- Email: [email protected]
4-21-04 Automated perimetry in migraine patients. Preliminary results
Headache
s240
Methods: Patients treated up to 3 migraine attacks with sumatriptan 50 mg tablets or placebo (2:l). For each attack, headache severity and other migraine symptoms were assessed, and adverse events were recorded. Results: 485 patients treated at least one migraine attack; 362 patients treated 3 attacks. Four hours postdose, a significantly (p < 0.01) greater percentage of patients in the sumatriptan group compared with placebo experienced headache relief (moderate or severe pretreatment headache reduced to mild or none) for all three attacks (attack 1, 62% vs 32%; attack 2, 59% vs 38%; attack 3. 59% vs 42%). In addition, a significantly (p < 0.05) greater percentage of patients in the sumatriptan group compared with placebo experienced headache resolution (moderate or severe pretreatment headache reduced to none) for all three attacks (attack 1, 43% vs 15%; attack 2,41% vs 16%; attack 3, 37% vs 24%). Sumatriptan 50 mg tablets were well-tolerated. Adverse events were reported by 25% of patients following sumatriptan and by 21% of patients following placebo. Conclusions: Sumatriptan 50 mg tablets were effective and well-tolerated in the acute treatment of up to 3 migraine attacks among patients previously naive to sumatfiptan.
4-21-03
Reduced late exteroceptive supression with headache history and frequency
L.A. Pliego, R. Fenaro, J. Leston. Buenos Aires, Argentina
/Xvi&n
Neurologia,
in relation
Hospifal
de Clinicas,
The late exteroceptive supression (ES2) was described to be decreased in patients with tension type headaches, in particular in those with chronic evolution, but patients suffering from episodic tension type headaches (ETH) displayed variable results. Several variables were interrelated with ES2, but no correlation was found, in particular between tenderness, increased EMG or intensity of pain. However ES2 duration tended to decrease with advancing headache history (years with headache), having was suggested that patients with ETH and reduced ES2 may be prone to develop chronic tension type headache. The purpose our study was to reevaluate the relationship between ES2 duration and headache frequency and history. We studied ES2 in 25 patients with ETH (according IHS criteria) and 22 control subjects without any previous headache complaints. Patients suffering from ETH had a moderate shortening of the ES2 duration (ETH 33.4 f 7.2 ms Vs. Control 43.3 f 5.2, p < 0.03). Only one patient had absent ES2. We observed correlation between ES2 duration and headache history (r = -0.42 p < 0.03) and headache frequency (attack per month) (r = -0.46 p < 0.02). In our study, we found significant ES2 duration differences between ETH and controls. The effect of headache history, so much, headache frequency was observed, and suggest a tendency to shortening ES2 with the increment of them. Shortened ES2 is probably relate to hypersensitivity of caudalis neurons in central pain control and it may be incremented by frequent headache.
4-21-04
Automated Preliminary
perimetry results
in migraine patients.
Carmen Garcia-Guijo, G. Rubio-Esteban, S. JimBnez-Carmona ‘, P. Alemany-Marquez ‘, C. Wilson *. Department of Neurology of the Hospital Universitario Puerto Real, Spain, ’ Department of Ophthalmology of the Hospital Universitado Puerto Real, Spain, *Department of Neurology of South Florida, USA Transient visual deficits are common complains in migraine patients. Although permanent visual loss has been reported in a limited number of patients, a methodical approach to analyse the prevalence of perimetric defects in long standing patients has not been developed. This study examined the prevalence of perimetric defects in twenty-six patients with migraine (range of age 37-68; average age 44.8) using a perimetric combined strategy. Perimetric testing was first performed with the 24-2 FASTPAC threshold strategy to minimize the learning effect, and with the 24-2 previous data STATPAC strategy one month later. The oatients had a neurolcalcal diagnosis of miaraine with or without aura, and no ocular, neurologic nor ~ystemic~llness. Eighteen patients (69.2%) had statistically significant field defects. Ten patie& had ;nilateral involvement, 6 with focal defects, 3 with generalized depression, and one with both. Seven patients had bilateral involvement. One patient had a congruous upper left sector-shaped homonomous defect. Four of the eiaht oatients with normal alobal indexes in their visual fields had significant deject; in the point-by-point-probability map analysis. Study supported by: F.I.S. (Fond0 de Investigaci6n Sanitariadel Ministerio de Sanidad y Consumo. SPAIN) register number 96/0734.
