- Email: [email protected]
1634 Internal carotid artery stenosis among saudis
$514
Poster Abstracts
Friday, November 11, 2005
in a day with interval of 30 minutes. Dopamine release during these tasks was measured with a high-speed voltammetry system. When rats met a criterion for task aclffevement, they were injected p-chlorophenylalanine (PCPA; 200mg/kg i.p., × 3 days), serotonin synthesis inhibiter. Results: Before injection PCPA, dopmnine release began to increase soon after the beginning of each session and decreased to the control level in a few minutes after the end of each session. In contrast, dopamine release was not observed during locomotive behaviour. This type of dopamine change was suppressed after the injection of PCPA. Conclusion: The slow dmnge in dopamine release may reflect the level of attention and interest that would be required for the lever-pressed task. Serotonin neuron may promote this type of dopamine release in the striatum. 1632 Hasldmoto's Eneephalopathy presenting as Retrobulber Neuritis: a ease report
coordinator). Each o f the modules included a set of lectures for all participants and an interactive training session, specially designed for each employee groups (e.g. doctors, nurses etc). Before the start of training the persomtel were send a questiommire in wlffch knowledge of and attitudes towards GCP were asked. Also the staff was asked of their opinion on the GCP compliance of the studies carried out at the department. The questionnaire was repeated after the training. Results: Over 90% of the nurses and about 50% of the physicians participated in the total program. The questionnaire showed that the program improved knowledge in such issues as the Helsinki declaration, the law on biomedical research and the rights of the study subject. Overall, positive attitudes towards GCP were strengthened. Conclusion: Our experience suggests that a simple in-house training program can increase GCP knowledge and thus help to improve GCP compliance.
Kaya, y1, Musapasaoghi, H 1, Benii, fiS 1, Celiker, G 1, Can, U 1.
1634 Internal Carotid Artery Stenos~s among Saudis
1Baskent University Hospital, Neurology Department, Ankara, Turkey
Waleed Khoja, M D 1. 2Neurosonology Laboratory, Stroke Program,
Hashimoto's encephalopathy is a condition that can affect a subset of patients with Hashimoto's disease. It includes neurologic symptoms such as stroke-like episodes, stupor, seizures, psychosis, tremor, nlyoclonus and nlyelopathy. The pathogenetic hypotheses proposed include autoim_mune vasculitis, autoim_mune reaction to antigens shared by the thyroid gland and CNS, and cerebral hypoperfusion. Hashimoto's encephalopathy is characterized by the association of symptoms with high levels of antithyroid antibodies independent of thyroid function tests, wlffcll usually have nomlal results. We report a 53 years old woman with the complaint of total visual loss in the left eye for 3 days was admitted to the hospital with the diagnosis of retrobulber neuritis. Neurologic examination findings were normal. T2 weighted MRI scans showed hyperintense lesion on the left temporal lobe localized in the optic radiation and the lesion enhanced gadolinimn. Using M R spectroscopy, we determined increased choline to creatine ratio, suggesting acute demyelination. GSF findings were normal. Blood tests for vasculitic syndromes were normal, except TSH decline. Antithyroglobuline antibody titers were twice elevated in blood than normal ratios reflecting Hashimoto's thyroiditis. Also thyroid USG supported the diagnosis. Intravenous methylprednisolone was given for treatment and 4 months later her visual field examination got better and the lesion that was shown in MRI disappeared. Clinical and radiological improvement to the treatment supported our diagnosis. Hashimoto's thyroiditis can rarely cause demyelination lesions due to autoimmune vasculitis. In patients who have acute demyelination in neuroimaging, we must keep in mind Haslffmoto's thyroiditis as diagnosis, although thyroid function tests were normal.
Neurology Division, Neuroscience Department, _PdyadhArmed Forces Hospital.
