20 Synchronous and metachronous lung cancer other than adenocarcinoma in women with breast cancer

Abstracts not presented at the Conference / Epidemiology/Tobacce control pat]ant felt well and the additional inspection has re,sod. In half year he was again hospitalized with approximately the same clinical and laboratory changes This time the pabent was surveyed more full. including the bone brain esplodng Inspection has not revealed a pathology esplaining blood changes In 6 months there was a third hoepitalizabon This time the pafient arrived in heavy enough condition and the cancer of left undersogment bronchial tube with metastasis's in sredostenia was revealed at inspection It the was the reason oftbe pabent death in one month Conclusions: Thus. the leukemoid reaction has arisen in this case not only as the eadiest attribute of a lung cancer, but also long before occurrence of direct att]lbutes of a lung cancer and establishment of the diagnosis (before more than one year).

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Epidemiology/Tobacco control ]

AnU tobacco ddve In Madhya Pradesh-lndla

D. Acharya ~'z3'4. 1Hen. Secteta~ Cancer Sectary of Madhya Prade~,

In#ore, India, 2Hen Secretary, International College of Surgeons(IS) In#ore Branch, tn#om, Indta: 3Secretary Trustee, In#ore Surgeons Research Foundabon, tndora, India, 4tram Past Chairman, Asseciation of Surgeons India, MP Chapter, Indore, India Background: Tobaoco4qas been proved beyond doubt to be the devourer of

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Thin section CT analyels of small pulmonary adsnocerdnomes

lees than lOmm In diameter correlated with clinical and hletopathologlcal characterlsUcs Y. Mizutani. H. Saito. K. Yamada. N. Hamanaka. N. Kate. F. Oshita. H Nakayama. Y Kameda. K Noda 1Department of Respratory Diseases,

St. Mananna Umvers~tySohool of Medtctne, Kawaka/o, Japan: 2Department ot 7horactc On~togy, Kanagewa Cancer Center, Yokohama, Japan, 3Departmsnt of Pa~ho/ogy, Kanagawa Cancer Center, Yokohama, Japan Background: The detection rate of small nodules in the lung field is increasing due to the wtdespread use of CT scanning. It is clfficult to invest]gate these all nodules. Therefore. it is necessary to determine how to detect small lung cancers using the thin section CT (TSCT) scan. We investigated the TS CT finclngs, clinical and histopathological characteristics of the small pulmonary adenocarcmoma less than 10mm in clameter. Methods: We evaluated 66 lung edenoca~nomas (20 men and 37 women) with a size of 10mm or less in diameter from 1992 through 2004. The clinical records, the findings of T S ~ T and the histopatholngical characteristics of resected specimens were analyzed TS-CTimagas ware acquired with a model TCT 900S super HELIX. X-Vigor/Real or Aqulllion CT scanner(Toshiba Medical Sysytom) TS-CT images targeted to the tumor were obtained continuously at 12(~135 kVp and 200 250 mAs with 1 2 mm secfion thickness Images were photographed onto each sheet of film using mediastinal (level. 40 HU. with. 400HU) and lung 0evel. 600 HU. 1600HU) window set'dng From the T S ~ T scan. tumors were classified into the ai~c,e~qtainlng type and the solid~clenslty type. The alr~,,ontaining type was defined am those in which areas of the turner opa~ty on the mediastinal window imagos were half er less of those on the lung window images. The solid density type was defined as these in which areas of tumor opacity on mediast]nal vandow images were more than half of these on the lung vandow images. Adenoca~noma is histologically subclassified into types A through F according to the Noguchrs classification. Re.=ult.=: Forty six ware air-containing type and 20 were sclid-density type The air-containing type were classified as type A in 2?'. type B in11. and type C in 8'. and the solid-ddnsity types were classified as type C in 9. type D in 5. and type F in 4 All of the solid-density type adenecarclnomas in the peripheral lung ware large than 7mm. and two nodules of adenocarclnoma (type D and type F) were larger than 8. mm The solid-density type adenocarclnoma with a size of 7 mm or more had a higher recurrence rate and worse prognosis Conclusions: We concluded it is important to detect solid
health & it threatens the life many of now victims every year and espeolally in developing wodd. According to the ICMR (Indian Council of Medical Research) figures, out of 100 teenagers smoking in India today 50 will eventually tie of tobacco related cisease And as per WHO preje~ons. India will have the highest rate of rise in tobaccorelated deaths by year 2020 Hence the urgent need to prepogate the hazards of tobacco c h a n g & smoldng In India Tobacco is consumed in various forms-cigarette smoking. Bidi smoking. tobacco powder. Gutka. quid eta The relationship of Tobacco and cancer has been proved beyond doubt Indian govt has also passed the legislature banning direct Ogarette/tobacca advertising, restricting its sales etc. I am the Hen. Secretary of Cancer Seclety of Madhya Pradesh. an NGO working for many years in the field of Cancer Awareness. Eady Detection and Tobacco Control in the state of Madhya Pradesh i.e. Central part of India. Methods: We participated in a big way at the Sinhastha Mela at Ullain (a religious fair attended by nearly 30 million people). The paper/poster will highlight the ways of our getting full support from local police to cleplay glow sign boards at strategic locations deep into the places tPickly. cistdbufing pamphlets, ca- stickers-higNighfing the hazards of tobacco eta (The photographs will be displayed ) Our anti-smelting pester of a dead body lying on a pyre of cigarettes has received the International Best Poster Creative Summit Award also We regularly participate with innovative ideas in the World No Tobacco Day on 31s~ May This year we took out the procession of cigarette through the main market, distnbut]ng the anti smoking law passed by the govt. In our oty. on the occasion of a particular festrval, a large number of tablc~ds cress through the city at right with more then a million people watching. We also participate by way of our Anti Smoking tabloids. We have prepared very short jingles, which have been aired through local TV Channels. to inform the hazards of Tobaoco to all ~ o o r as well as elite people. Our self esaminat]on of Oral Cavity muir]color poster is also almost ready. Results: These awareness programs may not show immediate quantifiable results but in long run they have their good impact Still many people are known to have given up tobacco or drastically reduced their number of cigarettes Conclusions: we shall show the vadous methodology used by in propagating the hazards of Tobacco Discuss the stTategy planning and ways of sponsorships for the campaigns

