4486530 Immunometric assays using monoclonal antibodies

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4486530 IMMUNOMETRIC MONOCLONAL

ASSAYS USING ANTIBODIES

Gary S David, Howard E Greene assigned to Hybritech Incorporated

Patents

preferentially to cancerous or malignant tumor cells in cell collections in vitro or in vivo and thus can be detected by any attached visible or other signal emitter. This preferential attachment to malignant tumor cells also makes these products useful for metabolic and therapeutic purposes.

4486540

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IDENTIFICATION OF REAGINS IN T H E B L O O D S E R U M O F ALLERGEN SENSITIZED VERTEBRATES John H Brewer, Terry Foster assigned to Science Research Center lnc t

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DATE

Two-site or sandwich immunometric assay techniques for determination of the presence and/or concentration of antigenic substances in fluids using monoclonal antibodies are described and compared to conventional assays using polyclonal antibodies. Also described are inhibition assays using complexes of antigens with a monoclonal antibody.

4486538 DETECTION OF MALIGNANT TUMOR CELLS Samuel Bogoch

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The disclosure is of an improved method for the in-vitro detection and identification of reagins in the blood serum of allergen sensitized vertebrates. The improvement comprises admixing the blood serum of the vertebrate with solid, porous carrier particles bearing surface adsorbed, known allergens. An agglutination reaction indicates the presence of reagins corresponding to the surface adsorbed allergen.

4487700

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METHOD AND APPARATUS FOR SEPARATING LYMPHOCYTES FROM ANTICOAGULATED BLOOD

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RAGWEED ALLERGY TEST

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•,:.,_,:-.:..--,--~.,-,-:,. . . . . Described herein is the production of two products which are distinct Sl~eciesof anti-malignin antibody, and the production of three artificially produced species of cell each of which has the distinguishing characteristic of manufacturing either one or both species of anti-maligninantibody. These anti-maligninproducts are useful to detect the presence of cancerous or malignant tumor cells. These anti-maligninproducts attach

Robert Kanter assigned to Technicon Instruments Corporation

The present invention relates to apparatus and method for separating, by centrifugation, blood lymphocytes from other leukocytes in a blood