- Email: [email protected]
16th International Symposium on Regulatory Peptides
Regulatory Peptides 135 (2006) 95 – 100 www.elsevier.com/locate/regpep
Abstracts
16 th International Symposium on Regulatory Peptides Shinagawa, Le Méridien Pacific Tokyo (August 30, 2006) Hakone, Hakone Prince Hotel (August 31–September 2, 2006)
Chairman of the Organizing Committee: Kentaro Sugano Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Tel.: +81 285 58 7347; fax: +81 285 40 6598 Email address: [email protected]
doi:10.1016/j.regpep.2006.06.007
96
Abstracts
International Steering Committee Daniel Fourmy, Ph.D. (France), Chairman Graham Baldwin, M.D. (Australia) Christoph Beglinger, M.D. (Switzerland) Daniel Drucker, M.D. (Canada) Linda Hilsted, M.D. DMed Sc. (Denmark) Andrew B. Leiter, M.D. Ph.D. (USA) Wolfgang Schmidt, M.D. Ph.D. (Germany) Kentaro Sugano, M.D. Ph.D. (Japan) Andrea Varro, M.D. PhD. (UK) Timothy C. Wang, M.D. Ph.D. (USA)
Local Organizing Committee
(Honorary Advisors)
(Advisors)
Zen Itoh Tsuneo Fujita Hisayuki Matsuo
Yasuhiko Ibata Makoto Otsuki Mitsugi Sugiyama
(Steering Committee)
Akemichi Baba
Seiji Shioda Kentaro Sugano, Chairman Toshiyuki Takeuchi Hirohito Tsubouchi Mamoru Watanabe Toshihiko Yada
Tsutomu Chiba Toshifumi Hibi Michio Kaminishi Itaru Kojima Masamitsu Nakazato Toru Shimosegawa
(Organizing Committee) Ryuichiro Doi Kazuma Fujimoto Koichi Hirata Masayuki Imamura Kinji Inoue Akio Inui Tetsuhide Ito Kenji Kangawa Sumio Kawata Masahito Kawatani Yoshikazu Kinoshita Yutaka Kohgo
Masayasu Kojima Atsukazu Kuwahara Takashi Matozaki Bunzo Matsuura Yasuhiko Minokoshi Soichiro Miura Kyoko Miyasaka Hisataka Moriwaki Satoru Naruse Toshikatsu Okumura Choitsu Sakamoto Takeshi Sakurai
Yutaka Sasaki Yasufumi Sato Yasuhisa Shinomura Goshi Shiota Keiko Shiratori Hidekazu Suzuki Noriko Takahashi Koji Takeuchi Koji Yakabi Yuichiro Yamada Ken Yamaguchi Masashi Yoneda
Abstracts
97
Acknowledgements We wish to express our sincere appreciation to the following for their generous support for the 16th International Symposium on Regulatory Peptides.
