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32-O-02-Zeolites and other porous materials in the toxicity of inhaled mineral dusts
170 32 - Zeolite m i n e r a l s and H e a l t h Sciences (Thursday pm)
3 2 - O - 0 1 - B i o m e d i c a l a p p l i c a t i o n s of zeolites *K. Pavelic 1, B. Subotic I and M. Colic 2 IRudjer Boskovic Institute, Zagreb, Croatia," 2Molecutec Corporation., Goleta, USA pavelic@rudjer, irb. hr Natural and synthetic zeolites as well as other mesoporous and microporous solids are used in many industrial and household applications. However, it is less known that in recent years these exciting materials are increasingly being used in biomedical applications. In this review different current and possible future biomedical applications, together with our own research results obtained from studies of such materials, are critically described. Current needs for synthesis and characterization of novel mesoporous and microporous materials which would be better suited for biomedical applications are also described.
3 2 - 0 - 0 2 - Zeolites and other p o r o u s materials in the toxicity o f inhaled m i n e r a l dusts I. Fenoglio, L. Prandi, M. Tomatis and B. Fubini* Dipartimento di Chimica IFM, Universitb di Torino, Torino, [email protected] Some porous materials, typically fibrous erionite, are toxic per se. Others may be used as "model solids" to mimic real pathogenic minerals. It has been hypothesized that erionite catalyses free radical generation which damage DNA. Erionite released OH" only when incubated with ferric iron. Iron mobility in asbestos has been studied by means of cyclic voltammetry. Ferrosilicalite and one Fe-Y zeolite were "model solids" for iron mobility. Porosils have been employed in the study of silica cytotoxicity. Cell growth inhibition correlates with the outer surface, measured from particle morphology, but not with the BET surface, suggesting particle-cell contact as a primary step in cell growth inhibition. MCM-41 with spin active labels, in contact with cells, acted as a sensor of phagocytosis, the active nitroxide being quenched by cell generated oxidant.
3 2 - 0 - 0 3 - S t u d y of the reaction of a Ca-clinoptilolite and h u m a n bile R. Sim6n Carballo (a), G. Rodriguez-Fuentes (b), C. Urbina (c) and A. Fleitas (a) a Instituto Nacional de Angiologia y Cirugia Vascular, [email protected], Cuba b Instituto de Materiales y Reactivos, Univ. La Habana, [email protected], Cuba c Universidad Central de, [email protected], re, Venezuela The calcium exchanged form of the purified natural clinoptilolite (NZ) from the Tasajeras deposit, Cuba, is the active ingredient of a drug designed to reduce total blood cholesterol and prevent atherosclerosis. The study of the Ca2+-NZ - human bile reaction has revealed that it occurs through the adsorption of three major human bile compounds: bile acids, phospholipids and bilirubin. The adsorption of phospholipids on the external surface of the clinoptilolite crystals produces a phospholipids-zeolite interface with anionic activity that allows the adsorption of bile acids.
3 2 - O - 0 1 - B i o m e d i c a l a p p l i c a t i o n s of zeolites *K. Pavelic 1, B. Subotic I and M. Colic 2 IRudjer Boskovic Institute, Zagreb, Croatia," 2Molecutec Corporation., Goleta, USA pavelic@rudjer, irb. hr Natural and synthetic zeolites as well as other mesoporous and microporous solids are used in many industrial and household applications. However, it is less known that in recent years these exciting materials are increasingly being used in biomedical applications. In this review different current and possible future biomedical applications, together with our own research results obtained from studies of such materials, are critically described. Current needs for synthesis and characterization of novel mesoporous and microporous materials which would be better suited for biomedical applications are also described.
3 2 - 0 - 0 2 - Zeolites and other p o r o u s materials in the toxicity o f inhaled m i n e r a l dusts I. Fenoglio, L. Prandi, M. Tomatis and B. Fubini* Dipartimento di Chimica IFM, Universitb di Torino, Torino, [email protected] Some porous materials, typically fibrous erionite, are toxic per se. Others may be used as "model solids" to mimic real pathogenic minerals. It has been hypothesized that erionite catalyses free radical generation which damage DNA. Erionite released OH" only when incubated with ferric iron. Iron mobility in asbestos has been studied by means of cyclic voltammetry. Ferrosilicalite and one Fe-Y zeolite were "model solids" for iron mobility. Porosils have been employed in the study of silica cytotoxicity. Cell growth inhibition correlates with the outer surface, measured from particle morphology, but not with the BET surface, suggesting particle-cell contact as a primary step in cell growth inhibition. MCM-41 with spin active labels, in contact with cells, acted as a sensor of phagocytosis, the active nitroxide being quenched by cell generated oxidant.
3 2 - 0 - 0 3 - S t u d y of the reaction of a Ca-clinoptilolite and h u m a n bile R. Sim6n Carballo (a), G. Rodriguez-Fuentes (b), C. Urbina (c) and A. Fleitas (a) a Instituto Nacional de Angiologia y Cirugia Vascular, [email protected], Cuba b Instituto de Materiales y Reactivos, Univ. La Habana, [email protected], Cuba c Universidad Central de, [email protected], re, Venezuela The calcium exchanged form of the purified natural clinoptilolite (NZ) from the Tasajeras deposit, Cuba, is the active ingredient of a drug designed to reduce total blood cholesterol and prevent atherosclerosis. The study of the Ca2+-NZ - human bile reaction has revealed that it occurs through the adsorption of three major human bile compounds: bile acids, phospholipids and bilirubin. The adsorption of phospholipids on the external surface of the clinoptilolite crystals produces a phospholipids-zeolite interface with anionic activity that allows the adsorption of bile acids.