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253: Coffee consumption is inversely associated with plasma adiponectin
Multiple Risk Factors in Cardiovascular Disease—Abstracts
M. Choi2. 1School of Life Science and Biotechnology, Kyungpook National University, Daegu, South Korea, 2Department of Food Science and Nutrition, Kyungpook National University, Daegu, South Korea, 3Amicogen, Inc., 694-4 Sangchon, Jinsung, Jinju, South Korea Objective: This study was performed to investigate the antiobese effects of brown seaweed ethanol extract containing fucoxanthin. Methods: Male C57BL/6J mice were fed either 1.43%(0.05% fucoxanthin, Ext I) or 5.72%(0.2% fucoxanthin, Ext II) seaweed ethanol extract in 20% high-fat(HF, 10% lard and 10% corn oil) control diet for 6 weeks. Conjugated linoleic acid(CLA, 0.2%,w/w) was used as a positive control(PC). Results: Ext I and II supplementation significantly lowered body weight, perirenal-, epididymal-, interscapular- and total white adipose tissue weights, plasma triglyceride(TG), free fatty acid and leptin concentrations and liver TG content, compared to the HF control diet. Fecal TG excretion was significantly elevated in two Ext groups compared to the HF control group. Hepatic and adipocytic malic enzyme, fatty acid synthase, G6PD activities, which are related to the TG or fatty acid synthesis, were significantly reduced in both Ext I and Ext II group. Whereas, adipocytic α-oxidation and CPT activities were significantly higher in two Ext groups than in the HF control group. Conclusions: These results indicated that the brown seaweed ethanol extract supplementation was effective not only in lowering body and WAT weight and plasma and hepatic TG levels but also in improving the lipid metabolism by inhibiting TG absorption and synthesis in high-fat fed mice. Funding: This study was supported by Ministry of Commerce, Industry and Energy, Korea
253 COFFEE CONSUMPTION IS INVERSELY ASSOCIATED WITH PLASMA ADIPONECTIN C. Lee1, J. Mok2, C. Park3, K. Lee4, S. Kim5, C. Kim6, S. Oh7, S. Kim8, S. Lee5, H. Lee9. 1Hanyang University Guri Hospital, Guri, South
S118
Korea, 2Soonchunhayng University Bucheon Hospital, Bucheon, South Korea, 3Sungkyunkwan University, Seoul, South Korea, 4Gachon University of Medicine and Science, Incheon, South Korea, 5Holy Family Hospital, The Catholic University of Korea, Bucheon, South Korea, 6 Sejong General Hospital, Bucheon, South Korea, 7Kyunghee University Hospital, Seoul, South Korea, 8Korea Univertiy Guro Hospital, Seoul, South Korea, 9Graduate School of Public Health, Yonsei University, Seoul, South Korea Background: Coffee has been widely studied in relation to many diseases, but the result is not consistent. Coffee consumption is sometimes beneficial and often harmful to human diseases. To know whether the beneficial effects of coffee consumption could be explained by adiponectin, we tried to find the relationship between the amount of coffee consumption and adiponection. Methods: The study population consisted of 1318 subjects who participated in the Korean Metabolic Syndrome Research Initiative and had routine health examinations at the Health Promotion Center in University Hospitals from January through December 2006. We evaluated the self reported amount of coffee consumption as a number of cup of coffee. Results: In baseline characteristics of the study population, age was 44.5 ± 9.2, body mass index was 23.9 ± 3.0(kg/ m2), and adiponectin was 8.0 ± 5.0 (ng/ml)(Mean ± SD). When the study population separated to four group by the amount of coffee consumption as none, lower than 7 cups, 8-14 cups, more than 14 cups per week, adiponectin decreased progressively in men(7.11±0.34, 6.67±0.22, 6.41±0.21, 5.93±0.21(ng/ml) (P for trend = 0.016, P= 0.014)). But adiponectin did not show any tendency in women(9.48±0.57, 9.27±0.27, 8.99±0.32, 9.83±0.44, P for trend = 0.685, P= 0.467). Conclusions: High consumption of caffeine-containing coffee is associated with lower adiponectin. In contrast to the result of recent study, our result shows the risky aspect of coffee consumption. Funding: This study was supported by a grant of the Seoul R&BD Program, Republic of Korea (10526)