1633 Good clinical practice principles can be promoted by in-house training Keranen, T 1, Kuusisto, H ~, Virkki, M ~, Wuolijoki, g 2, Mohmr, G 1, Snikkanen, T 1. 2Department Of Neurology, Tampere Universi(v
Hospital, Finland,"2Research Unit, Tampere University Hospital, Finland
Background: Good Clinical Practice (GCP) is a set o f ethical and scientific quality requirements for conducting clinical trials. Within the European Union tile standards of GCP have now been included in the legislation of the member states. Tiffs represents a challenge for academic drug research including a need for GCP training. We have developed an in-house GCP training program for the whole personnel (including nurses) at the Department of Neurology and Rehabilitation, Tampere University Hospital, Finland. Method: Tile training progranl comprised three modules (laws and rules concerning clinical research; responsibilities and tile investigator and conduct of a study; responsibilities of the study nurse/research
Introduction: Internal carotid (ICA) stenosis is a well known independent factor for ischemic stroke in adults. The prevalence of ICA stenosis among Saudis is still unknomt; however, carotid bruits have been reported to be only 1% among them. We believe that symptomatic and asymptomatic 1-CA stenosis is not rare among Saudis, due to the increasing cerebrovascular risk factors. Aim: Identify the prevalence o f ICA stenosis among Saudi adults with or without stroke/transient ischemic attacks (TIA's), and determine the relation between 1-CA stenosis and different risk factors. Also, determine whether severe 1-CA stenosis is more symptomatic among Saudis. Method: This study is part o f a continuous prospective transcranial Doppler (TCD) evaluation of extra and intracranial vessels disease among Saudis, which is still on going. Patients above the age of 40 years who presented between January 2001 and October 2003 were induded. ICA stenosis was calculated using a unified protocol where ICA was graded as no stenosis, 30-69% stenosis, 70-99% stenosis and occlusion. ICA stenosis grade in relation to risk factors were analyzed. Concordance of IC.A stenosis grade with brain neuroimages in stroke patients was made. Patient with poor ICA evaluation were excluded. Results: 737 patients (1474 carotids) were included. The mean age was 60.7 ± 11.6 years and there were 65.4% men. The prevalence of various degree o f I C A stenosis was 21.67%, with no gender preference. There were 468 patients with stroke or TIA (63.5%), where ICA stenosis was seen in 23.7% of them. However severe stenosis (i_>70% to occlusion) was seen in 8.28% of all population study, more in men (6.51%) and also more in patients with stroke/TIA compared to non stroke patients (6.24, and 2.04%, respectively). Hypertension and diabetes were significantly associated with sever ICA stenosis. ICA stenosis of more than 70% or occlusion was significantly concordant with the brain neuroimages in stroke patients when compared to less than 70% ICA stenosis. Conclusion: One out of 4-5 Saudi patients with ischemic stroke has a certain degree of an ICA stenosis on either side. It appears that severe stenosis is not uncommon among Saudis, particularly in symptomatic men. Hypertension and D M were the most important risk factors for ICA stenosis. The dear correlation of ischemic lesion and severity of ICA stenosis reflects the importance of screening all patients with ischemic stroke to identify legible ICA for endarterectomy. 1635 Vestibular evoked Myogenic potentials in Stroke patient
Kiln, S J ,1 Kim, K-K 1 . 2 Department o/Neurology, College of Medicine,
Kangwon National University, Republic of Korea
Poster Abstracts
Friday, November 11, 2005
in a day with interval of 30 minutes. Dopamine release during these tasks was measured with a high-speed voltammetry system. When rats met a criterion for task aclffevement, they were injected p-chlorophenylalanine (PCPA; 200mg/kg i.p., × 3 days), serotonin synthesis inhibiter. Results: Before injection PCPA, dopmnine release began to increase soon after the beginning of each session and decreased to the control level in a few minutes after the end of each session. In contrast, dopamine release was not observed during locomotive behaviour. This type of dopamine change was suppressed after the injection of PCPA. Conclusion: The slow dmnge in dopamine release may reflect the level of attention and interest that would be required for the lever-pressed task. Serotonin neuron may promote this type of dopamine release in the striatum. 1632 Hasldmoto's Eneephalopathy presenting as Retrobulber Neuritis: a ease report
coordinator). Each o f the modules included a set of lectures for all participants and an interactive training session, specially designed for each employee groups (e.g. doctors, nurses etc). Before the start of training the persomtel were send a questiommire in wlffch knowledge of and attitudes towards GCP were asked. Also the staff was asked of their opinion on the GCP compliance of the studies carried out at the department. The questionnaire was repeated after the training. Results: Over 90% of the nurses and about 50% of the physicians participated in the total program. The questionnaire showed that the program improved knowledge in such issues as the Helsinki declaration, the law on biomedical research and the rights of the study subject. Overall, positive attitudes towards GCP were strengthened. Conclusion: Our experience suggests that a simple in-house training program can increase GCP knowledge and thus help to improve GCP compliance.
Kaya, y1, Musapasaoghi, H 1, Benii, fiS 1, Celiker, G 1, Can, U 1.