JSPS International meeting series
Under the Auspices of: (in alphabetical order) Japan Neuroendocrine Society Japan Pancreas Society Japan Society for the Promotion of Science Japan Society for the Study of Obesity (JASSO) Japanese Society for Gastroenterological Carcinogenesis Japanese Society for Immunology Japanese Society for Mucosal Immunology Physiological Society of Japan The Japan Endocrine Society The Japan Society of Hepatology The Japanese Association of Anatomists The Japanese Biochemical Society The Japanese Pharmacological Society The Japanese Society of Gastroenterological Surgery The Japanese Society of Gastroenterology
Co-Sponsored by: Co-sponsored by the 21st Century COE Project, University of Miyazaki
Sponsored by: (in alphabetical order) Alumni Association of Gastroenterology, Jichi Medical University Astellas Pharma Inc. AstraZeneca K.K. Daiichi Asubio Pharma Co., Ltd. Dainippon Sumitomo Pharma Co., Ltd. Eisai Co., Ltd. GlaxoSmithKline Meirinkai Imaichi Hospital Koganei Chuo Hospital NIHON SCHERING K.K. ONO PHARMACEUTICAL CO., LTD. Otsuka Pharmaceutical Co., Ltd. Rakuwakai Marutamachi Hospital TAIHO PHARMACEUTICAL CO., LTD. Takeda Pharmaceutical Company Limited TANABE SEIYAKU CO., LTD. The Federation of Pharmaceutical Manufacturers' Associations of JAPAN The Uehara Memorial Foundation
98
Abstracts
Abstracts Reviewers: (in alphabetical order) Graham Baldwin Chung Owyang Christoph Beglinger Daniel Podolsky Tsutomu Chiba Choitsu Sakamoto Daniel Drucker Yutaka Sasaki Kazuma Fujimoto Wolfgang Schmidt Vay Liang Go Catherine Seva Akio Inui Yasuhisa Shinomura Tetsuhide Ito Seiji Shioda Michio Kaminishi Yvett Taché Masahito Kawatani Noriko Takahashi Itaru Kojima Toshiyuki Takeuchi Masayasu Kojima Andrea Todisco Andrew Leiter Andrea Varro Bunzo Matsuura Mamoru Watanabe Soichiro Miura Michael Wolfe Kyoko Miyasaka Toshihiko Yada Hisataka Moriwaki Yuichiro Yamada Masamitsu Nakazato Masashi Yoneda Satoru Naruse
Abstracts
99
Schedule (tentative) As of August 8, 2006 August 30 (Wednesday): Memorial Symposium at the Le Méridien Pacific Tokyo (Shinagawa, Tokyo) Chairs: D. Fourmy (INSERM, France), Y. Ibata (Kyoto Prefectural Government, Japan) 15:30–16:00 Gastrin - CCK: History and perspective J. F. Rehfeld (Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark) 16:00–16:30 Motilin and motilides Z. Itoh (Gunma University School of Medicine, Japan) 16:30–17:00 VIP and related peptides: Historical background and future perspective S. I. Said (SUNY at Stony Brook, NY, Department of Medicine, USA) 17:00–17:30 Physiologically active peptides involved in cell–cell communication H. Matsuo (National Cardiovascular Center Research Institute, Japan) 17:30–18:00 Realizing the drug discovery potential of the human genome T. Yamada (Global Health Program, Bill and Melinda Gates Foundation, USA) From August 31 (Thursday) to September 2 (Saturday): Symposium Lecturers and Invited Lecturers of the Sponsored Symposium at the Hakone Prince Hotel (Kanagawa, Japan) Symposium Lecturers: September 1 (Friday) Hedgehog signaling in development and disease P. A. Beachy (Johns Hopkins University, Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, USA) September 2 (Saturday) Beta-arrestin-dependent signaling by seven-transmembrane receptors S. K. Shenoy (Duke University Medical Center, USA) Invited Lecturers: (alphabetical order of presenter's name) Speakers at the Sponsored Symposium Effects of intraduodenal fatty acids on plasma CCK, PYY and ghrelin in humans C. Beglinger (Department of Gastroenterology, University of Basel, Switzerland ) Supramaximal cholecystokinin stimulates apoptosis and necrosis in pancreatic acinar cells: Role in pancreatitis A. Gukovskaya (West Los Angeles Veterans Affairs Healthcare Center, USA) GM-CSF efficacy in Crohn's disease: Lessons learned from a mouse model of colitis E. M. Hanna (Washington University in St. Louis, USA) Translational research of GLP-1 J. J. Holst (University of Copenhagen, Denmark) Transcriptional control of enteroendocrine cell fate specification A. B. Leiter (Tufts–New England Medical Center, USA) Evolving insights into IBD pathogenesis: Lessons from therapeutic successes and failures L. Mayer (The Mount Sinai Medical Center, USA) Differentiation of gastric mucus-secreting neck cell progenitors into mature digestive-enzyme-secreting zymogenic (chief ) cells J. C. Mills (Washington University School of Medicine, USA)
