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15. Scalp somatosensory evoked potentials recordings after human subthalamic and pedunculopontine tegmental nucleus stimulation
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Abstracts / Clinical Neurophysiology 127 (2016) e133–e159
13. Optical coherence tomography and multifocal visual evoked potential clinical usefulness in identifying visual pathway involvement—S. Guerrieri, G. Di Maggio, F. Vitali, R. Santangelo, S. Medaglini, L. Moiola, U. Del Carro, V. Martinelli, G. Comi, L. Leocani (Milano, Italy) Full-field visual evoked potentials (ff-VEP) are fundamental in neurological practice, for defining the nature of visual disturbances. We explored whether, in case of normal ff-VEP and suspected organic visual pathway involvement, multifocal visual evoked potentials (mf-VEP) and optical coherence tomography (OCT) can be useful in the diagnostic workup. Observational case reports on 3 patients presenting with visual disturbances. Two had relapsing optic neuritis (ON) and visual acuity (VA) loss, with normal or non-significant ff-VEP outside acute clinical episodes. In both cases OCT showed a retinal nerve fiber layer (RNFL) thickness reduction, allowing visual pathway damage identification. The third, with meningioma involving left optic nerve, complained of blurred vision in the nasal field of the left eye as confirmed by computerized perimetry (CP). While ff-VEP showed normal latency and non-significant amplitude reduction in the left eye, mf-VEP showed important amplitude reduction in the lower visual field of the left eye. OCT scan confirmed axonal damage showing left RNFL thinning. Sometimes ff-VEP fails in identifying abnormalities in patients with pathologic processes involving the visual pathway, particularly in cases with axonal or sectorial optic nerve involvement. We suggest the importance of a multimodal evaluation, including OCT and mf-VEP. doi:10.1016/j.clinph.2015.09.021
14. An abnormal transduction of the chromatic stimuli from the outer to the inner retinal layers may contribute to the mechanism of photophobia in migraine—G. Coppola, L. Corso, A. Di Renzo, A. Fadda, F. Martelli, C. Di Lorenzo, V. Parisi, J. Schoenen, B. Falsini, F. Pierelli (Rome, Latina, Italy, Liège BE, Belgium) Recent experimental evidences point out a possible involvement of retina in hypersensitivity of migraine patients to light stimuli. Our aim was to investigate the short-wavelength-sensitive and the medium/l ong-wavelength-sensitive cone photoreceptors of the visual pathways in migraine without aura (MO) patients between attacks and in healthy volunteers (HV) by using yellow-blue (Y-B) or red-blue (R-B) visual flicker stimuli. Square-wave focal electroretinograms (FERGs) were recorded in 22 MO patients and 20 HV. Fourier analysis allowed extracting from the FERG data the fundamental (1F) and the second harmonic (2F) components (amplitude and phase) that are related respectively to outer and inner retinal activity. Usual headache severity and photophobia during migraine were scored on a 0 to 10 visual analogue scale. When compared to HV, MO patients had an advanced 1F phase but normal amplitude in all blocks of Y-B FERG. Self-rated intensity of ictal photophobia positively correlated with attack frequency, headache severity, 1F Y-B phase, 1F R-B phase, 2F Y-B amplitude, habituation slope, and 2F R-B phase. These results suggest that an abnormal signal transduction from the outer to the inner retinal layers could contribute to the mechanisms by which light causes pain or discomfort during the migraine headache. doi:10.1016/j.clinph.2015.09.022
15. Scalp somatosensory evoked potentials recordings after human subthalamic and pedunculopontine tegmental nucleus stimulation—A. Insola, P. Mazzone, M. Valeriani (Roma, Italy) The study aimed to investigate the pathways activated by deep brain stimulation (DBS). Four patients, suffering from parkinson
disease (PD), underwent DBS electrode implant in the pedunculopontine (PPTg) nucleus (2 patients) and in the Subthalamic (STN) nucleus (2 patients) for neuromodulation. Somatosensory evoked potentials (SEPs) were recorded from the scalp to either median nerve or DBS electrode stimulation. The PPTg stimulation evoked a parietal negative and a frontal positive response at a latency of 3 ms, corresponding to the N20 and P20 potentials to median nerve stimulation, respectively. The STN stimulation evoked a negative potential at a latency of 6 ms in both the parietal and frontal electrodes. Our findings show that the electrical stimulation of the PPTg electrode contacts activate an oligosynaptic (probably lemniscal) pathway, while the scalp responses to STN stimulation are mediated by a polysynaptic pathway. doi:10.1016/j.clinph.2015.09.023
