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4693975 Human hybridroma fusion partner for production of human monoclonal antibodies
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PATENT ABSTRACTS
4692416 MONOCLONAL ANTIBODIES REACTIVE WITH SHARED IDIOTYPES ON HUMAN ANTIBODIES TO NATIVE DNA FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS Betty A Diamond assigned to Yeshiva University The invention relates to monoclonal antiidiotypic antibodies to human anti-DNA antibodies. Monoclonal, anti-idiotypic antibodies are produced using hybridoma technology. The antibodies are used as diagnostic reagents in methods to determine the presence of anti-native DNA antibodies in serum from patients suspected of having systemic lupus erythematosus.
4692509 RADIOACTIVE LABELING OF PROTEINS WITH NUCLEOSIDES OR NUCLEOTIDES Nanibhushan Dattagupta assigned to Molecular Diagnostics lnc A radioactively labeled protein comprising a protein, and a radioactive nucleoside or nucleotide, the protein being covalently linked to the nucleoside or nucleotide. Advantageously the linkage is through an NH2 group of the protein and through a carbonyl group of a ringopened sugar moiety of the nucleoside or nucleotide. The protein can be insulin, an immunoglobulin or protein A. The radioactive moiety may be a P, C, S, H, I or Hg atom. The labels can be used to indicate the presence and amount of the protein in a biological assay.
eggs and that reassorted viruses having it as a parent may also grow well in eggs. It has now been found that certain reassortants of A/PR/8/34 and equine influenza viruses, namely those which comprise the RNA7 se~nent from A/PR/8/34, will grow in cell culture, even though the parent equine influenza vius will not. Thus the specification describes and claims: reassorted viruses comprising genes for surface antigens of equine influenza viruses and the RNA7 segment from A/PR/8/34; methods of obtaining such viruses by reassortment; methods of propagating such reassorted viruses in cell culture, especially Vero cells; vaccines against equine influenza comprising such reassorted viruses; and methods of vaccinating equines against influenza.
469~73 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING BOVINE GROWTH HORMONE-LIKE POLYPEPTIDES IN HIGH YIELD Gary N Buell, Geneva, Switzerland assigned to Biogen N V DNA sequences, recombinant DNA molecules and processes for producing bovine growth hormone-like polypeptides in high yield and the novel polypeptides produced thereby. These polypeptides are useful in improving the rate of growth of and meat production and quality in cattle.
469~75
4693893
HUMAN HYBRIDROMA FUSION PARTNER FOR PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES
VACCINES FOR EQUINE INFLUENZA
Danuta Kozbor, Carlo M Croce assigned to The Wistar Institute
David Campbell assigned to Burroughs Wellcome
It is known that the human influenza Virus strain A/Puerto Rico/8/34 grows particularly well in
Somatic cell hybrids of purely human origin are described that are suitable fusion partners for producing hybridomas by fusion with antibody producing cells, which hybridomas are stable and continuous.
PATENT ABSTRACTS
4692416 MONOCLONAL ANTIBODIES REACTIVE WITH SHARED IDIOTYPES ON HUMAN ANTIBODIES TO NATIVE DNA FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS Betty A Diamond assigned to Yeshiva University The invention relates to monoclonal antiidiotypic antibodies to human anti-DNA antibodies. Monoclonal, anti-idiotypic antibodies are produced using hybridoma technology. The antibodies are used as diagnostic reagents in methods to determine the presence of anti-native DNA antibodies in serum from patients suspected of having systemic lupus erythematosus.
4692509 RADIOACTIVE LABELING OF PROTEINS WITH NUCLEOSIDES OR NUCLEOTIDES Nanibhushan Dattagupta assigned to Molecular Diagnostics lnc A radioactively labeled protein comprising a protein, and a radioactive nucleoside or nucleotide, the protein being covalently linked to the nucleoside or nucleotide. Advantageously the linkage is through an NH2 group of the protein and through a carbonyl group of a ringopened sugar moiety of the nucleoside or nucleotide. The protein can be insulin, an immunoglobulin or protein A. The radioactive moiety may be a P, C, S, H, I or Hg atom. The labels can be used to indicate the presence and amount of the protein in a biological assay.
eggs and that reassorted viruses having it as a parent may also grow well in eggs. It has now been found that certain reassortants of A/PR/8/34 and equine influenza viruses, namely those which comprise the RNA7 se~nent from A/PR/8/34, will grow in cell culture, even though the parent equine influenza vius will not. Thus the specification describes and claims: reassorted viruses comprising genes for surface antigens of equine influenza viruses and the RNA7 segment from A/PR/8/34; methods of obtaining such viruses by reassortment; methods of propagating such reassorted viruses in cell culture, especially Vero cells; vaccines against equine influenza comprising such reassorted viruses; and methods of vaccinating equines against influenza.
469~73 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING BOVINE GROWTH HORMONE-LIKE POLYPEPTIDES IN HIGH YIELD Gary N Buell, Geneva, Switzerland assigned to Biogen N V DNA sequences, recombinant DNA molecules and processes for producing bovine growth hormone-like polypeptides in high yield and the novel polypeptides produced thereby. These polypeptides are useful in improving the rate of growth of and meat production and quality in cattle.
469~75
4693893
HUMAN HYBRIDROMA FUSION PARTNER FOR PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES
VACCINES FOR EQUINE INFLUENZA
Danuta Kozbor, Carlo M Croce assigned to The Wistar Institute
David Campbell assigned to Burroughs Wellcome
It is known that the human influenza Virus strain A/Puerto Rico/8/34 grows particularly well in
Somatic cell hybrids of purely human origin are described that are suitable fusion partners for producing hybridomas by fusion with antibody producing cells, which hybridomas are stable and continuous.