100
Abstracts
Regulation of immune tolerance by emerging anti-inflammatory neuropeptides: Therapeutic applications on inflammation, autoimmunity and transplantation M. Delgado (Institute of Parasitology and Biomedicine, CSIC, Granada, Spain) Translational research of ghrelin M. Nakazato (Miyazaki Medical College, University of Miyazaki, Japan) Role of angiopoietin-like proteins (Angptls) in angiogenesis and metabolism Y. Oike (Laboratory of Vascular Biology and Metabolism Center for Integrated Medical Research, School of Medicine, Keio University, Japan) Ghrelin dynamics in upper gastroduodenal diseases H. Suzuki (Department of Internal Medicine, Keio University School of Medicine, Japan) Corticotropin releasing factor (CRF) receptors 1 and 2 (CRF1 and CRF2): Differential distribution and action in upper and lower gut function Y. Taché (University of California, Los Angeles, USA) Regulation of interdigestive motility by gastrointestinal hormonal factors such as ghrelin, motilin and leptin J. Tack (Department of Gastroenterology, University Hospital Leuven, Belgium) GPR 120 and receptors for free fatty acids G. Tsujimoto (Kyoto University, Japan) Crossing between Mucosal Immunity and Epithelial Regeneration/Differentiation in the Human Intestine M. Watanabe (Crossing between mucosal immunity and epithelial regeneration/differentiation in the human intestine) Regulation of epithelial cell differentiation by mesenchymal cells in the development of the digestive organs S. Yasugi (Department of Biological Sciences, Graduate School of Sciences, Tokyo Metropolitan University, Japan) Speakers at the Technical Seminar New peptide-based protein profiling technology for clinical proteomics R. Kobayashi (University of Texas MD Anderson Cancer Center, USA) Calcium signaling in the cytoplasm versus nucleus: Location is everything M. H. Nathanson (Yale University School of Medicine, USA) Viktor Mutt Lectureship: Discovery of ghrelin and its impact on the basic and clinical research M. Kojima (Kurume University, Institute of Life Science, Japan) Social Events: August 31 (Thursday) 17:30–19:00 Evening cruise 19:30–21:30 Symposium dinner at “Restaurant "Sakura"” September 1 (Friday) 19:00–21:00 Symposium party at “Hakone-en Hall”
Abstracts
16 th International Symposium on Regulatory Peptides Shinagawa, Le Méridien Pacific Tokyo (August 30, 2006) Hakone, Hakone Prince Hotel (August 31–September 2, 2006)
Chairman of the Organizing Committee: Kentaro Sugano Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Tel.: +81 285 58 7347; fax: +81 285 40 6598 Email address: [email protected]
doi:10.1016/j.regpep.2006.06.007
96
Abstracts
International Steering Committee Daniel Fourmy, Ph.D. (France), Chairman Graham Baldwin, M.D. (Australia) Christoph Beglinger, M.D. (Switzerland) Daniel Drucker, M.D. (Canada) Linda Hilsted, M.D. DMed Sc. (Denmark) Andrew B. Leiter, M.D. Ph.D. (USA) Wolfgang Schmidt, M.D. Ph.D. (Germany) Kentaro Sugano, M.D. Ph.D. (Japan) Andrea Varro, M.D. PhD. (UK) Timothy C. Wang, M.D. Ph.D. (USA)
Local Organizing Committee
(Honorary Advisors)
(Advisors)
Zen Itoh Tsuneo Fujita Hisayuki Matsuo
Yasuhiko Ibata Makoto Otsuki Mitsugi Sugiyama
(Steering Committee)
Akemichi Baba
Seiji Shioda Kentaro Sugano, Chairman Toshiyuki Takeuchi Hirohito Tsubouchi Mamoru Watanabe Toshihiko Yada
Tsutomu Chiba Toshifumi Hibi Michio Kaminishi Itaru Kojima Masamitsu Nakazato Toru Shimosegawa
(Organizing Committee) Ryuichiro Doi Kazuma Fujimoto Koichi Hirata Masayuki Imamura Kinji Inoue Akio Inui Tetsuhide Ito Kenji Kangawa Sumio Kawata Masahito Kawatani Yoshikazu Kinoshita Yutaka Kohgo
Masayasu Kojima Atsukazu Kuwahara Takashi Matozaki Bunzo Matsuura Yasuhiko Minokoshi Soichiro Miura Kyoko Miyasaka Hisataka Moriwaki Satoru Naruse Toshikatsu Okumura Choitsu Sakamoto Takeshi Sakurai
Yutaka Sasaki Yasufumi Sato Yasuhisa Shinomura Goshi Shiota Keiko Shiratori Hidekazu Suzuki Noriko Takahashi Koji Takeuchi Koji Yakabi Yuichiro Yamada Ken Yamaguchi Masashi Yoneda
Abstracts
97
Acknowledgements We wish to express our sincere appreciation to the following for their generous support for the 16th International Symposium on Regulatory Peptides.
