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4795703 Heparin assay
280
PATENT ABSTRACTS
acids. The resulting sample nucleic acids are contacted with the labelled probe under appropriate conditions to form duplexes. The labelled probe in the duplex is monitored to determine the amount of duplexes and the level of the subpopulation is calculated from the determined duplexes. The controlled variable is adjusted based on the calculated level of the subpopulation to bring the level toward the optimal level. The method is used to monitor and control the microbial population without reliance upon the phenotypical expression of the genetic information of the organisms.
4795704 MULTIPHASE ASYMMETRIC MEMBRANE REACTOR SYSTEMS Stephen L Matson assigned to Sepracor Inc
Stanle Tabor, Charles Richardson assigned to President and Fellows of Harvard College
A catalyst such as an enzyme is contained in an asymmetric membrane between two immiscible liquid streams. A catalytic reaction is carried out by introducing a reactant to one stream and removing a product from the other stream. When the catalyst becomes deactivated, the membrane can be recharged with catalyst by displacing the deactivated catalyst and introducing fresh catalyst. The membrane has a skin layer that has pores sufficiently small so as to prevent leakage of the catalyst and a highly porous region that contains the catalyst. Insolubility of the catalyst in the immiscible liquid prevents loss of the catalyst for the highly porous region.
This invention relates to T7-type DNA polymerases and method for using them.
4795822
4795699 T7 D N A P O L Y M E R A S E
4795700 NUCLEIC ACID PROBES AND METHODS OF USING SAME Peter B Dervan, Geoffrey B Dreyer assigned to California Institute of Technology A probe and method for specific recognition or cleavage of single-stranded DNA or RNA at desired loci utilizing sequence-specific polynucleotide-chelator probes. The probe may also be utilized as a diagnostic agent when the metal ion is replaced with a radiolabelled, fluorescing, or otherwise detectable metal. 4795703 HEPARIN ASSAY Moses J Folkman, Robert L Hannan, Robert W Thompson, Robert Langer assigned to The Children's Medical Center Corporation The level of heparin in a blood sample is measured by measuring the clotting time of two aliquots of the blood sample, using standard clotting assays, with one of the aliquots being firstly treated with a heparin-degrading compound, such as heparinase. The difference in clotting times is a direct measure of the heparin concentration in the sample.
NORTRIPTYLINE CONJUGATES TO ANTIGENIC PROTEINS AND ENZYMES Mae W Hu, Prithipal Singh assigned to Syntex (U S A ) lnc Nortriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find use in immunoassays for the determination of nortriptyline in a sample, while the enzyme conjugates find use in an enzyme assay for the determination of nortriptyline in a sample.
4797356 MONOCLONAL ANTIBODIES SPECIFIC TO GLACTOSYLTRANSFERASE ISOENZYME II AND THEIR USE IN CANCER IMMUNOASSAYS Alan E Brandt, Morito Uemura assigned to Konishiroku Photo Industries Co Ltd Murine monoclonal antibodies specific to the tumor marker galactosyltransferase II (GT-II) which have no measurable cross-reactivity with galactosyltransferase I (GT-I) are described.
PATENT ABSTRACTS
acids. The resulting sample nucleic acids are contacted with the labelled probe under appropriate conditions to form duplexes. The labelled probe in the duplex is monitored to determine the amount of duplexes and the level of the subpopulation is calculated from the determined duplexes. The controlled variable is adjusted based on the calculated level of the subpopulation to bring the level toward the optimal level. The method is used to monitor and control the microbial population without reliance upon the phenotypical expression of the genetic information of the organisms.
4795704 MULTIPHASE ASYMMETRIC MEMBRANE REACTOR SYSTEMS Stephen L Matson assigned to Sepracor Inc
Stanle Tabor, Charles Richardson assigned to President and Fellows of Harvard College
A catalyst such as an enzyme is contained in an asymmetric membrane between two immiscible liquid streams. A catalytic reaction is carried out by introducing a reactant to one stream and removing a product from the other stream. When the catalyst becomes deactivated, the membrane can be recharged with catalyst by displacing the deactivated catalyst and introducing fresh catalyst. The membrane has a skin layer that has pores sufficiently small so as to prevent leakage of the catalyst and a highly porous region that contains the catalyst. Insolubility of the catalyst in the immiscible liquid prevents loss of the catalyst for the highly porous region.
This invention relates to T7-type DNA polymerases and method for using them.
4795822
4795699 T7 D N A P O L Y M E R A S E
4795700 NUCLEIC ACID PROBES AND METHODS OF USING SAME Peter B Dervan, Geoffrey B Dreyer assigned to California Institute of Technology A probe and method for specific recognition or cleavage of single-stranded DNA or RNA at desired loci utilizing sequence-specific polynucleotide-chelator probes. The probe may also be utilized as a diagnostic agent when the metal ion is replaced with a radiolabelled, fluorescing, or otherwise detectable metal. 4795703 HEPARIN ASSAY Moses J Folkman, Robert L Hannan, Robert W Thompson, Robert Langer assigned to The Children's Medical Center Corporation The level of heparin in a blood sample is measured by measuring the clotting time of two aliquots of the blood sample, using standard clotting assays, with one of the aliquots being firstly treated with a heparin-degrading compound, such as heparinase. The difference in clotting times is a direct measure of the heparin concentration in the sample.
NORTRIPTYLINE CONJUGATES TO ANTIGENIC PROTEINS AND ENZYMES Mae W Hu, Prithipal Singh assigned to Syntex (U S A ) lnc Nortriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find use in immunoassays for the determination of nortriptyline in a sample, while the enzyme conjugates find use in an enzyme assay for the determination of nortriptyline in a sample.
4797356 MONOCLONAL ANTIBODIES SPECIFIC TO GLACTOSYLTRANSFERASE ISOENZYME II AND THEIR USE IN CANCER IMMUNOASSAYS Alan E Brandt, Morito Uemura assigned to Konishiroku Photo Industries Co Ltd Murine monoclonal antibodies specific to the tumor marker galactosyltransferase II (GT-II) which have no measurable cross-reactivity with galactosyltransferase I (GT-I) are described.