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4450149 radiohalogenation method
*vi1
New Patents
4450149 RADIOHALOGENATION, METHOD George W Kabalka assigned to Research Corporation Organoborane compounds are halogenated by reacting an organoborane with iodinemonochloride, brominemono-chloride or a halide salt in the presence of a mild oxidizing agent.
4451451 RADIOPHARMACEUTICAL COMPOSITION BASED ON TECHNETIUM-99M AND REAGENT FOR MAKING IT John Rimmer, Amersham, United Kingdom assigned to Amersham International plc NHR \ ‘c:
-Yen’ / ‘(In
Radiopharmaceutical compositions containing complexes of technetium-99m with a complexing agent are prone to time and activity-related decomposition and formation of pertechnetate. Stabilizing agents for such complexes are organic compounds having an amine group and a carboxylic acid group attached to an aromatic ring. A preferred stabilizing agent is the sodium salt of 4-aminobenzoic acid. There are claims to a composition comprising a technetium 99-m complex stabilized by means of the said stabilizing agent: and to a reagent which forms, on addition of an aqueous solution of pertechcomposition, netate. a radiopharrnaceutical which reagent comprises a tin metal or stannous reducing agent for the pertechnetate, a complexing agent for the reduced technetium, for example a phosphorus-containing bone scanning agent. and a stabilizing agent as defined.
4451571 PREPARATION OF SAMPLES FOR VITAMIN B12 AND/OR FOLATE ASSAY AND ASSAY Robert Allen assigned to University Patents Inc
Vitamin B12 (cobalamin) and/or folate (folic acid) assay techniques can be simplified, by -eliminating the step of heating or boiling the tobe-tested sample prior to its assay. This is accomplished by utilizing compositions and procedures: ( I ) which substantially completely liberate all vitamin B12 and/or folate from endogenous binding protein without heating or boiling; (2) which substantially completely destroy all endogenous binding protein which is present in the to-be-assayed sample, and which may bind natural and radioactive vitamin B 12 or folate both due to its liberation from vitamin Bl2 or folate in the original sample or due to its unbound presence in the original sample; (3) which substantially completely inhibit or block any undestroyed endogenous binding protein; and (4) which substantially completely inhibit or destroy any intrinsic factor-blocking antibodies which may be present in the to-be-assayed sample. In preferred embodiments the protein destroying compositions utilized include both a strong base and a sulfhydral compound which is a strong disulfide protein destroying material while the material of choice to bind with undestroyed endogenous binding protein is a vitamin Bl2 analogue. The sample is then assayed using known, for example, radioisotrope dilution assay techniques.
4452773 MAGNETIC IRON-DEXTRAN MICROSPHERES Robert S Molday, Vancouver, Canada assigned to Canadian Patents and Development Limited The invention relates to colloidal sized particles composed of magnetic iron oxide (Fe304) coated with a polysaccharide, preferably dextran. or a derivative thereof having pendant functional groups. The particles have a magnetic moment, are electron dense, and are stable and non-aggregating under physiological conditions. They can be covalently bonded to antibodies. enzymes and other biological molecules and used to label and separate cells, cellular membranes and other biological particles and molecules by means of a magnetic field.
New Patents
4450149 RADIOHALOGENATION, METHOD George W Kabalka assigned to Research Corporation Organoborane compounds are halogenated by reacting an organoborane with iodinemonochloride, brominemono-chloride or a halide salt in the presence of a mild oxidizing agent.
4451451 RADIOPHARMACEUTICAL COMPOSITION BASED ON TECHNETIUM-99M AND REAGENT FOR MAKING IT John Rimmer, Amersham, United Kingdom assigned to Amersham International plc NHR \ ‘c:
-Yen’ / ‘(In
Radiopharmaceutical compositions containing complexes of technetium-99m with a complexing agent are prone to time and activity-related decomposition and formation of pertechnetate. Stabilizing agents for such complexes are organic compounds having an amine group and a carboxylic acid group attached to an aromatic ring. A preferred stabilizing agent is the sodium salt of 4-aminobenzoic acid. There are claims to a composition comprising a technetium 99-m complex stabilized by means of the said stabilizing agent: and to a reagent which forms, on addition of an aqueous solution of pertechcomposition, netate. a radiopharrnaceutical which reagent comprises a tin metal or stannous reducing agent for the pertechnetate, a complexing agent for the reduced technetium, for example a phosphorus-containing bone scanning agent. and a stabilizing agent as defined.
4451571 PREPARATION OF SAMPLES FOR VITAMIN B12 AND/OR FOLATE ASSAY AND ASSAY Robert Allen assigned to University Patents Inc
Vitamin B12 (cobalamin) and/or folate (folic acid) assay techniques can be simplified, by -eliminating the step of heating or boiling the tobe-tested sample prior to its assay. This is accomplished by utilizing compositions and procedures: ( I ) which substantially completely liberate all vitamin B12 and/or folate from endogenous binding protein without heating or boiling; (2) which substantially completely destroy all endogenous binding protein which is present in the to-be-assayed sample, and which may bind natural and radioactive vitamin B 12 or folate both due to its liberation from vitamin Bl2 or folate in the original sample or due to its unbound presence in the original sample; (3) which substantially completely inhibit or block any undestroyed endogenous binding protein; and (4) which substantially completely inhibit or destroy any intrinsic factor-blocking antibodies which may be present in the to-be-assayed sample. In preferred embodiments the protein destroying compositions utilized include both a strong base and a sulfhydral compound which is a strong disulfide protein destroying material while the material of choice to bind with undestroyed endogenous binding protein is a vitamin Bl2 analogue. The sample is then assayed using known, for example, radioisotrope dilution assay techniques.
4452773 MAGNETIC IRON-DEXTRAN MICROSPHERES Robert S Molday, Vancouver, Canada assigned to Canadian Patents and Development Limited The invention relates to colloidal sized particles composed of magnetic iron oxide (Fe304) coated with a polysaccharide, preferably dextran. or a derivative thereof having pendant functional groups. The particles have a magnetic moment, are electron dense, and are stable and non-aggregating under physiological conditions. They can be covalently bonded to antibodies. enzymes and other biological molecules and used to label and separate cells, cellular membranes and other biological particles and molecules by means of a magnetic field.