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430 DOES THE AETIOLOGY OF AZOOSPERMIA AFFECT THE OUTCOME OF ICSI
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429
PREDICTIVE FACTORS OF THE SUCCESS OF MESA IN PATIENTS WITH PRIMARY OBSTRUCTIVE AZOOSPERMIA
6LQHVFX,9RLQHD60DQHD,+DLQHDOD%*DJLX&3UHGD$3DYHO& +DU]D00DWHL0'RKOH* 1 Fundeni Clinical Institute, Center of Urological Surgery, Dialysis and Renal Transplantation, Bucharest, Romania, 2Clinical Hospital CFR 2, Dept. of In Vitro Fertilization, Bucharest, Romania, 3Erasmus University Medical Centre Rotterdam, Dept. of Urology, Rotterdam, The Netherlands Introduction & Objectives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ᚏQG D FRUUHODWLRQ EHWZHHQ FOLQLFDO SUHRSHUDWLYH GDWD DQG WKH SUHVHQFH RI YLDEOH VSHUPDWR]RDZLWK0(6$LQSDWLHQWVZLWKSULPDU\2$ Material & Methods: SDWLHQWV PHDQ DJH UDQJH \HDUV ZHUH SURVSHFWLYHO\LQFOXGHGEHWZHHQ6HSWHPEHUDQG6HSWHPEHU XVLQJWKH IROORZLQJFULWHULDIRUSULPDU\2$ YDVGHIHUHQVFOLQLFDOO\SUHVHQW VHPLQDOYROXPH ุP/ VHPHQ S+ุ VHPLQDO IUXFWRVH SUHVHQW QRUPDO UHSURGXFWLYH KRUPRQHV WHVWLFXODU YROXPH ุFF ZLGWK RI HSLGLG\PLV FDSXW ุPP DV PHDVXUHG E\ XOWUDVRXQG$OOSDWLHQWVXQGHUZHQWVFURWDOH[SORUDWLRQZLWKWKHDLPWRSHUIRUP0(6$ DQGLISRVVLEOHUHFRQVWUXFWLRQRIWKHVSHUPDWLFWUDFW7KHHQWLUHFRKRUWZDVGLYLGHG LQWR JURXSV DFFRUGLQJO\ WR ZKDW ZDV IRXQG LQ HSLGLG\PLV JURXS ZLWK YLDEOH VSHUPDWR]RDದWHVWLFXODUXQLWVDQGJURXSZLWKDEVHQWGHDGVSHUPDWR]RDದ WHVWLFXODU XQLWV RQH SDWLHQW KDV VROLWDU\ WHVWLFOH &RUUHODWLRQV RI YDULDEOHV ZHUH FDOFXODWHGXVLQJ6366VRIWZDUHDQGE\FRPSDULVRQWKHJURXSV
430
DOES THE AETIOLOGY OF AZOOSPERMIA AFFECT THE OUTCOME OF ICSI
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431
IN THE ERA OF MICRODISSECTION TESE – ARE THERE ANY HISTOPATHOLOGICAL/ BIOCHEMICAL FACTORS PREDICTIVE FOR SUCCESSFUL SPERM RETRIEVAL IN MEN WITH SERTOLI CELL ONLY?
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Eur Urol Suppl 2010;9(2):156
Introduction & Objectives: 0DQ\ FOLQLFLDQV XVH DQ LVRODWHG WHVWLFXODU ELRSV\ LQ WKHLQYHVWLJDWLRQRIWKHD]RRVSHUPLFSDWLHQWZLWKRXWV\QFKURQRXVVSHUPUHWULHYDO 7KHUDWLRQDOHIRUWKLVLVWKDWDGLDJQRVWLFELRSV\PD\EHSUHGLFWLYHRIᚏQGLQJVSHUP LQPHQZLWKQRQREVWUXFWLYHD]RRVSHUPLD 12$ 7KLVSURVSHFWLYHVWXG\DVVHVVHG WKH RXWFRPH RI VSHUP UHWULHYDO XVLQJ PLFURGLVVHFWLRQ7(6( P7(6( DQG VLPXOWDQHRXVGLDJQRVWLFELRSV\WRGHWHUPLQHLIWKHGHᚏQLWLYHKLVWRORJ\FRUUHODWHG