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4687733 Early cancer detection method
PATENT ABSTRACTS
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4686191 RECOMBINANT PLASMID CONTAINING HUMAN INTERFERON-BETA GENE Seiga ltoh, Tatsunari Nishi, Tamio Mizukami, Tadash Matsumoto, Tetsuo Oka, Tadatsagu Taniguchi, Haruo Sugano, Sagamihara, Japan assigned to Kyowa Hakko Kogyo Co Ltd; Juridical Foundation Japanese Foundation for Cancer Researc Recombinant vector plasmids containing a DNA fragment coding for human interferon-£62 +0 inserted downstream from a tryptophan promoter are useful for transformation of microorganisms such as Escherichia coil which transformants produce human interferon- t 62. + RE
indirect means, a visualization polymer. The visualization polymer is composed of multiple units of a visualization monomer which are covalently linked together directly or indirectly covalently linked together by coupling agentl which bond to chemical groups of the monomer. The monomer may be an enzyme, a tagged polypeptide, a tagged polyol, a tagged polyolefin or a tagged carbohydrate. The detecting agent may be an antibody, an enzyme, a lectin, strand of a DNA receptor protein, avidin, streptavidin and the like. The visualization polymer produces a high degree of amplification for the detection of the target molecule.
4687733 EARLY CANCER DETECTION METHOD
4686319 SYNTHESIS OF GENETIC FEMALES AND THEIR USE IN HYBRID SEED PRODUCTION Ove Shifriss assigned to Rutgers The State University of New Jersey A synthetic method is described for the development of genetic females in squash (Cucurbita pepo L.) through crosses of monoecious varieties or inbreds followed by selection. The genetic females and true-breeding female lines can be propagated sexually following chemical induction of male flowers. Such female lines can be used as seed parents in production of hybrids as well as germplasm for future breeding programs. The new synthetic method is applicable to other monoecious species of plants.
4687732 VISUALIZATION POLYMERS AND THEIR APPLICATION TO DIAGNOSTIC MEDICINE David C Ward, Jeffry J Leary, David J Brigati assigned to Yale University A method for detecting a minute quantity of an inorganic or organic target molecule by combining it with a composition of a detecting agent for the target molecule which carries, by direct or
Ronald W Trewyn, Ambrosio Steven M D£3 assigned to Ohio State University The invention relates to a method of testing for the presence of cancer. An antibody is produced which contains antibodies specific to a modified nucleoside component. The antibody is admixed with a body fluid drawn from a subject mammal. An immunoassay is performed on the admixture to quantify an amount of cancer associated nucleoside present in the fluid and reactive with the antibody.
4687737 MAMMALIAN SUPPRESSOR GENES Phillip A Sharp, Mario Capecchi, Uttam RajBhandary, Frank A Laski assigned to Massachusetts Institute of Technology A method of suppressing a nonsense codon in a gene in a mammalian cell by preparing an oligonucleotide primer having a mismatched anticodon region corresponding to the nonsense codon; preparing a DNA template for production of a tRNA molecule enabling the insertion of an amino acid when the nonsense codon is translated; forming a suppressor gene from said template and primer by site specific mutagenesis; and transforming the suppressor gene into the cell.
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4686191 RECOMBINANT PLASMID CONTAINING HUMAN INTERFERON-BETA GENE Seiga ltoh, Tatsunari Nishi, Tamio Mizukami, Tadash Matsumoto, Tetsuo Oka, Tadatsagu Taniguchi, Haruo Sugano, Sagamihara, Japan assigned to Kyowa Hakko Kogyo Co Ltd; Juridical Foundation Japanese Foundation for Cancer Researc Recombinant vector plasmids containing a DNA fragment coding for human interferon-£62 +0 inserted downstream from a tryptophan promoter are useful for transformation of microorganisms such as Escherichia coil which transformants produce human interferon- t 62. + RE
indirect means, a visualization polymer. The visualization polymer is composed of multiple units of a visualization monomer which are covalently linked together directly or indirectly covalently linked together by coupling agentl which bond to chemical groups of the monomer. The monomer may be an enzyme, a tagged polypeptide, a tagged polyol, a tagged polyolefin or a tagged carbohydrate. The detecting agent may be an antibody, an enzyme, a lectin, strand of a DNA receptor protein, avidin, streptavidin and the like. The visualization polymer produces a high degree of amplification for the detection of the target molecule.
4687733 EARLY CANCER DETECTION METHOD
4686319 SYNTHESIS OF GENETIC FEMALES AND THEIR USE IN HYBRID SEED PRODUCTION Ove Shifriss assigned to Rutgers The State University of New Jersey A synthetic method is described for the development of genetic females in squash (Cucurbita pepo L.) through crosses of monoecious varieties or inbreds followed by selection. The genetic females and true-breeding female lines can be propagated sexually following chemical induction of male flowers. Such female lines can be used as seed parents in production of hybrids as well as germplasm for future breeding programs. The new synthetic method is applicable to other monoecious species of plants.
4687732 VISUALIZATION POLYMERS AND THEIR APPLICATION TO DIAGNOSTIC MEDICINE David C Ward, Jeffry J Leary, David J Brigati assigned to Yale University A method for detecting a minute quantity of an inorganic or organic target molecule by combining it with a composition of a detecting agent for the target molecule which carries, by direct or
Ronald W Trewyn, Ambrosio Steven M D£3 assigned to Ohio State University The invention relates to a method of testing for the presence of cancer. An antibody is produced which contains antibodies specific to a modified nucleoside component. The antibody is admixed with a body fluid drawn from a subject mammal. An immunoassay is performed on the admixture to quantify an amount of cancer associated nucleoside present in the fluid and reactive with the antibody.
4687737 MAMMALIAN SUPPRESSOR GENES Phillip A Sharp, Mario Capecchi, Uttam RajBhandary, Frank A Laski assigned to Massachusetts Institute of Technology A method of suppressing a nonsense codon in a gene in a mammalian cell by preparing an oligonucleotide primer having a mismatched anticodon region corresponding to the nonsense codon; preparing a DNA template for production of a tRNA molecule enabling the insertion of an amino acid when the nonsense codon is translated; forming a suppressor gene from said template and primer by site specific mutagenesis; and transforming the suppressor gene into the cell.