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4693994 Protective synthetic peptide against malaria and encoding gene
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PATENT ABSTRACTS
Somatic cell hybrids of purely human origin are described that are suitable fusion partners for producing hybridomas by fusion with antibody producing cells, which hybridomas are stable and continuous.
4693977 ENZYME IMMOBILIZATION FOR PRODUCING CEPHALOSPORIN ANTIBIOTICS Saul Wolfe, Donald Westlake, Susan Jensen, Kingston, Canada assigned to Queen£3 s University at Kingston Enzymes extracted from a prokaryotic £62 lactam producing microorganism are immobilized on a support for producing desacetoxyeephalosporin and analogs thereof from L- + 60 -aminoadipyl-L-cysteinyl-D-valine and analogs thereof. The enzymes are an epimerase, a eyclase and a ring expansion enzyme extracted preferably from + I S. clavuligerus, S. cattleya + L or + I S. lipmanii. + L The support is preferably a diethylaminoethyl ion exchange resin.
4693985 METHODS OF CONCENTRATING LIGANDS AND ACTIVE MEMBRANES USED THEREFOR Peter J Degen, Jerold Martin, Judy Schriefer, Brenda Shirley assigned to Pall Corporation A chemically active membrane having a large surface area is provided in which a hydrophilic, microporous, skinless, polyamide membrane is chemically bound to a residue of an activating agent which is capable of reacting with a biologically active material. The chemically active membrane, formed by reacting a hydrophilic, microporous, skinless, polyamide membrane with an activating agent may be used to prepare a biologically active membrane having a large surface area which comprises an acceptor molecule such as a monoclonal antibody, a polyclonal antibody, an antigenic substance, a glycoprotein, Protein A, a lectin, a carbohydrate, an enzyme substrate, a cofactor, an inhibitor, a hormone, an IgG class of immunoglobulin, a carrier protein, a receptor, heparin, a coagulation factor, or a histone covalently bound to the hydrophilie, microporous, skinless, polyamide membrane by reacting the
chemically activate membrane with the acceptor molecule.
4693994 PROTECTIVE SYNTHETIC PEPTIDE AGAINST MALARIA AND ENCODING GENE Thomas McCutchan, Richar Wistar assigned to The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services The present invention discloses a synthetic peptide capable of inducing antibodies protective against human malarial infection caused by Plasmodium vivax sporozoites and the cloning of a gene encoding said peptide. The amino acid and nucleotide sequences of the peptide and the gene, respectively, have been determined and described.
4694071 POLYPEPTIDES
USEFUL
IN
VACCINATION A G A I N S T ENTEROVIRUSES Jeffrey W Almond, Phillip D Minor, David M A Evans, Geoffrey C Schild, Leicester, United Kingdom assigned to National Research Development Corporation A synthetic polypeptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus, is an oetapeptide coded for by codons 93£14 100 in the RNA sequence coded for the structural capsid protein VPI for poliovirus type 3 Sabin strain or by equivalent eodons of another enterovirus or is an antigenic equivalent of such an oetapeptide, the numbers of the codons being counted from the 5+40 terminus of the nueleotide sequence for the VPI capsid protein.
4694074 PROCESS FOR THE P U R I F I C A T I O N O F HBSAG Yahiro Uemura, Takao Ohmura, Akimas Ohmizu, Akinori Sumi, Wataru Ohtani, Yoshitak Sakanishi, Hiroshi Morise, Hirofumi Arimura, Tadakazu Suyama, Osaka, Japan assigned to Green Cross Corporation
PATENT ABSTRACTS
Somatic cell hybrids of purely human origin are described that are suitable fusion partners for producing hybridomas by fusion with antibody producing cells, which hybridomas are stable and continuous.
4693977 ENZYME IMMOBILIZATION FOR PRODUCING CEPHALOSPORIN ANTIBIOTICS Saul Wolfe, Donald Westlake, Susan Jensen, Kingston, Canada assigned to Queen£3 s University at Kingston Enzymes extracted from a prokaryotic £62 lactam producing microorganism are immobilized on a support for producing desacetoxyeephalosporin and analogs thereof from L- + 60 -aminoadipyl-L-cysteinyl-D-valine and analogs thereof. The enzymes are an epimerase, a eyclase and a ring expansion enzyme extracted preferably from + I S. clavuligerus, S. cattleya + L or + I S. lipmanii. + L The support is preferably a diethylaminoethyl ion exchange resin.
4693985 METHODS OF CONCENTRATING LIGANDS AND ACTIVE MEMBRANES USED THEREFOR Peter J Degen, Jerold Martin, Judy Schriefer, Brenda Shirley assigned to Pall Corporation A chemically active membrane having a large surface area is provided in which a hydrophilic, microporous, skinless, polyamide membrane is chemically bound to a residue of an activating agent which is capable of reacting with a biologically active material. The chemically active membrane, formed by reacting a hydrophilic, microporous, skinless, polyamide membrane with an activating agent may be used to prepare a biologically active membrane having a large surface area which comprises an acceptor molecule such as a monoclonal antibody, a polyclonal antibody, an antigenic substance, a glycoprotein, Protein A, a lectin, a carbohydrate, an enzyme substrate, a cofactor, an inhibitor, a hormone, an IgG class of immunoglobulin, a carrier protein, a receptor, heparin, a coagulation factor, or a histone covalently bound to the hydrophilie, microporous, skinless, polyamide membrane by reacting the
chemically activate membrane with the acceptor molecule.
4693994 PROTECTIVE SYNTHETIC PEPTIDE AGAINST MALARIA AND ENCODING GENE Thomas McCutchan, Richar Wistar assigned to The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services The present invention discloses a synthetic peptide capable of inducing antibodies protective against human malarial infection caused by Plasmodium vivax sporozoites and the cloning of a gene encoding said peptide. The amino acid and nucleotide sequences of the peptide and the gene, respectively, have been determined and described.
4694071 POLYPEPTIDES
USEFUL
IN
VACCINATION A G A I N S T ENTEROVIRUSES Jeffrey W Almond, Phillip D Minor, David M A Evans, Geoffrey C Schild, Leicester, United Kingdom assigned to National Research Development Corporation A synthetic polypeptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus, is an oetapeptide coded for by codons 93£14 100 in the RNA sequence coded for the structural capsid protein VPI for poliovirus type 3 Sabin strain or by equivalent eodons of another enterovirus or is an antigenic equivalent of such an oetapeptide, the numbers of the codons being counted from the 5+40 terminus of the nueleotide sequence for the VPI capsid protein.
4694074 PROCESS FOR THE P U R I F I C A T I O N O F HBSAG Yahiro Uemura, Takao Ohmura, Akimas Ohmizu, Akinori Sumi, Wataru Ohtani, Yoshitak Sakanishi, Hiroshi Morise, Hirofumi Arimura, Tadakazu Suyama, Osaka, Japan assigned to Green Cross Corporation