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4772563 1,10-Phenanthroline derivatives and use in fluorescence immunoassays
PATENT ABSTRACTS
262
tides derived from the conserved region of the HTLVIII envelope proteins. These peptides are useful as reagents for immunoassays for detection of AIDS antibodies, as components of immunogenic compositions useful as vaccines, and for the production of anti-bodies selective to said envelope protein and methods for detecting the presence of AIDS antibodies in biological fluid samples.
1,10-phenanthroline-2,9-dicarboxylic acid and novel derivatives thereof such as 4,7-diphenyl1,10-phenanthroline-2,9-dicarboxylic acid and 4,5,9, 14-tetraaza-(1,2,3,4)-dibenzanthracene3,5-dicarboxylic acid can be coupled to proteins through coupling groups to form conjugates which form higly fluorescent chelates in the presence of lanthanide salts. Derivatives of the above acids reactive toward proteins can be readily manufactured by relatively simple synthetic routes, and are useful in fluorescent immunoassay.
4772558 BLOOD CULTURE SYSTEM Ranie Hammann, D 6901 Wiesenbacll', Rine Neckar District, Baden Wurttemberg, Federal Republic Of Germany A culture bottle assembly for the detection of micro-organisms in a fluid sample is provided. The culture bottle assembly is a container having a dividing wall which divides the culture into two compartments. A cap is provided for the container and means are provided for moving the cap axially with respect to the container. A resilient material is provided which is compressed by the cap moving means to provide a liquid tight seal between the two compartments.
4772563
1,10-PHENANTHROLINE DERIVATIVES AND USE IN FLUORESCENCE IMMUNOASSAYS Ramon Evangelista, Alfred Pollak, Scarborough, Canada assigned to HSC Research Development Corporation
4788140 ANALYTICAL ELEMENT CONTAINING PHOTOSENSITIVE COMPOUND AND FILTER LAYER AND METHOD OF USE John Findlay, Brent Burdick, Ronald A Wellman, Mark E Shafer assigned to Eastman Kodak Company A multilayer analytical element for the determination of a clinically significant enzyme analyte comprises a photosensitive compound (e.g. a photosensitive dye or dye precursor) and a filter layer containing one or more filter dyes. The filter layer is situated in the element such that incident radiation used to detect a density change resulting from interaction of the analyte and the photosensitive compound passes through the filter layer before it reaches the photosensitive compound. The use of the filter layer inhibits premature changes in the photosensitive compound caused by incident radiation. This element is particularly useful for the determination of creatine kinase or one of its isoenzymes, e.g. creatine kinase-MB.
262
tides derived from the conserved region of the HTLVIII envelope proteins. These peptides are useful as reagents for immunoassays for detection of AIDS antibodies, as components of immunogenic compositions useful as vaccines, and for the production of anti-bodies selective to said envelope protein and methods for detecting the presence of AIDS antibodies in biological fluid samples.
1,10-phenanthroline-2,9-dicarboxylic acid and novel derivatives thereof such as 4,7-diphenyl1,10-phenanthroline-2,9-dicarboxylic acid and 4,5,9, 14-tetraaza-(1,2,3,4)-dibenzanthracene3,5-dicarboxylic acid can be coupled to proteins through coupling groups to form conjugates which form higly fluorescent chelates in the presence of lanthanide salts. Derivatives of the above acids reactive toward proteins can be readily manufactured by relatively simple synthetic routes, and are useful in fluorescent immunoassay.
4772558 BLOOD CULTURE SYSTEM Ranie Hammann, D 6901 Wiesenbacll', Rine Neckar District, Baden Wurttemberg, Federal Republic Of Germany A culture bottle assembly for the detection of micro-organisms in a fluid sample is provided. The culture bottle assembly is a container having a dividing wall which divides the culture into two compartments. A cap is provided for the container and means are provided for moving the cap axially with respect to the container. A resilient material is provided which is compressed by the cap moving means to provide a liquid tight seal between the two compartments.
4772563
1,10-PHENANTHROLINE DERIVATIVES AND USE IN FLUORESCENCE IMMUNOASSAYS Ramon Evangelista, Alfred Pollak, Scarborough, Canada assigned to HSC Research Development Corporation
4788140 ANALYTICAL ELEMENT CONTAINING PHOTOSENSITIVE COMPOUND AND FILTER LAYER AND METHOD OF USE John Findlay, Brent Burdick, Ronald A Wellman, Mark E Shafer assigned to Eastman Kodak Company A multilayer analytical element for the determination of a clinically significant enzyme analyte comprises a photosensitive compound (e.g. a photosensitive dye or dye precursor) and a filter layer containing one or more filter dyes. The filter layer is situated in the element such that incident radiation used to detect a density change resulting from interaction of the analyte and the photosensitive compound passes through the filter layer before it reaches the photosensitive compound. The use of the filter layer inhibits premature changes in the photosensitive compound caused by incident radiation. This element is particularly useful for the determination of creatine kinase or one of its isoenzymes, e.g. creatine kinase-MB.