PATENT ABSTRACTS
decreased levels of which are related to respiratory distress syndrome, are disclosed. The antibodies are useful for prediction and diagnosis of respiratory problems in newborns.
456066O FIXATION SUPPORT MICROORGANISMS
FOR
Gille Geirnaert, Saint Palais sur Mer. France assigned to Argiles & Mineraux A G S - B M P A ceramic support for the fixation of microorganisms thereto consists of a silico-aluminate having 5-25~o magnesia and an average granulometry of 5-300 microns, with the coarsest grains being no more than two times the diameter of the finest grains, and preferably less than 1.5 times the diameter of the smallest grains. This support, which is suitably obtained by calcining a mixture o f kaolinic clay and talc or magnesium carbonate and containing no more than 5 0 ~ cordierite, then grinding and sintering to the desired granulometric distribution, is particularly desirable in the fixing thereto of hybridomas to produce monoclonal antibodies, or biological catalysts.
4561974 APPARATUS FOR THE ANAEROBIC FILTRATION WASTE WATER
OF
Jacques Bernard, Jean-Marie Rovel, Roger Nicol, Claude Prevot, Saint G e r m a n en Laye, France assigned to Degremont An apparatus for the anaerobic filtration o f waste water includes a filter of filling material through which the waste water to be treated is passed from the bottom to the top. The filter includes upper and lower superposed layers of filling material separated by an intermediate layer of material. The lower layer is in the form of an ordered arrangement of the material thereof. The upper and intermediate layers each include a loosely packed arrangement of the material thereof.
4562157 DIAGNOSTIC DEVICE INCORPORATING A BIOCHEMICAL LIGAND Christopher R Lowe, Fergus G P Earley. Newmarket. United Kingdom assigned to National Research Development Corporation A device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a B I O C H E M F E T it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realized under conditions of miniaturization, the invention makes possible printed circuits for proteins. In addition to the device are the process o f m a n u facture thereto, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species. 4563305 RADIOLABELLED SUBSTRATES FOR ASSAYING MAMMALIAN ENZYMES James W Ryan, Alfred C h u n g assigned to University of Miami
4562003 MONOCLONAL ANTIBODIES AGAINST ALVEOLAR SURFACTANT PROTEIN John Lewicki assigned to technology Inc
313
California
Bio-
Monoclonal antibodies specific for a protein associated with a lung surfactant complex,
C o m p o u n d s which are substrates for m a m malian enzymes, especially proteolytic and peptidase enzymes, are disclosed. These compounds, in general, have the general formula X-T, W-Y or X-(Pep)-Y, wherein X is a radiolabelled benzoyl or hydroxyphenylpropanoyl group, T is the -NH residue of a known chromogenic or fluorogenic substrate comprising at least one amino acid group which m a y be substituted with other organic groups, Y is a radiolabelled ben-