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4675291 Human cultured cell line
399
PATENT ABSTRACTS tritiated proline and tritiated thymidine are forced through respective liver biopsies, and thereafter the respective liver biopsies are evaluated for collagen synthesis and DNA synthesis, respectively, utilizing autoradiographic techniques. 4675287 MONOCLONAL ANTIBODY DIRECTED TO HUMAN GANGLIOSIDE GD2 Ralph A Reisfeld, Grego Schulz assigned to Scripps Clinic and Research Foundation A non-human, mammalian monoclonal receptor produced and secreted by a hybridoma having the ATCC accession number HB 8568 and methods of preparing and using same, as well as diagnostics utilizing the receptor are disclosed. The monoclonal receptor reacts with cells such as human neuroectodermal tumors having ganglioside GD2 antigen expressed on their cellular membrane surfaces. 4675291 HUMAN
CULTURED
are their methods of use and articles of manufacture containing them. 4677058 DETECTING MALIGNANT CELLS WITH MONOCLONAL ANTIBODIES SPECIFIC TO TYPE IV C O L L A G E N A S E ENZYME Kar Tryggvason, Lance Liotta, 90230 Oulu 23, MD, Finland Basement membrane collagen degrading enzymes are provided which are useful for the detection of malignant cells with metastatic activity. Means for detecting such cells are also provided. 4677061 T-CELL LYMPHOCYTE SUBSET MONITORING OF IMMUNOLOGIC DISEASE Lynn M Rose, Edward A Clark, Jeffrey A Ledbetter assigned to Genetic Systems Corporation
CELL LINE
Yuichi Yamamura, Tadamitsu Kishimoto, Satoru Nakai, Yoshikatsu Hirai, Takarazuka, Japan assigned to Otsuka Pharmaceutical Co Ltd This invention provides a novel cultured cell line which is derived from human T leukemic cells and which produces a colony-stimulating factor (CSF). This invention also provides a process for preparing such human cultured cell line, and a process of producing a CSF from such cell line. 4677057 DIAGNOSTIC ASSAY FOR THE PRESENCE OF APOLIPOPROTEINS ASSOCIATED WITH PLASMA HIGH DENSITY LIPOPROTEINS Linda K Curtiss, Thomas S Edgington assigned to Scripps Clinic and Research Foundation Monoclonal receptors that immunologically bind to human apolipoprotein A molecules, particularly apo-A-I and apo-A-ll, are described as
Methods and compositions are provided for determining a change in status of a multiple sclerosis victim. Particularly, the ratio of helper or suppressor T cell subsets having specific surface markers associated with proliferation is determined, where a particular ratio value is associated with a change in status.
4677~3 HUMAN
TUMOR NECROSIS FACTOR
David F Mark, Alice M Wang, Martha Ladner, Abla Creasey, Leo S Lin, Janelle Van Arsdell assigned to Cetus Corporation Human tumor necrosis factor (TNF) has been prepared using recombinant methods. A human promyelocytic leukemia cell line has been induced using an improved induction procedure, and the TNF purified to homogeneity. Methods, vectors, and cells useful in obtaining human TNF in practical amounts are disclosed. Muteins having N-terminal deletions, which muteins have superior biological activity, are also disclosed.
PATENT ABSTRACTS tritiated proline and tritiated thymidine are forced through respective liver biopsies, and thereafter the respective liver biopsies are evaluated for collagen synthesis and DNA synthesis, respectively, utilizing autoradiographic techniques. 4675287 MONOCLONAL ANTIBODY DIRECTED TO HUMAN GANGLIOSIDE GD2 Ralph A Reisfeld, Grego Schulz assigned to Scripps Clinic and Research Foundation A non-human, mammalian monoclonal receptor produced and secreted by a hybridoma having the ATCC accession number HB 8568 and methods of preparing and using same, as well as diagnostics utilizing the receptor are disclosed. The monoclonal receptor reacts with cells such as human neuroectodermal tumors having ganglioside GD2 antigen expressed on their cellular membrane surfaces. 4675291 HUMAN
CULTURED
are their methods of use and articles of manufacture containing them. 4677058 DETECTING MALIGNANT CELLS WITH MONOCLONAL ANTIBODIES SPECIFIC TO TYPE IV C O L L A G E N A S E ENZYME Kar Tryggvason, Lance Liotta, 90230 Oulu 23, MD, Finland Basement membrane collagen degrading enzymes are provided which are useful for the detection of malignant cells with metastatic activity. Means for detecting such cells are also provided. 4677061 T-CELL LYMPHOCYTE SUBSET MONITORING OF IMMUNOLOGIC DISEASE Lynn M Rose, Edward A Clark, Jeffrey A Ledbetter assigned to Genetic Systems Corporation
CELL LINE
Yuichi Yamamura, Tadamitsu Kishimoto, Satoru Nakai, Yoshikatsu Hirai, Takarazuka, Japan assigned to Otsuka Pharmaceutical Co Ltd This invention provides a novel cultured cell line which is derived from human T leukemic cells and which produces a colony-stimulating factor (CSF). This invention also provides a process for preparing such human cultured cell line, and a process of producing a CSF from such cell line. 4677057 DIAGNOSTIC ASSAY FOR THE PRESENCE OF APOLIPOPROTEINS ASSOCIATED WITH PLASMA HIGH DENSITY LIPOPROTEINS Linda K Curtiss, Thomas S Edgington assigned to Scripps Clinic and Research Foundation Monoclonal receptors that immunologically bind to human apolipoprotein A molecules, particularly apo-A-I and apo-A-ll, are described as
Methods and compositions are provided for determining a change in status of a multiple sclerosis victim. Particularly, the ratio of helper or suppressor T cell subsets having specific surface markers associated with proliferation is determined, where a particular ratio value is associated with a change in status.
4677~3 HUMAN
TUMOR NECROSIS FACTOR
David F Mark, Alice M Wang, Martha Ladner, Abla Creasey, Leo S Lin, Janelle Van Arsdell assigned to Cetus Corporation Human tumor necrosis factor (TNF) has been prepared using recombinant methods. A human promyelocytic leukemia cell line has been induced using an improved induction procedure, and the TNF purified to homogeneity. Methods, vectors, and cells useful in obtaining human TNF in practical amounts are disclosed. Muteins having N-terminal deletions, which muteins have superior biological activity, are also disclosed.