours intervals. Results: Among all patients 81 (74%) had initially increased blood pressure, 25 (123%) had disturbed rhythm of the heart, 57 (52%) had "ishemic'" cardiac disease with corresponding alteration in cardiac enzymes profile in 20 (35%) patients. 34 (31%) patients had ishemic hepatopathy and 46 (42%) were with acute renal failure. Those disturbances gain their pick the fourth day from the beginning. Combination of those conditions accompanying low Glasgow comma scale score represents malignant prognostic trias confirmed in 76 (69%) dead patients. Conclusions: Ishemic brain disease involving serious neurotransnfftter disorders (especially monoanffns) is accompanied by numerous somatic repercussions and comorbidity. High drculating catecholanffne levels and generalized autonomic "stom~" obviously have sympathetic, and parasympathetic, effects accompanying mulfiorganic failure. Treatment of those patients requires national therapeutic program based on the pathophysiologic events as well as multidisciplinary approach.
1404 Cerebrovascular Diseases by findings of pogt-mortem examinations Zubritsky, A 1. 1Municipal Institution "Taldom Central Regional
Hospital", Taldom, Russia Background and method: The aim of this study was to determine the incidence of cerebrovascular diseases (CVD) on pathoanatomical material of the Municipal Institution "Taldom Central Regional Hospital" over the period from 1989 to 1998. Results: The obtained findings revealed 99 cases of CVD (156 females and 43 males, mean age 63 years) from a total of 596 postmortem exanffnations of adults. In the majority of cases, the primary disease had been diagnosed as intracerebral haemorrhage (60 subjects) and myocardial infarction (39 cases), with all the CVDs having been registered on the background of hypertension and/or progressing diffuse atherosclerosis, however, not all the patients had even been on ambulatory medical records. Besides these risk factors, obesity (134 cases) and diabetes mellitus (17 cases) were revealed as concomitant diseases. The direct causes of death were the following complications of the combined primary disease: haemorrhage into the cerebral ventricles (53 cases), compression and dislocation of the truncas cerebri due to oedema or swelling o f the substantia medullaris (23), thromboembolism of the pulmonary artery (13), pneumonia (8), rupture of the ascending aortic wall followed by haemorrhage into the pericardial cavity (1 case), and renal nisuffidency (1 observation). Conclusion: Hence, CVDs on the background of hypertension and disseminated progressing atherosclerosis amounted to 16.6 % amongst the 596 postmortem exanffnations of adult subjects of the general somatic hospital over the above-mentioned decade. In order to decrease and prevent CVD morbidity, it is necessary to systematic.ally and thoroughly meticulously follow-up the health status of patients with cardiovascular diseases, to improve the organization of preventive measures, and to remove the risk factors amongst the adult population of the Taldom region by means of cardiological screeuing to be followed by ambulatory registration of the cohort revealed.
Thursday, November 10, 2005
$457
1405 The effect of response type on the Intracerehr.~d Digtribution of the slow cortical potentials in COntingent negative variation paradigm Bares, M 1, Nestrasil, M 1, Rektor, 11. Zl'~ Department of Neurology',
St. Anne's Hospital, Masaryk University Brno, Czech Republic Background: This study concerned the intracerebrally located generators of the Contingent Negative Variation in two different paradigm settings: (i) motor output required, (ii) silent counting required. Method: Stereoelectroencephalography (SEEG) recordings of the contingent negative variation (CNV) in a somatosensory stimulation paradigm with a motor or counting task were taken from nine patients with drug-resistant epilepsy. The intracerebral recordings were taken from 25 cortical areas (supplementary motor area-SMA; the dngulate gyms; the orbitofrontal, premotor and dorsolateral prefrontal cortices; tire tenrporal cortex, including the amygdalohippocampal complex; and the parietooccipital cortex). Results: We found the neural activity in the SMA, premotor, dorsolateral, orbitofrontal cortices, dngulate gyms, parts of the temporal and parietal lobes. We found a significant difference in the CNV potential generation between both tasks. While silent counting task was associated only with a limited numbers of CNV potential generators, the task with the motor output displayed broader range of those potentials. Contusion: The CNV potential generators varied between motor and non-motor tasks. The intracerebral distribution of the potentials linked with expectation is task dependent. Our study highlights an essential contribution from motor output in anticipatory attention and motor preparatory processes engendered by the task that are indexed electrophysiologically by the generation of the CNV. Tiffs study was supported by MSM0021622404. 1406 Synchronization during cognitive and self-regulative processes containing slow cortical potentials Ivanova, G 1, P~rez, D 1, Froeber, U 1, Knote, j2, Both, R2. 1Technische
Universita't Ibnenau, lbnenau, German),.."2Clinic for Neurology, Zentralklinilr Bad Berka GmbH, Bad Berlra, Germany Background: Both, the slow cortical potentials (SCP), acquired during self-regulative processes (SRP) and the contingent negative variations (CNV) originate with strong attendance of information processing, and contain components which are closed to 0 Hz. Despite different existing hypotheses, both generation mechanisms have not been proven yet. In this study, the interest was focused on the topological synchronization within the common E E G bands. Method: After appropriate preprocessing, single- and multi-trial classical and dynamical coherence analyses were applied to data acquired during a self-regulative procedure, based on SCP and such acquired by modified S1-$2 paradigm. All possible electrode (128 channels) combinations were computed. A comparison based on the consideration of the time, the frequency, and the localization was carried out. Results: The highest synchronization of the SRP based on SCP can be observed in the central and front-central areas in ttteta and alpha band. There is no difference in the coherences between task positivation and task negativation in the SRP. Depending on the applied feedback strategy (visual-, music feedback and association) additional areas, e.g. right front-temporal, could show higher coherences temporary. Very high theta coupling occur independently on the time interval within the trigger sequences. There is no significant difference between the SRP and CNV process regarding the localizations, the frequencies, and the highness of the coherences. Contusion: Both the SRP based on SCP and the CNV-processes evince similar coupling behavior. These facts indicate related or common neurological and psycho-ptrysiological generation mechanisms and will be explored in further detail in future studies.
