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4716151 Tripeptides and their use
274
PATENT ABSTRACTS 4716149
4716153
PARTIALLY MODIFIED, RETROINVERSO NEUROTENSIN ANALOGS
STABLE ORAL PREPARATION OF MACROLIDE ANTIBIOTICS AND METHOD FOR STABILIZING THE SAME
Fabio Bonelli, Antonell Pessi, Antonio S Verdini, Rome, Italy assigned to Enichem S p A; Eniricerche S p Pharmacologically active, partially retroinverso, neurotensin-like peptides lasting longer than the natural hormone, corresponding to the formula See Patent for Chemical Structure wherein R I and R2 are straight or branched (C1C7) alkyl radicals. The new compounds are useful as va=odilating and hypotensive agents.
4716151 TRIPEPTIDES
AND THEIR USE
Pierre Jolles, Daniele Migliore-Samour, Fabienne Parker, Paris, France assigned to Rhone-Poulenc Sante Tripeptides composed of the amino acids glycine, leucine, and phenylalanine or tyrosine obtainable by fractionation of hydrolysis products of human casein or by direct synthesis can be used as immunostimulants.
4716152 PHARMACEUTICAL USE OF SUBSTITUTED OACYLGLYCOSIDES Bernd-Wieland Kruger, Oswald Lockhoff, Karl G Metzger, Hans-Georg Opitz, Klaus Schaller, Klaus G Stunkel, Hans-Joachi Zeiler, Wuppertal, Federal Republic Of Germany assigned to Bayer Aktiengesellschaft Compounds of the formula See Patent jbr Chemical Structure in which X is hydrogen or the radical CH2OR5, R2, R3, R4 and R5 each independently is hydrogen or the radical See Patent for Chemical Structure Y is oxygen, sulphur, NH or CH2, and R1 and R6 each independently is an optionally substituted hydrocarbon radical having up to 50 carbon atoms, with the proviso that at least one of the radicals RI and/or R6 contains between 9 to 50 carbon atoms, some of which are known, stimulate the immune system's response and antibody production.
Masataka Morishita, Masaru Ono, Yukio Sumita, Shizuoka, Japan assigned to Toyo Jozo Company Ltd Stable oral preparations of 16-membered ring macrolide antibiotics such as SF-837, josamycin, 3"-propionyljosamycin, by incorporating stabilizers showing pH 3-10 in an aqueous medium, such as glycine, and dissolution accelerators showing pH 2.5-4 in an aqueous medium such as citric acid or tartaric acid. Coating such dissolution accelerators with a film-forming substance is useful to enhance the stability of the oral preparation of such antibiotics. 4716154 GEL OF CROSSLINKED HYALURONIC ACID FOR USE AS A VITREOUS HUMOR SUBSTITUTE Toma Malson, Bengt L Lindqvist, Uppsala, Sweden assigned to Pharmacia AB The invention is concerned with a vitreous humor substitute intended for ophthalmological uses and consisting of a gel of crosslinked hyaluronic acid and a method at retinal surgery and after vitrectomy when the vitreous humor completely or partially is exchanged for such a gel. 4716155 PHOSPHORUS CONTAINING COMPOUNDS AND HYPOTENSIVE USE THEREOF Donald S Karanewsky, Edward Petrillo assigned to E R Squibb & Sons Inc Phosphorus containing compounds of the formula See Patent for Chemical Structure wherein X is a substituted or unsubstituted imino or amino acid and A is See Patent for Chemical Structure These compounds possess angiotensin converting enzyme activity and are thus useful as hypertensive agents.
PATENT ABSTRACTS 4716149
4716153
PARTIALLY MODIFIED, RETROINVERSO NEUROTENSIN ANALOGS
STABLE ORAL PREPARATION OF MACROLIDE ANTIBIOTICS AND METHOD FOR STABILIZING THE SAME
Fabio Bonelli, Antonell Pessi, Antonio S Verdini, Rome, Italy assigned to Enichem S p A; Eniricerche S p Pharmacologically active, partially retroinverso, neurotensin-like peptides lasting longer than the natural hormone, corresponding to the formula See Patent for Chemical Structure wherein R I and R2 are straight or branched (C1C7) alkyl radicals. The new compounds are useful as va=odilating and hypotensive agents.
4716151 TRIPEPTIDES
AND THEIR USE
Pierre Jolles, Daniele Migliore-Samour, Fabienne Parker, Paris, France assigned to Rhone-Poulenc Sante Tripeptides composed of the amino acids glycine, leucine, and phenylalanine or tyrosine obtainable by fractionation of hydrolysis products of human casein or by direct synthesis can be used as immunostimulants.
4716152 PHARMACEUTICAL USE OF SUBSTITUTED OACYLGLYCOSIDES Bernd-Wieland Kruger, Oswald Lockhoff, Karl G Metzger, Hans-Georg Opitz, Klaus Schaller, Klaus G Stunkel, Hans-Joachi Zeiler, Wuppertal, Federal Republic Of Germany assigned to Bayer Aktiengesellschaft Compounds of the formula See Patent jbr Chemical Structure in which X is hydrogen or the radical CH2OR5, R2, R3, R4 and R5 each independently is hydrogen or the radical See Patent for Chemical Structure Y is oxygen, sulphur, NH or CH2, and R1 and R6 each independently is an optionally substituted hydrocarbon radical having up to 50 carbon atoms, with the proviso that at least one of the radicals RI and/or R6 contains between 9 to 50 carbon atoms, some of which are known, stimulate the immune system's response and antibody production.
Masataka Morishita, Masaru Ono, Yukio Sumita, Shizuoka, Japan assigned to Toyo Jozo Company Ltd Stable oral preparations of 16-membered ring macrolide antibiotics such as SF-837, josamycin, 3"-propionyljosamycin, by incorporating stabilizers showing pH 3-10 in an aqueous medium, such as glycine, and dissolution accelerators showing pH 2.5-4 in an aqueous medium such as citric acid or tartaric acid. Coating such dissolution accelerators with a film-forming substance is useful to enhance the stability of the oral preparation of such antibiotics. 4716154 GEL OF CROSSLINKED HYALURONIC ACID FOR USE AS A VITREOUS HUMOR SUBSTITUTE Toma Malson, Bengt L Lindqvist, Uppsala, Sweden assigned to Pharmacia AB The invention is concerned with a vitreous humor substitute intended for ophthalmological uses and consisting of a gel of crosslinked hyaluronic acid and a method at retinal surgery and after vitrectomy when the vitreous humor completely or partially is exchanged for such a gel. 4716155 PHOSPHORUS CONTAINING COMPOUNDS AND HYPOTENSIVE USE THEREOF Donald S Karanewsky, Edward Petrillo assigned to E R Squibb & Sons Inc Phosphorus containing compounds of the formula See Patent for Chemical Structure wherein X is a substituted or unsubstituted imino or amino acid and A is See Patent for Chemical Structure These compounds possess angiotensin converting enzyme activity and are thus useful as hypertensive agents.