16. Vestibular evoked myogenic potentials (c-Vemps and o-Vemps) in some otoneurological diseases—R. Del Colle, A. Lupato, S. Ricci, M. Turazzini, L. Bevacqua, A. Polo (Legnago, Italy) c-VEMPs and o-VEMPs are a new diagnostic tool to detect diseases of the inner ear and the vestibular pathways. The aim of our study was to assess the reliability of c-VEMPs and o-VEMPs in some otoneurological diseases. We examined 27 patients, 15 F, 12 M, mean age 42,5. 20 Ménière disease (MD), 3 Benign Paroxysmal Positional Vertigo (BPPV) and 4 vestibular neuritis (VN). c-VEMPs were recorded from electrodes placed over the SCM, with reference over the clavicle. o-VEMPs from the same electrodes placed beneath the eye and reference 2 cm below. For both c-VEMPs and o-VEMPs we used acoustic stimuli (tone burst, 117 dB SPL). MD: both c-VEMPs and o-VEMPs were normal in 13 patients (65%); c-VEMPs were abnormal in 1 patient (5%); o-VEMPs in 4 patients (20%) and both c-VEMPs and o-VEMPs in 2 patients (10%). BPPV: normal in 2 pts. (67%); o-VEMPs abnormal in 1 pt. (33%) VN: c-VEMPs abnormal in 1 pt; (25%), o-VEMPs in 1pt. (25%) both c-VEMPs and o-VEMPs in 2 pts. (50%). c-VEMPs and o-VEMPs seem to be reliable tests to improve the diagnosis of otoneurological diseases. We point out that in some subjects with MD the only abnormal test was o-VEMPs. doi:10.1016/j.clinph.2015.09.024
17. Pain modulation in patients with Multiple Sclerosis, pain and spasticity after oromucosal cannabinoid spray (THC/CBD): A study with quantitative sensory testing and laser evoked potentials—M. Turri, F. Donato, F. Teatini, G. Zanette, V. Tugnoli, L. Deotto, G. Moretto, G. Squintani (Bolzano, Italy, Verona, Italy, Peschiera del Garda, Italy, Ferrara, Italy) Oromucosal cannabinoid (THC/CBD) spray administration for the treatment of pain in patients affected by Multiple Sclerosis (MS) has been well documented and MS patients generally complain of different kind of pain, including spasticity-related and neuropathic pain. Our purpose was to examine pain modulation and thermal/pain threshold of MS patients before and after THC/CBD. 16 MS patients underwent clinical examination (including NRS scale), Quantitative Sensory Testing (QST) and Laser Evoked Potentials (LEPs) before and after one month of oromucosal spray. Psychophysiological and neurophysiological testing were compared to sex- and agematched controls. Patients reported a significant reduction in pain (NRS 7,2 /4,7 before/after THC/CBD); QST thresholds were altered in patients and did not change after THC/CBD; there was a significant reduction of LEPs amplitude and increase of LEPs latency in MS patients compared to controls and no significant threshold or LEPs parameters change was noted after drug administration. Our results
Abstracts / Clinical Neurophysiology 127 (2016) e133–e159
13. Optical coherence tomography and multifocal visual evoked potential clinical usefulness in identifying visual pathway involvement—S. Guerrieri, G. Di Maggio, F. Vitali, R. Santangelo, S. Medaglini, L. Moiola, U. Del Carro, V. Martinelli, G. Comi, L. Leocani (Milano, Italy) Full-field visual evoked potentials (ff-VEP) are fundamental in neurological practice, for defining the nature of visual disturbances. We explored whether, in case of normal ff-VEP and suspected organic visual pathway involvement, multifocal visual evoked potentials (mf-VEP) and optical coherence tomography (OCT) can be useful in the diagnostic workup. Observational case reports on 3 patients presenting with visual disturbances. Two had relapsing optic neuritis (ON) and visual acuity (VA) loss, with normal or non-significant ff-VEP outside acute clinical episodes. In both cases OCT showed a retinal nerve fiber layer (RNFL) thickness reduction, allowing visual pathway damage identification. The third, with meningioma involving left optic nerve, complained of blurred vision in the nasal field of the left eye as confirmed by computerized perimetry (CP). While ff-VEP showed normal latency and non-significant amplitude reduction in the left eye, mf-VEP showed important amplitude reduction in the lower visual field of the left eye. OCT scan confirmed axonal damage showing left RNFL thinning. Sometimes ff-VEP fails in identifying abnormalities in patients with pathologic processes involving the visual pathway, particularly in cases with axonal or sectorial optic nerve involvement. We suggest the importance of a multimodal evaluation, including OCT and mf-VEP. doi:10.1016/j.clinph.2015.09.021
