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4695277 Pharmaceutical adhesive plaster and method for manufacturing it
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New Patents
4694004 SEMICARBAZIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Osam Nakaguti, Norihiko Shimazaki, Yoshio Kawai, Masashi Hashimoto, Michie Nakatuka, Toyonaka, Japan assigned to Fujisawa Pharmaceutical Co Ltd A compound of the formula: See Patent for Chemical Structure wherein R1 is hydrogen, R2 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl, R3 is lower alkyl, ar(lower)alkyl, lower aikenyl or aryl, or R2 and R3 are taken together to form (C2£14 C + H D 6 + L )alkylidene group optionally substituted with aryl or taken together with the attached nitrogen atom to form a saturated or unsaturated, 5- or 6membered heterocyclic group optionally substituted with aryl or lower alkyl; or +RE+POR+HU 1 +LandR+HU 2 +Lare taken together with the attached nitrogen atoms to form a saturated or unsaturated, 5- or 6membered heterocyclic group or 1,2diazaspiroalkane- 1,2-diyl group, + RE + P0 R + H U 3 + L is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl; + RE + P0 R + H U 4 + L is lower alkyl optionally substituted with di(lower)alkylamino or a heterocyclic group, or a heterocyclic group optionally having suitable substituent(s), + RE +P0 R + H U 5 + L is hydrogen or lower alkyl, and + R E + P 0 X is O or S, + R E + P S and a pharmaceutically acceptable salt thereof may be used as anti-inflammatory and analgesic agents O or S, and a pharmaceutically acceptable s alt thereof may be used as anti-inflammatory and analgesic agents.
4694020 DERIVATIVES OF 2(SUBSTITUTED SULFAMYL)-6NITROBENZOIC ACIDS AND PHARMACEUTICAL COMPOSITIONS Edward L Engelhardt, Walfred Saari assigned to Merck & Co Inc
Derivatives of 2-(substituted sulfamyl) 6nitrobenzoic acids are disclosed, wherein at least one of the sulfamyl substituents is selected from amino-(lower alkyi), (lower alkyl)-amino-(lower alkyl), or di(lower alkyl)-amino-(lower alkyl), hydrogen, lower alkyl, hydroxy-(lower alkyl), allyl, or when taken together with the nitrogen of the sulfamyl moiety, form a heterocyclic ring. These compounds have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.
4695277 PHARMACEUTICAL ADHESIVE PLASTER AND METHOD FOR MANUFACTURING IT Willi Lauk, Schorndorf Haubersbronn, Federal Republic Of Germany assigned to Allpack Industrieile Lohnverpackung GmbH & Co KG In order that, in a plaster comprising a composite film having a recess for holding the medicament and having a layer of adhesive surrounding the recess and a composite covering film glued to the recess and covering it, the galenical may be optimized regardless of the properties of a matrix containing the medicament in the recess, it is proposed to close the recess by means of a membrane which is firmly connected to the composite film and is permeable to the active ingredient of the medicament, and to join the composite covering film hermetically to the composite film along a ring extending between the central membrane and the surrounding layer of adhesive. To provide a process for the production of such a plaster in which two separately produced, outer parts of the plaster are joined together in a separable manner by means of an inner layer of adhesive, which process should be capable of rational mass production of the plaster, it is proposed to produce the layer of adhesive as a component of an inner, third part of the plaster, which is produced separately from the two outer parts of the plaster and is subsequently firmly connected to these outer parts.
New Patents
4694004 SEMICARBAZIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Osam Nakaguti, Norihiko Shimazaki, Yoshio Kawai, Masashi Hashimoto, Michie Nakatuka, Toyonaka, Japan assigned to Fujisawa Pharmaceutical Co Ltd A compound of the formula: See Patent for Chemical Structure wherein R1 is hydrogen, R2 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl, R3 is lower alkyl, ar(lower)alkyl, lower aikenyl or aryl, or R2 and R3 are taken together to form (C2£14 C + H D 6 + L )alkylidene group optionally substituted with aryl or taken together with the attached nitrogen atom to form a saturated or unsaturated, 5- or 6membered heterocyclic group optionally substituted with aryl or lower alkyl; or +RE+POR+HU 1 +LandR+HU 2 +Lare taken together with the attached nitrogen atoms to form a saturated or unsaturated, 5- or 6membered heterocyclic group or 1,2diazaspiroalkane- 1,2-diyl group, + RE + P0 R + H U 3 + L is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl; + RE + P0 R + H U 4 + L is lower alkyl optionally substituted with di(lower)alkylamino or a heterocyclic group, or a heterocyclic group optionally having suitable substituent(s), + RE +P0 R + H U 5 + L is hydrogen or lower alkyl, and + R E + P 0 X is O or S, + R E + P S and a pharmaceutically acceptable salt thereof may be used as anti-inflammatory and analgesic agents O or S, and a pharmaceutically acceptable s alt thereof may be used as anti-inflammatory and analgesic agents.
4694020 DERIVATIVES OF 2(SUBSTITUTED SULFAMYL)-6NITROBENZOIC ACIDS AND PHARMACEUTICAL COMPOSITIONS Edward L Engelhardt, Walfred Saari assigned to Merck & Co Inc
Derivatives of 2-(substituted sulfamyl) 6nitrobenzoic acids are disclosed, wherein at least one of the sulfamyl substituents is selected from amino-(lower alkyi), (lower alkyl)-amino-(lower alkyl), or di(lower alkyl)-amino-(lower alkyl), hydrogen, lower alkyl, hydroxy-(lower alkyl), allyl, or when taken together with the nitrogen of the sulfamyl moiety, form a heterocyclic ring. These compounds have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.
4695277 PHARMACEUTICAL ADHESIVE PLASTER AND METHOD FOR MANUFACTURING IT Willi Lauk, Schorndorf Haubersbronn, Federal Republic Of Germany assigned to Allpack Industrieile Lohnverpackung GmbH & Co KG In order that, in a plaster comprising a composite film having a recess for holding the medicament and having a layer of adhesive surrounding the recess and a composite covering film glued to the recess and covering it, the galenical may be optimized regardless of the properties of a matrix containing the medicament in the recess, it is proposed to close the recess by means of a membrane which is firmly connected to the composite film and is permeable to the active ingredient of the medicament, and to join the composite covering film hermetically to the composite film along a ring extending between the central membrane and the surrounding layer of adhesive. To provide a process for the production of such a plaster in which two separately produced, outer parts of the plaster are joined together in a separable manner by means of an inner layer of adhesive, which process should be capable of rational mass production of the plaster, it is proposed to produce the layer of adhesive as a component of an inner, third part of the plaster, which is produced separately from the two outer parts of the plaster and is subsequently firmly connected to these outer parts.