- Email: [email protected]
239. Fluvoxamine for cormorbid anxiety and depression: 5-HTT effects
Friday Abstracts
BIOLPSYCHIATRY 1998;43:1s–133s
71s
educationalattainmentor parentaleducation.PMDpatientshad greater overallimpairmentthanNC (Kmskal-WallisANOVA,z=2.9, p=.004), with greater impairment(p<.05) on the alternatingfist-ringtask short term memoryand gaze impersistence.The motor sequencingsubtotal showed a stronger trend towards greater impairmentin the patients (p=.06) thandidthe sensoryintegrationor motorcoordinationsubtotals. Comparisonwiththe SC grouprevealednumericallymilderimpairment in the PMD group,but no statisticallysignificantdifferencesin total score (z1.8, p=.08) or subtotals (PZ.20). These findings confirm a generalnecrologicimpairmentin PMD,and demonstrateits presencein the initial stages of the illness. Althoughwe did not find significant differencesbetweenPMDand SC,wehavefoundsignificantdifferences between SC and combinednon-schizophrenicpsychotic groups (see abstractby Keshavanet al), whichtends to argue againstnon-specific impairmentdue to psychosisas the sole explanationfor these findings.
contacts. Postmortemstudies have shown abnormalitiesin neuronal populationsand synapticcontactsin the prefrontaland entorhimdcortex of schizoaffectiveBD or BD patients. This study was undertakento examine the status of brain monoaminergicsynaptic fields in BD I patients.FourteenBDI patients,euthyrnic,werematchedwith 13healthy subjects(ages 23-59).They were studiedwith PET and the radiotracer (+)[’lC]dihydrotctraberrazine (DTBZ).This tracer labels the non-selective vesiculartransporterfor the monoamine (VMAT2),a presynaptic markerwhichdoesnot appearregulatedby mostpsychotropicdrugs. 18 mCi [llC]DTBZwere adrnioistcrediv. in a bolus-continuousinfusion protocol to aebieve tracer equilibriumconditions.Imaging was conducted in a SiemensExact PET scanner in 3-D mode (reconstructed FWHMresolution6 mmin plane).Parametricimagesof tracertransport (Kl) and equilibriumdistributionvolume(DV, proportionalto Bmax) werethenproduced;6x6mmsquareregionsof interestwereplacedin the K1 images and then transferredto the DV images in the prefrontal, anterior cingulate and temporal cortices, caudate nuclei, thahmms, hypothalamus,and ponshnidbrain.
239. FLUVOXAMINE FOR CORMORBID ANXIETY AND DEPRESSION: 5-HTT EFFECTS
ANCOVAshowedsignificant(p
J.L. Rausch, H.M. Hobby, N. Shendarkar & J. Li Departmentof PsychiatryVeteransAdministrationSchoolof Medicine,The MedicalCollegeof GeorgiaAugusta,Georgia30910 Increasing evidence has emerged recently to indicate that selective serotoninreuptake inhibitor(SSRI) treatment may he effective for a varietyof anxietydisordersas well aa effectivefor depression,although it has beenunclearwhetherSSRIartxiolysisis correlatedwiththe degree of SSRI-inducedinhibitionof serotonintransport.Thegeneencodingfor the humanserotonirrtransportproteinis expressedon bloodplateletsas well as on serotoninneurons, and both tissues respond to reuptake inhibitionsimilarlyin responseto SSFUtreatment.In the presentstudy we examinedthe relationshiphetweenthe changein apparentserotonin transport affinity and the anxiolyticresponseto SSRI treatment in a groupof 18fluvoxarnine-treated patientsmeetingSCIDcriteriafor both generalizedanxietydisorderandmajordepression.Significantdecreases were found in both Hamiltonanxietyand Hamiltondepressionscores over a two monthtreatmentperiod,and robustincreaseswere foundin the apparentafhity constantfor platelet serotonintransporton drug. Moreover,there was a significantcovariancebetweenthe decrease in anxietyand the increase in apparentserotonintransportaffhity (F = 4.97,p<.03). Theseresults suggestthat the therapeuticanxiolyticeffect of SSRI treatmentcan be linkedto the magnitudeand time-courseof serotonintransportinhibitioneffected with drugs such as fluvoxamine whichmay be effectivefor anxietyas well as depressivesymptomatolWY.
