- Email: [email protected]
417 PREDICTING OCCULT MULTIFOCALITY OF RENAL CELL CARCINOMA
415
COMPARISON OF RENAL CELL CARCINOMAS IN END STAGE RENAL DISEASE AND GENERAL POPULATION PATIENTS
1HX]LOOHW</RQJ-$3DSDUHO36DORPRQ/%DVWLHQ/3HWLW- 6DLQW67LOORX;5LRX[/HFOHUFT10DWKLHX5%UX\HUH)%RXWLQ-0 %ULFKDUW15LJDXG- .DUDP* %UDQFKHUHDX- )HUULHUH-0 :DOOHUDQG+%DUEHW6(ONHQWDRXL++XEHUW-)HXLOOX% 7KHYHQLDXG3(9LOOHUV$=LQL/'HVFD]HDX[$5RXSUHW0 %DUURX%)HKUL./HEUHW77RVWDLQ-7HUULHU-(%DGHW/ 3RLVVRQQLHU/7HUULHU1.OHLQFODXVV)0DUWLQ/3ᚏVWHU& 'XJDUGLQ)*DOOLRW,6WDHUPDQ) $]HPDU0' ,UDQL-7LVVHUDQG% 0HMHDQ$7LPVLW026RXOLH06DOOXVWR)5LVFKPDQQ3*X\/ 9DOHUL$'HUXHOOH&*LJDQWH0$]]RX]L$5&KDXWDUG'%LJRW3 (VFXGLHU%&RUUHDV-0/DQJ+ %DXPHUW+3DWDUG-- 1 Hopital Foch, Dept. of Urology, Suresnes, France, 2Hopital Michallon, Dept. of Urology, Grenoble, France, 3Hopital Sud, Dept. of Urology, Lyon, France, 4Hopital Henri Mondor, Dept. of Urology, Creteil, France, 5Hopital Sud, Dept. of Urology, Amiens, France, 6Hopital Pontchaillou, Dept. of Pathology, Rennes, France, 7 Hopital Pontchaillou, Dept. of Urology, Rennes, France, 8Hopital Bretonneau, Dept. of Urology, Tours, France, 9Hopital Hôtel Dieu, Dept. of Urology, Nantes, France, 10Hopital Pellegrin, Dept. of Urology, Bordeaux, France, 11Hopital de Brabois, Dept. of Urology, Nancy, France, 12Hopital Claude Huriez, Dept. of Urology, Lille, France, 13Hopital Dupuytren, Dept. of Urology, Limoges, France, 14 Hopital de la Pitié, Dept. of Urology, Paris, France, 15Hopital Nord, Dept. of Urology, Saint-Etienne, France, 16Hopital Edouard Herriot, Dept. of Urology, Lyon, France, 17CHU, Dept. of Urology, Besançon, France, 18Hopital Charles Nicolle, Dept. of Urology, Rouen, France, 19Hopital Robert Debré, Dept. of Urology, Reims, France, 20Hopital de la Milétrie, Dept. of Urology, Poitiers, France, 21Hopital Necker, Dept. of Urology, Paris, France, 22Hopital Rangeuil, Dept. of Urology, Toulouse, France, 23Hopital Gabriel Montpied, Dept. of Urology, Clermont-Ferrand, France, 24 Hopital de la Cavale Blanche, Dept. of Urology, Brest, France, 25CHU, Dept. of Urology, Nice, France, 26CHU, Dept. of Urology, Angers, France, 27Institut Gustave Roussy, Dept. of Oncology, Villejuif, France, 28Hopital Necker, Dept. of Radiology, Paris, France, 