- Email: [email protected]
299. Detection of Spontaneous Schwannomas by MRI in a Transgenic Murine Model of Neurofibromatosis Type 2
"8 "! " ! 5,&" (
$*'
3 !)# !)#
"
1
" "
- $*?/ -'.=9 ?'!" $*?/ >8 >=%>6
- $*?/ !$ $*? ?'! '.=9 ?'!" $*? E
( " $ E B")C$'
>D('
6B 8,
$*? E
'.=9 ?'!" $*? -
$*? /
'.=9 ?'!" $*?
;9H $'
69H
3
) $*? " ?'! % $' E
299. Detection of Spontaneous Schwannomas by MRI in a T ransgenic Murine Model of Neurofibromatosis T ype Transgenic Type 2 Shanta M. Kumar,1 Yi Tang,2 Marco Giovannini,3 Rod T. Bronson,4 Ralph Weissleder,2 Xandra O. Breakefield.1 1 Neurology, Massachusetts General Hospital East, Charlestown, Massachusetts, United States; 2Molecular Imaging, Massachusetts General Hospital East, Charlestown, Massachusetts, United States; 33 Institut National de la Sante et de la Recherche Medicale (INSERM), U434-Institut Curie, Paris, France; 4Rodent Histopathology Core Facility, Harvard Medical School, Boston, Massachusetts, United States.
298. Neurodegeneration Prevented by Adenoviral Vector Delivery of GDNF in a Rat Model of Parkinson Parkinson′′s Disease Tiina Paunio,1 Anh Do Thi,1 Paulette Saillour,1 Lucy Ferrero,2 JeanFrancois Dedieu,2 Jacques Mallet.1 1 LGN, CNRS UMR7091, Paris, France; 2Aventis Pharma Devlopment, Aventis, Vitry sur Seine, France. ! V -!$/ G
-$'/
D"$ - / C
*
E
Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy
(
-#@/ *?, 3 ( !)
#@ ' 3 :&H -8,%86/
,6 ( ,8H
86H ; H ;H 3 86H ;H IBBH-,%=/
#
#@ ,8 H 8
#@
"$ !' ?
,
1 ? #@ C 3
(
("899 .(."
*?,
( 3
*?, ? #@
1
; H
#@
3 8 -C(./ @= N
#@ 1
C(. P
$ ' 4( ' @ #
@ # ' \ $'#$8;"
S99
"8 "! " ! 99"8"9&=; # C? #
$
(#A
-!&9"':B=&&/ ( ' -@,6" '5,;:,/
@0
300. Identification of Novel Stroke T argets Using Targets ™ Strategies SMARTOMICS™ SMARTOMICS Scott Ralph,1 Steven N. Parham,1 Sheena Lee,1 David Krige,1 Rob D. Barber,1 James W. Connell,1 Sue M. Kingsman,1 Nick D. Mazarakis,1 Chris Mundy.1 1 Oxford Biomedica Ltd, Oxford Science Park, Oxford, United Kingdom.
? G
!
3
3
0
3 G _( ™V"
( ™ 3
0
1
->'./ 3
>'."
C"8α >!'(
3
3 3 G
3 -C@> / G
G 3 3 C@> 3 C"8α%>!'(
?
3
' 3
301. AA VV ector-Mediated T ransduction in the Cat AAV Vector-Mediated Transduction Brain Charles H. Vite,1,2 Marco A. Passini,1,2 Aracelis Polesky,1,2 Patricia O′Donnell,1 Jean Zweigle,1 Anna Salvetti,3 Philippe Moullier,3 Mark E. Haskins,1 John H. Wolfe.1,2 1 School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States; 2Children′s Hospital of Philadelphia, Philadelphia, PA, United States; 3Laboratoire de Therapie Genique, Nantes, France. ' -*(/
G ( ′ # 1
" '
*( ' "
-''./ 3 " - 4(2/ 4(2 ''.
4(2 G
C 3 899 3 8999
''. G 3 4(2
G 3
S100
G ''.
4(2 4(2 - CβC / CβC
''. 6& 3 898, %
3 #@
, D E
G
G
3 ''."CβC E
E - 3 / - / :"
" G
8:
3 G G > 4(2 3 "
4(2 ''.
2
''.
302. Systemic Gene Delivery in Adult Mouse Brain by Adeno-Associated V iral V ectors Viral Vectors Lei Wang,1 Liqiao Zhou,2 Bing Wang,2 Zhong Wang,2 Juan Li,2 Xiao Xiao,2 Yan Xu.1,3 1 Departments of Anesthesiology; 2Molecular Genetics and Biochemistry; 3Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. # $ 3
0
0 "
,- ''.,/ =- ''.=/
"
$*'
- ?!/ E 4 3
3 8"
' E
9," )$
- 3 = 3 898= /
-(?/ '
& ,B =B E ?! 3 3
0 ?! 3
G -(.N/& E 3- "/ ,B =B E ) & 3 (.N E
3
,B =B E *
3 ''., ''.= 3
1
(? )
''., ''.=
"
*(
303. A Model System for Gene Therapy of Murine Mucopolysaccharidosis VII in the CNS Using an HSV-1 Vector Bradford K. Berges,1 Nigel W. Fraser.1 1 Microbiology, University of Pennsylvania, Philadelphia, PA, United States. # -#!(/ .
