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4812397 MAB-anti-DNA related to nephritis
New Patents
iV
Novel compositions and methods are provided for detecting lupus nephritis in patients suffering from SLE. Competitive or non-competitive assays may be employed, where monoconal antibodies may be used to compete with antiserum for a nucleic acid ligand or may be used for the detection of antiidiotype antibodies as diagnostic of the presence or absence of lupus nephritis.
zymatically converted into the corresponding hydantoins. The present invention provides a process for an optical resolution with a high efficiency which can be used for the synthesis of(S)4’-imidazolidine)6-fluoro-Spiro-(chroman-4, 2’,5’-dione (USAN; Sorbinil), which is an optically active hydrantoins attracting public attention as a preventive or a remedy for the particular chronic symptoms of diabetes such as cataract and neuropathy, and (S)- alpha-methyl3,4_dihydroxyphenylalanine (L-methyldopa), which is an optically active amino acid widely used as antihypertensives. Further, the present invention provides a novel finding that Ncarbamoyl- alpha-amino acid having no hydrogen atom on its alpha-carbon atom can be biochemically converted into hydantoins by an enzymatic cyclization reaction.
4812405
4812411
DOUBLE AUXOTROPHIC MUTANTS OF PICHIA PASTORIS AND METHODS FOR PREPARATION
METHOD OF PERFORMING MEDICAL ANALYSES, AND A CONDITIONING STRIP AND APPARATUS FOR PERFORMING THE METHOD
4812397 MAB-ANTI-DNA RELATED NEPHRITIS
TO
Richard H Weisbart assigned to The Regents of the University of California
Stephen V Lair, Mary Digan assigned to Phillips Petroleum Company Processes mutants of Pichia pastoris are provided, as well as novel double auxotrophic strains produced
4812406 PROCESS FOR PREPARING OPTICALLY ACTIVE HYDANTOINS Satomi Takahashi, Yukio Yamada, Yasuyoshi Ueda, Yasuhiro Katayama, Yoshio Shimada, Kiyoshi Watanabe, Kobe, Japan assigned to Kanegafuchi Kagaku Kogyo Kabushiki Kaisha A process for preparing optically active hydantoins having the general formula (II): See Parent fur Chemical Structure (II) wherein Rl and R2, which are different from each other, are independently alkyl group, aralkyl group, aryl group, substituted alkyl group, substituted aralkyl group, or substituted aryl group, or Rl and R2 form an asymmetric cyclic compound, characterized in that one configuration of racemic Ncarbamoyl- alpha-amino acid having the general formula (I): See Patentfor Chemical Structure (I) wherein Rl and R2 are as above, is en-
Jea
75008 Paris, France
The method in accordance with the invention provides antibiograms or bacteriological identification of colonies of micro-organisms. The method uses a cabinet (1) which supports a set of mechanical, thermal, optical, and electronic units, together with conditioning strips in which the various biochemical reactions take place. After being seeded with a micro-organism under investigation, a strip is placed on the cabinet and is then subjected to a sequence of mechanical, thermal, and optical operations.
4812554 SOMATOSTATIN PEPTIDE CONJUGATE Arthur D Riggs assigned to Genentech Inc The specification discloses: 1. Recombinant microbial cloning vehicles comprising heterologous DNA coding for the expression of mammalian hormone (e.g., somatostatin) and other polypeptides, including plasmids suited for the transformation of bacterial hosts. The latter incorporate a regulon homologous to the host in its untransformed state, in reading phase with the structural gene for the heterologous DNA; 2.
iV
Novel compositions and methods are provided for detecting lupus nephritis in patients suffering from SLE. Competitive or non-competitive assays may be employed, where monoconal antibodies may be used to compete with antiserum for a nucleic acid ligand or may be used for the detection of antiidiotype antibodies as diagnostic of the presence or absence of lupus nephritis.
zymatically converted into the corresponding hydantoins. The present invention provides a process for an optical resolution with a high efficiency which can be used for the synthesis of(S)4’-imidazolidine)6-fluoro-Spiro-(chroman-4, 2’,5’-dione (USAN; Sorbinil), which is an optically active hydrantoins attracting public attention as a preventive or a remedy for the particular chronic symptoms of diabetes such as cataract and neuropathy, and (S)- alpha-methyl3,4_dihydroxyphenylalanine (L-methyldopa), which is an optically active amino acid widely used as antihypertensives. Further, the present invention provides a novel finding that Ncarbamoyl- alpha-amino acid having no hydrogen atom on its alpha-carbon atom can be biochemically converted into hydantoins by an enzymatic cyclization reaction.
4812405
4812411
DOUBLE AUXOTROPHIC MUTANTS OF PICHIA PASTORIS AND METHODS FOR PREPARATION
METHOD OF PERFORMING MEDICAL ANALYSES, AND A CONDITIONING STRIP AND APPARATUS FOR PERFORMING THE METHOD
4812397 MAB-ANTI-DNA RELATED NEPHRITIS
TO
Richard H Weisbart assigned to The Regents of the University of California
Stephen V Lair, Mary Digan assigned to Phillips Petroleum Company Processes mutants of Pichia pastoris are provided, as well as novel double auxotrophic strains produced
4812406 PROCESS FOR PREPARING OPTICALLY ACTIVE HYDANTOINS Satomi Takahashi, Yukio Yamada, Yasuyoshi Ueda, Yasuhiro Katayama, Yoshio Shimada, Kiyoshi Watanabe, Kobe, Japan assigned to Kanegafuchi Kagaku Kogyo Kabushiki Kaisha A process for preparing optically active hydantoins having the general formula (II): See Parent fur Chemical Structure (II) wherein Rl and R2, which are different from each other, are independently alkyl group, aralkyl group, aryl group, substituted alkyl group, substituted aralkyl group, or substituted aryl group, or Rl and R2 form an asymmetric cyclic compound, characterized in that one configuration of racemic Ncarbamoyl- alpha-amino acid having the general formula (I): See Patentfor Chemical Structure (I) wherein Rl and R2 are as above, is en-
Jea
75008 Paris, France
The method in accordance with the invention provides antibiograms or bacteriological identification of colonies of micro-organisms. The method uses a cabinet (1) which supports a set of mechanical, thermal, optical, and electronic units, together with conditioning strips in which the various biochemical reactions take place. After being seeded with a micro-organism under investigation, a strip is placed on the cabinet and is then subjected to a sequence of mechanical, thermal, and optical operations.
4812554 SOMATOSTATIN PEPTIDE CONJUGATE Arthur D Riggs assigned to Genentech Inc The specification discloses: 1. Recombinant microbial cloning vehicles comprising heterologous DNA coding for the expression of mammalian hormone (e.g., somatostatin) and other polypeptides, including plasmids suited for the transformation of bacterial hosts. The latter incorporate a regulon homologous to the host in its untransformed state, in reading phase with the structural gene for the heterologous DNA; 2.