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4814375 High strength elastomers for pharmaceutical products
New Patents This invention relates to pharmaceutical compositions for the treatment of arthrosis by intraarticular administration of the compositions diluted in a suitable aqueous or lyophilized carder, comprising an effective amount of diphosphonates and amino acids, specifically aminocarboxylic acids, added thereto as stabilizers. The invention also relates to a therapeutic method for the treatment of arthrosis by intraanicular administration of the compositions into the body of human beings and animals.
4814327 11 B E T A - ( 4 ISOPROPENYLPHENYL)ESTRA4 , 9 - D I E N E S , THEIR
PRODUCTION, AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME Eckhard Ottow, Rudolf Wiechert, Gunter Neef, Sybille Beier, Walter Elger, David Henderson, Berlin, Federal Republic Of Germany assigned to Schering Aktiengesellschaft 11 beta-(4-isopropenylphenyl)-estra-4,9-dienes of general Formula I See Patent for Chemical Structure (I) wherein X is an oxygen atom or a hydroxyimino grouping N OH, R 1 is a hydrogen atom or a methyl group, R2 is a hydrogen atom or an acyl residue of 1-10 carbon atoms, R3 is a hydrogen atom, the cyanomethyl group, (CH2)n-, CH2Z, -CH double bondCH(CH2)mZ or -C triple bondC-Y wherein n = 0 to 5 and m = 1 to 4, Z meaning a hydrogen atom or the OR4 group with R4 meaning a hydrogen atom, an alkyi or aikanoyl group each of 1-4 carbon atoms, and Y meaning a hydrogen, chlorine, fluorine, iodine or bromine atom, an alkyl, hydroxyalkyl, alkoxyalkyl or acyloxyalkyl group each of 1-4 carbon atoms in the alkyl or acyl residue, possess antiprogestational activity.
4814345 I-PHENYL-2AMINOCARBONYLINDOLE COMPOUNDS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Heinrich-Wilhelm Ohlendorf, Wilhelm Kaup-
ix
mann, Ulrich Kuhl, Gerd Buschmann, Stephen J Magda, Garbsen, Federal Republic Of Germany assigned to Kali-Chemie Pharma GmbH Novel l-phenyl-2-aminocarbonylindole compounds are disclosed having the general formula I See Patent for Chemical Structure wherein RI is an aliphatic or aromatic acyl group or an optionally substituted benzyl group; R2 is hydrogen or a lower alkyl radical; R3 is a hydrogen, a halogen, a lower alkyl radical, or a lower alkoxy radical; R4 is hydrogen, a halogen, a lower alkyl radical, or a lower alkoxy radical; R5 has the significance given R3; R6 has the significance given for R4, or R6 is nitro or trifluoromethyl; R7 and R8 each represent hydrogen or a lower alkyl radical, or together with a nitrogen atom form a heterocyclic group; and Z signifies an alkylene chain optionally substituted by hydroxy or acyloxy. The compounds have pharmacological, in particular antiarrhythmic, properties.
4814375 HIGH STRENGTH ELASTOMERS FOR PHARMACEUTICAL PRODUCTS Anthony S Esposito assigned to The West Company A soft, high strength thermoplastic elastomeric composition for use in medical and pharmaceutical products, comprising an ethylene butylene block copolymer having terminal polystyrene units, a platicizer in an amount sufficient to soften the ethylene butylene phase of the copolymer, and a thermoplastic acrylic resin in an amount ranging from 15 to 65 parts per 100 parts of the copolymer.
481~70 TAXOL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Michel Colin, Danie Guenard, Francoise Gueritte-Voegelein, Pierre Potier, Thoiry, France assigned to Rhone-Poulenc Sante Taxol derivatives of formula See Patent for Chemical Structure I in which R represents hydrogen or acetyl, one of R1 or R2 represents
4814327 11 B E T A - ( 4 ISOPROPENYLPHENYL)ESTRA4 , 9 - D I E N E S , THEIR
PRODUCTION, AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME Eckhard Ottow, Rudolf Wiechert, Gunter Neef, Sybille Beier, Walter Elger, David Henderson, Berlin, Federal Republic Of Germany assigned to Schering Aktiengesellschaft 11 beta-(4-isopropenylphenyl)-estra-4,9-dienes of general Formula I See Patent for Chemical Structure (I) wherein X is an oxygen atom or a hydroxyimino grouping N OH, R 1 is a hydrogen atom or a methyl group, R2 is a hydrogen atom or an acyl residue of 1-10 carbon atoms, R3 is a hydrogen atom, the cyanomethyl group, (CH2)n-, CH2Z, -CH double bondCH(CH2)mZ or -C triple bondC-Y wherein n = 0 to 5 and m = 1 to 4, Z meaning a hydrogen atom or the OR4 group with R4 meaning a hydrogen atom, an alkyi or aikanoyl group each of 1-4 carbon atoms, and Y meaning a hydrogen, chlorine, fluorine, iodine or bromine atom, an alkyl, hydroxyalkyl, alkoxyalkyl or acyloxyalkyl group each of 1-4 carbon atoms in the alkyl or acyl residue, possess antiprogestational activity.
4814345 I-PHENYL-2AMINOCARBONYLINDOLE COMPOUNDS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Heinrich-Wilhelm Ohlendorf, Wilhelm Kaup-
ix
mann, Ulrich Kuhl, Gerd Buschmann, Stephen J Magda, Garbsen, Federal Republic Of Germany assigned to Kali-Chemie Pharma GmbH Novel l-phenyl-2-aminocarbonylindole compounds are disclosed having the general formula I See Patent for Chemical Structure wherein RI is an aliphatic or aromatic acyl group or an optionally substituted benzyl group; R2 is hydrogen or a lower alkyl radical; R3 is a hydrogen, a halogen, a lower alkyl radical, or a lower alkoxy radical; R4 is hydrogen, a halogen, a lower alkyl radical, or a lower alkoxy radical; R5 has the significance given R3; R6 has the significance given for R4, or R6 is nitro or trifluoromethyl; R7 and R8 each represent hydrogen or a lower alkyl radical, or together with a nitrogen atom form a heterocyclic group; and Z signifies an alkylene chain optionally substituted by hydroxy or acyloxy. The compounds have pharmacological, in particular antiarrhythmic, properties.
4814375 HIGH STRENGTH ELASTOMERS FOR PHARMACEUTICAL PRODUCTS Anthony S Esposito assigned to The West Company A soft, high strength thermoplastic elastomeric composition for use in medical and pharmaceutical products, comprising an ethylene butylene block copolymer having terminal polystyrene units, a platicizer in an amount sufficient to soften the ethylene butylene phase of the copolymer, and a thermoplastic acrylic resin in an amount ranging from 15 to 65 parts per 100 parts of the copolymer.
481~70 TAXOL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Michel Colin, Danie Guenard, Francoise Gueritte-Voegelein, Pierre Potier, Thoiry, France assigned to Rhone-Poulenc Sante Taxol derivatives of formula See Patent for Chemical Structure I in which R represents hydrogen or acetyl, one of R1 or R2 represents