29Hopital Civil, Dept. of Urology, Strasbourg, France, 30Hopital Saint Joseph, Dept. of Urology, Paris, France Introduction & Objectives: 3DWLHQWV ZLWK HQG VWDJH UHQDO GLVHDVH (65' DUH DW ULVN RI GHYHORSLQJ UHQDO WXPRXUV ZLWKLQ WKHLU QDWLYH NLGQH\ 2XU REMHFWLYH ZDV WR FRPSDUH FOLQLFDO SDWKRORJLFDO DQG RXWFRPH IHDWXUHV RI UHQDO FHOO FDUFLQRPDV 5&&V LQ(65'DQGLQJHQHUDOSRSXODWLRQSDWLHQWV Material & Methods: )UHQFK XQLYHUVLW\ GHSDUWPHQWV RI XURORJ\ DQG NLGQH\ WUDQVSODQWDWLRQ SDUWLFLSDWHG LQ WKLV UHWURVSHFWLYH VWXG\ FRPSDULQJ 5&&V DULVLQJ LQ (65' SDWLHQWV WR VSRUDGLF 5&&V ,QIRUPDWLRQ UHJDUGLQJ DJH VH[ V\PSWRPV WXPRXUVWDJLQJDQGJUDGLQJKLVWRORJLFDOVXEW\SHDQGRXWFRPHZHUHUHFRUGHGLQD XQLTXH GDWDEDVH 4XDOLWDWLYH DQG TXDQWLWDWLYH YDULDEOHV ZHUH FRPSDUHG E\ XVLQJ FKLVTXDUHDQG6WXGHQWVWDWLVWLFDODQDO\VHV&DQFHUVSHFLᚏFVXUYLYDOZDVDVVHVVHG E\.DSODQ0HLHUDQG&R[PHWKRGV Results: SDWLHQWVZLWKUHQDOWXPRXUVZHUHLQFOXGHGLQWKLVUHWURVSHFWLYHVWXG\ FRPSDULQJ (65' UHQDO WUDQVSODQW SDWLHQWV Q GLDO\]HG SDWLHQWV Q DQG JHQHUDOSRSXODWLRQSDWLHQWV,Q(65'SDWLHQWVZLWKQDWLYHNLGQH\WXPRXUV FRPSDUHG WR VSRUDGLF FDVHV DJH DW GLDJQRVLV ZDV \RXQJHU s YV s \HDUV PDOHJHQGHUSUHGRPLQDQFHZDVPRUHSURQRXQFHG YV0)UDWLR PHDQ WXPRXU VL]H ZDV VPDOOHU s YV s FP DV\PSWRPDWLF YV ORZJUDGH YV DQGSDSLOODU\WXPRXUVZHUHPRUHIUHTXHQW YV SRRU(&2*36 YV DQGDGYDQFHG76WDJHV ุ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ᚏFVXUYLYDOSUHGLFWRUVLQPXOWLYDULDWHDQDO\VLV Conclusions: 5&& DULVLQJ LQ QDWLYH NLGQH\V RI (65' SDWLHQWV VHHP WR H[KLELW PDQ\ IDYRXUDEOH FOLQLFDO SDWKRORJLFDO DQG RXWFRPH IHDWXUHV FRPSDUHG WR WKRVH GLDJQRVHG LQ JHQHUDO SRSXODWLRQ SDWLHQWV )XUWKHU UHVHDUFKHV DUH QHHGHG IRU GHWHUPLQLQJ ZKHWKHU LW LV GXH WR SDUWLFXODU PROHFXODU SDWKZD\V RU WR ELDVHV LQ UHODWLRQWRPRGHRIGLDJQRVLV
416
OBESITY IS ASSOCIATED WITH BETTER PATHOLOGIC FEATURES AND IMPROVED OUTCOME AMONG PATIENTS TREATED SURGICALLY FOR RENAL CELL CARCINOMA
:DDONHV60HUVHEXUJHU$6.UDPHU0:+HUUPDQQ75::HJHQHU* +HJHOH$+RIPDQQ5.XF]\N0$6FKUDGHU$- 1 Medical School Hanover, Dept. of Urology, Hanover, Germany, 2Medical School Hanover, Clinical Cancer Registry, Hanover, Germany, 3University of Marburg, Dept. of Urology, Marburg, Germany
Eur Urol Suppl 2010;9(2):152
