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4816249 Monoclonal anti-idiotype antibodies
PATENT
4814323
ABSTRACTS
443
4814435
PROCESS FOR THE TREATMENT AND THE PREVENTION OF AIDS AND OTHER DISORDERS INDUCED BY THE LAV/HTLV III VIRUS .IM Andrieu, P Even, Alain Venet, 75007 Paris,
METHOD OF PRODUCING A FACTOR VIII (AHF) CONTAINING FRACTION Otto Schwarz, Yendra Linnau, Vienna, Austria assigned to Immuno Aktiengesellschaft fur chemisch-medizinisch Produkte
France The invention relates to a process for the treatment and the prevention of the acquired immunodeficiency syndrome (AIDS) and AIDS related complex (ARC) induced by the LAV/HTLV III virus in a patient infected with said virus, comprising administering to said patient an effective amount of a compound selected from cyclosporins.
4814433 METHOD FOR OBTAINING A PAPAIN-FREE ANTIBODY FRAGMENT PREPARATION Robert Fredrickson
assigned to Miles Inc
A method for obtaining a papain-free F(ab’)Z antibody fragment preparation derived from papain digested whole IgG antibody employing an antibody to papain for binding to and removing papain-associated digestion products from the preparation. The method is particularly useful for digesting whole IgG antibodies which are otherwise sensitive to pepsin digestion to provide F(ab’)Z antibody fragments from which Fab’ antibody fragments can be obtained having available free sulfhydryl groups in the hinge region.
There is disclosed a method of producing a Factor VIII (AHF) containing fraction having a specific activity of at least 2.5 units of Factor VIII/mg protein as well as a portion of immunoglobulin G (IgG) of 10 mg/lOOO units of Factor VIII at the most. Its risk of transmission of viral or bacterial infections is to be avoided or largely reduced. The method consists in that undesired proteins are at first precipitated from a Factor VIII (AHF) containing plasma fraction in the presence of SPS. The purified Factor VIII containing solution is treated with suitable salts or salt mixtures in order to obtain a Factor VIII containing precipitate. This precipitate is dissolved, lyophilized and finally heat-treated.
4816249 MONOCLONAL ANTI-IDIOTYPE ANTIBODIES Ronald Levy, Jeanette Dilley, David Maloney, Richard A Miller assigned to The Board of Trustees of the Leland Stanford Junior University Monoclonal anti-idiotype antibodies against cell surface Ig of human B-cell tumors, labeled conjugates of such antibodies, immunotherapeutic compositions containing such antibodies, and a process for making such antibodies. The nodular lymphoma of a patient treated with a monoclonal anti-idiotype antibody against the cell surface IgM of the patient’s tumor went into complete remission.
4814434 INDUCER
Marcia F Laboratories
OF T-SUPPRESSOR CELLS
Goldfarb Inc
assigned
to
4816250 PREPARING VACCINE AGAINST HERPES SIMPLEX VIRUS
Ventres
A biologically active composition extracted from thymus tissue, capable of inducing immature bone marrow cells to differentiate into competent suppressor T-cells.
Gordon R B Skinner, Alexander Buchan, Solihull, United Kingdom assigned to University of Birmingham A vaccine against a DNA virus, for exmaple, Herpes simplex virus. is prepared by incubating
4814323
ABSTRACTS
443
4814435
PROCESS FOR THE TREATMENT AND THE PREVENTION OF AIDS AND OTHER DISORDERS INDUCED BY THE LAV/HTLV III VIRUS .IM Andrieu, P Even, Alain Venet, 75007 Paris,
METHOD OF PRODUCING A FACTOR VIII (AHF) CONTAINING FRACTION Otto Schwarz, Yendra Linnau, Vienna, Austria assigned to Immuno Aktiengesellschaft fur chemisch-medizinisch Produkte
France The invention relates to a process for the treatment and the prevention of the acquired immunodeficiency syndrome (AIDS) and AIDS related complex (ARC) induced by the LAV/HTLV III virus in a patient infected with said virus, comprising administering to said patient an effective amount of a compound selected from cyclosporins.
4814433 METHOD FOR OBTAINING A PAPAIN-FREE ANTIBODY FRAGMENT PREPARATION Robert Fredrickson
assigned to Miles Inc
A method for obtaining a papain-free F(ab’)Z antibody fragment preparation derived from papain digested whole IgG antibody employing an antibody to papain for binding to and removing papain-associated digestion products from the preparation. The method is particularly useful for digesting whole IgG antibodies which are otherwise sensitive to pepsin digestion to provide F(ab’)Z antibody fragments from which Fab’ antibody fragments can be obtained having available free sulfhydryl groups in the hinge region.
There is disclosed a method of producing a Factor VIII (AHF) containing fraction having a specific activity of at least 2.5 units of Factor VIII/mg protein as well as a portion of immunoglobulin G (IgG) of 10 mg/lOOO units of Factor VIII at the most. Its risk of transmission of viral or bacterial infections is to be avoided or largely reduced. The method consists in that undesired proteins are at first precipitated from a Factor VIII (AHF) containing plasma fraction in the presence of SPS. The purified Factor VIII containing solution is treated with suitable salts or salt mixtures in order to obtain a Factor VIII containing precipitate. This precipitate is dissolved, lyophilized and finally heat-treated.
4816249 MONOCLONAL ANTI-IDIOTYPE ANTIBODIES Ronald Levy, Jeanette Dilley, David Maloney, Richard A Miller assigned to The Board of Trustees of the Leland Stanford Junior University Monoclonal anti-idiotype antibodies against cell surface Ig of human B-cell tumors, labeled conjugates of such antibodies, immunotherapeutic compositions containing such antibodies, and a process for making such antibodies. The nodular lymphoma of a patient treated with a monoclonal anti-idiotype antibody against the cell surface IgM of the patient’s tumor went into complete remission.
4814434 INDUCER
Marcia F Laboratories
OF T-SUPPRESSOR CELLS
Goldfarb Inc
assigned
to
4816250 PREPARING VACCINE AGAINST HERPES SIMPLEX VIRUS
Ventres
A biologically active composition extracted from thymus tissue, capable of inducing immature bone marrow cells to differentiate into competent suppressor T-cells.
Gordon R B Skinner, Alexander Buchan, Solihull, United Kingdom assigned to University of Birmingham A vaccine against a DNA virus, for exmaple, Herpes simplex virus. is prepared by incubating