1634 Internal Carotid Artery Stenos~s among Saudis
1Baskent University Hospital, Neurology Department, Ankara, Turkey
Waleed Khoja, M D 1. 2Neurosonology Laboratory, Stroke Program,
Hashimoto's encephalopathy is a condition that can affect a subset of patients with Hashimoto's disease. It includes neurologic symptoms such as stroke-like episodes, stupor, seizures, psychosis, tremor, nlyoclonus and nlyelopathy. The pathogenetic hypotheses proposed include autoim_mune vasculitis, autoim_mune reaction to antigens shared by the thyroid gland and CNS, and cerebral hypoperfusion. Hashimoto's encephalopathy is characterized by the association of symptoms with high levels of antithyroid antibodies independent of thyroid function tests, wlffcll usually have nomlal results. We report a 53 years old woman with the complaint of total visual loss in the left eye for 3 days was admitted to the hospital with the diagnosis of retrobulber neuritis. Neurologic examination findings were normal. T2 weighted MRI scans showed hyperintense lesion on the left temporal lobe localized in the optic radiation and the lesion enhanced gadolinimn. Using M R spectroscopy, we determined increased choline to creatine ratio, suggesting acute demyelination. GSF findings were normal. Blood tests for vasculitic syndromes were normal, except TSH decline. Antithyroglobuline antibody titers were twice elevated in blood than normal ratios reflecting Hashimoto's thyroiditis. Also thyroid USG supported the diagnosis. Intravenous methylprednisolone was given for treatment and 4 months later her visual field examination got better and the lesion that was shown in MRI disappeared. Clinical and radiological improvement to the treatment supported our diagnosis. Hashimoto's thyroiditis can rarely cause demyelination lesions due to autoimmune vasculitis. In patients who have acute demyelination in neuroimaging, we must keep in mind Haslffmoto's thyroiditis as diagnosis, although thyroid function tests were normal.
Neurology Division, Neuroscience Department, _PdyadhArmed Forces Hospital.
1633 Good clinical practice principles can be promoted by in-house training Keranen, T 1, Kuusisto, H ~, Virkki, M ~, Wuolijoki, g 2, Mohmr, G 1, Snikkanen, T 1. 2Department Of Neurology, Tampere Universi(v
Hospital, Finland,"2Research Unit, Tampere University Hospital, Finland
Background: Good Clinical Practice (GCP) is a set o f ethical and scientific quality requirements for conducting clinical trials. Within the European Union tile standards of GCP have now been included in the legislation of the member states. Tiffs represents a challenge for academic drug research including a need for GCP training. We have developed an in-house GCP training program for the whole personnel (including nurses) at the Department of Neurology and Rehabilitation, Tampere University Hospital, Finland. Method: Tile training progranl comprised three modules (laws and rules concerning clinical research; responsibilities and tile investigator and conduct of a study; responsibilities of the study nurse/research
Introduction: Internal carotid (ICA) stenosis is a well known independent factor for ischemic stroke in adults. The prevalence of ICA stenosis among Saudis is still unknomt; however, carotid bruits have been reported to be only 1% among them. We believe that symptomatic and asymptomatic 1-CA stenosis is not rare among Saudis, due to the increasing cerebrovascular risk factors. Aim: Identify the prevalence o f ICA stenosis among Saudi adults with or without stroke/transient ischemic attacks (TIA's), and determine the relation between 1-CA stenosis and different risk factors. Also, determine whether severe 1-CA stenosis is more symptomatic among Saudis. Method: This study is part o f a continuous prospective transcranial Doppler (TCD) evaluation of extra and intracranial vessels disease among Saudis, which is still on going. Patients above the age of 40 years who presented between January 2001 and October 2003 were induded. ICA stenosis was calculated using a unified protocol where ICA was graded as no stenosis, 30-69% stenosis, 70-99% stenosis and occlusion. ICA stenosis grade in relation to risk factors were analyzed. Concordance of IC.A stenosis grade with brain neuroimages in stroke patients was made. Patient with poor ICA evaluation were excluded. Results: 737 patients (1474 carotids) were included. The mean age was 60.7 ± 11.6 years and there were 65.4% men. The prevalence of various degree o f I C A stenosis was 21.67%, with no gender preference. There were 468 patients with stroke or TIA (63.5%), where ICA stenosis was seen in 23.7% of them. However severe stenosis (i_>70% to occlusion) was seen in 8.28% of all population study, more in men (6.51%) and also more in patients with stroke/TIA compared to non stroke patients (6.24, and 2.04%, respectively). Hypertension and diabetes were significantly associated with sever ICA stenosis. ICA stenosis of more than 70% or occlusion was significantly concordant with the brain neuroimages in stroke patients when compared to less than 70% ICA stenosis. Conclusion: One out of 4-5 Saudi patients with ischemic stroke has a certain degree of an ICA stenosis on either side. It appears that severe stenosis is not uncommon among Saudis, particularly in symptomatic men. Hypertension and D M were the most important risk factors for ICA stenosis. The dear correlation of ischemic lesion and severity of ICA stenosis reflects the importance of screening all patients with ischemic stroke to identify legible ICA for endarterectomy. 1635 Vestibular evoked Myogenic potentials in Stroke patient
Kiln, S J ,1 Kim, K-K 1 . 2 Department o/Neurology, College of Medicine,
Kangwon National University, Republic of Korea