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4845200 Immunoglobulin conjugates
New Patents
4845197 MONOCLONAL ANTIBODIES AND METHODS FOR FUNGAL PATHOGEN DETECTION Frank Petersen, Adrianna M Maybroda, Gary Grothaus, Sally Miller assigned to AgriDiagnostics Associates
xvii
or portion thereof. The method is useful for genes found on minus-strand RNA viral genomes, such as those ofrhabdoviruses or paramyxoviruses. The protein or a portion thereof prepared by expression of the synthetic gene in a suitable host may be used for vaccine or diagnostic purposes.
4847199 This invention provides monoclonal antibodies useful for the detection of Phythiaceae infection of plants. Hybridoma producing the antibodies as well as materials and kits for carrying out the detection of the organisms are also disclosed.
4845200 IMMUNOGLOBULIN CONJUGATES George Cullinan, George Rowland, Robin Simmonds assigned to Lilly Industries Limited A conjugate comprising a vinca moiety convalently linked at the 4-position via a group of the formula -OCOXCO- where X represents a single chemical bond or an optionally substituted CI10 chain, to an immunoglobulin or an immunoglobulin fragment. The conjugates are useful in the treatment of cancer.
4847080 PRE-S GENE CODED PEPTIDE HEPATITIS B IMMUNOGENS, VACCINES, DIAGNOSTICS, AND SYNTHETIC LIPIDE VESICLE CARRIERS Alexander R Neurath, Stephen B Kent assigned to New York Blood Center Inc; California Institute of Technolo
AGGLUTINATION IMMUNOASSAY AND KIT FOR DETERMINATION OF A MULTIVALENT IMMUNE SPECIES USING A BUFFERED SALT WASH SOLUTION Brian Snyder, Robert Belly assigned to Eastman Kodak Company A test kit is used in an agglutination immunoassay to determine a multivalent immune species, such as Streptococcus A antigen, in a biological sample. The method includes contacting an aqueous solution of the species with an agglutination indicator reagent having receptor molecules reactive with the species to form an agglutinate of the reaction product of species and receptor. These receptor molecules are bound to polymeric particles which contain tracer molecules. The resulting agglutinate is captured on a microporous membrane which has an average pore size which is at least five times greater than the average diameter of the polymeric particles. Unagglutinated residual materials are washed through the membrane using a wash solution. This solution has a pH of from about 5 to about 10 and an ionic strength of at least about 0.25. Tracer is then determined either in the agglutinate or in the residual materials, The test kit includes the agglutination indicator reagent, the wash solution, and optionally an extraction composition.
4847244 4847~1 SYNTHETIC BOVINE PARAINFLUENZA VIRAL PROTEINS
TREATMENT OF HUMAN INFECTIONS
VIRAL
Janet L Rideout, David Barry, Sandra N Lehrman, Clair Martha H St, Phillip A Furman assigned to Burroughs Wellcome Co
John M Rice assigned to W R Grace & Co -Conn A method is disclosed for constructing a synthetic gene for the production of a viral protein
Treatments of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the corn-
4845197 MONOCLONAL ANTIBODIES AND METHODS FOR FUNGAL PATHOGEN DETECTION Frank Petersen, Adrianna M Maybroda, Gary Grothaus, Sally Miller assigned to AgriDiagnostics Associates
xvii
or portion thereof. The method is useful for genes found on minus-strand RNA viral genomes, such as those ofrhabdoviruses or paramyxoviruses. The protein or a portion thereof prepared by expression of the synthetic gene in a suitable host may be used for vaccine or diagnostic purposes.
4847199 This invention provides monoclonal antibodies useful for the detection of Phythiaceae infection of plants. Hybridoma producing the antibodies as well as materials and kits for carrying out the detection of the organisms are also disclosed.
4845200 IMMUNOGLOBULIN CONJUGATES George Cullinan, George Rowland, Robin Simmonds assigned to Lilly Industries Limited A conjugate comprising a vinca moiety convalently linked at the 4-position via a group of the formula -OCOXCO- where X represents a single chemical bond or an optionally substituted CI10 chain, to an immunoglobulin or an immunoglobulin fragment. The conjugates are useful in the treatment of cancer.
4847080 PRE-S GENE CODED PEPTIDE HEPATITIS B IMMUNOGENS, VACCINES, DIAGNOSTICS, AND SYNTHETIC LIPIDE VESICLE CARRIERS Alexander R Neurath, Stephen B Kent assigned to New York Blood Center Inc; California Institute of Technolo
AGGLUTINATION IMMUNOASSAY AND KIT FOR DETERMINATION OF A MULTIVALENT IMMUNE SPECIES USING A BUFFERED SALT WASH SOLUTION Brian Snyder, Robert Belly assigned to Eastman Kodak Company A test kit is used in an agglutination immunoassay to determine a multivalent immune species, such as Streptococcus A antigen, in a biological sample. The method includes contacting an aqueous solution of the species with an agglutination indicator reagent having receptor molecules reactive with the species to form an agglutinate of the reaction product of species and receptor. These receptor molecules are bound to polymeric particles which contain tracer molecules. The resulting agglutinate is captured on a microporous membrane which has an average pore size which is at least five times greater than the average diameter of the polymeric particles. Unagglutinated residual materials are washed through the membrane using a wash solution. This solution has a pH of from about 5 to about 10 and an ionic strength of at least about 0.25. Tracer is then determined either in the agglutinate or in the residual materials, The test kit includes the agglutination indicator reagent, the wash solution, and optionally an extraction composition.
4847244 4847~1 SYNTHETIC BOVINE PARAINFLUENZA VIRAL PROTEINS
TREATMENT OF HUMAN INFECTIONS
VIRAL
Janet L Rideout, David Barry, Sandra N Lehrman, Clair Martha H St, Phillip A Furman assigned to Burroughs Wellcome Co
John M Rice assigned to W R Grace & Co -Conn A method is disclosed for constructing a synthetic gene for the production of a viral protein
Treatments of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the corn-