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1439. UK plastics toxicity symposium
830
PROCESSING AND PACKAGING CONTAMINANTS
Triton (I) has been shown to decrease fat absorption, as assessed by serum esterified fatty acid (EFA) levels (Cited in F.C.T. 1966, 4, 115). For this reason taking I with a meal would be expected to reduce calorie intake. But before advocating this measure for slimming, it is important to establish that I is not absorbed (since intravenous injection of I produces a deleterious elevation of blood lipids) and also that fat retention as well as fat absorption is decreased by I. This has now been tested in rats fed diets containing 20 70 corn oil supplemented or not with I in the food and/or drinking water. It was found that the total body fat of rats fed 2-5 70 1 was considerably less than that of untreated animals. The reduction in serum EFA at the end of the 12-wk experimental period showed that I was not absorbed. Moreover, the normal growth and well-being of the rats suggested a low toxicity for I.
1439. UK plastics toxicity symposium Transactions and Journal of the Plastics Institute (1967). Symposium on Toxicity in Plastics. ibid 35, 447. A brief account has already been given in these pages of the proceedings of the Symposium on Toxicity in Plastics, organized by the National College of Rubber Technology, London and held in December 1966 (Cited hz F.C.T. 1967, 5, 400). Summaries of nine of the ten papers have now been published as an official record of the proceedings of the Symposium.
1440. Fate and toxicity of 2,6-dioctadecyl-p-cresol Terhaar, C. J., Roudabush, R. L., Fassett, D. W. & Weinberg, M. S. (1967). Physiologic effects of 2,6-dioctadecyl-p-cresol (DOPC) in the rat and dog. Toxic. appl. Pharmac. 10, 401. Astill, B. D. & Fassett, D. W. (1967). Fate of 2,6-bis-(1 '-methylheptadecyl)-p-cresol (DOPC) in rats. Toxic. appl. Pharmac. 10, 400. 2,6-Dioctadecyl-p-cresol (DOPC) is an antioxidant with potential use as a stabilizer in food-packaging material. Preliminary reports on its toxicity and fate in the body have now been published. Terhaar et al. (cited above) have found a low acute oral toxicity, doses of 6400 and 3200 mg/kg being well tolerated by rats and mice respectively. It produced very slight skin irritation in guinea-pigs. Short-term dietary administration of 0-1% DOPC to rats had no effect on the appearance or behaviour of the animals or on food utilization, haematology, clinical chemistry or histology. The only adverse effect observed was a slight growth reduction in males at the 1% level. Dogs, too, tolerated 0-1 70 DOPC in the diet for 90 days apart from a slight, transient food refusal and weight loss. The low oral toxicity is not surprising since Astill & Fassett (cited above) have found that rats given DOPC orally excrete most of the dose in the faeces. After administration of a single oral dose (190-860) mg/kg), labelled with carbon-14 (~4C) in the l'-methyl groups, 96-99 % of the 14C was eliminated in the faeces and less than 1 Yo in the urine, while none was detected in the expired air. Similar results were obtained with a dietary level of 0.01 Yo given for 15 days. Only traces of 14C were found in the tissues (in the liver and brain after dietary administration, in the liver after low single doses and in the liver, brain, kidney and fat after high single doses), but these traces were eliminated at different rates from the body. 1441. Concerning triaryl phosphates Pegum, J. S. (1966). Contact dermatitis from plastics containing tri-aryl phosphates. Br. J. Derm. 78, 626. Seward, C. R., Vaughan, G., Shue, G. M. & Hove, E. L. (1966). Accentuation of essential fatty acid deficiency by dietary tri-o-cresyl phosphate. J. Nutr. 90, 245.
PROCESSING AND PACKAGING CONTAMINANTS
Triton (I) has been shown to decrease fat absorption, as assessed by serum esterified fatty acid (EFA) levels (Cited in F.C.T. 1966, 4, 115). For this reason taking I with a meal would be expected to reduce calorie intake. But before advocating this measure for slimming, it is important to establish that I is not absorbed (since intravenous injection of I produces a deleterious elevation of blood lipids) and also that fat retention as well as fat absorption is decreased by I. This has now been tested in rats fed diets containing 20 70 corn oil supplemented or not with I in the food and/or drinking water. It was found that the total body fat of rats fed 2-5 70 1 was considerably less than that of untreated animals. The reduction in serum EFA at the end of the 12-wk experimental period showed that I was not absorbed. Moreover, the normal growth and well-being of the rats suggested a low toxicity for I.
1439. UK plastics toxicity symposium Transactions and Journal of the Plastics Institute (1967). Symposium on Toxicity in Plastics. ibid 35, 447. A brief account has already been given in these pages of the proceedings of the Symposium on Toxicity in Plastics, organized by the National College of Rubber Technology, London and held in December 1966 (Cited hz F.C.T. 1967, 5, 400). Summaries of nine of the ten papers have now been published as an official record of the proceedings of the Symposium.
1440. Fate and toxicity of 2,6-dioctadecyl-p-cresol Terhaar, C. J., Roudabush, R. L., Fassett, D. W. & Weinberg, M. S. (1967). Physiologic effects of 2,6-dioctadecyl-p-cresol (DOPC) in the rat and dog. Toxic. appl. Pharmac. 10, 401. Astill, B. D. & Fassett, D. W. (1967). Fate of 2,6-bis-(1 '-methylheptadecyl)-p-cresol (DOPC) in rats. Toxic. appl. Pharmac. 10, 400. 2,6-Dioctadecyl-p-cresol (DOPC) is an antioxidant with potential use as a stabilizer in food-packaging material. Preliminary reports on its toxicity and fate in the body have now been published. Terhaar et al. (cited above) have found a low acute oral toxicity, doses of 6400 and 3200 mg/kg being well tolerated by rats and mice respectively. It produced very slight skin irritation in guinea-pigs. Short-term dietary administration of 0-1% DOPC to rats had no effect on the appearance or behaviour of the animals or on food utilization, haematology, clinical chemistry or histology. The only adverse effect observed was a slight growth reduction in males at the 1% level. Dogs, too, tolerated 0-1 70 DOPC in the diet for 90 days apart from a slight, transient food refusal and weight loss. The low oral toxicity is not surprising since Astill & Fassett (cited above) have found that rats given DOPC orally excrete most of the dose in the faeces. After administration of a single oral dose (190-860) mg/kg), labelled with carbon-14 (~4C) in the l'-methyl groups, 96-99 % of the 14C was eliminated in the faeces and less than 1 Yo in the urine, while none was detected in the expired air. Similar results were obtained with a dietary level of 0.01 Yo given for 15 days. Only traces of 14C were found in the tissues (in the liver and brain after dietary administration, in the liver after low single doses and in the liver, brain, kidney and fat after high single doses), but these traces were eliminated at different rates from the body. 1441. Concerning triaryl phosphates Pegum, J. S. (1966). Contact dermatitis from plastics containing tri-aryl phosphates. Br. J. Derm. 78, 626. Seward, C. R., Vaughan, G., Shue, G. M. & Hove, E. L. (1966). Accentuation of essential fatty acid deficiency by dietary tri-o-cresyl phosphate. J. Nutr. 90, 245.