240. PET MEASURES OF MONOAMINERGIC SYNAPTIC DENSITY IN BIPOLAR I DISORDER: RELATIONSHIP WITH AGE OF ONSET J.-K. Zubieta, P. Huguelet, L.E. Ohl, M.R. Kilbourn, R.A. Koeppe & K.A. Frey
This data confirms the presence of trait anomaliesin the density of monoamirrergicsynapticfields in patientsdiagnosedwith BD I. These may reflect different patterns of monoaminergicsynaptic contacts in variousforms of illness (i.e., early vs. older age of onset), or disease severity.
Neurobiology/Clinical Pathology I Friday, May 29, 2:30 PM-5:00 PM, Location; Pier 9 Chairperson:Peter Roy-Byrne 241. THE COLLABORATIVE STUDY OF THE GENETICS OF ALCOHOLISM: INITIAL RESULTS AND FUTURE GOALS J.I. Nurnberger Jr.1, V. Hesselbrock2, R. Crowe3, B. Porjesz4, R. Cloninge~, M. Schuckit6, S. O’Connor7, K. Bucholz8, H. Edenberg9, A. Goatel”, J. Tischfieldll, T. Foroud12, J. Rice13, P.M. Conneally14, T.K. Li15, T. Reich16 & H. Begleiter17
MentalHealthResearchInstitute,Divisionof NuclearMedicineand Departmentof PsychiatryThe Universityof Michigan,ArmArbor
%rdirmaUniversity,Indianapolis,IN 46202;‘Universityof Connecticut,Farmington,CT 06030;3Univeraityof Iowa State, Iowa City, IA 52242;4Univeratiyof New York,Brooklyn,NY 11266; ‘WashingtonUniversityof St. Louis,St.Louis,MO 63110;%Jniversity of SouthernCalifornia,San Diego,CA 92161
It hasbeensuggestedthatBipolarDisorder(BD)maybe charactenzedby anomaliesin cell migrationor in the density or patterns of synaptic
The CollaborativeStudyof the Genetics of Alcoholism(COGA)is a six-site study of families with multiple cases of severe alcoholism.
BIOLPSYCHIATRY 1998;43:1s–133s
71s
educationalattainmentor parentaleducation.PMDpatientshad greater overallimpairmentthanNC (Kmskal-WallisANOVA,z=2.9, p=.004), with greater impairment(p<.05) on the alternatingfist-ringtask short term memoryand gaze impersistence.The motor sequencingsubtotal showed a stronger trend towards greater impairmentin the patients (p=.06) thandidthe sensoryintegrationor motorcoordinationsubtotals. Comparisonwiththe SC grouprevealednumericallymilderimpairment in the PMD group,but no statisticallysignificantdifferencesin total score (z1.8, p=.08) or subtotals (PZ.20). These findings confirm a generalnecrologicimpairmentin PMD,and demonstrateits presencein the initial stages of the illness. Althoughwe did not find significant differencesbetweenPMDand SC,wehavefoundsignificantdifferences between SC and combinednon-schizophrenicpsychotic groups (see abstractby Keshavanet al), whichtends to argue againstnon-specific impairmentdue to psychosisas the sole explanationfor these findings.
contacts. Postmortemstudies have shown abnormalitiesin neuronal populationsand synapticcontactsin the prefrontaland entorhimdcortex of schizoaffectiveBD or BD patients. This study was undertakento examine the status of brain monoaminergicsynaptic fields in BD I patients.FourteenBDI patients,euthyrnic,werematchedwith 13healthy subjects(ages 23-59).They were studiedwith PET and the radiotracer (+)[’lC]dihydrotctraberrazine (DTBZ).This tracer labels the non-selective vesiculartransporterfor the monoamine (VMAT2),a presynaptic markerwhichdoesnot appearregulatedby mostpsychotropicdrugs. 18 mCi [llC]DTBZwere adrnioistcrediv. in a bolus-continuousinfusion protocol to aebieve tracer equilibriumconditions.Imaging was conducted in a SiemensExact PET scanner in 3-D mode (reconstructed FWHMresolution6 mmin plane).Parametricimagesof tracertransport (Kl) and equilibriumdistributionvolume(DV, proportionalto Bmax) werethenproduced;6x6mmsquareregionsof interestwereplacedin the K1 images and then transferredto the DV images in the prefrontal, anterior cingulate and temporal cortices, caudate nuclei, thahmms, hypothalamus,and ponshnidbrain.