Introduction & Objectives: 2EHVLW\ LQFUHDVHV WKH ULVN RI GHYHORSLQJ UHQDO FHOO FDUFLQRPD 5&& KRZHYHULWUHPDLQVXQFOHDUZKHWKHUREHVLW\LVDVVRFLDWHGZLWK 5&& DJJUHVVLYHQHVV DQG VXUYLYDO :H DVVHVVHG ZKHWKHU GLᚎHUHQW ERG\ PDVV LQGH[ %0, OHYHOVDWWKHWLPHRIVXUJHU\KDGDQHᚎHFWRQORQJWHUPSURJQRVLVRI 5&&SDWLHQWV Material & Methods: :H HYDOXDWHG SDWLHQWV ZLWK FRPSOHWH LQIRUPDWLRQ DERXWWKHLU%0,ZKRKDGXQGHUJRQHVXUJHU\IRUUHQDOFHOOFDQFHUDWWKH8QLYHUVLW\ KRVSLWDOVLQ+DQRYHUDQG0DUEXUJEHWZHHQ DQG7KHPHDQIROORZXS ZDV\HDUV Results: 8QGHUZHLJKWQRUPDOZHLJKWSUHREHVLW\DQGREHVLW\ZHUHGLDJQRVHGLQ DQG 5&&SDWLHQWVUHVSHFWLYHO\ 2YHUZHLJKW %0,! DQGREHVLW\ZHUHVLJQLᚏFDQWO\DVVRFLDWHGZLWK\RXQJHUDJH S .UXVNDO:DOOLV DQGPHWDVWDWLFGLVHDVH S ˴ EXWQRWZLWKWXPRXU VWDJH JUDGH RU JHQGHU %RWK XQL DQG PXOWLYDULDWH DQDO\VHV VKRZHG WKDW REHVH SDWLHQWVKDGDVLJQLᚏFDQWO\ORZHUULVNRIGHDWK WKHPHGLDQ\HDURYHUDOOVXUYLYDO UDWHZDVDQG IRUSDWLHQWVZLWKD%0,EHORZDQG RYHU S /RQJ5DQN ,QWHUHVWLQJO\VXEJURXSDQDO\VLVUHYHDOHGWKDWWKH SRVLWLYHDVVRFLDWLRQEHWZHHQRYHUZHLJKWDQGVXUYLYDOZDVHYHQPRUHSURQRXQFHG LQRUJDQFRQᚏQHGGLVHDVH S FR[UHJUHVVLRQ DFRUUHODWLRQLQDGYDQFHG GLVHDVHFRXOGQRWEHFRQᚏUPHGLQPXOWLYDULDWHDQDO\VHV S Conclusions: :HZHUHDEOHWRLGHQWLI\RYHUZHLJKWDVDQLQGHSHQGHQWSURJQRVWLF PDUNHURILPSURYHGVXUYLYDOLQSDWLHQWVZLWKRUJDQFRQᚏQHG5&&%DVLFUHVHDUFK LV UHTXLUHG WR UHVROYH WKH GLOHPPD RI ZK\ LI D KLJKHU %0, SUHGLVSRVHV WR 5&& LW FRQFXUUHQWO\ SURORQJV VXUYLYDO DIWHU SDWLHQWV KDYH XQGHUJRQH SDUWLDO QHSKUHFWRP\
417
PREDICTING OCCULT MULTIFOCALITY OF RENAL CELL CARCINOMA
7VLYLDQ00RUHLUD'0&DVR-50RXUDYLHY90DGGHQ) %UDWVODYVN\*$OEDOD'03RODVFLN7- 1 Duke University Medical Center, Dept. of Urologic Surgery, Durham, United States of America, 2Duke University Medical Center, Dept. of Pathology, Durham, United States of America, 3National Cancer Center, National Institute of Health, Urologic Oncology Branch, Bethesda, United States of America Introduction & Objectives: 1HSKURQVSDULQJ VXUJHU\ 166 IRU UHQDO FHOO FDUFLQRPD 5&& KDV JDLQHG ZLGH DFFHSWDQFH 2QH SRWHQWLDO SLWIDOO RI 166 LV RFFXOWPXOWLIRFDOLW\RI5&&WKDWPD\UHTXLUHVXEVHTXHQWDGGLWLRQDOWUHDWPHQWVZKHQ LWODWHUEHFRPHVFOLQLFDOO\UHFRJQL]HG:HGHYHORSHGDQGDVVHVVHGDSUHRSHUDWLYH QRPRJUDPWRSUHGLFWRFFXOWPXOWLIRFDO5&& Material & Methods: FRQVHFXWLYH SDWLHQWV XQGHUJRLQJ UDGLFDO QHSKUHFWRP\ IRUFOLQLFDOO\ORFDOL]HGVXVSHFWHGVSRUDGLF5&&EHWZHHQLQDWHUWLDU\ FHQWHUZHUHHYDOXDWHG&OLQLFDOO\PDQLIHVWPXOWLIRFDOOHVLRQVZHUHH[FOXGHG/RJLVWLF UHJUHVVLRQPRGHOVZHUHXVHGWRDVVHVVSRWHQWLDOULVNIDFWRUVRIRFFXOWPXOWLIRFDOLW\ ZLWK DQG ZLWKRXW SDWKRORJLFDO YDULDEOHV WKDW PD\ EH DYDLODEOH ZLWK SUHRSHUDWLYH ELRSV\ $ QRPRJUDP ZDV GHYHORSHG DQG DVVHVVHG IRU GLDJQRVWLF SURSHUWLHV LQ SUHGLFWLQJRFFXOWPXOWLIRFDO5&& Results: 7KHLQFLGHQFHRIRFFXOWPXOWLIRFDOLW\ZDV6LJQLᚏFDQWO\DVVRFLDWHG SUHGLFWRUV RI PXOWLIRFDOLW\ ZHUH PDOH JHQGHU IDPLO\ KLVWRU\ RI PDOLJQDQF\ RWKHU WKDQ5&&UDGLRJUDSKLFVL]HRIWKHOHVLRQDQGSDWKRORJLFDOYDULDEOHV KLVWRORJLFDO VXEW\SH RWKHU WKDQ FOHDU FHOO DQG KLJK )XKUPDQ JUDGH 2XU QRPRJUDPVಬ KDG FRQFRUGDQFHLQGH[HVRIDQGZLWKRXWDQGZLWKKLVWRORJLFDOVXEW\SHDQG )XKUPDQJUDGHLQFOXGHGUHVSHFWLYHO\ Conclusions: 2XU GDWD VXJJHVW WKDW RFFXOW PXOWLIRFDO 5&& LV PRUH IUHTXHQWO\ DVVRFLDWHGZLWKVPDOOHUUHQDOOHVLRQV0DOHJHQGHUIDPLO\KLVWRU\RINLGQH\FDQFHU KLVWRORJLFDO VXEW\SH DQG JUDGH DUH VWURQJO\ DVVRFLDWHG ZLWK DQ LQFUHDVHG ULVN RI RFFXOW PXOWLIRFDO 5&& 7KHVH IDFWRUV VKRXOG EH FRQVLGHUHG ZKHQ HYDOXDWLQJ FDQGLGDWHVIRU166%DVHGRQWKHVHSUHGLFWRUVZHGHYHORSHGDQRPRJUDPWKDWLV DYDOXDEOHWRROIRUSDWLHQWVDQGSK\VLFLDQVWRSUHGLFWRFFXOWPXOWLIRFDO5&&
418
NEW PROGNOSTIC STRATIFICATION SYSTEM IN LOCALLY ADVANCED RENAL CELL CARCINOMA PATIENTS WHO ARE CANDIDATES FOR ADJUVANT TREATMENT
%HUQKDUG-&5DYDXG$3DQWXFN$-&UHSHO09HUKRHVW* %HQVDODK.&LQGROR/'H/D7DLOOH$)HUULHUH-06DORPRQ/ 7RVWDLQ-)LFDUD91RYDUD*=LQL/ 9LOOHUV$ %HOOGHJUXQ$6 3DWDUG-- 1 University Hospital, Dept. of Urology, Bordeaux, France, 2University Hospital, Dept. of Medical Oncology, Bordeaux, France, 3University of California Los Angeles, Dept. of Urology, Los Angeles, United States of America, 4University Hospital, Dept. of Urology, Rennes, France, 5S. Pio Dal Pietralcina Hospital, Dept. of Urology, Vasto, Italy, 6University Hospital, Dept. of Urology, Creteil, France, 7 University Hospital, Dept. of Urology, Saint-Etienne, France, 8University Hospital, Dept. of Urology, Padua, Italy, 9University Hospital, Dept. of Urology, Lille, France Introduction & Objectives: 7KHUH LV QR DSSURYHG DGMXYDQW WUHDWPHQW LQ ORFDOO\ DGYDQFHG5HQDO&HOO&DUFLQRPDV 5&&V $WOHDVWLQWHUQDWLRQDOSKDVH,,,WULDOV DUHFXUUHQWO\FRPSDULQJ7\URVLQH.LQDVH,QKLELWRUV 7.,V ZLWKSODFHERIROORZLQJ VXUJHU\LQWKHDGMXYDQWVHWWLQJ7KHREMHFWLYHRIWKLVVWXG\ZDVWRIXUWKHULGHQWLI\