ZLWKWKHRXWFRPHRIVSHUPUHWULHYDOE\P7(6(LQPHQZLWK6HUWROLFHOORQO\:H DOVR VRXJKW WR GHWHUPLQH LI /+)6+ OHYHOV DQG WHVWLV VL]H FRUUHODWHG ZLWK VSHUP UHWULHYDOUDWHV Material & Methods: %HWZHHQ DOO SDWLHQWV XQGHUJRLQJ P7(6( IRU D]RRVSHUPLDZHUHDVVHVVHGZLWKUHVSHFWWRKLVWRORJ\DQGVSHUPUHWULHYDOUDWHV 3DWLHQWV XQGHUZHQW JHQHWLF VFUHHQLQJ LQFOXGLQJ NDU\RW\SLQJ < GHOHWLRQ DQG KRUPRQDOHYDOXDWLRQ )6+/+ DQGPHDVXUHPHQWRIWHVWLFXODUVL]H8QGHUJHQHUDO
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429
PREDICTIVE FACTORS OF THE SUCCESS OF MESA IN PATIENTS WITH PRIMARY OBSTRUCTIVE AZOOSPERMIA
6LQHVFX,9RLQHD60DQHD,+DLQHDOD%*DJLX&3UHGD$3DYHO& +DU]D00DWHL0'RKOH* 1 Fundeni Clinical Institute, Center of Urological Surgery, Dialysis and Renal Transplantation, Bucharest, Romania, 2Clinical Hospital CFR 2, Dept. of In Vitro Fertilization, Bucharest, Romania, 3Erasmus University Medical Centre Rotterdam, Dept. of Urology, Rotterdam, The Netherlands Introduction & Objectives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ᚏQG D FRUUHODWLRQ EHWZHHQ FOLQLFDO SUHRSHUDWLYH GDWD DQG WKH SUHVHQFH RI YLDEOH VSHUPDWR]RDZLWK0(6$LQSDWLHQWVZLWKSULPDU\2$ Material & Methods: SDWLHQWV PHDQ DJH UDQJH \HDUV ZHUH SURVSHFWLYHO\LQFOXGHGEHWZHHQ6HSWHPEHUDQG6HSWHPEHU XVLQJWKH IROORZLQJFULWHULDIRUSULPDU\2$ YDVGHIHUHQVFOLQLFDOO\SUHVHQW VHPLQDOYROXPH ุP/ VHPHQ S+ุ VHPLQDO IUXFWRVH SUHVHQW QRUPDO UHSURGXFWLYH KRUPRQHV WHVWLFXODU YROXPH ุFF ZLGWK RI HSLGLG\PLV FDSXW ุPP DV PHDVXUHG E\ XOWUDVRXQG$OOSDWLHQWVXQGHUZHQWVFURWDOH[SORUDWLRQZLWKWKHDLPWRSHUIRUP0(6$ DQGLISRVVLEOHUHFRQVWUXFWLRQRIWKHVSHUPDWLFWUDFW7KHHQWLUHFRKRUWZDVGLYLGHG LQWR JURXSV DFFRUGLQJO\ WR ZKDW ZDV IRXQG LQ HSLGLG\PLV JURXS ZLWK YLDEOH VSHUPDWR]RDದWHVWLFXODUXQLWVDQGJURXSZLWKDEVHQWGHDGVSHUPDWR]RDದ WHVWLFXODU XQLWV RQH SDWLHQW KDV VROLWDU\ WHVWLFOH &RUUHODWLRQV RI YDULDEOHV ZHUH FDOFXODWHGXVLQJ6366VRIWZDUHDQGE\FRPSDULVRQWKHJURXSV
430
DOES THE AETIOLOGY OF AZOOSPERMIA AFFECT THE OUTCOME OF ICSI
.DOVL-67KXP0<$EGXOODK+3U\RU-0XQHHU$0LQKDV6 1 University College London Hospitals, Dept. of Urology, London, United Kingdom, 2 The Lister Hospital, Dept. of Fertility, London, United Kingdom Introduction & Objectives: 7KH WHFKQLTXH RI LQWUDF\WRSODVPLF VSHUP LQMHFWLRQ ,&6, KDVEHHQLQFUHDVLQJO\XWLOLVHGLQWKHPDQDJHPHQWRIPDOHIDFWRULQIHUWLOLW\ 8VLQJWKLVWHFKQLTXHD]RRVSHUPLFSDWLHQWVQRZKDYHWKHDELOLW\WRIDWKHUFKLOGUHQ DIWHUHLWKHU HSLGLG\PDO RU WHVWLFXODU