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4710519 Process for preparing spray dried acetaminophen powder and the powder prepared thereby
PATENT ABSTRACTS
260 4710513
SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS Alvin K Willard, Frederick C Novello, William Hoffman, Edward J Cragoe assigned to Merck & Co Inc 6-Phenyl-, phenylalkyl- and phenylethenyl-4hydroxytetrahydropyran-2-ones in the 4(R)trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3methylglutaryl-coenzyme A reductase.
4710515 SUBSTITUTED BIPHENYL DERIVATIVES Alan R Kirk, Robert A Scherrer assigned to Riker Laboratories Inc Novel compounds which are 2,6-di-tertiarybutylphenols substituted in the 4 position by an acylaminophenyl group, which acylaminophenyl group is substituted by a moiety which includes a carboxyl group, are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents.
4710517 MEDICAL COMPOSITION FOR INJECTION CONTAINING A SPERGUALIN AS ACTIVE INGREDIENT AND PROCESS FOR
PREPARING THE S A M E Hamao Umezawa, Shintaro Suzuki, Taka'ak Ohkuma, Fumihiro Sato, Teruya Nakamura, Tokyo, Japan assigned to Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai The present invention relates to a stable medical composition for injection containing (1) a Spergualin of the formula: See Patent for Chemical Structure See Patent for Tabular Presentation PS (wherein R is See Patent for Chemical Structure -(CH2)6-, -(CH2)4-CH double bondCH-, See Patent for Chemical Structure (wherein R' is a lower alkyl group having 1 to 4 carbon atoms), -(CH2)8-, or See Patent for Chemical Structure or a salt thereof and (2) at
least one stabilizer selected from the group consisting of mannitol, maltose, dextran, lactose, cyclodextrin, gelatin, chondroitin sulfate, and human serum albumin; when R is See PatentJbr Chemical Structure mannitol is expected. A spergualin is useful as cancer control agents and immunomodulators. 4710519
P R O C E S S FOR PREPARING SPRAY DRIED A C E T A M I N O P H E N P O W D E R A N D THE P O W D E R PREPARED THEREBY Jeffrey Finnan, Rudolph E Lisa, Douglass Schmidt assigned to BASF Corporation The subject invention relates to a process for preparing acetaminophen powders by spray drying the acetaminophen in the presence of various excipients. Preferably a lubricant is incorporated into the acetaminophen powder during the spray drying process or after the spray drying process by passing the spray dried acetaminophen powder through a fluidized bed dryer which contains a lubricant.
4710568 CARBAPENEM
ANTIBIOTICS
Choung Un Kim, Peter F Misco assigned to Bristol-Myers Company Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula See Patent for Chemical Structure in which A represents cyclopentylene, cyclohexylene or C2C6 alkylene optionally substituted by one or more CI-C4 alkyl groups and See Patent for Chemical Structure represents a quaternized nitrogen-containing aromatic heterocycle. Such derivatives are useful as potent antibacterial agents. Also disclosed are processes for the preparation of such derivatives and novel intermediates utilized in these processes.
4710572 HISTAMINE
HIANTAGONISTS
Magid A Abou-Gharbia, Susan T Nielsen assigned to American Home Products Corporation
260 4710513
SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS Alvin K Willard, Frederick C Novello, William Hoffman, Edward J Cragoe assigned to Merck & Co Inc 6-Phenyl-, phenylalkyl- and phenylethenyl-4hydroxytetrahydropyran-2-ones in the 4(R)trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3methylglutaryl-coenzyme A reductase.
4710515 SUBSTITUTED BIPHENYL DERIVATIVES Alan R Kirk, Robert A Scherrer assigned to Riker Laboratories Inc Novel compounds which are 2,6-di-tertiarybutylphenols substituted in the 4 position by an acylaminophenyl group, which acylaminophenyl group is substituted by a moiety which includes a carboxyl group, are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents.
4710517 MEDICAL COMPOSITION FOR INJECTION CONTAINING A SPERGUALIN AS ACTIVE INGREDIENT AND PROCESS FOR
PREPARING THE S A M E Hamao Umezawa, Shintaro Suzuki, Taka'ak Ohkuma, Fumihiro Sato, Teruya Nakamura, Tokyo, Japan assigned to Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai The present invention relates to a stable medical composition for injection containing (1) a Spergualin of the formula: See Patent for Chemical Structure See Patent for Tabular Presentation PS (wherein R is See Patent for Chemical Structure -(CH2)6-, -(CH2)4-CH double bondCH-, See Patent for Chemical Structure (wherein R' is a lower alkyl group having 1 to 4 carbon atoms), -(CH2)8-, or See Patent for Chemical Structure or a salt thereof and (2) at
least one stabilizer selected from the group consisting of mannitol, maltose, dextran, lactose, cyclodextrin, gelatin, chondroitin sulfate, and human serum albumin; when R is See PatentJbr Chemical Structure mannitol is expected. A spergualin is useful as cancer control agents and immunomodulators. 4710519
P R O C E S S FOR PREPARING SPRAY DRIED A C E T A M I N O P H E N P O W D E R A N D THE P O W D E R PREPARED THEREBY Jeffrey Finnan, Rudolph E Lisa, Douglass Schmidt assigned to BASF Corporation The subject invention relates to a process for preparing acetaminophen powders by spray drying the acetaminophen in the presence of various excipients. Preferably a lubricant is incorporated into the acetaminophen powder during the spray drying process or after the spray drying process by passing the spray dried acetaminophen powder through a fluidized bed dryer which contains a lubricant.
4710568 CARBAPENEM
ANTIBIOTICS
Choung Un Kim, Peter F Misco assigned to Bristol-Myers Company Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula See Patent for Chemical Structure in which A represents cyclopentylene, cyclohexylene or C2C6 alkylene optionally substituted by one or more CI-C4 alkyl groups and See Patent for Chemical Structure represents a quaternized nitrogen-containing aromatic heterocycle. Such derivatives are useful as potent antibacterial agents. Also disclosed are processes for the preparation of such derivatives and novel intermediates utilized in these processes.
4710572 HISTAMINE
HIANTAGONISTS
Magid A Abou-Gharbia, Susan T Nielsen assigned to American Home Products Corporation