COMPARISON OF RENAL CELL CARCINOMAS IN END STAGE RENAL DISEASE AND GENERAL POPULATION PATIENTS
1HX]LOOHW</RQJ-$3DSDUHO36DORPRQ/%DVWLHQ/3HWLW- 6DLQW67LOORX;5LRX[/HFOHUFT10DWKLHX5%UX\HUH)%RXWLQ-0 %ULFKDUW15LJDXG- .DUDP* %UDQFKHUHDX- )HUULHUH-0 :DOOHUDQG+%DUEHW6(ONHQWDRXL++XEHUW-)HXLOOX% 7KHYHQLDXG3(9LOOHUV$=LQL/'HVFD]HDX[$5RXSUHW0 %DUURX%)HKUL./HEUHW77RVWDLQ-7HUULHU-(%DGHW/ 3RLVVRQQLHU/7HUULHU1.OHLQFODXVV)0DUWLQ/3ᚏVWHU& 'XJDUGLQ)*DOOLRW,6WDHUPDQ) $]HPDU0' ,UDQL-7LVVHUDQG% 0HMHDQ$7LPVLW026RXOLH06DOOXVWR)5LVFKPDQQ3*X\/ 9DOHUL$'HUXHOOH&*LJDQWH0$]]RX]L$5&KDXWDUG'%LJRW3 (VFXGLHU%&RUUHDV-0/DQJ+ %DXPHUW+3DWDUG-- 1 Hopital Foch, Dept. of Urology, Suresnes, France, 2Hopital Michallon, Dept. of Urology, Grenoble, France, 3Hopital Sud, Dept. of Urology, Lyon, France, 4Hopital Henri Mondor, Dept. of Urology, Creteil, France, 5Hopital Sud, Dept. of Urology, Amiens, France, 6Hopital Pontchaillou, Dept. of Pathology, Rennes, France, 7 Hopital Pontchaillou, Dept. of Urology, Rennes, France, 8Hopital Bretonneau, Dept. of Urology, Tours, France, 9Hopital Hôtel Dieu, Dept. of Urology, Nantes, France, 10Hopital Pellegrin, Dept. of Urology, Bordeaux, France, 11Hopital de Brabois, Dept. of Urology, Nancy, France, 12Hopital Claude Huriez, Dept. of Urology, Lille, France, 13Hopital Dupuytren, Dept. of Urology, Limoges, France, 14 Hopital de la Pitié, Dept. of Urology, Paris, France, 15Hopital Nord, Dept. of Urology, Saint-Etienne, France, 16Hopital Edouard Herriot, Dept. of Urology, Lyon, France, 17CHU, Dept. of Urology, Besançon, France, 18Hopital Charles Nicolle, Dept. of Urology, Rouen, France, 19Hopital Robert Debré, Dept. of Urology, Reims, France, 20Hopital de la Milétrie, Dept. of Urology, Poitiers, France, 21Hopital Necker, Dept. of Urology, Paris, France, 22Hopital Rangeuil, Dept. of Urology, Toulouse, France, 23Hopital Gabriel Montpied, Dept. of Urology, Clermont-Ferrand, France, 24 Hopital de la Cavale Blanche, Dept. of Urology, Brest, France, 25CHU, Dept. of Urology, Nice, France, 26CHU, Dept. of Urology, Angers, France, 27Institut Gustave Roussy, Dept. of Oncology, Villejuif, France, 28Hopital Necker, Dept. of Radiology, Paris, France, 29Hopital Civil, Dept. of Urology, Strasbourg, France, 