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4716227 Process for manufacturing cephalosporin esters
PATENT ABSTRACTS 4716224
4716177 TOLRESTAT FOR INHIBITION WEIGHT GAIN
279
OF
CROSSLINKED HYALURONIC ACID AND ITS USE
Steven W Ryder, David G Shand, John F Mullane assigned to American Home Products Corporation
Katukiyo Sakurai, Yoshio Ueno, Takashi Okuyama, Higashiyamato, Japan assigned to Seikagaku Kogyo Co Ltd
A method is disclosed for inhibiting weight gain by administering an effective amount of tolrestat.
Crosslinked hyaluronic acid or salts thereof prepared by crosslinking hyaluronic acid or salts thereof with a polyfunctional epoxy compound wherein a crosslinking index or number is 5 or more per 1000 repeating disaccharides composed of glucronic acid in hyaluronic acid and N-acetylglucosamine, and having various medical and cosmetic uses.
4716178 SUBSTITUTED DI-TBUTYLPHENOLS Robert A Scherrer, Mark Rustad assigned to Riker Laboratories Inc Novel compounds which are 2,6-di-tbutylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a group which includes carboxyl, tetrazolyl or N-methyltetrazolyl are useful as inhibitors of leukotriene synthesis and as antiallergic agents. Pharmaceutical compositions containing such compounds and pharmacological methods for use of such compounds are also disclosed.
4716179 USE OF NON-IRRITATING OR SLIGHTLY IRRITATING AND[OR PROMOTING DITERPENE ALCOHOL AND OF DERIVATIVES THEREOF AS ANTINEOPLASTIC PREPARATIONS Erich Hecker, Hans Osswald, Raine Schmidt, Heidelberg Handschuhsheim, Federal Republic Of Germany assigned to Stiftung Deutches Krebsforschungszentrum The present invention is directed to a method of inhibiting the growth of cancer cells in a lower animal host through the use of phorbol.
4716225 RADIOOPAQUE SUGAR DERIVATIVES AND A METHOD OF METABOLIC MAPPING USING THE SAME Robert S Ledley, Douglas M Gersten assigned to Georgetown University A method of metabolically mapping one or more central nervous system components of a mammalian body by computerized axial tomography scanning which entails injecting an effective amount of a 2-, 5- or 6-iodo-substituted hexose, as a contrast medium, into the mammalian body, and scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said hexose in the central nervous system component or components. 4716227 PROCESS FOR MANUFACTURING CEPHALOSPORIN ESTERS Andre Furlenmeier, Basle, Switzerland assigned to Hoffmann-La Roche Inc Cephalosporin esters of the formula See Patent for Chemical Structure I wherein R2 is hydrogen or acyl and RI is a group which is readily removable by hydrolysis, and pharmaceutically acceptable acid addition salts of basic compounds of formula I in which R2 is an acyl group, may be prepared by reacting 7-amino-3-
280
PATENT ABSTRACTS
methyl-3-cephem-4-carboxylic acid (7-ADCA) in a partially chlorinated lower alkane with a bicyclic amidine of the formula See Patent for Chemical Structure II wherein n is the integer 3, 4 or 5, and a halide of the formula See Patent for Tabular Presentation PS wherein X is halogen and RI has the above significance, if desired, treating the resulting compound of formula I in which R2 is hydrogen with an unprotected or optionally protected acylating agent, cleaving off a protecting group which may be present and, if desired, treating a resulting basic compound of formula I in which R2 is an acyl group into a pharmaceutically acceptable acid addition salt.
4716228 CONDENSED THIAZOLE
2-SUBSTITUTED DERIVATIVES
Ugo Scarponi, Anna Lazzarini, Daniela Toti, Castiglione Roberto de, Arese, Italy assigned to Farmitalia Carlo Erba S p A A process for preparing compounds of the formula I See Patent for Chemical Structure (I) wherein either (i) each of RI and R2 independently represents H or an organic group, or (ii) NR1 R2 is a heterocyclic ring or (iii) R2 is H and R I is See Patent for Chemical Structure wherein each of R6 and R7 independently represents H or an organic group, m is 1 or 2, n is 0-3, X is O, S, NH, NR8, CHNO2 or CHSO2R4 wherein R8 and R4 are organic groups and R3 represents an organic group is characterized by the following reaction sequence: See Patent for Chemical Structure See Patent for Tabular Presentation See Patent for Tabular Presentation There are also provided new compounds of the formula I wherein n is 0 and m is 2 and pharmaceutical compositions containing them. These compounds and their pharmaceutically acceptable acid addition salts are active as anti-ulcer agents.