M. Choi2. 1School of Life Science and Biotechnology, Kyungpook National University, Daegu, South Korea, 2Department of Food Science and Nutrition, Kyungpook National University, Daegu, South Korea, 3Amicogen, Inc., 694-4 Sangchon, Jinsung, Jinju, South Korea Objective: This study was performed to investigate the antiobese effects of brown seaweed ethanol extract containing fucoxanthin. Methods: Male C57BL/6J mice were fed either 1.43%(0.05% fucoxanthin, Ext I) or 5.72%(0.2% fucoxanthin, Ext II) seaweed ethanol extract in 20% high-fat(HF, 10% lard and 10% corn oil) control diet for 6 weeks. Conjugated linoleic acid(CLA, 0.2%,w/w) was used as a positive control(PC). Results: Ext I and II supplementation significantly lowered body weight, perirenal-, epididymal-, interscapular- and total white adipose tissue weights, plasma triglyceride(TG), free fatty acid and leptin concentrations and liver TG content, compared to the HF control diet. Fecal TG excretion was significantly elevated in two Ext groups compared to the HF control group. Hepatic and adipocytic malic enzyme, fatty acid synthase, G6PD activities, which are related to the TG or fatty acid synthesis, were significantly reduced in both Ext I and Ext II group. Whereas, adipocytic α-oxidation and CPT activities were significantly higher in two Ext groups than in the HF control group. Conclusions: These results indicated that the brown seaweed ethanol extract supplementation was effective not only in lowering body and WAT weight and plasma and hepatic TG levels but also in improving the lipid metabolism by inhibiting TG absorption and synthesis in high-fat fed mice. Funding: This study was supported by Ministry of Commerce, Industry and Energy, Korea
253 COFFEE CONSUMPTION IS INVERSELY ASSOCIATED WITH PLASMA ADIPONECTIN C. Lee1, J. Mok2, C. Park3, K. Lee4, S. Kim5, C. Kim6, S. Oh7, S. Kim8, S. Lee5, H. Lee9. 1Hanyang University Guri Hospital, Guri, South
S118
Korea, 2Soonchunhayng University Bucheon Hospital, Bucheon, South Korea, 3Sungkyunkwan University, Seoul, South Korea, 4Gachon University of Medicine and Science, Incheon, South Korea, 5Holy Family Hospital, The Catholic University of Korea, Bucheon, South Korea, 6 Sejong General Hospital, Bucheon, South Korea, 7Kyunghee University Hospital, Seoul, South Korea, 8Korea Univertiy Guro Hospital, Seoul, South Korea, 9Graduate School of Public Health, Yonsei University, Seoul, South Korea Background: Coffee has been widely studied in relation to many diseases, but the result is not consistent. Coffee consumption is sometimes beneficial and often harmful to human diseases. To know whether the beneficial effects of coffee consumption could be explained by adiponectin, we tried to find the relationship between the amount of coffee consumption and adiponection. Methods: The study population consisted of 1318 subjects who participated in the Korean Metabolic Syndrome Research Initiative and had routine health examinations at the Health Promotion Center in University Hospitals from January through December 2006. We evaluated the self reported amount of coffee consumption as a number of cup of coffee. Results: In baseline characteristics of the study population, age was 44.5 ± 9.2, body mass index was 23.9 ± 3.0(kg/ m2), and adiponectin was 8.0 ± 5.0 (ng/ml)(Mean ± SD). When the study population separated to four group by the amount of coffee consumption as none, lower than 7 cups, 8-14 cups, more than 14 cups per week, adiponectin decreased progressively in men(7.11±0.34, 6.67±0.22, 6.41±0.21, 5.93±0.21(ng/ml) (P for trend = 0.016, P= 0.014)). But adiponectin did not show any tendency in women(9.48±0.57, 9.27±0.27, 8.99±0.32, 9.83±0.44, P for trend = 0.685, P= 0.467). Conclusions: High consumption of caffeine-containing coffee is associated with lower adiponectin. In contrast to the result of recent study, our result shows the risky aspect of coffee consumption. Funding: This study was supported by a grant of the Seoul R&BD Program, Republic of Korea (10526)