30Hopital Saint Joseph, Dept. of Urology, Paris, France Introduction & Objectives: 3DWLHQWV ZLWK HQG VWDJH UHQDO GLVHDVH (65' DUH DW ULVN RI GHYHORSLQJ UHQDO WXPRXUV ZLWKLQ WKHLU QDWLYH NLGQH\ 2XU REMHFWLYH ZDV WR FRPSDUH FOLQLFDO SDWKRORJLFDO DQG RXWFRPH IHDWXUHV RI UHQDO FHOO FDUFLQRPDV 5&&V LQ(65'DQGLQJHQHUDOSRSXODWLRQSDWLHQWV Material & Methods: )UHQFK XQLYHUVLW\ GHSDUWPHQWV RI XURORJ\ DQG NLGQH\ WUDQVSODQWDWLRQ SDUWLFLSDWHG LQ WKLV UHWURVSHFWLYH VWXG\ FRPSDULQJ 5&&V DULVLQJ LQ (65' SDWLHQWV WR VSRUDGLF 5&&V ,QIRUPDWLRQ UHJDUGLQJ DJH VH[ V\PSWRPV WXPRXUVWDJLQJDQGJUDGLQJKLVWRORJLFDOVXEW\SHDQGRXWFRPHZHUHUHFRUGHGLQD XQLTXH GDWDEDVH 4XDOLWDWLYH DQG TXDQWLWDWLYH YDULDEOHV ZHUH FRPSDUHG E\ XVLQJ FKLVTXDUHDQG6WXGHQWVWDWLVWLFDODQDO\VHV&DQFHUVSHFLᚏFVXUYLYDOZDVDVVHVVHG E\.DSODQ0HLHUDQG&R[PHWKRGV Results: SDWLHQWVZLWKUHQDOWXPRXUVZHUHLQFOXGHGLQWKLVUHWURVSHFWLYHVWXG\ FRPSDULQJ (65' UHQDO WUDQVSODQW SDWLHQWV Q GLDO\]HG SDWLHQWV Q DQG JHQHUDOSRSXODWLRQSDWLHQWV,Q(65'SDWLHQWVZLWKQDWLYHNLGQH\WXPRXUV FRPSDUHG WR VSRUDGLF FDVHV DJH DW GLDJQRVLV ZDV \RXQJHU s YV s \HDUV PDOHJHQGHUSUHGRPLQDQFHZDVPRUHSURQRXQFHG YV0)UDWLR PHDQ WXPRXU VL]H ZDV VPDOOHU s YV s FP DV\PSWRPDWLF YV ORZJUDGH YV DQGSDSLOODU\WXPRXUVZHUHPRUHIUHTXHQW YV SRRU(&2*36 YV DQGDGYDQFHG76WDJHV ุ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ᚏFVXUYLYDOSUHGLFWRUVLQPXOWLYDULDWHDQDO\VLV Conclusions: 5&& DULVLQJ LQ QDWLYH NLGQH\V RI (65' SDWLHQWV VHHP WR H[KLELW PDQ\ IDYRXUDEOH FOLQLFDO SDWKRORJLFDO DQG RXWFRPH IHDWXUHV FRPSDUHG WR WKRVH GLDJQRVHG LQ JHQHUDO SRSXODWLRQ SDWLHQWV )XUWKHU UHVHDUFKHV DUH QHHGHG IRU GHWHUPLQLQJ ZKHWKHU LW LV GXH WR SDUWLFXODU PROHFXODU SDWKZD\V RU WR ELDVHV LQ UHODWLRQWRPRGHRIGLDJQRVLV
416
OBESITY IS ASSOCIATED WITH BETTER PATHOLOGIC FEATURES AND IMPROVED OUTCOME AMONG PATIENTS TREATED SURGICALLY FOR RENAL CELL CARCINOMA
:DDONHV60HUVHEXUJHU$6.UDPHU0:+HUUPDQQ75::HJHQHU* +HJHOH$+RIPDQQ5.XF]\N0$6FKUDGHU$- 1 Medical School Hanover, Dept. of Urology, Hanover, Germany, 2Medical School Hanover, Clinical Cancer Registry, Hanover, Germany, 3University of Marburg, Dept. of Urology, Marburg, Germany
Eur Urol Suppl 2010;9(2):152