4716230 CERTAIN BIS(DI-2 OR 4PYRIDYL-PHOSPHINO) A L K A N E S HAVING ANTI-TUMOR
PROPERTIES David T Hill assigned to Smithkline Beckman Corporation Heterocyclic phosphine compounds, pharmaceutical compositions containing an effective,
tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a compound which comprises administering a tumor cell growthinhibiting amount of such a compound to an animal afflicted by said tumor cells.
4717506 PYRAN DERIVATIVES AND PERFUME COMPOSITION CONTAINING THE SAME Hiroshi Takada, Shin'ichi Masuda, Motoki Nakajima, Wakayama, Japan assigned to Kao Corporation The present invention relates to a novel pyran derivative mixture represented by the following general formula (I): See Patent for Chemical Structure (I) wherein RI is H or CH3, R2 is CH2 or CH3, one of the bonds X, Y, or Z is a double bond and the remaining two bonds are single bonds. The present invention relates to a process for the preparation of the above-mentioned pyran derivative mixture. The pyran derivative compound (I) of the present invention is produced by reacting a compound represented by the following formula (II): See Patent for Chem&al Structure (II) with a compound represented by the general formula (III): See Patent for Chemical Structure (III) in the presence of an acid catalyst wherein R1 is as defined above. In addition, the present invention relates to a perfume composition containing an effective aromal amount of the pyran derivative compound represented by the general formula (I) above, in the presence of an acceptable carrier therefore.
4717512 PREPARATION OF ACYLATED GLYCERO-PHOSPHOCHOLINES AND GLYCEROPHOSPHOETHANOLAMINES Friedrich Paltauf, Albin Hermetter, Graz, Austria assigned to Chemie Linz AktiengeselIschaft Preparation of chemically defined pure enantiomeric 1, 2-diacyl-sn-glycero-3phosphocholines and 1, 2-diacyl-sn-glycero-3phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, by acylation of
4716177 TOLRESTAT FOR INHIBITION WEIGHT GAIN
279
OF
CROSSLINKED HYALURONIC ACID AND ITS USE
Steven W Ryder, David G Shand, John F Mullane assigned to American Home Products Corporation
Katukiyo Sakurai, Yoshio Ueno, Takashi Okuyama, Higashiyamato, Japan assigned to Seikagaku Kogyo Co Ltd
A method is disclosed for inhibiting weight gain by administering an effective amount of tolrestat.
Crosslinked hyaluronic acid or salts thereof prepared by crosslinking hyaluronic acid or salts thereof with a polyfunctional epoxy compound wherein a crosslinking index or number is 5 or more per 1000 repeating disaccharides composed of glucronic acid in hyaluronic acid and N-acetylglucosamine, and having various medical and cosmetic uses.
4716178 SUBSTITUTED DI-TBUTYLPHENOLS Robert A Scherrer, Mark Rustad assigned to Riker Laboratories Inc Novel compounds which are 2,6-di-tbutylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a group which includes carboxyl, tetrazolyl or N-methyltetrazolyl are useful as inhibitors of leukotriene synthesis and as antiallergic agents. Pharmaceutical compositions containing such compounds and pharmacological methods for use of such compounds are also disclosed.
4716179 USE OF NON-IRRITATING OR SLIGHTLY IRRITATING AND[OR PROMOTING DITERPENE ALCOHOL AND OF DERIVATIVES THEREOF AS ANTINEOPLASTIC PREPARATIONS Erich Hecker, Hans Osswald, Raine Schmidt, Heidelberg Handschuhsheim, Federal Republic Of Germany assigned to Stiftung Deutches Krebsforschungszentrum The present invention is directed to a method of inhibiting the growth of cancer cells in a lower animal host through the use of phorbol.
