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4582845 Pharmaceutical composition for injection
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New Patents
4582822 ANTIBIOTIC A80190, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND METHOD OF USE Robert Hamill, Raymond C Yao assigned to Eli Lilly and Company New polyether antibiotic A80190, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80190 by culture of Actinomodura oligospora NRRL 15877 and synergistic compositions of the A80190 compounds with nicarbazin, 4, 4'dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
4582830 PHARMACEUTICAL COMPOSITIONS Betty L Richardson, Harrow, United Kingdom assigned to Glaxo Group Limited A solid pharmaceutical composition comprising one or more beta-lactam antibiotics in acid or amphoteric form in association with at least one physiologically acceptable base in the presence of a gaseous atmosphere containing a stabilizing amount of carbon dioxide at a concentration greater than that of atmospheric air. The compositions exhibit enhanced stability. A preferred antibiotic for the compositions is ceftazidime or a hydrate thereof, and a preferred base is sodium carbonate or a mixture thereof with one or more other bases.
4582845 PHARMACEUTICAL COMPOSITION FOR INJECTION Yoshiya Yamahira, Keiji Fujioka, Ibaraki, Japan assigned to Sumitomo Pharmaceuticals Co Ltd A pharmaceutical composition i s provided herein containing as a key ingredient 4carbamoyl-imidazolium-5-oleate of the formula (I) See Patent for Chemical Structure (I) its salt
or hydrate thereof, and one or more of a sulfur compound capable of producing at least one of the ions selected from HSO3-, SO32- and $2052• The sulfur compounds prevent discoloration of the composition. The stabilization against coloration is further enhanced by the presence of L-cysteine hydrochloride. The solubility of the compound (I) can be further enhanced by the presence of a basic substance. The active ingredient is known as a therapeutic agent for the treatment of such diseases as rheumatism and nephritis.
4582850 TOPICAL AND SYSTEMIC TREATMENT OF PSORIASIS USING 7-CHLORO-N-(3, 4DICHLOROPHENYL)-2,3DIHYDRO-5-HYDROXY-IBENZOTHIEPIN-4CARBOXAMIDE 1, 1-DIOXIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Hui-Lian Liauw, Howard H Oei, Edmond C Ku assigned to Ciba-Geigy Corporation Psoriasis is treated by the topical or oral administration of an effective endogenous lipoxygenase inhibiting amount of a compound of the formula See Patent for Chemical Structure (I) and the pharmaceutically acceptable salts thereof to a patient in need of the same.
4584197 PROCESS FOR PREPARATION OF FISH AND SHELLFISH EXTRACTS HAVING PHARMACEUTICAL FUNCTIONS Takashi Takasaki, Mitsunori Iwamoto, Karatsu, Japan assigned to Nihon Bussan Kabushiki Kaisha A process for the preparation offish and/or shellfish extracts having various pharmaceutical functions is provided. The process comprises decomposing raw fish and/or shellfish at a pH of 6.0 to 7.0 with a Bacillus subtilis derived pi'oteinase and decomposing at the same pH range with a Koji mould derived proteinase. The product extracts contain peptide amino acids each having a molecular weight of substantially less than 3000 and free amino acids. According to the
New Patents
4582822 ANTIBIOTIC A80190, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND METHOD OF USE Robert Hamill, Raymond C Yao assigned to Eli Lilly and Company New polyether antibiotic A80190, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80190 by culture of Actinomodura oligospora NRRL 15877 and synergistic compositions of the A80190 compounds with nicarbazin, 4, 4'dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
4582830 PHARMACEUTICAL COMPOSITIONS Betty L Richardson, Harrow, United Kingdom assigned to Glaxo Group Limited A solid pharmaceutical composition comprising one or more beta-lactam antibiotics in acid or amphoteric form in association with at least one physiologically acceptable base in the presence of a gaseous atmosphere containing a stabilizing amount of carbon dioxide at a concentration greater than that of atmospheric air. The compositions exhibit enhanced stability. A preferred antibiotic for the compositions is ceftazidime or a hydrate thereof, and a preferred base is sodium carbonate or a mixture thereof with one or more other bases.
4582845 PHARMACEUTICAL COMPOSITION FOR INJECTION Yoshiya Yamahira, Keiji Fujioka, Ibaraki, Japan assigned to Sumitomo Pharmaceuticals Co Ltd A pharmaceutical composition i s provided herein containing as a key ingredient 4carbamoyl-imidazolium-5-oleate of the formula (I) See Patent for Chemical Structure (I) its salt
or hydrate thereof, and one or more of a sulfur compound capable of producing at least one of the ions selected from HSO3-, SO32- and $2052• The sulfur compounds prevent discoloration of the composition. The stabilization against coloration is further enhanced by the presence of L-cysteine hydrochloride. The solubility of the compound (I) can be further enhanced by the presence of a basic substance. The active ingredient is known as a therapeutic agent for the treatment of such diseases as rheumatism and nephritis.
4582850 TOPICAL AND SYSTEMIC TREATMENT OF PSORIASIS USING 7-CHLORO-N-(3, 4DICHLOROPHENYL)-2,3DIHYDRO-5-HYDROXY-IBENZOTHIEPIN-4CARBOXAMIDE 1, 1-DIOXIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Hui-Lian Liauw, Howard H Oei, Edmond C Ku assigned to Ciba-Geigy Corporation Psoriasis is treated by the topical or oral administration of an effective endogenous lipoxygenase inhibiting amount of a compound of the formula See Patent for Chemical Structure (I) and the pharmaceutically acceptable salts thereof to a patient in need of the same.
4584197 PROCESS FOR PREPARATION OF FISH AND SHELLFISH EXTRACTS HAVING PHARMACEUTICAL FUNCTIONS Takashi Takasaki, Mitsunori Iwamoto, Karatsu, Japan assigned to Nihon Bussan Kabushiki Kaisha A process for the preparation offish and/or shellfish extracts having various pharmaceutical functions is provided. The process comprises decomposing raw fish and/or shellfish at a pH of 6.0 to 7.0 with a Bacillus subtilis derived pi'oteinase and decomposing at the same pH range with a Koji mould derived proteinase. The product extracts contain peptide amino acids each having a molecular weight of substantially less than 3000 and free amino acids. According to the