JSPS International meeting series
Under the Auspices of: (in alphabetical order) Japan Neuroendocrine Society Japan Pancreas Society Japan Society for the Promotion of Science Japan Society for the Study of Obesity (JASSO) Japanese Society for Gastroenterological Carcinogenesis Japanese Society for Immunology Japanese Society for Mucosal Immunology Physiological Society of Japan The Japan Endocrine Society The Japan Society of Hepatology The Japanese Association of Anatomists The Japanese Biochemical Society The Japanese Pharmacological Society The Japanese Society of Gastroenterological Surgery The Japanese Society of Gastroenterology
Co-Sponsored by: Co-sponsored by the 21st Century COE Project, University of Miyazaki
Sponsored by: (in alphabetical order) Alumni Association of Gastroenterology, Jichi Medical University Astellas Pharma Inc. AstraZeneca K.K. Daiichi Asubio Pharma Co., Ltd. Dainippon Sumitomo Pharma Co., Ltd. Eisai Co., Ltd. GlaxoSmithKline Meirinkai Imaichi Hospital Koganei Chuo Hospital NIHON SCHERING K.K. ONO PHARMACEUTICAL CO., LTD. Otsuka Pharmaceutical Co., Ltd. Rakuwakai Marutamachi Hospital TAIHO PHARMACEUTICAL CO., LTD. Takeda Pharmaceutical Company Limited TANABE SEIYAKU CO., LTD. The Federation of Pharmaceutical Manufacturers' Associations of JAPAN The Uehara Memorial Foundation
98
Abstracts
Abstracts Reviewers: (in alphabetical order) Graham Baldwin Chung Owyang Christoph Beglinger Daniel Podolsky Tsutomu Chiba Choitsu Sakamoto Daniel Drucker Yutaka Sasaki Kazuma Fujimoto Wolfgang Schmidt Vay Liang Go Catherine Seva Akio Inui Yasuhisa Shinomura Tetsuhide Ito Seiji Shioda Michio Kaminishi Yvett Taché Masahito Kawatani Noriko Takahashi Itaru Kojima Toshiyuki Takeuchi Masayasu Kojima Andrea Todisco Andrew Leiter Andrea Varro Bunzo Matsuura Mamoru Watanabe Soichiro Miura Michael Wolfe Kyoko Miyasaka Toshihiko Yada Hisataka Moriwaki Yuichiro Yamada Masamitsu Nakazato Masashi Yoneda Satoru Naruse
Abstracts
99
Schedule (tentative) As of August 8, 2006 August 30 (Wednesday): Memorial Symposium at the Le Méridien Pacific Tokyo (Shinagawa, Tokyo) Chairs: D. Fourmy (INSERM, France), Y. Ibata (Kyoto Prefectural Government, Japan) 15:30–16:00 Gastrin - CCK: History and perspective J. F. Rehfeld (Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark) 16:00–16:30 Motilin and motilides Z. Itoh (Gunma University School of Medicine, Japan) 16:30–17:00 VIP and related peptides: Historical background and future perspective S. I. Said (SUNY at Stony Brook, NY, Department of Medicine, USA) 17:00–17:30 Physiologically active peptides involved in cell–cell communication H. Matsuo (National Cardiovascular Center Research Institute, Japan) 17:30–18:00 Realizing the drug discovery potential of the human genome T. Yamada (Global Health Program, Bill and Melinda Gates Foundation, USA) From August 31 (Thursday) to September 2 (Saturday): Symposium Lecturers and Invited Lecturers of the Sponsored Symposium at the Hakone Prince Hotel (Kanagawa, Japan) Symposium Lecturers: September 1 (Friday) Hedgehog signaling in development and disease P. A. Beachy (Johns Hopkins University, Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, USA) September 2 (Saturday) Beta-arrestin-dependent signaling by seven-transmembrane receptors S. K. Shenoy (Duke University Medical Center, USA) Invited