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3-dimensional echocardiographic and strain evaluation of right ventricular function in pediatric sickle cell disease population
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Echocardiography and imaging
Fig. 1 From 3D echocardiographic full volume acquisition (A) to right ventricle dynamic model (B). Disclosure of interest peting interest. Fig. 1
RAP estimation by echo and right heart catheterization.
The authors declare that they have no com-
https://doi.org/10.1016/j.acvdsp.2019.09.144 097
Disclosure of interest peting interest.
The authors declare that they have no com-
https://doi.org/10.1016/j.acvdsp.2019.09.143 562
3-dimensional echocardiographic and strain evaluation of right ventricular function in pediatric sickle cell disease population Blanc ∗ ,
A. A. Guitarte Vidaure , R. Vincent , K. Hadeed , Y. Dulac , P. Acar , C. Karsenty Paediatric and Congenital Cardiology, M3C CHU de Toulouse, Toulouse, France ∗ Corresponding author. E-mail address: [email protected] (A. Blanc) Introduction Sickle cell disease (SCD) is characterized by chronic hemolytic anemia and intermittent vaso-occlusive events associated with cardiac abnormalities. Aim To assess 3 dimensional (3D) echocardiographic of right ventricle (RV) volumes and function in a pediatric SCD population. Methods Eighteen patients with SCD aged 4 to 17 years old (mean age: 8.0 ± 4 years, 56% male, body surface area (BSA) 1.0 ± 0.35) and 18 healthy controls matched for age, gender and BSA were prospectively included and compared. Echocardiograms were performed using a commercially available ultrasound Philipps EPIQ 7 C system using matrix X5-1 transducer. 3D indexed RV volumes and ejection fraction (3D-RVEF) were obtained using full volume acquisitions. RV free wall strain, tricuspid S-wave, tricuspid annular plane systolic excursion (TAPSE), indexed cardiac output, systolic pulmonary pressure (sPAP) and hemoglobin were assessed. Data were analyzed with TomtecArena© software (v2.3, Germany). Results Cardiac output was significantly higher in SCD children (4.5 vs. 3.6 l/min/m2 , P = 0.025), as sPAP (24.9 vs. 21.9 mmHg, P = 0.015), 3D-RV diastolic volume (58.1 vs. 47.5 ml/m2 , P = 0.025) and 3D-RV systolic volume (28.8 vs. 21.4 mL/m2 , P = 0.005). 3D-RVEF and RV free wall strain were significantly lower in SCD compared to control population (respectively 51.9 vs. 56.3%, P = 0.018; −28.6 vs. −32, P = 0.017). There were no difference regarding TAPSE and doppler S-wave. Mean hemoglobin in SCD population was 9.6 ± 1.7 g/dl (Fig. 1). Conclusion Despite normal RV systolic function parameters, 3DRVEF and RV free wall strain are lower in children with SCD. Chronic anemia generating volume overload and vaso-occlusive events could explain these findings. This data must be confirmed by cardiac magnetic resonance imaging.
Diagnostic echocardiographic parameters of early cardiotoxicity of anthracyclines in pediatric population S. Chibane ∗ , M. Abdulhakeem , R. Bah , R. Habbal Chu Ibn Rochd, Casablanca, Maroc ∗ Corresponding author. E-mail address: [email protected] (S. Chibane) Introduction Hematological malignancies are the most common tumors in pediatrics. Anthracyclines represent the molecule of choice in their treatments, and are responsible for improving survival. Their cardiovascular complications, increased the morbidity. Purpose Evaluate diagnostic echocardiographic parameters of early cardiotoxicity of anthracyclines in children. Methods Prospective observational study (18 months) including 43 patients followed in onco-hematology for hematological malignancy, on anthracycline, who had a cardiovascular assessment and follow-up. Results The average age is 7.4 years (range 6 months to 16 years), with male predominance (sex ratio = 2.07). All patients were followed for hematologic malignancy: 14 cases of LH, 12 cases of NHL, 12 cases of ALL, and 5 cases of AML. 21 patients were in treatment, 12 patients in remission, and 10 patients scheduled for bone marrow transplantation. All patients were on anthracyclines, with an average cumulative dose of 223 mg/m2 . A complete cardiovascular assessment was performed in all patients with a control before each treatment in patients in treatment and every 3 months in patients in remission. Echocardiographic parameters that varied significantly in post chemotherapy were: Ea, Sa, and SGL. Tissue Doppler parameters decreased in 14% of cases after an average cumulative dose of 160 mg/m2 . SGL decreased significantly in 7% of cases after an average cumulative anthracycline dose of 290 mg/m2 . Conclusion The tissue doppler and the global longitudinal strain have an interest in both the child and the adult in the early detection of anthracycline cardiotoxicity, allowing better management. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2019.09.145
Echocardiography and imaging
Fig. 1 From 3D echocardiographic full volume acquisition (A) to right ventricle dynamic model (B). Disclosure of interest peting interest. Fig. 1
RAP estimation by echo and right heart catheterization.