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Synchronous and metachronous lung cancer other than adsnocarclnoma In women with breast cancer

I3 BerTineoI J Detvay 2 lSpecialised lns~uta of St Zoerardus, Nitre, Slovak

Repu~tC, 2 TeactHng Hospttal, Nrtra, Slovaloa ]

Measurement of endobronchlal temperature as the contribution to dlagnosUce and staging of lung cancer

J. Votruba ~ T. Bn~a 2. ~Pulmonary department ofNemocntce na Homeloa,

Prague, Czech Republic, 2Measurement group of ENEX ltd Praha, Prague, Czech Republic Background: Despite novel combined therapies lung cancer kills over 8'5% of those it afflicts wtthin five years However when diagnosed in the early stages survival is escallent. Recently there is a big effort towards inb'oducmg new methods of diagnosis that would help the clinician to disolminate lung cancer in its earliest stages. One of the newly tested methods is based on thermodiagnesfics Method,=: Temperature in the area of the bronchial mucosa changed by the tumor and on the centToI area have bean measured by the contact thermometer with the resistance sensor Results: The results show significant cifferencos in the temperature of the tumor fissue compared with acqacant normal mucosa (up to1 4°C) Major clinical significance can stem from the measurement of the temperature on the otherwise normal appearing area of mucosa adjacent to tumoreusiy changed lymphatic node. This measurement also showed higher temperature compared to normal mucosa (up to 0.8'°C) Conclusions: These results =gnificantly support the use of endobroncllal thermal mapping applicat]en by infl-avision.

Background: There are no data about the incidence of lung cancer (LC) in women with breast c~,qcar (BC)in Slevalda Aim of this study was to estimate the incidence of synchronous or metachronous LC other than adonocarcinoma in women with BC in the western part of Slevalda Methods: Data about the women with BC and synchronous or meteohronous LC ware obtained from the patients' files/databases of the Ins~ute of St Zoerardus. Nitre. and the Teaching Hospital. Nitre Further data were obtained fi'om publications of the Nat]onal Cancer Rogisb-y. Brat]slava. Slovakia. Follovang patients were included into the group of patients with BC and synchronous or metachrenous LC: patients from the western part of Slovakia (region of Nitza and some surroundng regions with total populat]en of about 400 000 ichabitants), beth LC and BC diagnosed during the penod of 1991 2004. ilstologlcally/cytclogically confirmed LC other than adenoca~noma (to avoid problems with dif~renfiabon of metastafie BC versus primary LC) Results: Seven patients with BC and synchronous or metachroneus LC were identified according to the above menboned chtena This t]'ansforms to the esfimated incidence given in the Table and thus to the odds rabo 22 4 (gb%CI: 10 4 - 48 4). i e these resuitts show that the esbmated risk of LC other than adenocarclnoma in women with BC is 2240% of that without BC. with g,5%CI of 1040% to 4840% However. the real incidence of LC in population of women with BC may be much higher as patients with lung adenoca~noma, the most often seen hlstcloglcal type of LC in women, were escluded from this analysis. In addition. net all patients with BC and lung turnoure have been sent to speoal[zed poeumologlcal diagnost]cs (inducing bronchoscopy).