4-21-05
immunological
C. irkep, B. Nazllel, Neurology, Ankara,
S. Aslan. Turkey
evaluation
of migraine
Gazi Universitv;
Medical
patients
School,
Department
of
Immunological studies in the investigation of the pathogenesis of migraine have gained importance in recent years. An increase of basophyl, T lymphocytes and immunoglobulins during the onset of pain, the appearance of immuncomplexes, complementary activation and an increase of antiphosfolipid antibodies especially in migraneus stroke patients during the attack have been shown. In this study lg G, lg M, lg A, lg E, C3, C4 antiphospholipid antibodies of 56 migraine patients were compared with normal controls to determine the importance of immunological parameters in the pathogenesis.
4-21-06 n
The occurrence children
of migraine
with aura in young
J.C. Marcus, A. Visudtibhan, P. Palat, M.F. Alam. State University York-Health Sciences Center at Brooklyn, USA
of New
Migraine is common in children; adults, too, often can trace the onset of their headaches back to childhood. Many studies have shown an equal sex incidence in childhood. Many studies have shown an equal sex incidence in childhood, changing, after puberty, to a marked female preponderance. We have seen an unusual variation of this in children referred to our clinic for headaches. All headaches were classified according to the International Headache Society criteria. There were 21 girls, aged 6 to 16 years, and 15 boys, 6 to 16 years old, diagnosed as suffering from migraine. The female to male ratio, pre-pubertal, was 14:11, and IO:1 post-pubertal, in keeping with previous studies. However, separating off those children with migraine with aura gave a female to male ratio of 1:l post-pubertal, but 7:3 pre-pubertal, a 2:l female preponderance. The change from equal sex incidence of migraine in childhood to mainly female in adulthood is attributed to hormonal activity, but the mechanisms causing the changes are unknown. The increased numbers of girls seen here with pre-pubertal migraine with aura does not appear to have been noted in previous studies. This finding may relate to earlier brain maturation in girls rather than endocrine changes, producing the functional and blood flow changes of migrainous auras at an earlier age than in boys.
4-21-07
Visual evoked potentials
Rog&io R. Marques. Paula, Brazil
Department
in migraine
of Neurology;
Universifyof
headaches S&o Paula, Sio
Visual evoked potentials (‘1/EP”) have been used in migraine headache research with the objective of becoming a diagnostic marker in this illness. Study’s objective attempts to correlate the alterations found and the physiopathology of migraine headaches. Methods: VEP, by pattern reversal, of 20 migraine patients (17 female, 3 male, mean age = 32.3 years, International Headache Society criteria, 1968) were carried out at a stimulus frequency of 1.9 Hz, check size of 14’ and 28’, responses averaged = 100, sweep length = 250 msec, filter settings between 5 and 100 Hz, surface electrodes placed at Fz, Cz and Oz of the 10-20 system. It was used a Pathfinder-Mega, serial number 900.193 with Visual Stimulator NIC 1015, Nicolet Biomedical, Wisconsin-U.S.A. Acontrol group of 21 subjects (14 female, 7 male, mean age = 32.7 years) with no past neurological disease was used to compare the data. Results: Higher amplitude (p -Z 0.01) and shortened latencies considering the waves N75 and PlOO were observed. Conclusions: This may reflect an evidence of neuronal hyperexcitability as a factor involved in the pathogenesis of migraine headaches.
