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198. Progressive effects of an anti-androgen on sebaceous secretion and body hair growth in hirsute women
854
Abstracts
improvemenl
in symptoms
menorrhagia.
intenderness
in pelvis. The
pregnancy
and clinical
cluded decrease of dyspareunia, nnd nodularity
and thickening
findings. These
rate was XY,, in the group of patients where endometriosis was the only cause of infertility. Side effects included spotting and br~kthrough bleeding. Patients were anovulatory during treatment cycles and resumed ovulation twenty-two days after discontinuance. Oral MPA is an effective form of treatment for endometriosis.
196. Effect of hormonal steroid on calcium, phosphorusand
levels than normal males before the test. and although serum LH in the -BPH group more closely resembled the + BPH group the level was not statlstically different from the normal range. During stimulation. + BPH serum LH and TSH differed from the normal levels and the -BPH levels. which resembled the normal values. Since 5~-dihydrotestosterone is secreted by the BPH prostate. is elevated in the blood of BPH patients and decreases in the circulation after prostatectomy. it is possrble that the BPH adenoma exerts an influence on the hypothalamic-pituitary axis to suppress the production of pituitary hormones. especially LH. by way of circulating androgens.
magnesium metabolism Rrzvr. S. N. A. and VAISHNAVA. H.. Medicine, Maulana Azad Medical Delhi. India
apartment
College.
of
New
1983.Progressive effects of an anti-a~rogen on sebaceoussecretion and body hair growth in hirsute women EBLINQ. F. J.. RANDALL.
Twenty-five patients were selected for the study. Ten cases had bronchial asthma, 5 systemic lupus erythematosis. and
the rest were sufiering from minimal-change glomerulonephritis. They were kept on constant diet contajnin8 6OOmg of calcium. Serum calcium. phosphorus. magnesium and alkaline phosphatase. and 24-h urinary calcium. phosphorus and magnesium were estimated in all subjects. and a double tracer technique of radioactive Ca“’ and Srss including calcium balance was carried out in 15 cases before the start of glucorticoid therapy. All were given prednisolone orally in doses ranging from 60 to lZOm8, day. Serum and urine chemistry were restudied at the end of 4 weeks in all cases. Tracer studies including calcium balance were repeated in I5 cases. Calcium balance studies were performed in IO patients after supplementation of vitamin D orally ([email protected] I.U.;day) along with steroid therapy to see the effect of vitamin D on calcium turnover. It was observed that there was significant reduction in the levels of serum calcium and phosphorus and there was increase in urinary calcium. phosphorus and magnesium after steroid therapy (P < 0.001). The radioactive tracer study revealed a significant reduction in the peak absorption of calcium at the 7-h period when compared with the basal value (P c 0.0051. There was a marked increase in the endogenous. as well as in total. faecal calcium (P 6 0.0051. The patients had developed negative calcium balance which returned to normal after vitamin D supplement. We are of the opinion that glucocorticoid influences the calcium and phosphorus metabov lism (their absorption and excretion). probably through antagonism to vitamin D and we suggest that its supplementation is necessary to prevent their derangement in patients receiving glucocorticoid therapy.
197. Pituitary function in normal mobs and patients with benign prostatic hypertrophy HAMMOND,
G.
L.. KONTTURI.
M..
LUKICARINEN. 0..
VtHlio, P. and VIHKO. R.. Departments of Clinical Chemistry. Surgery and Anatomy. University of Oulu, SF-90220 Oulu 12. Finland We observed that patients with benign prostatic hypertro(BPH) do not display the age-related rise in serum LH typical of normal elderly males. but found no difference in serum FSH or prolactin when comparing these populations. We have also determined the concentration
phy
of FSH. LH’and prolactin in serum collected before. and up to 3 years after prostatectomy. and found no change in their levels. Since serum LH did not return to normal. pituitary stimulation tests were conducted to assess the pituitary reserve in BPH patients. before (+ BPH) and after prostatectomy (- BPH). Blood was drawn before and after administration of IOOyg of Gnrh and 2OOpg of TSHrh. Serum FSH. LH. prolactin and TSH were estimated by radioimmunoassay. Patients with + BPH had lower LH
V. A. and C(K)KE. 1. D..*
Department of Zoology. University of Sheffield. Sheffield SIO ?TN, U.K. and *Department of Obstetrics and Gynaecology. Jessop Hospital for Women. Leacygreave. Sheffield 10. U.K. The progressive changes in sebaceous secretion. body hair growth and endocrine parameters were monitored at monthly intervals in 11 hirsute women on 3 “reverse sequential” regime of lOOmg cyproterone acetate (CPA) and 50~9 of ethinyl oestradiol. In the first monthly cycle the subjects received cyproterone acetate alone from days 5-14: subsequently ethinyi oestradiol was also given from days 5-25. A si8nificant decrease in sebum production to 55”,, of the initial level was evident after the first cycle on CPA alone. and this fell to 30”,, by the end of the second month, when it was maintained. The rate of hair growth and hair diameter decreased gradually from the second to the fourth months of treatment to stabilise at levels about XY’,,of those before treatment. In all patients there was significant reduction in hirsutism. and any acne was completely cleared by treatment.