The authors declare that they have no com-
https://doi.org/10.1016/j.acvdsp.2019.09.144 097
Disclosure of interest peting interest.
The authors declare that they have no com-
https://doi.org/10.1016/j.acvdsp.2019.09.143 562
3-dimensional echocardiographic and strain evaluation of right ventricular function in pediatric sickle cell disease population Blanc ∗ ,
A. A. Guitarte Vidaure , R. Vincent , K. Hadeed , Y. Dulac , P. Acar , C. Karsenty Paediatric and Congenital Cardiology, M3C CHU de Toulouse, Toulouse, France ∗ Corresponding author. E-mail address: [email protected] (A. Blanc) Introduction Sickle cell disease (SCD) is characterized by chronic hemolytic anemia and intermittent vaso-occlusive events associated with cardiac abnormalities. Aim To assess 3 dimensional (3D) echocardiographic of right ventricle (RV) volumes and function in a pediatric SCD population. Methods Eighteen patients with SCD aged 4 to 17 years old (mean age: 8.0 ± 4 years, 56% male, body surface area (BSA) 1.0 ± 0.35) and 18 healthy controls matched for age, gender and BSA were prospectively included and compared. Echocardiograms were performed using a commercially available ultrasound Philipps EPIQ 7 C system using matrix X5-1 transducer. 3D indexed RV volumes and ejection fraction (3D-RVEF) were obtained using full volume acquisitions. RV free wall strain, tricuspid S-wave, tricuspid annular plane systolic excursion (TAPSE), indexed cardiac output, systolic pulmonary pressure (sPAP) and hemoglobin were assessed. Data were analyzed with TomtecArena© software (v2.3, Germany). Results Cardiac output was significantly higher in SCD children (4.5 vs. 3.6 l/min/m2 , P = 0.025), as sPAP (24.9 vs. 21.9 mmHg, P = 0.015), 3D-RV diastolic volume (58.1 vs. 47.5 ml/m2 , P = 0.025) and 3D-RV systolic volume (28.8 vs. 21.4 mL/m2 , P = 0.005). 3D-RVEF and RV free wall strain were significantly lower in SCD compared to control population (respectively 51.9 vs. 56.3%, P = 0.018; −28.6 vs. −32, P = 0.017). There were no difference regarding TAPSE and doppler S-wave. Mean hemoglobin in SCD population was 9.6 ± 1.7 g/dl (Fig. 1). Conclusion Despite normal RV systolic function parameters, 3DRVEF and RV free wall strain are lower in children with SCD. Chronic anemia generating volume overload and vaso-occlusive events could explain these findings. This data must be confirmed by cardiac magnetic resonance imaging.
Diagnostic echocardiographic parameters of early cardiotoxicity of anthracyclines in pediatric population S. Chibane ∗ , M. Abdulhakeem , R. Bah , R. Habbal Chu Ibn Rochd, Casablanca, Maroc ∗ Corresponding author. E-mail address: [email protected] (S. Chibane) Introduction Hematological malignancies are the most common tumors in pediatrics. Anthracyclines represent the molecule of choice in their treatments, and are responsible for improving survival. Their cardiovascular complications, increased the morbidity. Purpose Evaluate diagnostic echocardiographic parameters of early cardiotoxicity of anthracyclines in children. Methods Prospective observational study (18 months) including 43 patients followed in onco-hematology for hematological malignancy, on anthracycline, who had a cardiovascular assessment and follow-up. Results The average age is 7.4 years (range 6 months to 16 years), with male predominance (sex ratio = 2.07). All patients were followed for hematologic malignancy: 14 cases of LH, 12 cases of NHL, 12 cases of ALL, and 5 cases of AML. 21 patients were in treatment, 12 patients in remission, and 10 patients scheduled for bone marrow transplantation. All patients were on anthracyclines, with an average cumulative dose of 223 mg/m2 . A complete cardiovascular assessment was performed in all patients with a control before each treatment in patients in treatment and every 3 months in patients in remission. Echocardiographic parameters that varied significantly in post chemotherapy were: Ea, Sa, and SGL. Tissue Doppler parameters decreased in 14% of cases after an average cumulative dose of 160 mg/m2 . SGL decreased significantly in 7% of cases after an average cumulative anthracycline dose of 290 mg/m2 . Conclusion The tissue doppler and the global longitudinal strain have an interest in both the child and the adult in the early detection of anthracycline cardiotoxicity, allowing better management. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2019.09.145