14. An abnormal transduction of the chromatic stimuli from the outer to the inner retinal layers may contribute to the mechanism of photophobia in migraine—G. Coppola, L. Corso, A. Di Renzo, A. Fadda, F. Martelli, C. Di Lorenzo, V. Parisi, J. Schoenen, B. Falsini, F. Pierelli (Rome, Latina, Italy, Liège BE, Belgium) Recent experimental evidences point out a possible involvement of retina in hypersensitivity of migraine patients to light stimuli. Our aim was to investigate the short-wavelength-sensitive and the medium/l ong-wavelength-sensitive cone photoreceptors of the visual pathways in migraine without aura (MO) patients between attacks and in healthy volunteers (HV) by using yellow-blue (Y-B) or red-blue (R-B) visual flicker stimuli. Square-wave focal electroretinograms (FERGs) were recorded in 22 MO patients and 20 HV. Fourier analysis allowed extracting from the FERG data the fundamental (1F) and the second harmonic (2F) components (amplitude and phase) that are related respectively to outer and inner retinal activity. Usual headache severity and photophobia during migraine were scored on a 0 to 10 visual analogue scale. When compared to HV, MO patients had an advanced 1F phase but normal amplitude in all blocks of Y-B FERG. Self-rated intensity of ictal photophobia positively correlated with attack frequency, headache severity, 1F Y-B phase, 1F R-B phase, 2F Y-B amplitude, habituation slope, and 2F R-B phase. These results suggest that an abnormal signal transduction from the outer to the inner retinal layers could contribute to the mechanisms by which light causes pain or discomfort during the migraine headache. doi:10.1016/j.clinph.2015.09.022
15. Scalp somatosensory evoked potentials recordings after human subthalamic and pedunculopontine tegmental nucleus stimulation—A. Insola, P. Mazzone, M. Valeriani (Roma, Italy) The study aimed to investigate the pathways activated by deep brain stimulation (DBS). Four patients, suffering from parkinson
disease (PD), underwent DBS electrode implant in the pedunculopontine (PPTg) nucleus (2 patients) and in the Subthalamic (STN) nucleus (2 patients) for neuromodulation. Somatosensory evoked potentials (SEPs) were recorded from the scalp to either median nerve or DBS electrode stimulation. The PPTg stimulation evoked a parietal negative and a frontal positive response at a latency of 3 ms, corresponding to the N20 and P20 potentials to median nerve stimulation, respectively. The STN stimulation evoked a negative potential at a latency of 6 ms in both the parietal and frontal electrodes. Our findings show that the electrical stimulation of the PPTg electrode contacts activate an oligosynaptic (probably lemniscal) pathway, while the scalp responses to STN stimulation are mediated by a polysynaptic pathway. doi:10.1016/j.clinph.2015.09.023
16. Vestibular evoked myogenic potentials (c-Vemps and o-Vemps) in some otoneurological diseases—R. Del Colle, A. Lupato, S. Ricci, M. Turazzini, L. Bevacqua, A. Polo (Legnago, Italy) c-VEMPs and o-VEMPs are a new diagnostic tool to detect diseases of the inner ear and the vestibular pathways. The aim of our study was to assess the reliability of c-VEMPs and o-VEMPs in some otoneurological diseases. We examined 27 patients, 15 F, 12 M, mean age 42,5. 20 Ménière disease (MD), 3 Benign Paroxysmal Positional Vertigo (BPPV) and 4 vestibular neuritis (VN). c-VEMPs were recorded from electrodes placed over the SCM, with reference over the clavicle. o-VEMPs from the same electrodes placed beneath the eye and reference 2 cm below. For both c-VEMPs and o-VEMPs we used acoustic stimuli (tone burst, 117 dB SPL). MD: both c-VEMPs and o-VEMPs were normal in 13 patients (65%); c-VEMPs were abnormal in 1 patient (5%); o-VEMPs in 4 patients (20%) and both c-VEMPs and o-VEMPs in 2 patients (10%). BPPV: normal in 2 pts. (67%); o-VEMPs abnormal in 1 pt. (33%) VN: c-VEMPs abnormal in 1 pt; (25%), o-VEMPs in 1pt. (25%) both c-VEMPs and o-VEMPs in 2 pts. (50%). c-VEMPs and o-VEMPs seem to be reliable tests to improve the diagnosis of otoneurological diseases. We point out that in some subjects with MD the only abnormal test was o-VEMPs. doi:10.1016/j.clinph.2015.09.024
17. Pain modulation in patients with Multiple Sclerosis, pain and spasticity after oromucosal cannabinoid spray (THC/CBD): A study with quantitative sensory testing and laser evoked potentials—M. Turri, F. Donato, F. Teatini, G. Zanette, V. Tugnoli, L. Deotto, G. Moretto, G. Squintani (Bolzano, Italy, Verona, Italy, Peschiera del Garda, Italy, Ferrara, Italy) Oromucosal cannabinoid (THC/CBD) spray administration for the treatment of pain in patients affected by Multiple Sclerosis (MS) has been well documented and MS patients generally complain of different kind of pain, including spasticity-related and neuropathic pain. Our purpose was to examine pain modulation and thermal/pain threshold of MS patients before and after THC/CBD. 16 MS patients underwent clinical examination (including NRS scale), Quantitative Sensory Testing (QST) and Laser Evoked Potentials (LEPs) before and after one month of oromucosal spray. Psychophysiological and neurophysiological testing were compared to sex- and agematched controls. Patients reported a significant reduction in pain (NRS 7,2 /4,7 before/after THC/CBD); QST thresholds were altered in patients and did not change after THC/CBD; there was a significant reduction of LEPs amplitude and increase of LEPs latency in MS patients compared to controls and no significant threshold or LEPs parameters change was noted after drug administration. Our results