4-21 06 m
Tc-99m HM-PA0 SPECT in migraine attacks
between
S.M. Sung, D.S. Jung, D.S. Kim, K.H. Park, Y.K. Kim ‘. Depr of Neurology Co//ege of Medicine, Pusan National University; Korea, ’ Dept of Nuclear Medicine, College of Medicine, Pusan National Universi@ Korea Technetium-99 m hexamethylene-propyleneamine oxime (Tc-99 m HM-PAO) SPECT brain imaging was performed inpatients with migraine without aura (n = 32) and migraine with aura (n = 29) during the headache-free period. A regional alteration of tracer uptake into brain was observed in 21 cases (65.6%) 16 cases: reduction, 3 cases: increment) of migraine without aura and in 20 cases (69%, all cases: reduction) of migaine with aura (including 10 cases: hemiplegic or hemisensory aura, 10 cases: only visual aura). In most cases (73.3%) of migraine with aura, the areas of decreased tracer uptake was exclusively concordant with the areas of unilateral aura. The concordance between the areas of associated focal neurological symptoms (aura) and the area of
s240
Methods: Patients treated up to 3 migraine attacks with sumatriptan 50 mg tablets or placebo (2:l). For each attack, headache severity and other migraine symptoms were assessed, and adverse events were recorded. Results: 485 patients treated at least one migraine attack; 362 patients treated 3 attacks. Four hours postdose, a significantly (p < 0.01) greater percentage of patients in the sumatriptan group compared with placebo experienced headache relief (moderate or severe pretreatment headache reduced to mild or none) for all three attacks (attack 1, 62% vs 32%; attack 2, 59% vs 38%; attack 3. 59% vs 42%). In addition, a significantly (p < 0.05) greater percentage of patients in the sumatriptan group compared with placebo experienced headache resolution (moderate or severe pretreatment headache reduced to none) for all three attacks (attack 1, 43% vs 15%; attack 2,41% vs 16%; attack 3, 37% vs 24%). Sumatriptan 50 mg tablets were well-tolerated. Adverse events were reported by 25% of patients following sumatriptan and by 21% of patients following placebo. Conclusions: Sumatriptan 50 mg tablets were effective and well-tolerated in the acute treatment of up to 3 migraine attacks among patients previously naive to sumatfiptan.
4-21-03
Reduced late exteroceptive supression with headache history and frequency
L.A. Pliego, R. Fenaro, J. Leston. Buenos Aires, Argentina
/Xvi&n
Neurologia,
in relation
Hospifal
de Clinicas,
The late exteroceptive supression (ES2) was described to be decreased in patients with tension type headaches, in particular in those with chronic evolution, but patients suffering from episodic tension type headaches (ETH) displayed variable results. Several variables were interrelated with ES2, but no correlation was found, in particular between tenderness, increased EMG or intensity of pain. However ES2 duration tended to decrease with advancing headache history (years with headache), having was suggested that patients with ETH and reduced ES2 may be prone to develop chronic tension type headache. The purpose our study was to reevaluate the relationship between ES2 duration and headache frequency and history. We studied ES2 in 25 patients with ETH (according IHS criteria) and 22 control subjects without any previous headache complaints. Patients suffering from ETH had a moderate shortening of the ES2 duration (ETH 33.4 f 7.2 ms Vs. Control 43.3 f 5.2, p < 0.03). Only one patient had absent ES2. We observed correlation between ES2 duration and headache history (r = -0.42 p < 0.03) and headache frequency (attack per month) (r = -0.46 p < 0.02). In our study, we found significant ES2 duration differences between ETH and controls. The effect of headache history, so much, headache frequency was observed, and suggest a tendency to shortening ES2 with the increment of them. Shortened ES2 is probably relate to hypersensitivity of caudalis neurons in central pain control and it may be incremented by frequent headache.
4-21-04
Automated Preliminary
perimetry results
in migraine patients.
Carmen Garcia-Guijo, G. Rubio-Esteban, S. JimBnez-Carmona ‘, P. Alemany-Marquez ‘, C. Wilson *. Department of Neurology of the Hospital Universitario Puerto Real, Spain, ’ Department of Ophthalmology of the Hospital Universitado Puerto Real, Spain, *Department of Neurology of South Florida, USA Transient visual deficits are common complains in migraine patients. Although permanent visual loss has been reported in a limited number of patients, a methodical approach to analyse the prevalence of perimetric defects in long standing patients has not been developed. This study examined the prevalence of perimetric defects in twenty-six patients with migraine (range of age 37-68; average age 44.8) using a perimetric combined strategy. Perimetric testing was first performed with the 24-2 FASTPAC threshold strategy to minimize the learning effect, and with the 24-2 previous data STATPAC strategy one month later. The oatients had a neurolcalcal diagnosis of miaraine with or without aura, and no ocular, neurologic nor ~ystemic~llness. Eighteen patients (69.2%) had statistically significant field defects. Ten patie& had ;nilateral involvement, 6 with focal defects, 3 with generalized depression, and one with both. Seven patients had bilateral involvement. One patient had a congruous upper left sector-shaped homonomous defect. Four of the eiaht oatients with normal alobal indexes in their visual fields had significant deject; in the point-by-point-probability map analysis. Study supported by: F.I.S. (Fond0 de Investigaci6n Sanitariadel Ministerio de Sanidad y Consumo. SPAIN) register number 96/0734.
4-21-05
immunological
C. irkep, B. Nazllel, Neurology, Ankara,
S. Aslan. Turkey
evaluation
of migraine
Gazi Universitv;
Medical
patients
School,
Department
of
Immunological studies in the investigation of the pathogenesis of migraine have gained importance in recent years. An increase of basophyl, T lymphocytes and immunoglobulins during the onset of pain, the appearance of immuncomplexes, complementary activation and an increase of antiphosfolipid antibodies especially in migraneus stroke patients during the attack have been shown. In this study lg G, lg M, lg A, lg E, C3, C4 antiphospholipid antibodies of 56 migraine patients were compared with normal controls to determine the importance of immunological parameters in the pathogenesis.
4-21-06 n
The occurrence children
of migraine
with aura in young
J.C. Marcus, A. Visudtibhan, P. Palat, M.F. Alam. State University York-Health Sciences Center at Brooklyn, USA
of New
Migraine is common in children; adults, too, often can trace the onset of their headaches back to childhood. Many studies have shown an equal sex incidence in childhood. Many studies have shown an equal sex incidence in childhood, changing, after puberty, to a marked female preponderance. We have seen an unusual variation of this in children referred to our clinic for headaches. All headaches were classified according to the International Headache Society criteria. There were 21 girls, aged 6 to 16 years, and 15 boys, 6 to 16 years old, diagnosed as suffering from migraine. The female to male ratio, pre-pubertal, was 14:11, and IO:1 post-pubertal, in keeping with previous studies. However, separating off those children with migraine with aura gave a female to male ratio of 1:l post-pubertal, but 7:3 pre-pubertal, a 2:l female preponderance. The change from equal sex incidence of migraine in childhood to mainly female in adulthood is attributed to hormonal activity, but the mechanisms causing the changes are unknown. The increased numbers of girls seen here with pre-pubertal migraine with aura does not appear to have been noted in previous studies. This finding may relate to earlier brain maturation in girls rather than endocrine changes, producing the functional and blood flow changes of migrainous auras at an earlier age than in boys.
4-21-07
Visual evoked potentials
Rog&io R. Marques. Paula, Brazil
Department
in migraine
of Neurology;
Universifyof
headaches S&o Paula, Sio
Visual evoked potentials (‘1/EP”) have been used in migraine headache research with the objective of becoming a diagnostic marker in this illness. Study’s objective attempts to correlate the alterations found and the physiopathology of migraine headaches. Methods: VEP, by pattern reversal, of 20 migraine patients (17 female, 3 male, mean age = 32.3 years, International Headache Society criteria, 1968) were carried out at a stimulus frequency of 1.9 Hz, check size of 14’ and 28’, responses averaged = 100, sweep length = 250 msec, filter settings between 5 and 100 Hz, surface electrodes placed at Fz, Cz and Oz of the 10-20 system. It was used a Pathfinder-Mega, serial number 900.193 with Visual Stimulator NIC 1015, Nicolet Biomedical, Wisconsin-U.S.A. Acontrol group of 21 subjects (14 female, 7 male, mean age = 32.7 years) with no past neurological disease was used to compare the data. Results: Higher amplitude (p -Z 0.01) and shortened latencies considering the waves N75 and PlOO were observed. Conclusions: This may reflect an evidence of neuronal hyperexcitability as a factor involved in the pathogenesis of migraine headaches.
4-21 06 m
Tc-99m HM-PA0 SPECT in migraine attacks
between
S.M. Sung, D.S. Jung, D.S. Kim, K.H. Park, Y.K. Kim ‘. Depr of Neurology Co//ege of Medicine, Pusan National University; Korea, ’ Dept of Nuclear Medicine, College of Medicine, Pusan National Universi@ Korea Technetium-99 m hexamethylene-propyleneamine oxime (Tc-99 m HM-PAO) SPECT brain imaging was performed inpatients with migraine without aura (n = 32) and migraine with aura (n = 29) during the headache-free period. A regional alteration of tracer uptake into brain was observed in 21 cases (65.6%) 16 cases: reduction, 3 cases: increment) of migraine without aura and in 20 cases (69%, all cases: reduction) of migaine with aura (including 10 cases: hemiplegic or hemisensory aura, 10 cases: only visual aura). In most cases (73.3%) of migraine with aura, the areas of decreased tracer uptake was exclusively concordant with the areas of unilateral aura. The concordance between the areas of associated focal neurological symptoms (aura) and the area of