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4762711 Live vaccine for bovine babesiosis
PATENT ABSTRACTS
86 4761373
HERBICIDE RESISTANCE IN PLANTS Paul C Anderson, Kenneth A Hibberd assigned to Molecular Genetics Inc This invention is directed to the production of plants, plant tissues and plant seeds which are resistant to inhibition by an herbicide which normally inhibits the growth and development of those plants, plant tissues and plant seeds. In particular this invention is directed to altered acetohydroxyacid synthase enzymes which are resistant to inhibition by herbicides which normally inhibit the activity of the synthase before such alteration. This invention further relates to genes encoding such enzymes, and to processes for utilizing these novel genes and enzymes. Further products of the invention include plants, plant tissues and seeds which exhibit resistance to such herbicides resulting from expression of genes encoding herbicide resistant acetohydroxyacid synthase enzyme.
of virulent and avirulent babesia by progressive dilution culturing to obtain cultures containing single parasites, propagating the single parasites under favorable conditions for growth, and selecting a fast-growing avirulent clone line for either in vitro or in vivo propagation to prepare the vaccines.
4762780 METHOD AND COMPOSITION FOR SCREENING AND DIAGNOSING HCMV Deborah H Spector, Stephen A Spector assigned to The Regents of the University of California DNA sequences of hCMV are obtained by restriction of the hCMV genome, the resulting fragments free of fragments cross-hybridizing with human DNA and other viruses may be used for hybridization with clinical samples suspected of containing hCMV to provide a sensitive method for detection of hCMV at low particle number.
4761375 4762784 HUMAN
INTERLEU, KIN-2 CDNA SEQUENCE
Steven C Clark assigned to Genetics Institute Inc The mRNA of a distinct human Interleukin-2 concentrated from a plasma source lead to the production and cloning of its cDNA and the elucidation o fits sequence and that of the mature protein. Transfer vectors for production of such Interleukin-2 are disclosed along with useful intermediate expression products. 4762711 LIVE VACCINE FOR BOVINE BABESIOSIS Gerald Buening, Charles Carson assigned to The Curators of the University of Missouri A live vaccine for bovine babesiosis comprises viable bovine erythrocytes parasitized with a cloned population of Babesia bovis, the clone strain being fast-growing, avirulent, and producing a mild but immunizing infection when administered. The vaccine is free of slowgrowing virulent B. bovis. The clone strain used in the vaccine is prepared from a natural mixture
FERMEMTATION PROCESS FOR THE HIGH LEVEL PRODUCTION OF BOVINE GROWTH HORMONE Paula M Keith, Wendy J Cain assigned to International Minerals & Chemical Corp A high density fermentation process for high yield production of bovine growth hormone by transformant E. coli is described. The process employs transformant strains of E. coli containing an expression vector coding for bovine growth hormone under the control of a bacteriophage lambda promoter-operator and a plasmid containing the lambdac1857 gene which codes for the temperature-sensitive repressor protein. In the initial growth period, the level of dissolved oxygen in the fermentation medium is maintained at about 20% to 60% saturation and the temperature of the medium is kept at 26 degrees-30 degrees C. Production of bovine growth hormone is then induced by raising the temperature of the medium to at least about 42 degrees C. The temperature is then reduced to about 38 degrees C. to 41 degrees C. to optimize cell growth for the remainder of the induction period, during which the level of dissolved oxygen in the medium is maintained at about 10% to 40% saturation.
86 4761373
HERBICIDE RESISTANCE IN PLANTS Paul C Anderson, Kenneth A Hibberd assigned to Molecular Genetics Inc This invention is directed to the production of plants, plant tissues and plant seeds which are resistant to inhibition by an herbicide which normally inhibits the growth and development of those plants, plant tissues and plant seeds. In particular this invention is directed to altered acetohydroxyacid synthase enzymes which are resistant to inhibition by herbicides which normally inhibit the activity of the synthase before such alteration. This invention further relates to genes encoding such enzymes, and to processes for utilizing these novel genes and enzymes. Further products of the invention include plants, plant tissues and seeds which exhibit resistance to such herbicides resulting from expression of genes encoding herbicide resistant acetohydroxyacid synthase enzyme.
of virulent and avirulent babesia by progressive dilution culturing to obtain cultures containing single parasites, propagating the single parasites under favorable conditions for growth, and selecting a fast-growing avirulent clone line for either in vitro or in vivo propagation to prepare the vaccines.
4762780 METHOD AND COMPOSITION FOR SCREENING AND DIAGNOSING HCMV Deborah H Spector, Stephen A Spector assigned to The Regents of the University of California DNA sequences of hCMV are obtained by restriction of the hCMV genome, the resulting fragments free of fragments cross-hybridizing with human DNA and other viruses may be used for hybridization with clinical samples suspected of containing hCMV to provide a sensitive method for detection of hCMV at low particle number.
4761375 4762784 HUMAN
INTERLEU, KIN-2 CDNA SEQUENCE
Steven C Clark assigned to Genetics Institute Inc The mRNA of a distinct human Interleukin-2 concentrated from a plasma source lead to the production and cloning of its cDNA and the elucidation o fits sequence and that of the mature protein. Transfer vectors for production of such Interleukin-2 are disclosed along with useful intermediate expression products. 4762711 LIVE VACCINE FOR BOVINE BABESIOSIS Gerald Buening, Charles Carson assigned to The Curators of the University of Missouri A live vaccine for bovine babesiosis comprises viable bovine erythrocytes parasitized with a cloned population of Babesia bovis, the clone strain being fast-growing, avirulent, and producing a mild but immunizing infection when administered. The vaccine is free of slowgrowing virulent B. bovis. The clone strain used in the vaccine is prepared from a natural mixture
FERMEMTATION PROCESS FOR THE HIGH LEVEL PRODUCTION OF BOVINE GROWTH HORMONE Paula M Keith, Wendy J Cain assigned to International Minerals & Chemical Corp A high density fermentation process for high yield production of bovine growth hormone by transformant E. coli is described. The process employs transformant strains of E. coli containing an expression vector coding for bovine growth hormone under the control of a bacteriophage lambda promoter-operator and a plasmid containing the lambdac1857 gene which codes for the temperature-sensitive repressor protein. In the initial growth period, the level of dissolved oxygen in the fermentation medium is maintained at about 20% to 60% saturation and the temperature of the medium is kept at 26 degrees-30 degrees C. Production of bovine growth hormone is then induced by raising the temperature of the medium to at least about 42 degrees C. The temperature is then reduced to about 38 degrees C. to 41 degrees C. to optimize cell growth for the remainder of the induction period, during which the level of dissolved oxygen in the medium is maintained at about 10% to 40% saturation.