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348 cases of suspected neonatal alloimmune thrombocytopenia
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Citations fromthe Litemture
pump to allow pulsatile tocolytic infusion, hoping to reduce the total dose and thus the side effects. In 33 patients pulsatile bolus tocolysis was compared with continuous tocolysis in a control group of 38 patients. Bolus tocolysis required considerably less beta-sympathomimetic agent for comparable therapeutic success (median dosage 3.0 versus 15.9 mg, P < 0.001). Duration of therapy under bolus tocolysis was also significantly shorter (P < 0.05). Birth weight was higher after bolus tocolysis (median 3,070 versus 2,580 gm, P = 0.05). Additional indicators favored bolus tocolysis but were not statistically significant: a longer gestational period, fewer infants weighing < 2500 gm, and a lower incidence of respiratory distress syndrome. Pulmonary edema occurred in one patient during continuous tocolysis.
suspected neonatal alloimmune thrombocytopenia (NAT). Of the 144 mothers who were Zw’-negative, 107 had Zw* antibodies alone (94); with HLA antibodies (12); or with Br” antibodies (1). Antibodies were detected in 12 of the 204 Zw”-positive mothers as follows: anti-BP (9). anti-Zwb (1), anti-Bak” with HLA antibody (1), and blood group B isoagglutinins (1). The frequency of NAT due to Bra incompatibility (19%) was second to Zw*(78%). Zw-Nat was clinically the more severe (14% had intracranial haemorrhages) and responded well to either maternal platelet transfusions or intravenous IgG. In B&NAT intracranial haemorrhages were not observed and most children recovered without specific therapy.
Efficacy of neonatal ocular prophylaxis for the prevention of chlamydlal and gonococcal conjunctivitis
Naessens A; Foulon W; Breynaert J; Lauwers S Department of Microbiology, Akademisch Ziekenhuis Vrije Universiteit. B 1090 Brussels; Belgium American Journal of Obstetrics and Gynecology116013 (647650)/1989/ The influence of placental colonization and postpartum bacteria with genital mycoplasmas on the course of delivery and the immediate postpartum period was evaluated in 5 11 women who gave birth to live infants of at least 26 weeks’ gestation. Genital mycoplasmas were isolated from the placenta in 153 patients (29.9%) and from blood in four patients (0.80/o). These four isolates were all Ureaplasma urealyticum. Patients with genital mycoplasmas isolated from the placenta were delivered of infants with birth weights and gestational ages similar to those of infants of patients who did not have genital mycoplasmas in the placenta (3,260 gm and 39.2 weeks versus 3,272 gut and 39.3 weeks). No adverse effects of maternal postpartum bacteremia with genital mycoplasmas were observed, either in the mother or in the baby. We conclude that, whereas genital mycoplasmas frequently can be isolated from the placenta, there is no evident relationship between the presence of genital mycoplasmas and pregnancy outcome. In a few instances U. urealyticum has been isolated from the blood of afebrile postpartum women. In these women the presence of this bacteria is probably related to the birth process. This bacteremia does not precede an infectious complication.
Hammerschlag MR; Cummings C; Roblin PM; Williams TH; Delke I Department of Pediatrics, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203; USA New England Journal of Medicine/320/12 (769-772)/1989/ Opinions differ concerning the efficacy of prophylaxis against neonatal chlamydial and gonococcal conjunctivitis. From January 1986 through June 1988, we gave all infants born at Kings County Hospital Medical Center one of three prophylactic agents - silver nitrate drops, erythromycin ophthalmic ointment, or tetracycline ophthalmic ointment. The treatments were rotated monthly. Gonoccal ophthalmia occurred in 8 of the 12,431 infants born during the study (0.06 percent), 1 in the silver nitrate group, 4 in the erythromycin group, and 3 in the tetracycline group (P not significant). Seven of these infants were born to women who had received no prenatal care. From September 1985 through December 1987, we screened 4357 pregnant women for cervical chlamydial infection, of whom 341 (8 percent) had positive cultures. Of their offspring, 230 were evaluated for neonatal chlamydial conjunctivitis; the incidence was 20 percent in the silver nitrate group, 14 percent in the erythromycin group, and 11 percent in the tetracycline group (P not significant). We conclude that neonatal ocular prophylaxis with either erythromycin or tetracycline ophthalmic ointment does not significantly reduce the incidence of chlamydial conjunctivitis in the offspring of mothers with chlamydial infection as compared with silver nitrate, and that better management of maternal chlamydial infection is therefore required. We also conclude that there is a small but appreciable incidence of neonatal gonococcal ophthalmia that could be prevented by better prenatal screening and treatment of maternal gonococcal infection. 348 casts of suspected neonatal alloimmune thrombocytopenia
Mueller-Eckhardt C; Grubert A; Weisheit M; Mueller-Eckhardt G; Kiefel V; Kroll H; Schmidt S; Santoso S Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, D-6300 Giessen; German Federal Republic Lancetill (363-366)/1989/ Serological and clinical data were collected in 348 cases of Int J Gynecol Obstet 30
Postpartum bacteremia and placental colonization with genital mycoplasmas and pregnancy outcome
FERTILITY AND STERILITY A prospective study on the lack of development of antisperm antibodies in women undergoing intrauterine insemination
Horvath PM; Beck M; Bohrer MK; Shelden RM; Kemmann E Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Albany Medical Center Hospital, Albany, NY 12208; USA American Journal of Obstetrics and Gynecology/l60/3 (631637)/1989/ To test the hypothesis that intrauterine insemination with washed spermatozoa induces antisperm antibody formation, we measured serum antisperm antibody levels by the Immunobead technique in a population of women receiving exogenous
Citations fromthe Litemture
pump to allow pulsatile tocolytic infusion, hoping to reduce the total dose and thus the side effects. In 33 patients pulsatile bolus tocolysis was compared with continuous tocolysis in a control group of 38 patients. Bolus tocolysis required considerably less beta-sympathomimetic agent for comparable therapeutic success (median dosage 3.0 versus 15.9 mg, P < 0.001). Duration of therapy under bolus tocolysis was also significantly shorter (P < 0.05). Birth weight was higher after bolus tocolysis (median 3,070 versus 2,580 gm, P = 0.05). Additional indicators favored bolus tocolysis but were not statistically significant: a longer gestational period, fewer infants weighing < 2500 gm, and a lower incidence of respiratory distress syndrome. Pulmonary edema occurred in one patient during continuous tocolysis.
