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184-P: Distribution of KIR genotype among pediatric Lebanese patients with recurrent tonsillitis: Absence of the BB genotype? Preliminary results
S108
184-P
Abstracts
DISTRIBUTION OF KIR GENOTYPE AMONG PEDIATRIC LEBANESE PATIENTS WITH RECURRENT TONSILLITIS: ABSENCE OF THE BB GENOTYPE? PRELIMINARY RESULTS. Mona Ghasham,1 Mohamad Bitar,2 Amira Sabbagh,1 Nady El Hajj,1 Ghazi Zaatari,1 Nabil Fleihan,2 Rami Mahfouz.1 1Pathology & Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon; 2Otolaryngology, American University of Beirut Medical Center, Beirut, Lebanon. Aim: KIR Genotypic profiles have been reported to be correlated with many clinical entities but not in recurrent tonsillitis. Our aim is to study this relationship among pediatric Lebanese patients with recurrent tonsillitis. Samples and Methods: Using PEL-FREEZ DYNAL KIR Genotyping SSP kit, we typed the DNA of 18 pediatric Lebanese patients with recurrent tonsillitis for the absence or presence of 16 gene loci with their variants. Results: Three new out of 9 different genotypic profiles were not previously reported. The A:B haplotype ratio of 1.4:1 was similar to the general population (1.3:1). However, complete absence of the BB genotype is noted. Conclusions: Because of this interesting finding, we are in the process of recruiting additional patients to resolve the question: Is the Natural Killer Cell Receptor BB genotype protective against recurrent tonsillitis?
184-P
Abstracts
DISTRIBUTION OF KIR GENOTYPE AMONG PEDIATRIC LEBANESE PATIENTS WITH RECURRENT TONSILLITIS: ABSENCE OF THE BB GENOTYPE? PRELIMINARY RESULTS. Mona Ghasham,1 Mohamad Bitar,2 Amira Sabbagh,1 Nady El Hajj,1 Ghazi Zaatari,1 Nabil Fleihan,2 Rami Mahfouz.1 1Pathology & Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon; 2Otolaryngology, American University of Beirut Medical Center, Beirut, Lebanon. Aim: KIR Genotypic profiles have been reported to be correlated with many clinical entities but not in recurrent tonsillitis. Our aim is to study this relationship among pediatric Lebanese patients with recurrent tonsillitis. Samples and Methods: Using PEL-FREEZ DYNAL KIR Genotyping SSP kit, we typed the DNA of 18 pediatric Lebanese patients with recurrent tonsillitis for the absence or presence of 16 gene loci with their variants. Results: Three new out of 9 different genotypic profiles were not previously reported. The A:B haplotype ratio of 1.4:1 was similar to the general population (1.3:1). However, complete absence of the BB genotype is noted. Conclusions: Because of this interesting finding, we are in the process of recruiting additional patients to resolve the question: Is the Natural Killer Cell Receptor BB genotype protective against recurrent tonsillitis?