4716225 RADIOOPAQUE SUGAR DERIVATIVES AND A METHOD OF METABOLIC MAPPING USING THE SAME Robert S Ledley, Douglas M Gersten assigned to Georgetown University A method of metabolically mapping one or more central nervous system components of a mammalian body by computerized axial tomography scanning which entails injecting an effective amount of a 2-, 5- or 6-iodo-substituted hexose, as a contrast medium, into the mammalian body, and scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said hexose in the central nervous system component or components. 4716227 PROCESS FOR MANUFACTURING CEPHALOSPORIN ESTERS Andre Furlenmeier, Basle, Switzerland assigned to Hoffmann-La Roche Inc Cephalosporin esters of the formula See Patent for Chemical Structure I wherein R2 is hydrogen or acyl and RI is a group which is readily removable by hydrolysis, and pharmaceutically acceptable acid addition salts of basic compounds of formula I in which R2 is an acyl group, may be prepared by reacting 7-amino-3-
280
PATENT ABSTRACTS
methyl-3-cephem-4-carboxylic acid (7-ADCA) in a partially chlorinated lower alkane with a bicyclic amidine of the formula See Patent for Chemical Structure II wherein n is the integer 3, 4 or 5, and a halide of the formula See Patent for Tabular Presentation PS wherein X is halogen and RI has the above significance, if desired, treating the resulting compound of formula I in which R2 is hydrogen with an unprotected or optionally protected acylating agent, cleaving off a protecting group which may be present and, if desired, treating a resulting basic compound of formula I in which R2 is an acyl group into a pharmaceutically acceptable acid addition salt.
4716228 CONDENSED THIAZOLE
2-SUBSTITUTED DERIVATIVES
Ugo Scarponi, Anna Lazzarini, Daniela Toti, Castiglione Roberto de, Arese, Italy assigned to Farmitalia Carlo Erba S p A A process for preparing compounds of the formula I See Patent for Chemical Structure (I) wherein either (i) each of RI and R2 independently represents H or an organic group, or (ii) NR1 R2 is a heterocyclic ring or (iii) R2 is H and R I is See Patent for Chemical Structure wherein each of R6 and R7 independently represents H or an organic group, m is 1 or 2, n is 0-3, X is O, S, NH, NR8, CHNO2 or CHSO2R4 wherein R8 and R4 are organic groups and R3 represents an organic group is characterized by the following reaction sequence: See Patent for Chemical Structure See Patent for Tabular Presentation See Patent for Tabular Presentation There are also provided new compounds of the formula I wherein n is 0 and m is 2 and pharmaceutical compositions containing them. These compounds and their pharmaceutically acceptable acid addition salts are active as anti-ulcer agents.
4716230 CERTAIN BIS(DI-2 OR 4PYRIDYL-PHOSPHINO) A L K A N E S HAVING ANTI-TUMOR
PROPERTIES David T Hill assigned to Smithkline Beckman Corporation Heterocyclic phosphine compounds, pharmaceutical compositions containing an effective,
tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a compound which comprises administering a tumor cell growthinhibiting amount of such a compound to an animal afflicted by said tumor cells.
4717506 PYRAN DERIVATIVES AND PERFUME COMPOSITION CONTAINING THE SAME Hiroshi Takada, Shin'ichi Masuda, Motoki Nakajima, Wakayama, Japan assigned to Kao Corporation The present invention relates to a novel pyran derivative mixture represented by the following general formula (I): See Patent for Chemical Structure (I) wherein RI is H or CH3, R2 is CH2 or CH3, one of the bonds X, Y, or Z is a double bond and the remaining two bonds are single bonds. The present invention relates to a process for the preparation of the above-mentioned pyran derivative mixture. The pyran derivative compound (I) of the present invention is produced by reacting a compound represented by the following formula (II): See Patent for Chem&al Structure (II) with a compound represented by the general formula (III): See Patent for Chemical Structure (III) in the presence of an acid catalyst wherein R1 is as defined above. In addition, the present invention relates to a perfume composition containing an effective aromal amount of the pyran derivative compound represented by the general formula (I) above, in the presence of an acceptable carrier therefore.
4717512 PREPARATION OF ACYLATED GLYCERO-PHOSPHOCHOLINES AND GLYCEROPHOSPHOETHANOLAMINES Friedrich Paltauf, Albin Hermetter, Graz, Austria assigned to Chemie Linz AktiengeselIschaft Preparation of chemically defined pure enantiomeric 1, 2-diacyl-sn-glycero-3phosphocholines and 1, 2-diacyl-sn-glycero-3phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, by acylation of