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4742003 Human transforming growth factor
PATENT ABSTRACTS in the chemical synthesis of DNA, in the conversion of double stranded DNA into single stranded DNA, and in the chemical modification of DNA.
777
4740470 BIOLOGICALLY MOLECULAR
FUNCTIONAL CHIMERAS
Stanley N Cohen, Herbert W Boyer assigned to The Board of Trustees of the Leland Stanford Jr University 4740464 FERMENTATION PROCESS AND MICROORGANISM FOR PRODUCING ACONITIC ACID Kelvin Holdom, Norma Winskill, Ramsgate, NY, United Kingdom assigned to Pfizer Inc Aconitic acid, an unsaturated tricarboxylic acid, is obtained by fermentation of an aconitic acidaccumulating strain of Aspergillus terreus or Aspergillus itaconicus, under aerobic conditions, in a carbohydrate-containing medium, followed by isolation of the aconitic acid or a salt thereof. A preferred aconitic acid-accumulating microorganism is the strain of Aspergillus terreus which is on deposit in the Culture Collection of the Commonewealth Mycological Institute at Kew, Surrey, United Kingdom, under Accession No. CMI CC 281924.
Method and compositions are provided for replication and expression of exogenous genes in microorganisms. Plasmids or virus DNA are cleaved to provide linear DNA having ligatable termini, which are bound to a gene having complementary termini, to provide a biologically functional replicon with a desired phenotypical property. The replicon is inserted into a microorganism cell by transformation. Isolation of the transformants provides cells for replication and expression of the DNA molecules present in the modified plasmid. The method provides a convenient and efficient way to introduce genetic capability into microorganisms for the production of nucleic acids and proteins, such as medically or commercially useful enzymes, which may have direct usefulness, or may find expression in the production of drugs, such as hormones, antibiotics, or the like, fixation of nitrogen, Termentation, utilization of specific feedstocks, or the like. The invention was supported by generous grants of NIH, NSF and the American Cancer Society.
4740466
4740593
INDUCTION OF SETTLEMENT AND METAMORPHOSIS IN CRASSOSTREA VIRGINICA BY MELANIN-SYNTHESIZING BACTERIA
DERIVED NISIN PRODUCING MICROORGANISMS, METHOD OF PRODUCTION AND USE AND PRODUCTS OBTAINED THEREBY
Ronald Weiner, Rita Colwell, Dale B Bonar, Steven Coon assigned to Research Corporation The present invention relates to the discovery of a new bacterium, alteromonas calwellii, which has been found to attract oyster larvae by the production of a compound involved in melanin synthesis. More specifically, the present invention contemplates a method for inducing the settlement and metamorphosis of Crassostrea virginica larvae by induction with certain metabolic substances produced by the present bacterium and its mutagenically altered variants. Furthermore, the present invention is directed to other and derivative metabolic products which can be employed for their desired utility and application.
Carlos F Gonzalez, Alfred J Gryczka assigned to Microlife Technics lnc Derived microorganisms containing foreign DNA encoding for nisin production and a method for producing the derived microorganisms by transferring DNA to a recipient microorganism are described. The recipient microorganisms are preferably bacteria lacking in the ability to produce nisin. Nisin inhibits the growth of spoilage bacteria and is used in various materials for preservation, including foods and particularly at refrigeration temperatures. Nisin is also used in animals for improving the health of the animal. The foreign DNA is obtained from a donor microorganism and encodes for nisin production when transferred to the recipient microorganism.
777
4740470 BIOLOGICALLY MOLECULAR
FUNCTIONAL CHIMERAS
Stanley N Cohen, Herbert W Boyer assigned to The Board of Trustees of the Leland Stanford Jr University 4740464 FERMENTATION PROCESS AND MICROORGANISM FOR PRODUCING ACONITIC ACID Kelvin Holdom, Norma Winskill, Ramsgate, NY, United Kingdom assigned to Pfizer Inc Aconitic acid, an unsaturated tricarboxylic acid, is obtained by fermentation of an aconitic acidaccumulating strain of Aspergillus terreus or Aspergillus itaconicus, under aerobic conditions, in a carbohydrate-containing medium, followed by isolation of the aconitic acid or a salt thereof. A preferred aconitic acid-accumulating microorganism is the strain of Aspergillus terreus which is on deposit in the Culture Collection of the Commonewealth Mycological Institute at Kew, Surrey, United Kingdom, under Accession No. CMI CC 281924.
Method and compositions are provided for replication and expression of exogenous genes in microorganisms. Plasmids or virus DNA are cleaved to provide linear DNA having ligatable termini, which are bound to a gene having complementary termini, to provide a biologically functional replicon with a desired phenotypical property. The replicon is inserted into a microorganism cell by transformation. Isolation of the transformants provides cells for replication and expression of the DNA molecules present in the modified plasmid. The method provides a convenient and efficient way to introduce genetic capability into microorganisms for the production of nucleic acids and proteins, such as medically or commercially useful enzymes, which may have direct usefulness, or may find expression in the production of drugs, such as hormones, antibiotics, or the like, fixation of nitrogen, Termentation, utilization of specific feedstocks, or the like. The invention was supported by generous grants of NIH, NSF and the American Cancer Society.
4740466
4740593
INDUCTION OF SETTLEMENT AND METAMORPHOSIS IN CRASSOSTREA VIRGINICA BY MELANIN-SYNTHESIZING BACTERIA
DERIVED NISIN PRODUCING MICROORGANISMS, METHOD OF PRODUCTION AND USE AND PRODUCTS OBTAINED THEREBY
Ronald Weiner, Rita Colwell, Dale B Bonar, Steven Coon assigned to Research Corporation The present invention relates to the discovery of a new bacterium, alteromonas calwellii, which has been found to attract oyster larvae by the production of a compound involved in melanin synthesis. More specifically, the present invention contemplates a method for inducing the settlement and metamorphosis of Crassostrea virginica larvae by induction with certain metabolic substances produced by the present bacterium and its mutagenically altered variants. Furthermore, the present invention is directed to other and derivative metabolic products which can be employed for their desired utility and application.
Carlos F Gonzalez, Alfred J Gryczka assigned to Microlife Technics lnc Derived microorganisms containing foreign DNA encoding for nisin production and a method for producing the derived microorganisms by transferring DNA to a recipient microorganism are described. The recipient microorganisms are preferably bacteria lacking in the ability to produce nisin. Nisin inhibits the growth of spoilage bacteria and is used in various materials for preservation, including foods and particularly at refrigeration temperatures. Nisin is also used in animals for improving the health of the animal. The foreign DNA is obtained from a donor microorganism and encodes for nisin production when transferred to the recipient microorganism.