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4459300 Pharmaceutically active aza-bicyclo benzamide derivatives
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New Patents
alkanoyl, optionally substituted benzoyl, phenylacetyl, or phenylpropionyl or optionally substituted phenylglycyl or phenylalanyl; and of the formula: See Patent for Chemical Structure 2 wherein: R6 and R7 together form a CH2 double bond group or R6 is R80- and R7 is methyl; R8 is C1-C4-alkyl, benzyl or phenethyl; and R1, R2 and R3 are as defined in formula 1; and salts thereof are useful antibiotics or intermediates to antibiotics.
4459291 COMPOUNDS HAVING ANTIBIOTIC ACTIVITY, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICAMENTS Kunikatsu Shirahata, Takao Iida, Machida, Japan assigned to Kyowa Hakko Kogyo Kabushiki Kaisha New antibacterial compounds, DC-45-A1 and DC-45-A2 are produced by fermentation of a microorganism belonging to the genus Streptomyces. The antibiotics are accumulated in the culture liquor and are isolated therefrom. These compounds are also prepared by acid hydrolysis of known compounds, DC-45-A or DC-45-B2. DC-45-A2 is also prepared by acid hydrolysis of DC-45-A1.
4459300 PHARMACEUTICALLY ACTIVE AZA-BICYCLO BENZAMIDE DERIVATIVES Eric A Watts, Harlow, United Kingdom assigned to Beecham Group p 1 c Compounds of formula (I) and pharmaceutically acceptable salts thereof: See Patent for Chemical Structure (I) wherein: n, p and q independently are 0 to 2; R5 is hydrogen or C1-6 alkyl; R6 is C1-7 alkyl or a group -(CH2)sR7 where s is 0 to 2 and R7 is a C3-8 cycloalkyl group, or a group -(CH2)tR8 where t is 1 or 2 and R8 is C2-5 alkenyl or a phenyl group optionally substituted by one or two substituents selected from C1-6 alkyl, C1-4 alkoxy, trifluoromethyl and halogen, or a thienyl group; R12 is CI-6 alkylsulphonyl; and either R1 is C16 alkoxy or C1-6 alkylthio; and one of R2 and R l l is hydrogen and the other is C1-6 alkoxy, C1-6 alkyl or hydroxy; or R1 and R2 together are C1-3 alkylenedioxy; and R l l is hydrogen, halogen, CF3, C1-6 alkoxy, hydroxy, nitro, C1-7 acyl, amino, C1-7 acylamino, aminocarbonyl optionally substituted by one or two C 1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl, phenyl or phenyl C1-4 alkyl groups any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C1-6 alkoxy or nitro groups or N-disubstituted by C4-6 polymethylene, having useful pharmacological activity, e.g. in the treatment of impaired gastric motility, a process for their preparation and their use.
For information about P A T S E A R C H ®
Pergamon InfoLine Inc. 1340 Old Chain Bridge Road McLean, Virginia 22101 USA Telephone (703) 442-0900 Telex: 90-1811
Pergamon InfoLine Limited 12 Vandy Street London EC2A 2DE England Telephone (01) 377-4650 Telex: 8814614
Pergamon Press Canada Ltd 150 Consumers Road, Suite 104 Willowdale, Ontario Canada M2J 1P9 Telephone (416) 497-8337
New Patents
alkanoyl, optionally substituted benzoyl, phenylacetyl, or phenylpropionyl or optionally substituted phenylglycyl or phenylalanyl; and of the formula: See Patent for Chemical Structure 2 wherein: R6 and R7 together form a CH2 double bond group or R6 is R80- and R7 is methyl; R8 is C1-C4-alkyl, benzyl or phenethyl; and R1, R2 and R3 are as defined in formula 1; and salts thereof are useful antibiotics or intermediates to antibiotics.
4459291 COMPOUNDS HAVING ANTIBIOTIC ACTIVITY, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICAMENTS Kunikatsu Shirahata, Takao Iida, Machida, Japan assigned to Kyowa Hakko Kogyo Kabushiki Kaisha New antibacterial compounds, DC-45-A1 and DC-45-A2 are produced by fermentation of a microorganism belonging to the genus Streptomyces. The antibiotics are accumulated in the culture liquor and are isolated therefrom. These compounds are also prepared by acid hydrolysis of known compounds, DC-45-A or DC-45-B2. DC-45-A2 is also prepared by acid hydrolysis of DC-45-A1.
4459300 PHARMACEUTICALLY ACTIVE AZA-BICYCLO BENZAMIDE DERIVATIVES Eric A Watts, Harlow, United Kingdom assigned to Beecham Group p 1 c Compounds of formula (I) and pharmaceutically acceptable salts thereof: See Patent for Chemical Structure (I) wherein: n, p and q independently are 0 to 2; R5 is hydrogen or C1-6 alkyl; R6 is C1-7 alkyl or a group -(CH2)sR7 where s is 0 to 2 and R7 is a C3-8 cycloalkyl group, or a group -(CH2)tR8 where t is 1 or 2 and R8 is C2-5 alkenyl or a phenyl group optionally substituted by one or two substituents selected from C1-6 alkyl, C1-4 alkoxy, trifluoromethyl and halogen, or a thienyl group; R12 is CI-6 alkylsulphonyl; and either R1 is C16 alkoxy or C1-6 alkylthio; and one of R2 and R l l is hydrogen and the other is C1-6 alkoxy, C1-6 alkyl or hydroxy; or R1 and R2 together are C1-3 alkylenedioxy; and R l l is hydrogen, halogen, CF3, C1-6 alkoxy, hydroxy, nitro, C1-7 acyl, amino, C1-7 acylamino, aminocarbonyl optionally substituted by one or two C 1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl, phenyl or phenyl C1-4 alkyl groups any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C1-6 alkoxy or nitro groups or N-disubstituted by C4-6 polymethylene, having useful pharmacological activity, e.g. in the treatment of impaired gastric motility, a process for their preparation and their use.
For information about P A T S E A R C H ®
Pergamon InfoLine Inc. 1340 Old Chain Bridge Road McLean, Virginia 22101 USA Telephone (703) 442-0900 Telex: 90-1811
Pergamon InfoLine Limited 12 Vandy Street London EC2A 2DE England Telephone (01) 377-4650 Telex: 8814614
Pergamon Press Canada Ltd 150 Consumers Road, Suite 104 Willowdale, Ontario Canada M2J 1P9 Telephone (416) 497-8337