199. Investigations of testosterone and gonadotropin secretion in chronic renal insufficiencv. hemodialvsis and after renai transplantation
MIES. R.. HEESEN.D..
MADDER, B. and WINREL.MANN. W.. II Department of Internal Medicine. University. Cologne. Federal Republic of Germany
A comparative study with investigations on testosterone and gonadotropin secretion was performed in 69 male patients with various degrees of renal insufficiency, 31 patients at different schedules of hemodialysis and I9 patients l-5 years after renal transplantation. Testosterone. LH and FSH were determined by radioimmunoassay basally and after HCG or LH FSH-RH respectively. Testosterone secretion was significantly impaired at creatinine levels of 7 mg”,t and depressed to half normal at creatinine levels of I3 mg”,,. Various dialysis schedules were without effect on diminished testosterone plasma levels. After renal transplantation Leydig cell function was restored proportional to length of post-transplantation period and recovered completely in some cases. Anterior pituitary insufficiency could be demonstrated during hemodialysis. Compared to the same gonadal insufficiency of IO Klinefelter patients LH and FSH secretion was sienificantly reduced. In conclusion diminished Leydig cell function and altered gonadotropin reeulation correlate to the extent of renal insuficiency. Both cannot be improved by dialysis
but may
be restored
after
renal
tr3nsplantation.
200. Plasma levels of Il?-OH-corticosterone in normal sub jects: effects of sodium intake, ACTH administration MARTIN.
and metyrapone
V. I. and EDWARDS. C. R. W..
Department
Abstracts
improvemenl
in symptoms
menorrhagia.
intenderness
in pelvis. The
pregnancy
and clinical
cluded decrease of dyspareunia, nnd nodularity
and thickening
findings. These
rate was XY,, in the group of patients where endometriosis was the only cause of infertility. Side effects included spotting and br~kthrough bleeding. Patients were anovulatory during treatment cycles and resumed ovulation twenty-two days after discontinuance. Oral MPA is an effective form of treatment for endometriosis.
196. Effect of hormonal steroid on calcium, phosphorusand
levels than normal males before the test. and although serum LH in the -BPH group more closely resembled the + BPH group the level was not statlstically different from the normal range. During stimulation. + BPH serum LH and TSH differed from the normal levels and the -BPH levels. which resembled the normal values. Since 5~-dihydrotestosterone is secreted by the BPH prostate. is elevated in the blood of BPH patients and decreases in the circulation after prostatectomy. it is possrble that the BPH adenoma exerts an influence on the hypothalamic-pituitary axis to suppress the production of pituitary hormones. especially LH. by way of circulating androgens.
magnesium metabolism Rrzvr. S. N. A. and VAISHNAVA. H.. Medicine, Maulana Azad Medical Delhi. India
apartment
College.
of
New
1983.Progressive effects of an anti-a~rogen on sebaceoussecretion and body hair growth in hirsute women EBLINQ. F. J.. RANDALL.
