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β2GPI COMPLEX BUT NOT FREE OXLDL IS ASSOCIATED WITH CAD SEVERITY IN STATIN NAïVE PATIENTS UNDERGOING ELECTIVE CARDIAC CATHETERIZATION
A1576 JACC March 17, 2015 Volume 65, Issue 10S
Stable Ischemic Heart Disease OxLDL/β2GPI Complex but Not Free OxLDL Is Associated with CAD Severity in Statin Naïve Patients Undergoing Elective Cardiac Catheterization Moderated Poster Contributions Stable Ischemic Heart Disease Moderated Poster Theater, Poster Hall B1 Saturday, March 14, 2015, 3:45 p.m.-3:55 p.m. Session Title: Stable Ischemic Heart Disease: Focus on Basic Science Abstract Category: 25. Stable Ischemic Heart Disease: Basic Presentation Number: 1171M-03 Authors: Paul A. Gurbel, Kevin Bliden, Kirk Guyer, Martin Gesheff, Christopher Franzese, Himabindu Kaza, Peter Toth, Udaya Tantry, Sinai Center for Thrombosis Research, Baltimore, MD, USA, University of Illinois College of Medicine, Peoria, IL, USA Background: Oxidized low-density lipoprotein (OxLDL) and β2 glycoprotein I (β2GPI) have been identified in human atherosclerotic lesions and when complexed have been implicated as a pro-atherothrombotic antigen. We examined the association of OxLDL alone and OxLDL/β2GPI complex in patients with coronary artery disease (CAD) undergoing elective cardiac catheterization (ECC).
Methods: Serum was collected immediately prior to ECC in patients with suspected CAD who were either treated (n=385) or not treated (n=150) with statins. OxLDL and OxLDL/β2GPI complex levels were determined by ELISA. Disease severity was defined as none-minimal (<20%), moderate (20-75%), and severe >75% luminal diameter obstruction of any major coronary vessel.
Results: Both OxLDL and OxLDL/β2GPI complex were lower in patients on statins (p<0.001). In statin naïve patients, OxLDL/β2GPI complex, but not OxLDL alone, was associated with severe CAD (figure, p=0.036 by ANOVA). However, no association was observed in patients on statins. LDL4 and triglycerides increased with OxLDL/β2GPI complex quartiles (p=0.001 by ANOVA). OxLDL/β2GPI complex >0.26 mg/dl was predictive of severe atherosclerosis by ROC analysis in statin naïve patients (AUC=0.60, p=0.05). Conclusion: In statin naïve patients, OxLDL/β2GPI appears more predictive of CAD severity than OxLDL alone. Further prospective studies are required to explore the clinical utility of this novel biomarker.
Stable Ischemic Heart Disease OxLDL/β2GPI Complex but Not Free OxLDL Is Associated with CAD Severity in Statin Naïve Patients Undergoing Elective Cardiac Catheterization Moderated Poster Contributions Stable Ischemic Heart Disease Moderated Poster Theater, Poster Hall B1 Saturday, March 14, 2015, 3:45 p.m.-3:55 p.m. Session Title: Stable Ischemic Heart Disease: Focus on Basic Science Abstract Category: 25. Stable Ischemic Heart Disease: Basic Presentation Number: 1171M-03 Authors: Paul A. Gurbel, Kevin Bliden, Kirk Guyer, Martin Gesheff, Christopher Franzese, Himabindu Kaza, Peter Toth, Udaya Tantry, Sinai Center for Thrombosis Research, Baltimore, MD, USA, University of Illinois College of Medicine, Peoria, IL, USA Background: Oxidized low-density lipoprotein (OxLDL) and β2 glycoprotein I (β2GPI) have been identified in human atherosclerotic lesions and when complexed have been implicated as a pro-atherothrombotic antigen. We examined the association of OxLDL alone and OxLDL/β2GPI complex in patients with coronary artery disease (CAD) undergoing elective cardiac catheterization (ECC).
Methods: Serum was collected immediately prior to ECC in patients with suspected CAD who were either treated (n=385) or not treated (n=150) with statins. OxLDL and OxLDL/β2GPI complex levels were determined by ELISA. Disease severity was defined as none-minimal (<20%), moderate (20-75%), and severe >75% luminal diameter obstruction of any major coronary vessel.
Results: Both OxLDL and OxLDL/β2GPI complex were lower in patients on statins (p<0.001). In statin naïve patients, OxLDL/β2GPI complex, but not OxLDL alone, was associated with severe CAD (figure, p=0.036 by ANOVA). However, no association was observed in patients on statins. LDL4 and triglycerides increased with OxLDL/β2GPI complex quartiles (p=0.001 by ANOVA). OxLDL/β2GPI complex >0.26 mg/dl was predictive of severe atherosclerosis by ROC analysis in statin naïve patients (AUC=0.60, p=0.05). Conclusion: In statin naïve patients, OxLDL/β2GPI appears more predictive of CAD severity than OxLDL alone. Further prospective studies are required to explore the clinical utility of this novel biomarker.