Abstracts not presented at the Conference / EpiderniologytTobacce control

$384 Population of women

Cancer

Incidence per 100.0go

General General With breast cancer

Lung Breast Lung

10 60 224

Conclusions: The incidence of synchronous or metachronous LC other than adenocarcinoma in patients with BC seems to be very high. This deserves further attention and suggests that histological/cytological confrmat]on of suspected lung tumours/metastesos should be widely used in patients with BC.

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"Smoking Damages Relationships, smoking Is for sissies." ComrnunlcaUon sb-ategles In a campaign against environmental tobacco smoke (ETS) addressing school-age children In the province of Alessandrla

P Betta I M Brusa 2. M Brezzi ~. C Gaedini 4 lItaJian League for the Fight

agatnst Cancer. Alessandna branch, Alessandna Italy, 2ASL 21 Reglone Piemonfa, Casale Monferrafo, Italy, 3ASL 20 Regione Piemonfa, A/essanclria, Italy, 4studio60 Agenzia d Comunicazione e Market]ng, A/essandna, Italy For many years campaigns against tobacco smoking have tamed a prevalently "threatening" message, sometimes even rather strong, based on the cause effect concept that "smoking can sonously damage your health", an idea which is now generally accepted and shared, and whoso offeot]voness has therefore nee become somewhat reduced. Although in the past this model had the mont of mal~ng people aware of the problem, the time seems to have come. especially in the school environment, to induce a solfampesod desire for change and involve the more emotional processes and bohavlour patterns which come into play in interpersonal relations and which are linked to common values Two slogans wore created ("Smoking damages relationships" and "Smoking is for sissies"), designed to make the target thiok, highlighting the negative effect that smoking can have on relationships and reciprocal affeotJon With the intToductJon of the health threat of ETS. backed up by growing medical evidence over the last two decades, smokers began to feel a bit "contagious". and a breach was made into the idea that a smoker only harms himsel[ "Smoking not only damages your health, but other people's as well. and it messes qo your relations with the people you love . . . . So why net give up once and for all. or at least ITy not to smoke when you are close to your children, your family, your frleeds or whoever you generally happen to like?": this summanses the message delivered to the smokers. In line with tnls communication strategy the graphics were designed to reach the target effectively. Particular care was given to the testimonial, studied ad hoc to strongly impersonate the whole campaign: the character "SmokeIte". totally original and easily recognisable and distinguishable, was created to provide an immediate link between the message and its bearer Drawn in a ca'lcatural, but linear way. the testimonial was intended to raise immediate lildng, and was partJoularty suitable for the juvenile sector of the campaign's target, both in its three-cimonsional version a large inflatable puppet going around schools and public places - and in its two
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Hormonal risk factors In woman lung cancer

F Gibollino ~. M Nicolos42, G Grasso ~ ~Pathophysiology Unit Canntzzaro

Hospta/, Catania, Italy, 2 Thoracic Surgery ~vision Canni/]aro Hospital, 3Pa~ology Untt Cannlzzaro Hospital, Italy Lung cancer is the leading cause of cancer deaths among women accounting for about 10% of all cancer deaths worldwide Lung cancer is related to smoldng history, women may have a greater susoeptJbility to tobacco carcinogens, lung cancer risk is 1 5 times higher in woman for any level of sigarette smoking and the prepo~en of non smoking patients is double in women. A nlgber frequency of adoneoarOnoma has been found in non smoWng women compared to men. suggesting a possible role of ondocrln factors. The presence of estrogen and progosteron receptors has been reported in women adonecarclnoma. The aim of tnls study is:

to evaluate the ineldonca of specific nsk factors other than sigaretto smoking in women lung cancer - to study the role of eatTngen and progesteron receptors in pnmary pulmonary adenocarcinema Metedais and Methods: All women admitted to Thoracic Surgery Division operated for lung cancer from January 2002 to December 2004 were selected They were 35. age range 45 81 years old. and were civided in ,5 groups following the hystolngical diagnosis: sixteen had primWve adenocarcinoma. six adenocarclnoma metastasis from colon and utero, four leiomiosarcoma metastasis from breast and utoro, five ca~noides and four squamous cellular cancer. The following rlsk factors wore analyzed: smoking, family history of cancer, personal nlstory of cancer, pulmonary, ondconn and metabolic clseases, pulmonary fiJnctJon. The presence of esb'ogen and progesteren receptors were researched by JmmunohJstochemJcal using AvJdJn~JotJn comples. Results: Smoking: 30% of smokers had adenecercinoma. ,50% metastasis from adenocercinoma. 25% cercinoides and 75% squamouscellular cancer Family history of cancer: women with lelomiosercoma all had negative family history. 50% of women with both primitive adenocarcinoma or squamouscellular cancer was positive Personal history of cancer: all women with squamous cellular were negalJve, in adenocarcinema group five women had personal history of cancer: breast, utero, colon Personal history of endocrln, metabolic and pulmonary diseases: all women with sqamous cellular wore negative. In prlmWve adencoa~noma. 30% of the patients had diabetes and 30% tyreid dysfunction. Only four women in all sample reported previous pulmonary diseases. Pulmonary funet]en was normal or milcly reduced in all women. Estrogen receptors were found in 30% of the patients with primary adenocarclnema and pregestoren receptors in 20%. Receptors both for estrogen or progestoren in sguamouscellular cancer were not found. Conclusion: These results show the importance of family and personal history of cancer as risk factor in the patogenesis of lung cancer the absence of correlation with lung func~en and history of previous pulmonary ciseases the possible role of hormonal ciseases in women with adenocarcinoma: the lee presence of eedocdn receptors suggests the possibility that cancers considered of pnmary pulmonary origin instead are metastasis from an ex'ma polm onary neoplasm The sample is small, largo numbers could show different results, the study is still in progress.

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Epldemlology of lung cancer In Belarus

D K,azakevich. V Vdovichenko. G Zaborevsky Grodno State Medical

Universir~, Grodno, Belarus Background For the past 30 years it was a significant increase of cancer incidence and in particular lung cancer incidence in Belarus Which factors made the most important influence on it'~ We t]-y to eslJmete them by studying epidemiology of this disease Methods: StalJsticai data from official stalJsticel reviews, periodical literature wore analyzed. Period from 1992 bll 2003 have been studied. Dynamics of lung cancer inadenca, mortality level, disb-lbut]on wore analyzed for sos. ago. place of residence (city or counb'y, radioaot]ve polluted areas and relatively "dean"). stage. Unfortunately it was net separation of tobaoco smokers among patients. But it have been made estimation of dynamics of tobacco consuming in Belarus by using data from sociological studios and information about selling tobacco from economic review,vs. Results: For the pest 30 years it was observed the significant increase of incidence of lung cancer IJll the year 1998 and after that slowly decreases of it Lung cancer incidence in men was 8 limes more common than in women it has to be mentioned that the highest level of incidence was observed in rural populalJon and especially among men (about 2 limes more than among urban men populalJon) Lung cancer incidence is on the first place in structure of cancer incidence among men but dunng analyzed period slowly year by year decrease was observed. It has been observed increase of skin cancer and prostate cancer among men. Incidence in polluted areas was not higher than in other areas. The highest levels of lung cancer incidence were between age 60 and 74 varying with time. In mortality rates slowly decrease during last several years. It on first place among encopathology deaths in men population and it has been observed slowly decrease of it among women population. It has been observed not significant increase of disb-lbut]on of newly diagnosed lung cancer according to the disease stage to stages 1 and 2 Number of lung cancer palJents was is increasing with time especially in rural populalJon, especially among man Accorcing to economic and sociological studies expenditures on tobacco were Pigher among rural populalJen IJll year 2002 Sales of tobacco products were increasing till 1997 and after that stayed dose to the same level Nee 42% of population smoke (64% of men and 20% of women) Conclusions: Higher level of lung cancer incidence and mortality level in rural population could be explained by higher tobacoo consuming among rural population. Further investigations with bettor design to conb-ol tobacco consuming in Belarus need to be performed. However this work shows how tobacco even despite some other factors induces lung cancer. Urbanization and radioactive pollution as seems did not make such Jmpaot as tobacco.