suspected neonatal alloimmune thrombocytopenia (NAT). Of the 144 mothers who were Zw’-negative, 107 had Zw* antibodies alone (94); with HLA antibodies (12); or with Br” antibodies (1). Antibodies were detected in 12 of the 204 Zw”-positive mothers as follows: anti-BP (9). anti-Zwb (1), anti-Bak” with HLA antibody (1), and blood group B isoagglutinins (1). The frequency of NAT due to Bra incompatibility (19%) was second to Zw*(78%). Zw-Nat was clinically the more severe (14% had intracranial haemorrhages) and responded well to either maternal platelet transfusions or intravenous IgG. In B&NAT intracranial haemorrhages were not observed and most children recovered without specific therapy.
Efficacy of neonatal ocular prophylaxis for the prevention of chlamydlal and gonococcal conjunctivitis
Naessens A; Foulon W; Breynaert J; Lauwers S Department of Microbiology, Akademisch Ziekenhuis Vrije Universiteit. B 1090 Brussels; Belgium American Journal of Obstetrics and Gynecology116013 (647650)/1989/ The influence of placental colonization and postpartum bacteria with genital mycoplasmas on the course of delivery and the immediate postpartum period was evaluated in 5 11 women who gave birth to live infants of at least 26 weeks’ gestation. Genital mycoplasmas were isolated from the placenta in 153 patients (29.9%) and from blood in four patients (0.80/o). These four isolates were all Ureaplasma urealyticum. Patients with genital mycoplasmas isolated from the placenta were delivered of infants with birth weights and gestational ages similar to those of infants of patients who did not have genital mycoplasmas in the placenta (3,260 gm and 39.2 weeks versus 3,272 gut and 39.3 weeks). No adverse effects of maternal postpartum bacteremia with genital mycoplasmas were observed, either in the mother or in the baby. We conclude that, whereas genital mycoplasmas frequently can be isolated from the placenta, there is no evident relationship between the presence of genital mycoplasmas and pregnancy outcome. In a few instances U. urealyticum has been isolated from the blood of afebrile postpartum women. In these women the presence of this bacteria is probably related to the birth process. This bacteremia does not precede an infectious complication.
Hammerschlag MR; Cummings C; Roblin PM; Williams TH; Delke I Department of Pediatrics, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203; USA New England Journal of Medicine/320/12 (769-772)/1989/ Opinions differ concerning the efficacy of prophylaxis against neonatal chlamydial and gonococcal conjunctivitis. From January 1986 through June 1988, we gave all infants born at Kings County Hospital Medical Center one of three prophylactic agents - silver nitrate drops, erythromycin ophthalmic ointment, or tetracycline ophthalmic ointment. The treatments were rotated monthly. Gonoccal ophthalmia occurred in 8 of the 12,431 infants born during the study (0.06 percent), 1 in the silver nitrate group, 4 in the erythromycin group, and 3 in the tetracycline group (P not significant). Seven of these infants were born to women who had received no prenatal care. From September 1985 through December 1987, we screened 4357 pregnant women for cervical chlamydial infection, of whom 341 (8 percent) had positive cultures. Of their offspring, 230 were evaluated for neonatal chlamydial conjunctivitis; the incidence was 20 percent in the silver nitrate group, 14 percent in the erythromycin group, and 11 percent in the tetracycline group (P not significant). We conclude that neonatal ocular prophylaxis with either erythromycin or tetracycline ophthalmic ointment does not significantly reduce the incidence of chlamydial conjunctivitis in the offspring of mothers with chlamydial infection as compared with silver nitrate, and that better management of maternal chlamydial infection is therefore required. We also conclude that there is a small but appreciable incidence of neonatal gonococcal ophthalmia that could be prevented by better prenatal screening and treatment of maternal gonococcal infection. 348 casts of suspected neonatal alloimmune thrombocytopenia
Mueller-Eckhardt C; Grubert A; Weisheit M; Mueller-Eckhardt G; Kiefel V; Kroll H; Schmidt S; Santoso S Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, D-6300 Giessen; German Federal Republic Lancetill (363-366)/1989/ Serological and clinical data were collected in 348 cases of Int J Gynecol Obstet 30
Postpartum bacteremia and placental colonization with genital mycoplasmas and pregnancy outcome
FERTILITY AND STERILITY A prospective study on the lack of development of antisperm antibodies in women undergoing intrauterine insemination
Horvath PM; Beck M; Bohrer MK; Shelden RM; Kemmann E Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Albany Medical Center Hospital, Albany, NY 12208; USA American Journal of Obstetrics and Gynecology/l60/3 (631637)/1989/ To test the hypothesis that intrauterine insemination with washed spermatozoa induces antisperm antibody formation, we measured serum antisperm antibody levels by the Immunobead technique in a population of women receiving exogenous