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3135. Another iodine hypothesis
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Cancer research and Teratogenesis CANCER
3135. Another iodine hypothesis Stadel, B. V. (1976). Dietary iodine and risk of breast. endometrial, and ovarian cancer. Luncet I. 890. It has been suggested that variations in the incidence of large-bowel cancer may be related to dietary differences (Cited in F.C.T. 1971, 9, 900). and the author cited above now suggests that the parallel incidence rates of breast, endometrial and ovarian cancer in different regions of the world are also due to dietary rather than genetic factors. Regional differences in the incidence of breast cancer appear to vary with
RESEARCH the prevalence of goitre, and a high incidence of goitre has been observed in women with endometrial cancer. In addition, young women at relatively high risk for endometrial and breast cancer have relatively high levels of oestrogen, although there is no evidence for a hyperoestrogenic state in women at risk for ovarian cancer. Since a deficiency in dietary iodine is associated with goitre (ibid 1976, 14, 356) and since the diets of populations at higher risk for breast, endometrial and ovarian cancers tend to be deficient in iodine, the effects on the endocrine system of a diet relatively low in iodine may be responsible for the increased incidence of these cancers.
TERATOGENESIS 3136. Warfarin
under suspicion
Fourie, D. T. & Hay, I. T. (1975). Warfarin ible teratogen. S. Afr. med. J. 49, 2081.
as a poss-
The birth of offspring showing various types of defective development has been described after maternal treatment with the indanedione anticoagulant, warfarin (Cited in F.C.T. 1972, 10, 275), and evidence incriminating warfarin in embryopathic conditions is increasing. The authors of the paper cited above have traced six babies with congenital stippled epiphyses (chondrodysplasia punctata) born to mothers who had been taking warfarin during pregnancy. They report
the case of a woman aged 37 who was treated, after a heart-valve replacement, with 5 mg warfarin daily, together with digoxin. frusemide, verapamil and potassium supplements. This treatment was continued during pregnancy, the warfarin being replaced by parenteral heparin only 1 wk before delivery. The woman gave birth to an infant with a hypoplastic upturned nose, mild choanal stenosis, short fingers with dystrophic nails and stippled calcification in the epiphyses of the cuboids, proximal femora, sacrum and vertebral column. This is the fourth such case to be reported in South Africa, although warfarin treatment during pregnancy is relatively uncommon, and warfarin is strongly suspected of being responsible for the malformation observed in this case.
Cancer research and Teratogenesis CANCER
3135. Another iodine hypothesis Stadel, B. V. (1976). Dietary iodine and risk of breast. endometrial, and ovarian cancer. Luncet I. 890. It has been suggested that variations in the incidence of large-bowel cancer may be related to dietary differences (Cited in F.C.T. 1971, 9, 900). and the author cited above now suggests that the parallel incidence rates of breast, endometrial and ovarian cancer in different regions of the world are also due to dietary rather than genetic factors. Regional differences in the incidence of breast cancer appear to vary with
RESEARCH the prevalence of goitre, and a high incidence of goitre has been observed in women with endometrial cancer. In addition, young women at relatively high risk for endometrial and breast cancer have relatively high levels of oestrogen, although there is no evidence for a hyperoestrogenic state in women at risk for ovarian cancer. Since a deficiency in dietary iodine is associated with goitre (ibid 1976, 14, 356) and since the diets of populations at higher risk for breast, endometrial and ovarian cancers tend to be deficient in iodine, the effects on the endocrine system of a diet relatively low in iodine may be responsible for the increased incidence of these cancers.
TERATOGENESIS 3136. Warfarin
under suspicion
Fourie, D. T. & Hay, I. T. (1975). Warfarin ible teratogen. S. Afr. med. J. 49, 2081.
as a poss-
The birth of offspring showing various types of defective development has been described after maternal treatment with the indanedione anticoagulant, warfarin (Cited in F.C.T. 1972, 10, 275), and evidence incriminating warfarin in embryopathic conditions is increasing. The authors of the paper cited above have traced six babies with congenital stippled epiphyses (chondrodysplasia punctata) born to mothers who had been taking warfarin during pregnancy. They report
the case of a woman aged 37 who was treated, after a heart-valve replacement, with 5 mg warfarin daily, together with digoxin. frusemide, verapamil and potassium supplements. This treatment was continued during pregnancy, the warfarin being replaced by parenteral heparin only 1 wk before delivery. The woman gave birth to an infant with a hypoplastic upturned nose, mild choanal stenosis, short fingers with dystrophic nails and stippled calcification in the epiphyses of the cuboids, proximal femora, sacrum and vertebral column. This is the fourth such case to be reported in South Africa, although warfarin treatment during pregnancy is relatively uncommon, and warfarin is strongly suspected of being responsible for the malformation observed in this case.