Introduction & Objectives: 2EHVLW\ LQFUHDVHV WKH ULVN RI GHYHORSLQJ UHQDO FHOO FDUFLQRPD 5&& KRZHYHULWUHPDLQVXQFOHDUZKHWKHUREHVLW\LVDVVRFLDWHGZLWK 5&& DJJUHVVLYHQHVV DQG VXUYLYDO :H DVVHVVHG ZKHWKHU GLᚎHUHQW ERG\ PDVV LQGH[ %0, OHYHOVDWWKHWLPHRIVXUJHU\KDGDQHᚎHFWRQORQJWHUPSURJQRVLVRI 5&&SDWLHQWV Material & Methods: :H HYDOXDWHG SDWLHQWV ZLWK FRPSOHWH LQIRUPDWLRQ DERXWWKHLU%0,ZKRKDGXQGHUJRQHVXUJHU\IRUUHQDOFHOOFDQFHUDWWKH8QLYHUVLW\ KRVSLWDOVLQ+DQRYHUDQG0DUEXUJEHWZHHQ DQG7KHPHDQIROORZXS ZDV\HDUV Results: 8QGHUZHLJKWQRUPDOZHLJKWSUHREHVLW\DQGREHVLW\ZHUHGLDJQRVHGLQ DQG 5&&SDWLHQWVUHVSHFWLYHO\ 2YHUZHLJKW %0,! DQGREHVLW\ZHUHVLJQLᚏFDQWO\DVVRFLDWHGZLWK\RXQJHUDJH S .UXVNDO:DOOLV DQGPHWDVWDWLFGLVHDVH S ˴ EXWQRWZLWKWXPRXU VWDJH JUDGH RU JHQGHU %RWK XQL DQG PXOWLYDULDWH DQDO\VHV VKRZHG WKDW REHVH SDWLHQWVKDGDVLJQLᚏFDQWO\ORZHUULVNRIGHDWK WKHPHGLDQ\HDURYHUDOOVXUYLYDO UDWHZDVDQG IRUSDWLHQWVZLWKD%0,EHORZDQG RYHU S /RQJ5DQN ,QWHUHVWLQJO\VXEJURXSDQDO\VLVUHYHDOHGWKDWWKH SRVLWLYHDVVRFLDWLRQEHWZHHQRYHUZHLJKWDQGVXUYLYDOZDVHYHQPRUHSURQRXQFHG LQRUJDQFRQᚏQHGGLVHDVH S FR[UHJUHVVLRQ DFRUUHODWLRQLQDGYDQFHG GLVHDVHFRXOGQRWEHFRQᚏUPHGLQPXOWLYDULDWHDQDO\VHV S Conclusions: :HZHUHDEOHWRLGHQWLI\RYHUZHLJKWDVDQLQGHSHQGHQWSURJQRVWLF PDUNHURILPSURYHGVXUYLYDOLQSDWLHQWVZLWKRUJDQFRQᚏQHG5&&%DVLFUHVHDUFK LV UHTXLUHG WR UHVROYH WKH GLOHPPD RI ZK\ LI D KLJKHU %0, SUHGLVSRVHV WR 5&& LW FRQFXUUHQWO\ SURORQJV VXUYLYDO DIWHU SDWLHQWV KDYH XQGHUJRQH SDUWLDO QHSKUHFWRP\
417
PREDICTING OCCULT MULTIFOCALITY OF RENAL CELL CARCINOMA
7VLYLDQ00RUHLUD'0&DVR-50RXUDYLHY90DGGHQ) %UDWVODYVN\*$OEDOD'03RODVFLN7- 1 Duke University Medical Center, Dept. of Urologic Surgery, Durham, United States of America, 2Duke University Medical Center, Dept. of Pathology, Durham, United States of America, 3National Cancer Center, National Institute of Health, Urologic Oncology Branch, Bethesda, United States of America Introduction & Objectives: 1HSKURQVSDULQJ VXUJHU\ 166 IRU UHQDO FHOO FDUFLQRPD 5&& KDV JDLQHG ZLGH DFFHSWDQFH 2QH SRWHQWLDO SLWIDOO RI 166 LV RFFXOWPXOWLIRFDOLW\RI5&&WKDWPD\UHTXLUHVXEVHTXHQWDGGLWLRQDOWUHDWPHQWVZKHQ LWODWHUEHFRPHVFOLQLFDOO\UHFRJQL]HG:HGHYHORSHGDQGDVVHVVHGDSUHRSHUDWLYH QRPRJUDPWRSUHGLFWRFFXOWPXOWLIRFDO5&& Material & Methods: FRQVHFXWLYH SDWLHQWV XQGHUJRLQJ UDGLFDO QHSKUHFWRP\ IRUFOLQLFDOO\ORFDOL]HGVXVSHFWHGVSRUDGLF5&&EHWZHHQLQDWHUWLDU\ FHQWHUZHUHHYDOXDWHG&OLQLFDOO\PDQLIHVWPXOWLIRFDOOHVLRQVZHUHH[FOXGHG/RJLVWLF