1404 Cerebrovascular Diseases by findings of pogt-mortem examinations Zubritsky, A 1. 1Municipal Institution "Taldom Central Regional
Hospital", Taldom, Russia Background and method: The aim of this study was to determine the incidence of cerebrovascular diseases (CVD) on pathoanatomical material of the Municipal Institution "Taldom Central Regional Hospital" over the period from 1989 to 1998. Results: The obtained findings revealed 99 cases of CVD (156 females and 43 males, mean age 63 years) from a total of 596 postmortem exanffnations of adults. In the majority of cases, the primary disease had been diagnosed as intracerebral haemorrhage (60 subjects) and myocardial infarction (39 cases), with all the CVDs having been registered on the background of hypertension and/or progressing diffuse atherosclerosis, however, not all the patients had even been on ambulatory medical records. Besides these risk factors, obesity (134 cases) and diabetes mellitus (17 cases) were revealed as concomitant diseases. The direct causes of death were the following complications of the combined primary disease: haemorrhage into the cerebral ventricles (53 cases), compression and dislocation of the truncas cerebri due to oedema or swelling o f the substantia medullaris (23), thromboembolism of the pulmonary artery (13), pneumonia (8), rupture of the ascending aortic wall followed by haemorrhage into the pericardial cavity (1 case), and renal nisuffidency (1 observation). Conclusion: Hence, CVDs on the background of hypertension and disseminated progressing atherosclerosis amounted to 16.6 % amongst the 596 postmortem exanffnations of adult subjects of the general somatic hospital over the above-mentioned decade. In order to decrease and prevent CVD morbidity, it is necessary to systematic.ally and thoroughly meticulously follow-up the health status of patients with cardiovascular diseases, to improve the organization of preventive measures, and to remove the risk factors amongst the adult population of the Taldom region by means of cardiological screeuing to be followed by ambulatory registration of the cohort revealed.
Thursday, November 10, 2005
$457
1405 The effect of response type on the Intracerehr.~d Digtribution of the slow cortical potentials in COntingent negative variation paradigm Bares, M 1, Nestrasil, M 1, Rektor, 11. Zl'~ Department of Neurology',
St. Anne's Hospital, Masaryk University Brno, Czech Republic Background: This study concerned the intracerebrally located generators of the Contingent Negative Variation in two different paradigm settings: (i) motor output required, (ii) silent counting required. Method: Stereoelectroencephalography (SEEG) recordings of the contingent negative variation (CNV) in a somatosensory stimulation paradigm with a motor or counting task were taken from nine patients with drug-resistant epilepsy. The intracerebral recordings were taken from 25 cortical areas (supplementary motor area-SMA; the dngulate gyms; the orbitofrontal, premotor and dorsolateral prefrontal cortices; tire tenrporal cortex, including the amygdalohippocampal complex; and the parietooccipital cortex). Results: We found the neural activity in the SMA, premotor, dorsolateral, orbitofrontal cortices, dngulate gyms, parts of the temporal and parietal lobes. We found a significant difference in the CNV potential generation between both tasks. While silent counting task was associated only with a limited numbers of CNV potential generators, the task with the motor output displayed broader range of those potentials. Contusion: The CNV potential generators varied between motor and non-motor tasks. The intracerebral distribution of the potentials linked with expectation is task dependent. Our study highlights an essential contribution from motor output in anticipatory attention and motor preparatory processes engendered by the task that are indexed electrophysiologically by the generation of the CNV. Tiffs study was supported by MSM0021622404. 1406 Synchronization during cognitive and self-regulative processes containing slow cortical potentials Ivanova, G 1, P~rez, D 1, Froeber, U 1, Knote, j2, Both, R2. 1Technische
Universita't Ibnenau, lbnenau, German),.."2Clinic for Neurology, Zentralklinilr Bad Berka GmbH, Bad Berlra, Germany Background: Both, the slow cortical potentials (SCP), acquired during self-regulative processes (SRP) and the contingent negative variations (CNV) originate with strong attendance of information processing, and contain components which are closed to 0 Hz. Despite different existing hypotheses, both generation mechanisms have not been proven yet. In this study, the interest was focused on the topological synchronization within the common E E G bands. Method: After appropriate preprocessing, single- and multi-trial classical and dynamical coherence analyses were applied to data acquired during a self-regulative procedure, based on SCP and such acquired by modified S1-$2 paradigm. All possible electrode (128 channels) combinations were computed. A comparison based on the consideration of the time, the frequency, and the localization was carried out. Results: The highest synchronization of the SRP based on SCP can be observed in the central and front-central areas in ttteta and alpha band. There is no difference in the coherences between task positivation and task negativation in the SRP. Depending on the applied feedback strategy (visual-, music feedback and association) additional areas, e.g. right front-temporal, could show higher coherences temporary. Very high theta coupling occur independently on the time interval within the trigger sequences. There is no significant difference between the SRP and CNV process regarding the localizations, the frequencies, and the highness of the coherences. Contusion: Both the SRP based on SCP and the CNV-processes evince similar coupling behavior. These facts indicate related or common neurological and psycho-ptrysiological generation mechanisms and will be explored in further detail in future studies.