Lecturers: (alphabetical order of presenter's name) Speakers at the Sponsored Symposium Effects of intraduodenal fatty acids on plasma CCK, PYY and ghrelin in humans C. Beglinger (Department of Gastroenterology, University of Basel, Switzerland ) Supramaximal cholecystokinin stimulates apoptosis and necrosis in pancreatic acinar cells: Role in pancreatitis A. Gukovskaya (West Los Angeles Veterans Affairs Healthcare Center, USA) GM-CSF efficacy in Crohn's disease: Lessons learned from a mouse model of colitis E. M. Hanna (Washington University in St. Louis, USA) Translational research of GLP-1 J. J. Holst (University of Copenhagen, Denmark) Transcriptional control of enteroendocrine cell fate specification A. B. Leiter (Tufts–New England Medical Center, USA) Evolving insights into IBD pathogenesis: Lessons from therapeutic successes and failures L. Mayer (The Mount Sinai Medical Center, USA) Differentiation of gastric mucus-secreting neck cell progenitors into mature digestive-enzyme-secreting zymogenic (chief ) cells J. C. Mills (Washington University School of Medicine, USA)
100
Abstracts
Regulation of immune tolerance by emerging anti-inflammatory neuropeptides: Therapeutic applications on inflammation, autoimmunity and transplantation M. Delgado (Institute of Parasitology and Biomedicine, CSIC, Granada, Spain) Translational research of ghrelin M. Nakazato (Miyazaki Medical College, University of Miyazaki, Japan) Role of angiopoietin-like proteins (Angptls) in angiogenesis and metabolism Y. Oike (Laboratory of Vascular Biology and Metabolism Center for Integrated Medical Research, School of Medicine, Keio University, Japan) Ghrelin dynamics in upper gastroduodenal diseases H. Suzuki (Department of Internal Medicine, Keio University School of Medicine, Japan) Corticotropin releasing factor (CRF) receptors 1 and 2 (CRF1 and CRF2): Differential distribution and action in upper and lower gut function Y. Taché (University of California, Los Angeles, USA) Regulation of interdigestive motility by gastrointestinal hormonal factors such as ghrelin, motilin and leptin J. Tack (Department of Gastroenterology, University Hospital Leuven, Belgium) GPR 120 and receptors for free fatty acids G. Tsujimoto (Kyoto University, Japan) Crossing between Mucosal Immunity and Epithelial Regeneration/Differentiation in the Human Intestine M. Watanabe (Crossing between mucosal immunity and epithelial regeneration/differentiation in the human intestine) Regulation of epithelial cell differentiation by mesenchymal cells in the development of the digestive organs S. Yasugi (Department of Biological Sciences, Graduate School of Sciences, Tokyo Metropolitan University, Japan) Speakers at the Technical Seminar New peptide-based protein profiling technology for clinical proteomics R. Kobayashi (University of Texas MD Anderson Cancer Center, USA) Calcium signaling in the cytoplasm versus nucleus: Location is everything M. H. Nathanson (Yale University School of Medicine, USA) Viktor Mutt Lectureship: Discovery of ghrelin and its impact on the basic and clinical research M. Kojima (Kurume University, Institute of Life Science, Japan) Social Events: August 31 (Thursday) 17:30–19:00 Evening cruise 19:30–21:30 Symposium dinner at “Restaurant "Sakura"” September 1 (Friday) 19:00–21:00 Symposium party at “Hakone-en Hall”