239. FLUVOXAMINE FOR CORMORBID ANXIETY AND DEPRESSION: 5-HTT EFFECTS
ANCOVAshowedsignificant(p
J.L. Rausch, H.M. Hobby, N. Shendarkar & J. Li Departmentof PsychiatryVeteransAdministrationSchoolof Medicine,The MedicalCollegeof GeorgiaAugusta,Georgia30910 Increasing evidence has emerged recently to indicate that selective serotoninreuptake inhibitor(SSRI) treatment may he effective for a varietyof anxietydisordersas well aa effectivefor depression,although it has beenunclearwhetherSSRIartxiolysisis correlatedwiththe degree of SSRI-inducedinhibitionof serotonintransport.Thegeneencodingfor the humanserotonirrtransportproteinis expressedon bloodplateletsas well as on serotoninneurons, and both tissues respond to reuptake inhibitionsimilarlyin responseto SSFUtreatment.In the presentstudy we examinedthe relationshiphetweenthe changein apparentserotonin transport affinity and the anxiolyticresponseto SSRI treatment in a groupof 18fluvoxarnine-treated patientsmeetingSCIDcriteriafor both generalizedanxietydisorderandmajordepression.Significantdecreases were found in both Hamiltonanxietyand Hamiltondepressionscores over a two monthtreatmentperiod,and robustincreaseswere foundin the apparentafhity constantfor platelet serotonintransporton drug. Moreover,there was a significantcovariancebetweenthe decrease in anxietyand the increase in apparentserotonintransportaffhity (F = 4.97,p<.03). Theseresults suggestthat the therapeuticanxiolyticeffect of SSRI treatmentcan be linkedto the magnitudeand time-courseof serotonintransportinhibitioneffected with drugs such as fluvoxamine whichmay be effectivefor anxietyas well as depressivesymptomatolWY.
240. PET MEASURES OF MONOAMINERGIC SYNAPTIC DENSITY IN BIPOLAR I DISORDER: RELATIONSHIP WITH AGE OF ONSET J.-K. Zubieta, P. Huguelet, L.E. Ohl, M.R. Kilbourn, R.A. Koeppe & K.A. Frey
This data confirms the presence of trait anomaliesin the density of monoamirrergicsynapticfields in patientsdiagnosedwith BD I. These may reflect different patterns of monoaminergicsynaptic contacts in variousforms of illness (i.e., early vs. older age of onset), or disease severity.
Neurobiology/Clinical Pathology I Friday, May 29, 2:30 PM-5:00 PM, Location; Pier 9 Chairperson:Peter Roy-Byrne 241. THE COLLABORATIVE STUDY OF THE GENETICS OF ALCOHOLISM: INITIAL RESULTS AND FUTURE GOALS J.I. Nurnberger Jr.1, V. Hesselbrock2, R. Crowe3, B. Porjesz4, R. Cloninge~, M. Schuckit6, S. O’Connor7, K. Bucholz8, H. Edenberg9, A. Goatel”, J. Tischfieldll, T. Foroud12, J. Rice13, P.M. Conneally14, T.K. Li15, T. Reich16 & H. Begleiter17
MentalHealthResearchInstitute,Divisionof NuclearMedicineand Departmentof PsychiatryThe Universityof Michigan,ArmArbor
%rdirmaUniversity,Indianapolis,IN 46202;‘Universityof Connecticut,Farmington,CT 06030;3Univeraityof Iowa State, Iowa City, IA 52242;4Univeratiyof New York,Brooklyn,NY 11266; ‘WashingtonUniversityof St. Louis,St.Louis,MO 63110;%Jniversity of SouthernCalifornia,San Diego,CA 92161
It hasbeensuggestedthatBipolarDisorder(BD)maybe charactenzedby anomaliesin cell migrationor in the density or patterns of synaptic
The CollaborativeStudyof the Genetics of Alcoholism(COGA)is a six-site study of families with multiple cases of severe alcoholism.