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4831157 Preparation of angiotensin-converting enzyme inhibitors
Enzymes
and
Enzyme
4831157
Systems
The concentration of othel" substances can be determined, for example a device with an enzyme's substrate can be used for detecting the concentration of an enzyme.
PREPARATION OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
4855233
Elijah H Gold, Bernard R Neustadt, Elizabeth M Smith assigned to Schering Corporation
PROCESS
Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma. Also disclosed is a novel process for preparing intermediates useful in the preparation of the claimed compounds.
FOR CARRYING
OUT
ENZYMATIC REACTIONS IN AN ORGANIC SOLVENT Christian Gancet, Claude Guignard, Philipp Fourmentraux, Billere, France assigned to Societe Nationale Elf Aquitaine Process for carrying out an enzymatic reaction, in which the substrate treated is in an organic liquid which is a fluorinated hydrocarbon, which can include halogens other than fluorine.
4839000 BUFFER COMPENSATION IN ENZYME-MODIFIED ION SENSITIVE DEVICES
4857454 SPECTROPHOTOMETRIC METHOD FOR KINETIC ABSORBANCE MEASUREMENTS
Mark J Eddowes, Uxbridge, United Kingdom assigned to Thorn EMI plc A system suitable for determining the concentration of an enzyme's substrate in a solution 21 containing a buffer comprises two ion-sensitive devices 22, 23, such as ISFETS, in contact with the solution, one of the devices 23, e.g. an ENFET, having a layer 24 containing an enzyme, the enzyme producing ions from its substrate, and the system comparing the responses of the two devices and providing a control signal to consume ions as they are generated at the ENFET, or to produce an equal concentration of ions at the other device, such that the coocentrations sensed by each are equal. The signal gives an indication of the concentration of the substrate. Other ion-sensitive devices may be used.
IN TWO-PHASE
ENZYME
IMMUNOASSAY A N D APPARATUS
THEREFOR
Lawrence Freundlich, Vadiraja Murthy, Arthur Karmen assigned to Albert Einstein College of Medicine of Yeshiva University a Division of Yeshiva University A method is described for kinetic measurement of enzyme activity bound to a solid matrix which improves both the sensitivity and speed of one immunoassay method. The immunoassay typically consists of reaction of the analyte with two specific antibodies, one fixed to the surface 433
and
Enzyme
4831157
Systems
The concentration of othel" substances can be determined, for example a device with an enzyme's substrate can be used for detecting the concentration of an enzyme.
PREPARATION OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
4855233
Elijah H Gold, Bernard R Neustadt, Elizabeth M Smith assigned to Schering Corporation
PROCESS
Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma. Also disclosed is a novel process for preparing intermediates useful in the preparation of the claimed compounds.
FOR CARRYING
OUT
ENZYMATIC REACTIONS IN AN ORGANIC SOLVENT Christian Gancet, Claude Guignard, Philipp Fourmentraux, Billere, France assigned to Societe Nationale Elf Aquitaine Process for carrying out an enzymatic reaction, in which the substrate treated is in an organic liquid which is a fluorinated hydrocarbon, which can include halogens other than fluorine.
4839000 BUFFER COMPENSATION IN ENZYME-MODIFIED ION SENSITIVE DEVICES
4857454 SPECTROPHOTOMETRIC METHOD FOR KINETIC ABSORBANCE MEASUREMENTS
Mark J Eddowes, Uxbridge, United Kingdom assigned to Thorn EMI plc A system suitable for determining the concentration of an enzyme's substrate in a solution 21 containing a buffer comprises two ion-sensitive devices 22, 23, such as ISFETS, in contact with the solution, one of the devices 23, e.g. an ENFET, having a layer 24 containing an enzyme, the enzyme producing ions from its substrate, and the system comparing the responses of the two devices and providing a control signal to consume ions as they are generated at the ENFET, or to produce an equal concentration of ions at the other device, such that the coocentrations sensed by each are equal. The signal gives an indication of the concentration of the substrate. Other ion-sensitive devices may be used.
IN TWO-PHASE
ENZYME
IMMUNOASSAY A N D APPARATUS
THEREFOR
Lawrence Freundlich, Vadiraja Murthy, Arthur Karmen assigned to Albert Einstein College of Medicine of Yeshiva University a Division of Yeshiva University A method is described for kinetic measurement of enzyme activity bound to a solid matrix which improves both the sensitivity and speed of one immunoassay method. The immunoassay typically consists of reaction of the analyte with two specific antibodies, one fixed to the surface 433