Twenty-five patients were selected for the study. Ten cases had bronchial asthma, 5 systemic lupus erythematosis. and
the rest were sufiering from minimal-change glomerulonephritis. They were kept on constant diet contajnin8 6OOmg of calcium. Serum calcium. phosphorus. magnesium and alkaline phosphatase. and 24-h urinary calcium. phosphorus and magnesium were estimated in all subjects. and a double tracer technique of radioactive Ca“’ and Srss including calcium balance was carried out in 15 cases before the start of glucorticoid therapy. All were given prednisolone orally in doses ranging from 60 to lZOm8, day. Serum and urine chemistry were restudied at the end of 4 weeks in all cases. Tracer studies including calcium balance were repeated in I5 cases. Calcium balance studies were performed in IO patients after supplementation of vitamin D orally ([email protected] I.U.;day) along with steroid therapy to see the effect of vitamin D on calcium turnover. It was observed that there was significant reduction in the levels of serum calcium and phosphorus and there was increase in urinary calcium. phosphorus and magnesium after steroid therapy (P < 0.001). The radioactive tracer study revealed a significant reduction in the peak absorption of calcium at the 7-h period when compared with the basal value (P c 0.0051. There was a marked increase in the endogenous. as well as in total. faecal calcium (P 6 0.0051. The patients had developed negative calcium balance which returned to normal after vitamin D supplement. We are of the opinion that glucocorticoid influences the calcium and phosphorus metabov lism (their absorption and excretion). probably through antagonism to vitamin D and we suggest that its supplementation is necessary to prevent their derangement in patients receiving glucocorticoid therapy.
197. Pituitary function in normal mobs and patients with benign prostatic hypertrophy HAMMOND,
G.
L.. KONTTURI.
M..
LUKICARINEN. 0..
VtHlio, P. and VIHKO. R.. Departments of Clinical Chemistry. Surgery and Anatomy. University of Oulu, SF-90220 Oulu 12. Finland We observed that patients with benign prostatic hypertro(BPH) do not display the age-related rise in serum LH typical of normal elderly males. but found no difference in serum FSH or prolactin when comparing these populations. We have also determined the concentration
phy
of FSH. LH’and prolactin in serum collected before. and up to 3 years after prostatectomy. and found no change in their levels. Since serum LH did not return to normal. pituitary stimulation tests were conducted to assess the pituitary reserve in BPH patients. before (+ BPH) and after prostatectomy (- BPH). Blood was drawn before and after administration of IOOyg of Gnrh and 2OOpg of TSHrh. Serum FSH. LH. prolactin and TSH were estimated by radioimmunoassay. Patients with + BPH had lower LH
V. A. and C(K)KE. 1. D..*
Department of Zoology. University of Sheffield. Sheffield SIO ?TN, U.K. and *Department of Obstetrics and Gynaecology. Jessop Hospital for Women. Leacygreave. Sheffield 10. U.K. The progressive changes in sebaceous secretion. body hair growth and endocrine parameters were monitored at monthly intervals in 11 hirsute women on 3 “reverse sequential” regime of lOOmg cyproterone acetate (CPA) and 50~9 of ethinyl oestradiol. In the first monthly cycle the subjects received cyproterone acetate alone from days 5-14: subsequently ethinyi oestradiol was also given from days 5-25. A si8nificant decrease in sebum production to 55”,, of the initial level was evident after the first cycle on CPA alone. and this fell to 30”,, by the end of the second month, when it was maintained. The rate of hair growth and hair diameter decreased gradually from the second to the fourth months of treatment to stabilise at levels about XY’,,of those before treatment. In all patients there was significant reduction in hirsutism. and any acne was completely cleared by treatment.
199. Investigations of testosterone and gonadotropin secretion in chronic renal insufficiencv. hemodialvsis and after renai transplantation
MIES. R.. HEESEN.D..
MADDER, B. and WINREL.MANN. W.. II Department of Internal Medicine. University. Cologne. Federal Republic of Germany
A comparative study with investigations on testosterone and gonadotropin secretion was performed in 69 male patients with various degrees of renal insufficiency, 31 patients at different schedules of hemodialysis and I9 patients l-5 years after renal transplantation. Testosterone. LH and FSH were determined by radioimmunoassay basally and after HCG or LH FSH-RH respectively. Testosterone secretion was significantly impaired at creatinine levels of 7 mg”,t and depressed to half normal at creatinine levels of I3 mg”,,. Various dialysis schedules were without effect on diminished testosterone plasma levels. After renal transplantation Leydig cell function was restored proportional to length of post-transplantation period and recovered completely in some cases. Anterior pituitary insufficiency could be demonstrated during hemodialysis. Compared to the same gonadal insufficiency of IO Klinefelter patients LH and FSH secretion was sienificantly reduced. In conclusion diminished Leydig cell function and altered gonadotropin reeulation correlate to the extent of renal insuficiency. Both cannot be improved by dialysis
but may
be restored
after
renal
tr3nsplantation.
200. Plasma levels of Il?-OH-corticosterone in normal sub jects: effects of sodium intake, ACTH administration MARTIN.
and metyrapone
V. I. and EDWARDS. C. R. W..
Department