UHJUHVVLRQPRGHOVZHUHXVHGWRDVVHVVSRWHQWLDOULVNIDFWRUVRIRFFXOWPXOWLIRFDOLW\ ZLWK DQG ZLWKRXW SDWKRORJLFDO YDULDEOHV WKDW PD\ EH DYDLODEOH ZLWK SUHRSHUDWLYH ELRSV\ $ QRPRJUDP ZDV GHYHORSHG DQG DVVHVVHG IRU GLDJQRVWLF SURSHUWLHV LQ SUHGLFWLQJRFFXOWPXOWLIRFDO5&& Results: 7KHLQFLGHQFHRIRFFXOWPXOWLIRFDOLW\ZDV6LJQLᚏFDQWO\DVVRFLDWHG SUHGLFWRUV RI PXOWLIRFDOLW\ ZHUH PDOH JHQGHU IDPLO\ KLVWRU\ RI PDOLJQDQF\ RWKHU WKDQ5&&UDGLRJUDSKLFVL]HRIWKHOHVLRQDQGSDWKRORJLFDOYDULDEOHV KLVWRORJLFDO VXEW\SH RWKHU WKDQ FOHDU FHOO DQG KLJK )XKUPDQ JUDGH 2XU QRPRJUDPVಬ KDG FRQFRUGDQFHLQGH[HVRIDQGZLWKRXWDQGZLWKKLVWRORJLFDOVXEW\SHDQG )XKUPDQJUDGHLQFOXGHGUHVSHFWLYHO\ Conclusions: 2XU GDWD VXJJHVW WKDW RFFXOW PXOWLIRFDO 5&& LV PRUH IUHTXHQWO\ DVVRFLDWHGZLWKVPDOOHUUHQDOOHVLRQV0DOHJHQGHUIDPLO\KLVWRU\RINLGQH\FDQFHU KLVWRORJLFDO VXEW\SH DQG JUDGH DUH VWURQJO\ DVVRFLDWHG ZLWK DQ LQFUHDVHG ULVN RI RFFXOW PXOWLIRFDO 5&& 7KHVH IDFWRUV VKRXOG EH FRQVLGHUHG ZKHQ HYDOXDWLQJ FDQGLGDWHVIRU166%DVHGRQWKHVHSUHGLFWRUVZHGHYHORSHGDQRPRJUDPWKDWLV DYDOXDEOHWRROIRUSDWLHQWVDQGSK\VLFLDQVWRSUHGLFWRFFXOWPXOWLIRFDO5&&
418
NEW PROGNOSTIC STRATIFICATION SYSTEM IN LOCALLY ADVANCED RENAL CELL CARCINOMA PATIENTS WHO ARE CANDIDATES FOR ADJUVANT TREATMENT
%HUQKDUG-&5DYDXG$3DQWXFN$-&UHSHO09HUKRHVW* %HQVDODK.&LQGROR/'H/D7DLOOH$)HUULHUH-06DORPRQ/ 7RVWDLQ-)LFDUD91RYDUD*=LQL/ 9LOOHUV$ %HOOGHJUXQ$6 3DWDUG-- 1 University Hospital, Dept. of Urology, Bordeaux, France, 2University Hospital, Dept. of Medical Oncology, Bordeaux, France, 3University of California Los Angeles, Dept. of Urology, Los Angeles, United States of America, 4University Hospital, Dept. of Urology, Rennes, France, 5S. Pio Dal Pietralcina Hospital, Dept. of Urology, Vasto, Italy, 6University Hospital, Dept. of Urology, Creteil, France, 7 University Hospital, Dept. of Urology, Saint-Etienne, France, 8University Hospital, Dept. of Urology, Padua, Italy, 9University Hospital, Dept. of Urology, Lille, France Introduction & Objectives: 7KHUH LV QR DSSURYHG DGMXYDQW WUHDWPHQW LQ ORFDOO\ DGYDQFHG5HQDO&HOO&DUFLQRPDV 5&&V $WOHDVWLQWHUQDWLRQDOSKDVH,,,WULDOV DUHFXUUHQWO\FRPSDULQJ7\URVLQH.LQDVH,QKLELWRUV 7.,V ZLWKSODFHERIROORZLQJ VXUJHU\LQWKHDGMXYDQWVHWWLQJ7KHREMHFWLYHRIWKLVVWXG\ZDVWRIXUWKHULGHQWLI\