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4470955 Removal of tritiated species from gas streams comprised thereof
xxvi
New Patents
This invention relates to the immobilization of toxic, e.g., radioactive, materials in a silicate glass or silica gel matrix for extremely long periods of time. Toxic materials, such as radioactive wastes containing radioactive cations, which may be in the form of liquids, or solids dissolved or dispersed in liquids or gases, are incorporated into a glass or silica gel matrix, having alkali metal, Group Ib metal and/or ammonium cations bonded to silicon atoms of said glass or silica gel through divalent oxygen linkages, by a process which involves the ion exchange of said toxic or radioactive cations with said alkali metal, Group Ib metal and/or ammonium cations to bind said toxic or radioactive cations to silicon atoms of said glass or silica gel through said silicon-bonded divalent oxygen linkages. Thereafter, the resulting glass or silica gel now characterized by toxic or radioactive cations bonded to silicon atoms through divalent oxygen linkages can be stored, or packaged in suitable containers, or disposed of as by burial, and/or sintered to collapse the pores thereof.
A radioassay test for the rapid and sensitive determination of the concentration of monosialoglycosphingolipid GM I ganglioside concentrations in small volumes of cerebrospinal fluid from individual patients is based on the high affinity interaction between cholera enterotoxin and GM1 ganglioside. The level of GM1 ganglioside present in the cerebrospinal fluid has been shown to be an indicator of active central nervous system pathology. In the present invention, the use of highly specific toxins eliminates cross reactivity with the other gangliosides, thereby eliminating the need to process the cerebrospinal sample prior to assay. except for centrifugation. Results of a specific application of the subject radioassay to newborn infants and older infants and children (some of the latter having active neurologic disease) indicated that the GM 1 ganglioside concentration in the cerebrospinal fluid is probably a function of both central nervous system tissue ganglioside content and turnover.
4470955 REMOVAL OF TRITIATED SPECIES FROM GAS STREAMS COMPRISED THEREOF Martin F Collins, Romuald Michalek assigned to Engelhard Corporation
4449795 RADIOASSAY FOR MONOSIALOGLYCOSPHINGOLIPID (GMl) GANGLIOSIDE CONCENTRATION Edward Ginns, Josep French
Tritiated species, e.g., tritium. tritiated water. and/or tritiated hydrocarbons. are removed from gas streams comprised thereof by reacting the same over a precious metal catalyst with sufficient air or oxygen to convert all tritiated species to tritiated water and. if hydrocarbons are present in the gaseous feedstock, carbon dioxide. The tritiated water and any other moisture that might be present in the reaction effluent are next adsorbed by a desiccant dryer. preferably to a level of less than one part per million. Most desirably, the desiccant dryer effluent is then diluted with non-radioactive water such that the tritiated water is diluted by a factor of at least 1,000 to I; the resulting water mixture can
New
be adsorbed from the diluted effluent by a second desiccant dryer to provide a value in the ultimate effluent gas of less than about one-half parts per billion tritiated water.
4472299 GENERATOR FOR RADIONUCLIDE AND PROCESS OF USE THEREOF Peter S Weisner. Terence R Forrest, Amersham, United Kingdom assigned to Amersham International plc
xxvii
Patents
other anti-TAAs, such as human melanomaassociated antigen, human neuroblastoma_ associated antigen, human breast cancerassociated antigen, human ovary-associated antigen, human sarcoma-associated antigen, etc. The biodistribution of the labeled product composition accumulates at cancer sites, e.g.. tumors that produce or express TAA, due to the affinity that the antibody has for the given tumor antigen. The accumulation at the tumor site(s) of a suitable amount of Tc-99m associated with the antibody allows detection via external scintigraphy and other means. Detection of the Tc99m antibody composition by external scintigraphy permits localization and detection of tumors in vivo via a semi-noninvasive technique.
4472508 TEST FOR DETECTING AND MEASURING THE GRAVES’ DISEASE-SPECIFIC IMMUNOGLOBULINS
A generator of radionuclides such as technetium-99m comprises a generator column (10) containing the radionuclide, a first reservoir ( 16) for eluent. a second reservoir (18) to contain a volume of the eluent required for a single elution. and a vessel 40 to contain eluate. First, a pre-set volume of eluent is transferred from the first to the second reservoir; then the eluent is sucked from the second reservoir through the column into the eluate vessel. A hydrophobic filter 32 adjacent the second reservoir (18) permits the use of air to dry the column (10) and to bring the partly filled eluate vessel (40) to atmospheric pressure.
4472371 RADIOLABELED ANTIBODY TO ANTI-TUMOR ASSOCIATED ANTIGEN AND PROCESS
Sidney Ingbar assigned Hospital Association
to The
Beth Israel
An immunoassay for a specific antibody. particularly Graves’ disease-specific antibody, in which interfering reactions by the reactive ends of similar antibodies are eliminated by the step of occluding the interfering reactive ends with an antibody against the interfering reactive ends.
4472829 RADIOGRAPHIC PHANTOM WITH IODINATED CHANNELS Stephen J Riederer, Edmund R Steinike. Frank A DiBianca assigned to General Electric Company
Scott W Burchiel. Buck A Rhodes. David Crockford assigned to Summa Medical Corporation: University Patents I Antibodies to human carcinoembryonic antigen (CEA). human alphafetoprotein (AFP) and/or to other anti-human tumor associated antigens (TAA) labeled with technetium-99m (Tc-99m) are administered to a human after the human has been administered anti-CEA, anti-AFP and/or
A radiographic phantom is comprised of only two materials, a non-iodinated material composing the base and an iodinated material disposed in a channel simulating a blood vessel, thus providing for a resultant signal attributable
New Patents
This invention relates to the immobilization of toxic, e.g., radioactive, materials in a silicate glass or silica gel matrix for extremely long periods of time. Toxic materials, such as radioactive wastes containing radioactive cations, which may be in the form of liquids, or solids dissolved or dispersed in liquids or gases, are incorporated into a glass or silica gel matrix, having alkali metal, Group Ib metal and/or ammonium cations bonded to silicon atoms of said glass or silica gel through divalent oxygen linkages, by a process which involves the ion exchange of said toxic or radioactive cations with said alkali metal, Group Ib metal and/or ammonium cations to bind said toxic or radioactive cations to silicon atoms of said glass or silica gel through said silicon-bonded divalent oxygen linkages. Thereafter, the resulting glass or silica gel now characterized by toxic or radioactive cations bonded to silicon atoms through divalent oxygen linkages can be stored, or packaged in suitable containers, or disposed of as by burial, and/or sintered to collapse the pores thereof.
A radioassay test for the rapid and sensitive determination of the concentration of monosialoglycosphingolipid GM I ganglioside concentrations in small volumes of cerebrospinal fluid from individual patients is based on the high affinity interaction between cholera enterotoxin and GM1 ganglioside. The level of GM1 ganglioside present in the cerebrospinal fluid has been shown to be an indicator of active central nervous system pathology. In the present invention, the use of highly specific toxins eliminates cross reactivity with the other gangliosides, thereby eliminating the need to process the cerebrospinal sample prior to assay. except for centrifugation. Results of a specific application of the subject radioassay to newborn infants and older infants and children (some of the latter having active neurologic disease) indicated that the GM 1 ganglioside concentration in the cerebrospinal fluid is probably a function of both central nervous system tissue ganglioside content and turnover.
4470955 REMOVAL OF TRITIATED SPECIES FROM GAS STREAMS COMPRISED THEREOF Martin F Collins, Romuald Michalek assigned to Engelhard Corporation
4449795 RADIOASSAY FOR MONOSIALOGLYCOSPHINGOLIPID (GMl) GANGLIOSIDE CONCENTRATION Edward Ginns, Josep French
Tritiated species, e.g., tritium. tritiated water. and/or tritiated hydrocarbons. are removed from gas streams comprised thereof by reacting the same over a precious metal catalyst with sufficient air or oxygen to convert all tritiated species to tritiated water and. if hydrocarbons are present in the gaseous feedstock, carbon dioxide. The tritiated water and any other moisture that might be present in the reaction effluent are next adsorbed by a desiccant dryer. preferably to a level of less than one part per million. Most desirably, the desiccant dryer effluent is then diluted with non-radioactive water such that the tritiated water is diluted by a factor of at least 1,000 to I; the resulting water mixture can
New
be adsorbed from the diluted effluent by a second desiccant dryer to provide a value in the ultimate effluent gas of less than about one-half parts per billion tritiated water.
4472299 GENERATOR FOR RADIONUCLIDE AND PROCESS OF USE THEREOF Peter S Weisner. Terence R Forrest, Amersham, United Kingdom assigned to Amersham International plc
xxvii
Patents
other anti-TAAs, such as human melanomaassociated antigen, human neuroblastoma_ associated antigen, human breast cancerassociated antigen, human ovary-associated antigen, human sarcoma-associated antigen, etc. The biodistribution of the labeled product composition accumulates at cancer sites, e.g.. tumors that produce or express TAA, due to the affinity that the antibody has for the given tumor antigen. The accumulation at the tumor site(s) of a suitable amount of Tc-99m associated with the antibody allows detection via external scintigraphy and other means. Detection of the Tc99m antibody composition by external scintigraphy permits localization and detection of tumors in vivo via a semi-noninvasive technique.
4472508 TEST FOR DETECTING AND MEASURING THE GRAVES’ DISEASE-SPECIFIC IMMUNOGLOBULINS
A generator of radionuclides such as technetium-99m comprises a generator column (10) containing the radionuclide, a first reservoir ( 16) for eluent. a second reservoir (18) to contain a volume of the eluent required for a single elution. and a vessel 40 to contain eluate. First, a pre-set volume of eluent is transferred from the first to the second reservoir; then the eluent is sucked from the second reservoir through the column into the eluate vessel. A hydrophobic filter 32 adjacent the second reservoir (18) permits the use of air to dry the column (10) and to bring the partly filled eluate vessel (40) to atmospheric pressure.
4472371 RADIOLABELED ANTIBODY TO ANTI-TUMOR ASSOCIATED ANTIGEN AND PROCESS
Sidney Ingbar assigned Hospital Association
to The
Beth Israel
An immunoassay for a specific antibody. particularly Graves’ disease-specific antibody, in which interfering reactions by the reactive ends of similar antibodies are eliminated by the step of occluding the interfering reactive ends with an antibody against the interfering reactive ends.
4472829 RADIOGRAPHIC PHANTOM WITH IODINATED CHANNELS Stephen J Riederer, Edmund R Steinike. Frank A DiBianca assigned to General Electric Company
Scott W Burchiel. Buck A Rhodes. David Crockford assigned to Summa Medical Corporation: University Patents I Antibodies to human carcinoembryonic antigen (CEA). human alphafetoprotein (AFP) and/or to other anti-human tumor associated antigens (TAA) labeled with technetium-99m (Tc-99m) are administered to a human after the human has been administered anti-CEA, anti-AFP and/or
A radiographic phantom is comprised of only two materials, a non-iodinated material composing the base and an iodinated material disposed in a channel simulating a blood vessel, thus providing for a resultant signal attributable