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4795804 Bone morphogenetic agents
243
PATENT ABSTRACTS polypeptide or an immunogenically active subsequence thereof or a precursor therefor which is convertible to an immunogenically active form, antibodies against which determinant react with the adhesion polypeptide produced by pathogenic adhesin-forming bacteria which adhere to mammalian tissue, antibodies against such antigen, and DNA expressing, as a principal gene product thereof, such antigen.
is disclosed. The process involves the combination ofa DNA fragment comprising a heat shock inducible gene o f an appropriate yeast microorganism and a second DNA fragment comprising a selected gene with a suitable transfer vector, thereby producing a recombinant transfer vector. A suitable host yeast is contacted with the recombinant transfer vector, cultured and transforments having the desired genetic capability are selected.
4795804 BONE MORPHOGENETIC AGENTS
4798791
Marshall Urist assigned to The Regents of the University of California
VECTOR FOR HIGH LEVEL GENE EXPRESSION
The production and isolation of bone morphogenetic peptide agents displaying the osteoinductire and immunoreactive activity of bone morphogenetic protein (BMP) and deriving from natural, synthetic or recombinant DNA sources, and said agents.
David M Anderson, Jeffrey C McGuire assigned to Genex Corporation
4797279 INSECTICIDAL HYBRID B A C T E R I A F R O M B.T. K U R S T A K I A N D B.T. T E N E B R I O N I S
Methods and vectors for high level expression of genes in bacteria are disclosed. A terminal mRNA sequence from a gene coding for a stable bacterial protein mRNA is ligated to a gene coding for the desired protein adjacent the translation termination codon of the gene. The gene for the desired protein and the terminal mRNA sequence are situated in an expression vector in which the gene is operably linked to a transcription promoter.
Dimitri Karamata, Jean-Christophe Piot, Epalinges, Switzerland assigned to Sandoz Ltd The invention provides hybrid microorganisms comprising the gene coding for b.t. kurstaki delta-endotoxin and the gene coding for b.t. tenebrionis delta-endotoxin, their preparation, insecticidal compositions comprising such microorganisms and their use.
4798885 COMPOSITIONS OF HORMONALLY ACTIVE HUMAN AND PORCINE INHIBIN CONTAINING AN ALPHA CHAIN A N D 62 C H A I N
4797359
Anthony J Mason, Peter H Seeburg assigned to Genentech Inc
HEAT SHOCK REGULATED PRODUCTION OF SELECTED AND FUSED PROTEINS IN YEAST
DNA encoding the prepro inhibin alpha and beta chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin alpha or beta chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
David B Finkelstein assigned to Board of Regents The University of Texas System A process for producing a yeast capable of heat regulated synthesis of selected and fused proteins
PATENT ABSTRACTS polypeptide or an immunogenically active subsequence thereof or a precursor therefor which is convertible to an immunogenically active form, antibodies against which determinant react with the adhesion polypeptide produced by pathogenic adhesin-forming bacteria which adhere to mammalian tissue, antibodies against such antigen, and DNA expressing, as a principal gene product thereof, such antigen.
is disclosed. The process involves the combination ofa DNA fragment comprising a heat shock inducible gene o f an appropriate yeast microorganism and a second DNA fragment comprising a selected gene with a suitable transfer vector, thereby producing a recombinant transfer vector. A suitable host yeast is contacted with the recombinant transfer vector, cultured and transforments having the desired genetic capability are selected.
4795804 BONE MORPHOGENETIC AGENTS
4798791
Marshall Urist assigned to The Regents of the University of California
VECTOR FOR HIGH LEVEL GENE EXPRESSION
The production and isolation of bone morphogenetic peptide agents displaying the osteoinductire and immunoreactive activity of bone morphogenetic protein (BMP) and deriving from natural, synthetic or recombinant DNA sources, and said agents.
David M Anderson, Jeffrey C McGuire assigned to Genex Corporation
4797279 INSECTICIDAL HYBRID B A C T E R I A F R O M B.T. K U R S T A K I A N D B.T. T E N E B R I O N I S
Methods and vectors for high level expression of genes in bacteria are disclosed. A terminal mRNA sequence from a gene coding for a stable bacterial protein mRNA is ligated to a gene coding for the desired protein adjacent the translation termination codon of the gene. The gene for the desired protein and the terminal mRNA sequence are situated in an expression vector in which the gene is operably linked to a transcription promoter.
Dimitri Karamata, Jean-Christophe Piot, Epalinges, Switzerland assigned to Sandoz Ltd The invention provides hybrid microorganisms comprising the gene coding for b.t. kurstaki delta-endotoxin and the gene coding for b.t. tenebrionis delta-endotoxin, their preparation, insecticidal compositions comprising such microorganisms and their use.
4798885 COMPOSITIONS OF HORMONALLY ACTIVE HUMAN AND PORCINE INHIBIN CONTAINING AN ALPHA CHAIN A N D 62 C H A I N
4797359
Anthony J Mason, Peter H Seeburg assigned to Genentech Inc
HEAT SHOCK REGULATED PRODUCTION OF SELECTED AND FUSED PROTEINS IN YEAST
DNA encoding the prepro inhibin alpha and beta chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin alpha or beta chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
David B Finkelstein assigned to Board of Regents The University of Texas System A process for producing a yeast capable of heat regulated synthesis of selected and fused proteins