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4695562 Synthetic peptide compounds
PATENT ABSTRACTS
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not effect the other cell types. The material is added prior to centrifugation of the blood sample. An example of a bonding agent is a monoclonal antibody.
biological and pharmacological properties but which substantially retain other such properties.
4695562
MONOCLONAL ANTI-PROTEIN C ANTIBODY, ITS PREPARATION AND USE THEREOF
SYNTHETIC PEPTIDE COMPOUNDS Edwin H Beachey, Andr Tartar, Helene GrasMasse, Michel Jolivet, Francoise Audibert, Louis Chedid assigned to Univ of Tennessee Research Corp Peptide fragment of M protein of S. pyrogenes elecit opsonic antibodies which are type-specific for type 24 streptococci.
4695623 CONSENSUS HUMAN LEUKOCYTE INTERFERON Yitzha Stabinsky assigned to Amgen Described are rapid and highly efficient procedures for the total synthesis of linear, double stranded DNA sequences in excess of about 200 base pairs in length, which sequences may comprise entire structural genes. Novel sequences are prepared from two or more DNA subunits provided with terminal regions comprising restriction endonuclease cleavage sites facilitating insertion of subunits into a selected vector for purposes of amplification during the course of the total assembly process. The total, finallyassembled assembled sequences include at least one, and preferably two or more, unique restriction endonuclease cleavage site(s) at intermediate positions along the sequence, allowing for easy excision and replacement of subunits and the correspondingly facile preparation of multiple structural analogs of polypeptides coded for by the sequences. Manufactured genes preferably include codons selected from among alternative codons specifying the same amino acid on the basis of preferential expression in a projected host microorganism (e.g., E. coil) to be transformed. Illustrated is the preparation and expression of manufactured genes capable of directing synthesis of human immune and leukocyte interferons and of other biologically active proteinaceous products, which products differ from naturally-occurring forms in terms of the identity and/or relative position of one or more amino acids, and in terms of one or more
4696895
Tatsuo Yamashita, Masafumi Terada, Koji Suzuki, Kobe, Japan assigned to Fujisawa Pharmaceutical Co Ltd Monoclonal anti-human protein C antibodies which bind to the heavy chain of protein C are disclosed.
4696896 GONOCOCCAL PILl PROCESSES FOR THE PREPARATION THEREOF AND THE USE THEREOF FOR THE DETECTION OF AND PREVENTION OF INFECTIONS CAUSED BY NEISSERIA GONORRHOEAE Charles C Brinton, John C McMichael assigned to Bactex Inc There are provided a crystalline and single rod products derivable from the Pili of Type 1 and Type 2 Neisseria gonorrhoese organisms. There are provided methods of growing said organisms to produce the maximum yield of Pili and procedures for purifying said Pill to produce said crystalline material. There are further provided methods of utilizing said Pili to determine the presence, in a system infectable by N. gonorrhoese organisms, of antibodies to the Pili of said organisms, and methods of serotyping said Pili. There is also provided a mode of utilizing said crystalline material to provide a substantial degree of immunization infection by N. gonorrhoese in mammalian systems susceptible to such infection.
4696899 PROCESS FOR THE PREPARATION OF HUMAN LEUKOCYTE AND HUMAN GAMMA INTERFERON Miklos Toth, Valeria Endresz, llona Beladi, Sandor Toth, Szeged, Hungary assigned to EGYT Gyogyszervegyeszeti Gyar
110
not effect the other cell types. The material is added prior to centrifugation of the blood sample. An example of a bonding agent is a monoclonal antibody.
biological and pharmacological properties but which substantially retain other such properties.
4695562
MONOCLONAL ANTI-PROTEIN C ANTIBODY, ITS PREPARATION AND USE THEREOF
SYNTHETIC PEPTIDE COMPOUNDS Edwin H Beachey, Andr Tartar, Helene GrasMasse, Michel Jolivet, Francoise Audibert, Louis Chedid assigned to Univ of Tennessee Research Corp Peptide fragment of M protein of S. pyrogenes elecit opsonic antibodies which are type-specific for type 24 streptococci.
4695623 CONSENSUS HUMAN LEUKOCYTE INTERFERON Yitzha Stabinsky assigned to Amgen Described are rapid and highly efficient procedures for the total synthesis of linear, double stranded DNA sequences in excess of about 200 base pairs in length, which sequences may comprise entire structural genes. Novel sequences are prepared from two or more DNA subunits provided with terminal regions comprising restriction endonuclease cleavage sites facilitating insertion of subunits into a selected vector for purposes of amplification during the course of the total assembly process. The total, finallyassembled assembled sequences include at least one, and preferably two or more, unique restriction endonuclease cleavage site(s) at intermediate positions along the sequence, allowing for easy excision and replacement of subunits and the correspondingly facile preparation of multiple structural analogs of polypeptides coded for by the sequences. Manufactured genes preferably include codons selected from among alternative codons specifying the same amino acid on the basis of preferential expression in a projected host microorganism (e.g., E. coil) to be transformed. Illustrated is the preparation and expression of manufactured genes capable of directing synthesis of human immune and leukocyte interferons and of other biologically active proteinaceous products, which products differ from naturally-occurring forms in terms of the identity and/or relative position of one or more amino acids, and in terms of one or more
4696895
Tatsuo Yamashita, Masafumi Terada, Koji Suzuki, Kobe, Japan assigned to Fujisawa Pharmaceutical Co Ltd Monoclonal anti-human protein C antibodies which bind to the heavy chain of protein C are disclosed.
4696896 GONOCOCCAL PILl PROCESSES FOR THE PREPARATION THEREOF AND THE USE THEREOF FOR THE DETECTION OF AND PREVENTION OF INFECTIONS CAUSED BY NEISSERIA GONORRHOEAE Charles C Brinton, John C McMichael assigned to Bactex Inc There are provided a crystalline and single rod products derivable from the Pili of Type 1 and Type 2 Neisseria gonorrhoese organisms. There are provided methods of growing said organisms to produce the maximum yield of Pili and procedures for purifying said Pill to produce said crystalline material. There are further provided methods of utilizing said Pili to determine the presence, in a system infectable by N. gonorrhoese organisms, of antibodies to the Pili of said organisms, and methods of serotyping said Pili. There is also provided a mode of utilizing said crystalline material to provide a substantial degree of immunization infection by N. gonorrhoese in mammalian systems susceptible to such infection.
4696899 PROCESS FOR THE PREPARATION OF HUMAN LEUKOCYTE AND HUMAN GAMMA INTERFERON Miklos Toth, Valeria Endresz, llona Beladi, Sandor Toth, Szeged, Hungary assigned to EGYT Gyogyszervegyeszeti Gyar