G " - 4(2/ #!( .
1 4(2 $*'
#!( . 3 4(2 1
4(2
Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy
$*'
3 !)# !)#
"
1
" "
- $*?/ -'.=9 ?'!" $*?/ >8 >=%>6
- $*?/ !$ $*? ?'! '.=9 ?'!" $*? E
( " $ E B")C$'
>D('
6B 8,
$*? E
'.=9 ?'!" $*? -
$*? /
'.=9 ?'!" $*?
;9H $'
69H
3
) $*? " ?'! % $' E
299. Detection of Spontaneous Schwannomas by MRI in a T ransgenic Murine Model of Neurofibromatosis T ype Transgenic Type 2 Shanta M. Kumar,1 Yi Tang,2 Marco Giovannini,3 Rod T. Bronson,4 Ralph Weissleder,2 Xandra O. Breakefield.1 1 Neurology, Massachusetts General Hospital East, Charlestown, Massachusetts, United States; 2Molecular Imaging, Massachusetts General Hospital East, Charlestown, Massachusetts, United States; 33 Institut National de la Sante et de la Recherche Medicale (INSERM), U434-Institut Curie, Paris, France; 4Rodent Histopathology Core Facility, Harvard Medical School, Boston, Massachusetts, United States.
298. Neurodegeneration Prevented by Adenoviral Vector Delivery of GDNF in a Rat Model of Parkinson Parkinson′′s Disease Tiina Paunio,1 Anh Do Thi,1 Paulette Saillour,1 Lucy Ferrero,2 JeanFrancois Dedieu,2 Jacques Mallet.1 1 LGN, CNRS UMR7091, Paris, France; 2Aventis Pharma Devlopment, Aventis, Vitry sur Seine, France. ! V -!$/ G
-$'/
D"$ - / C
*
E
Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy
(
-#@/ *?, 3 ( !)
#@ ' 3 :&H -8,%86/
,6 ( ,8H
86H ; H ;H 3 86H ;H IBBH-,%=/
#
#@ ,8 H 8
#@
"$ !' ?
,
1 ? #@ C 3
(
("899 .(."
*?,
( 3
*?, ? #@
1
; H
#@
3 8 -C(./ @= N
#@ 1
C(. P
$ ' 4( ' @ #
@ # ' \ $'#$8;"
S99
"8 "! " ! 99"8"9&=; # C? #
$
(#A
-!&9"':B=&&/ ( ' -@,6" '5,;:,/
@0
300. Identification of Novel Stroke T argets Using Targets ™ Strategies SMARTOMICS™ SMARTOMICS Scott Ralph,1 Steven N. Parham,1 Sheena Lee,1 David Krige,1 Rob D. Barber,1 James W. Connell,1 Sue M. Kingsman,1 Nick D. Mazarakis,1 Chris Mundy.1 1 Oxford Biomedica Ltd, Oxford Science Park, Oxford, United Kingdom.
? G
!
3
3
0
3 G _( ™V"
( ™ 3
0
1
->'./ 3
>'."
C"8α >!'(
3
3 3 G
3 -C@> / G
G 3 3 C@> 3 C"8α%>!'(
?
3
' 3
301. AA VV ector-Mediated T ransduction in the Cat AAV Vector-Mediated Transduction Brain Charles H. Vite,1,2 Marco A. Passini,1,2 Aracelis Polesky,1,2 Patricia O′Donnell,1 Jean Zweigle,1 Anna Salvetti,3 Philippe Moullier,3 Mark E. Haskins,1 John H. Wolfe.1,2 1 School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States; 2Children′s Hospital of Philadelphia, Philadelphia, PA, United States; 3Laboratoire de Therapie Genique, Nantes, France. ' -*(/
G ( ′ # 1
" '
*( ' "
-''./ 3 " - 4(2/ 4(2 ''.
4(2 G
C 3 899 3 8999
''. G 3 4(2
G 3
S100
G ''.
4(2 4(2 - CβC / CβC
''. 6& 3 898, %
3 #@
, D E
G
G
3 ''."CβC E
E - 3 / - / :"
" G
8:
3 G G > 4(2 3 "
4(2 ''.
2
''.
302. Systemic Gene Delivery in Adult Mouse Brain by Adeno-Associated V iral V ectors Viral Vectors Lei Wang,1 Liqiao Zhou,2 Bing Wang,2 Zhong Wang,2 Juan Li,2 Xiao Xiao,2 Yan Xu.1,3 1 Departments of Anesthesiology; 2Molecular Genetics and Biochemistry; 3Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. # $ 3
0
0 "
,- ''.,/ =- ''.=/
"
$*'
- ?!/ E 4 3
3 8"
' E
9," )$
- 3 = 3 898= /
-(?/ '
& ,B =B E ?! 3 3
0 ?! 3
G -(.N/& E 3- "/ ,B =B E ) & 3 (.N E
3
,B =B E *
3 ''., ''.= 3
1
(? )
''., ''.=
"
*(
303. A Model System for Gene Therapy of Murine Mucopolysaccharidosis VII in the CNS Using an HSV-1 Vector Bradford K. Berges,1 Nigel W. Fraser.1 1 Microbiology, University of Pennsylvania, Philadelphia, PA, United States. # -#!(/ .
G " - 4(2/ #!( .
1 4(2 $*'
#!( . 3 4(2 1
4(2
Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy