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4762786 Vectors and conditions which allow genetic transformation of cephalosporium
NEW PATENTS This Section contains abstracts and, where appropriate, illustrations of recently issued United States patents and published patent applications filed from over 30 countries under the Patent Cooperation Treaty. This information was obtained from recent additions to the Pergamon PATSEARCH~ online database in aceor6ance with interest profiles developed by the Editors. Further information about Pergamon PATSEARCH~ can be obtained from Pergamon Orbit InfoLine Inc., 8000 Westpark Drive, McLean, Virginia 22102 U.S.A. Copies of complete patents announced in this Section are available from Pergamon Orbit InfoLine Inc. for $8 per copy. Payment with order is required. Orders outside North America add $2 for air postage. Order by patent number for Pergamon Orbit InfoLine only.
Mutation/Genetic Engineering Techniques 4762785
cloning vector comprising a Saccharomyces cerevisiae transcriptional and translational activating sequence positioned for expression of hygromycin phosphotransferase into a host cell and then growing the host cell under selective conditions. The vectors optionally further comprise Cephalosporium ribosomal DNA and also sequences that allow for replication and selection in E. coli and Streptomyces.
NOVEL METHOD AND COMPOSITIONS FOR I N T R O D U C T I N G ALLEN D N A I N
VIVO Luca Comai assigned to Calgene Inc Method and compositions are provided for introducing alien DNA into a nucleic acid in vivo by providing a plasmid capable of replication in a first host, which is capable of conjugation with a second host into which the alien DNA is to be introducted. The plasmid is characterized by being capable of maintenance in said first host, being incapable of maintenance in said second host, having a region of homology with DNA present in said second host, not selftransmissable but capable of mobilization by a helper plasmid and having a marker, which may be the alien DNA, for selection in said second host. The invention finds particular application for introducing alien DNA into the Ti plasmid of Agrobacterium tumefaciens for introduction into plant cells.
4762791 HUMAN IMMUNE
INTERFERON
David V Goeddel, Patrick W Gray assigned to Genentech lnc Disclosed is a complete discription of the preparation of novel, recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultures. The recombinant human immune (gamma) interferon (IFN- gamma), is isolated and characterized in terms of its DNA and amino acid sequences, physical attributes and biological activity. A des-CYS-TYR-CYS species is also prepared.
4762786 4762914 VECTORS AND CONDITIONS WHICH ALLOW GENETIC TRANSFORMATION OF CEPHALOSPORIUM
TRUNCATED PROTEIN OF INTERLEUKIN-1 Philip Auron, Andrew Webb, Le Gehrke, Charles A Dinarello, Lanny J Rosenwasser, Alexander Rich, Sheldon Wolff
Jerry L Chapman, Thomas Ingolia, Kevin R Kaster, Stephen W Queener, Paul L Skatrud assigned to Eli Lilly and Company
The subject invention concerns truncated human IL-I cDNA sequences which encode biologically-active novel human IL-I proteins. These truncated human IL-I cDNA sequences
A method for transforming Cephalosporium and other lower eukaryotes is disclosed. The method involves inserting a recombinant DNA
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Mutation/Genetic Engineering Techniques 4762785
cloning vector comprising a Saccharomyces cerevisiae transcriptional and translational activating sequence positioned for expression of hygromycin phosphotransferase into a host cell and then growing the host cell under selective conditions. The vectors optionally further comprise Cephalosporium ribosomal DNA and also sequences that allow for replication and selection in E. coli and Streptomyces.
NOVEL METHOD AND COMPOSITIONS FOR I N T R O D U C T I N G ALLEN D N A I N
VIVO Luca Comai assigned to Calgene Inc Method and compositions are provided for introducing alien DNA into a nucleic acid in vivo by providing a plasmid capable of replication in a first host, which is capable of conjugation with a second host into which the alien DNA is to be introducted. The plasmid is characterized by being capable of maintenance in said first host, being incapable of maintenance in said second host, having a region of homology with DNA present in said second host, not selftransmissable but capable of mobilization by a helper plasmid and having a marker, which may be the alien DNA, for selection in said second host. The invention finds particular application for introducing alien DNA into the Ti plasmid of Agrobacterium tumefaciens for introduction into plant cells.
4762791 HUMAN IMMUNE
INTERFERON
David V Goeddel, Patrick W Gray assigned to Genentech lnc Disclosed is a complete discription of the preparation of novel, recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultures. The recombinant human immune (gamma) interferon (IFN- gamma), is isolated and characterized in terms of its DNA and amino acid sequences, physical attributes and biological activity. A des-CYS-TYR-CYS species is also prepared.
4762786 4762914 VECTORS AND CONDITIONS WHICH ALLOW GENETIC TRANSFORMATION OF CEPHALOSPORIUM
TRUNCATED PROTEIN OF INTERLEUKIN-1 Philip Auron, Andrew Webb, Le Gehrke, Charles A Dinarello, Lanny J Rosenwasser, Alexander Rich, Sheldon Wolff
Jerry L Chapman, Thomas Ingolia, Kevin R Kaster, Stephen W Queener, Paul L Skatrud assigned to Eli Lilly and Company
The subject invention concerns truncated human IL-I cDNA sequences which encode biologically-active novel human IL-I proteins. These truncated human IL-I cDNA sequences
A method for transforming Cephalosporium and other lower eukaryotes is disclosed. The method involves inserting a recombinant DNA
61