VSHUP H[WUDFWLRQ 7KHREMHFWLYH RIWKLVVWXG\ ZDVWRDVVHVVZKHWKHUWKHDHWLRORJ\RID]RRVSHUPLDDᚎHFWVWKHRXWFRPHRI,&6, Material & Methods: 7KH UHFRUGV RI SDWLHQWV XQGHUJRLQJ ᚏUVWDWWHPSW ,&6, EHWZHHQ DQG DW 7KH /LVWHU +RVSLWDO /RQGRQ ZHUH UHWURVSHFWLYHO\ UHYLHZHG)UHVKWHVWLFXODUVSHUP )76 ZDVXVHGLQF\FOHVIUR]HQWHVWLFXODU VSHUP )776 ZDV XVHG LQ F\FOHV IUHVK HSLGLG\PDO VSHUP )(6 ZDV XVHG LQ F\FOHV DQG IUR]HQ HSLGLG\PDO VSHUP )7(6 ZDV XVHG LQ F\FOHV :LWKLQHDFKJURXSWKHDHWLRORJ\RIWKHD]RRVSHUPLDZDVDVVHVVHG Q 7KH IHUWLOLVDWLRQFOLQLFDOSUHJQDQF\DQGGHOLYHU\UDWHVZHUHFDOFXODWHGIRUHDFKJURXS ZLWKUHVSHFWWRWKHW\SHRIVSHUPUHWULHYDOXVHG Results: $QDO\VLV RI WKH GDWD VKRZHG QR VLJQLᚏFDQW GLᚎHUHQFHV EHWZHHQ DQ\ RI WKH JURXSV LQ WHUPV RI IHUWLOL]DWLRQ FOLQLFDO SUHJQDQF\ RU GHOLYHU\ UDWHV EHWZHHQ REVWUXFWLYH DQG QRQREVWUXFWLYH DHWLRORJLHV ,Q WKH REVWUXFWLYH JURXS WKHUH ZHUH QRGLᚎHUHQFHVVHHQEHWZHHQIUHVKYVIUR]HQHSLGLG\PDOVSHUPRUEHWZHHQIUHVK HSLGLG\PDO DQG WHVWLFXODU VSHUP ,Q WKH QRQREVWUXFWLYH JURXS WKHUH ZDV QR GLᚎHUHQFHEHWZHHQIUHVKRUIUR]HQWHVWLFXODUVSHUP7KHUHVXOWVVXJJHVWDWHQGHQF\ IRUEHWWHUSUHJQDQF\DQGELUWKUDWHVIRUIUR]HQYVIUHVKWHVWLFXODULQERWKREVWUXFWLYH DQGQRQREVWUXFWLYHEXWGLGQRWUHDFKVWDWLVWLFDOVLJQLᚏFDQFH 7DEOH 1RQREVWUXFWLYH
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431
IN THE ERA OF MICRODISSECTION TESE – ARE THERE ANY HISTOPATHOLOGICAL/ BIOCHEMICAL FACTORS PREDICTIVE FOR SUCCESSFUL SPERM RETRIEVAL IN MEN WITH SERTOLI CELL ONLY?
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Eur Urol Suppl 2010;9(2):156
Introduction & Objectives: 0DQ\ FOLQLFLDQV XVH DQ LVRODWHG WHVWLFXODU ELRSV\ LQ WKHLQYHVWLJDWLRQRIWKHD]RRVSHUPLFSDWLHQWZLWKRXWV\QFKURQRXVVSHUPUHWULHYDO 7KHUDWLRQDOHIRUWKLVLVWKDWDGLDJQRVWLFELRSV\PD\EHSUHGLFWLYHRIᚏQGLQJVSHUP LQPHQZLWKQRQREVWUXFWLYHD]RRVSHUPLD 12$ 7KLVSURVSHFWLYHVWXG\DVVHVVHG WKH RXWFRPH RI VSHUP UHWULHYDO XVLQJ PLFURGLVVHFWLRQ7(6( P7(6( DQG VLPXOWDQHRXVGLDJQRVWLFELRSV\WRGHWHUPLQHLIWKHGHᚏQLWLYHKLVWRORJ\FRUUHODWHG ZLWKWKHRXWFRPHRIVSHUPUHWULHYDOE\P7(6(LQPHQZLWK6HUWROLFHOORQO\:H DOVR VRXJKW WR GHWHUPLQH LI /+)6+ OHYHOV DQG WHVWLV VL]H FRUUHODWHG ZLWK VSHUP UHWULHYDOUDWHV Material & Methods: %HWZHHQ DOO SDWLHQWV XQGHUJRLQJ P7(6( IRU D]RRVSHUPLDZHUHDVVHVVHGZLWKUHVSHFWWRKLVWRORJ\DQGVSHUPUHWULHYDOUDWHV 3DWLHQWV XQGHUZHQW JHQHWLF VFUHHQLQJ LQFOXGLQJ NDU\RW\SLQJ < GHOHWLRQ DQG KRUPRQDOHYDOXDWLRQ )6+/+ DQGPHDVXUHPHQWRIWHVWLFXODUVL]H8QGHUJHQHUDO